Identification of the region of non-Aβ component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity

Journal of Neurochemistry

Volumn 78, Issue 2, 2001, Pages 384-395

  Bodles, Angela M ^a   Guthrie, David J S ^a   Greer, Brett ^a   Brent Irvine, G ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

synuclein; MTT; NAC; Neurotoxicity; Parkinson's disease

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETONITRILE; ALPHA SYNUCLEIN; AMYLOID; AMYLOID A PROTEIN; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT;

ACETONITRILES; ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID; ANIMALS; CELL SURVIVAL; CIRCULAR DICHROISM; EXOCYTOSIS; HUMANS; MICROFIBRILS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PC12 CELLS; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PROTEIN CONFORMATION; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SYNUCLEINS;

ANIMALIA;

EID: 0034922671     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00408.x     Document Type: Article

References (42)

1. α-synuclein-positive structures in cases with sporadic Alzheimer's disease: Morphology and its relationship to tau aggregation
2. Alpha-synuclein accumulates in Lewy bodies in Parknison's disease and dementia with Lewy bodies but in Alzheimer's disease beta-amyloid plaque cores
3. Parkinson's disease-associated α-synuclein is more fibrillogenic than β- and γ-synuclein and cannot cross-seed its homologs
4. Toxicity of non-Aβ component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of β-sheet structure and fibrils
5. Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects
6. Conformations of synthetic β-peptides in solid state and in aqueous solution: Relation to toxicity in PC12 cells
7. Media from Rhabdomyosarcoma and neuroblastoma cell cultures stimulate in vitro aggregation and fibrillization of amyloid beta-protein
8. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson's disease
9. Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited. NAC and α-synuclein are not associated with Aβ amyloid
10. The N-terminal region of non-Aβ component of Alzheimer's disease amyloid is responsible for its tendency to assume β-sheet and aggregate to form fibrils
11. Aggregates from mutant and wild type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like fibrils
12. Review: Formation and properties of amyloid-like fibrils derived from α-synuclein and related proteins
13. Comparative analysis of human and Dutch-type Alzheimer β-amyloid peptides by infrared spectroscopy and circular dichroism
14. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
15. Alzheimer's disease: Initial report of the purification and characterisation of a novel cerebrovascular amyloid protein
16. The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: Is NAC a common trigger or target in neurodegenerative disease?
17. Assembly of Aβ amyloid protofibrils: And in vitro model for a possible early event in Alzheimer's disease
18. Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease
19. Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic
20. Binding of Aβ to α- and β-synucleins: Identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC
21. Alpha-synuclein binds to tau and stimulates the protein kinase A-catalysed tau phosphorylation of serine residues 262 and 356
22. A cell-based method for detection of nanomolar concentrations of bioactive amyloid
23. β-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
24. Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease
25. Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
26. Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration
27. Structure-activity analyses of β-amyloid peptides: Contributions of the β25-35 region to aggregation and neurotoxicity
28. Fiber diffraction of synthetic α-synuclein filaments show amyloid-like cross-beta conformation
29. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death
30. The intracellular component of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by β-amyloid peptides
31. Secondary structure of amyloid β-peptide correlates with neurotoxic activity in vitro
32. Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation
33. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
34. Controlling amyloid beta-peptide fibril formation with protease-stable ligands
35. Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies
36. Molecular cloning of cDNA encoding an unrecognised component of amyloid in Alzheimer's disease
37. Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-Aβ component of Alzheimer's disease amyloid
38. Amyloid β-protein fibrillogenesis: Structure and biological activity of protofibrillar intermediates
39. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
40. Lewy body variant of Alzheimer's disease: Alpha-synuclein in dystrophic neurites of A beta plaques
41. Neurotrophic and neurotoxic effects of amyloid β-protein - Reversal by tachykinin neuropeptides
42. NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, binds Aβ and stimulates Aβ aggregation