Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 10, 2005, Pages 3777-3781

  Agrawal, Namita ^a   Pallos, Judit ^a   Slepko, Natalia ^b   Apostol, Barbara L ^b   Bodai, Laszlo ^a,d   Chang, Ling Wen ^c   Chiang, Ann Shyn ^c   Thompson, Leslie Michels ^b   Marsh, J Lawrence ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Combinatorial treatments; Neurodegeneration

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CONGO RED; CYSTAMINE; GELDANAMYCIN; HUNTINGTIN; VORINOSTAT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DROSOPHILA; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; HUNTINGTON CHOREA; MALE; NERVE CELL DEGENERATION; NONHUMAN; PHOTORECEPTOR; PRACTICE GUIDELINE; PRIORITY JOURNAL;

AMIDES; ANIMALS; BENZOQUINONES; DISEASE MODELS, ANIMAL; DROSOPHILA; DRUG THERAPY, COMBINATION; FEMALE; HUNTINGTON DISEASE; HYDROXAMIC ACIDS; LACTAMS, MACROCYCLIC; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PYRIDINES; QUINONES;

MAMMALIA;

EID: 14844341251     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500055102     Document Type: Article

References (36)

1. The Huntington's Disease Collaborative Research Group (1993) Cell 72, 971-983.
2. Zoghbi, H. Y. & Orr, H. T. (2000) Annu. Rev. Neurosci. 23, 217-247.
3. Ross, C. A. (2002) Neuron 35, 819-822.
4. Bates, G., Harper, P. & Jones, L. (2002) Huntington's Disease (Oxford Univ. Press, Oxford).
5. Marsh, J. L. & Thompson, L. M. (2004) BioEssays 26, 485-496.
6. Torrance, C. J., Jackson, P. E., Montgomery, E., Kinzler, K. W., Vogelstein, B., Wissner, A., Nunes, M., Frost, P. & Discafani, C. M. (2000) Nat. Med. 6, 1024-1028.
7. Slack, J. L. (1999) Curr. Opin. Hematol. 6, 236-240.
8. Johnson, S. C. & Gerber, J. G. (2000) Adv. Intern. Med. 45, 1-40.
9. Zhang, W., Narayanan, M. & Friedlander, R. M. (2003) Ann. Neurol. 53, 267-270.
10. Ikezoe, T., Hisatake, Y., Takeuchi, T., Ohtsuki, Y., Yang, Y., Said, J. W., Taguchi, H. & Koeffler, H. P. (2004) Cancer Res. 64, 7426-7431.
11. Marsh, J. L., Pallos, J. & Thompson, L. M. (2003) Hum. Mol. Genet. 2, R187-R193.
12. Bonini, N. M. & Fortini, M. E. (2003) Annu. Rev. Neurosci. 26, 627-656.
13. Ganetzky, B. & Flanagan, J. R. (1978) Exp. Gerontol. 13, 189-196.
14. Truman, J. W., Taylor, B. J. & Awad, T. A. (1993) in The Development of Drosophila melanogaster, ed. Bate, M. & Martinez Arias, A. (Cold Spring Harbor Lab. Press, Plainview, NY), Vol. 2, p. 746.
15. Franceschini, N. (1972) in Information Processing in the Visual Systems of Arthropods, ed. Wehner, R. (Springer, Berlin), pp. 75-82.
16. Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y. Z., Greenwald, M., et al. (2001) Nature 413, 739-743.
17. Heisenberg, M. (2003) Nat. Rev. Neurosci. 4, 266-275.
18. Heisenberg, M. (1998) Learn. Mem. 5, 1-10.
19. de Belle, J. S. & Heisenberg, M. (1994) Science 263, 692-695.
20. Heisenberg, M., Borst, A., Wagner, S. & Byers, D. (1985) J. Neurogenet. 2, 1-30.
21. Connolly, J. B., Roberts, I. J., Armstrong, J. D., Kaiser, K., Forte, M., Tully, T. & O'Kane, C. J. (1996) Science 274, 2104-2107.
22. Apostol, B. L., Kazantsev, A., Raffioni, S., Illes, K., Pallos, J., Bodai, L., Slepko, N., Bear, J. E., Gertler, F. B., Hersch, S., et al. (2003) Proc. Natl. Acad. Sci. USA 100, 5950-5955.
23. Hockly, E., Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi-Noori, S., Mahal, A., Lowden, P. A., et al. (2003) Proc. Natl. Acad. Sci. USA 100, 2041-2046.
24. Ferrante, R. J., Kubilus, J. K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, N. W., Ratan, R. R., Luthi-Carter, R. & Hersch, S. M. (2003) J. Neurosci. 23, 9438-9427.
25. Pollitt, S., Pallos, J., Shao, J., Ma, A., Thompson, L., Marsh, J. & Diamond, M. (2003) Neuron 40, 685-694.
26. Sittler, A., Lurz, R., Lueder, G., Priller, J., Lehrach, H., Hayer-Hartl, M. K., Hartl, F. U. & Wanker, E. E. (2001) Hum. Mol. Genet. 10, 1307-1315.
27. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E. & Neckers, L. M. (1994) Proc. Natl. Acad. Sci. USA 91, 8324-8328.
28. Auluck, P. K. & Bonini, N. M. (2002) Nat. Med. 8, 1185-1186.
29. Klunk, W. E., Debnath, M. L., Koros, A. M. & Pettegrew, J. W. (1998) Life Sci. 63, 1807-1814.
30. Carter, D. B. & Chou, K. C. (1998) Neurobiol. Aging 19, 37-40.
31. Heiser, V., Scherzinger, E., Boeddrich, A., Nordhoff, E., Lurz, R., Schugardt, N., Lehrach, H. & Wanker, E. E. (2000) Proc. Natl. Acad. Sci. USA 97, 6739-6744.
32. Karpuj, M. V., Becher, M. W., Springer, J. E., Chabas, D., Youssef, S., Pedotti, R., Mitchell, D. & Steinman, L. (2002) Nat. Med. 8, 143-149.
33. Dedeoglu, A., Kubilus, J. K., Jeitner, T. M., Matson, S. A., Bogdanov, M., Kowall, N. W., Matson, W. R., Cooper, A. J., Ratan, R. R., Beal, M. F., et al. (2002) J. Neurosci. 22, 8942-8950.
34. Lesort, M., Chun, W., Tucholski, J. & Johnson, G. V. (2002) Neurochem. Int. 40, 37-52.
35. Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J. & Rubinsztein, D. C. (2004) Nat. Genet. 36, 585-595.
36. Ferrante, R. J., Ryu, H., Kubilus, J. K., D'Mello, S., Sugars, K. L., Lee, J., Lu, P., Smith, K., Browne, S., Beal, M. F., et al. (2004) J. Neurosci. 24, 10335-10342.