Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

Science

Volumn 298, Issue 5599, 2002, Pages 1785-1788

  Ma, Jiyan ^a,c   Lindquist, Susan ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONFORMATIONS; DISEASES;

CYTOSOL;

PROTEINS;

ISOPROTEIN; PRION PROTEIN; PRION PROTEIN SC; UNCLASSIFIED DRUG;

DISEASE; PROTEIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; DISEASE TRANSMISSION; ENDOPLASMIC RETICULUM; INFECTION; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RETROGRADE NERVE FIBER TRANSPORT;

ACETYLCYSTEINE; ANIMALS; COS CELLS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOSOL; ENDOPEPTIDASE K; ENDOPLASMIC RETICULUM; LEUPEPTINS; MICE; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; NEURONS; OLIGOPEPTIDES; PRIONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TRANSPORT; PRPSC PROTEINS; SOLUBILITY; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA;

EID: 0037195617     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1073619     Document Type: Article

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