Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

Human Molecular Genetics

Volumn 10, Issue 19, 2001, Pages 2109-2121

  Mazarakis, Nicholas D ^a   Azzouz, Mimoun ^a   Rohll, Jonathan B ^a   Ellard, Fiona M ^a   Wilkes, Fraser J ^a   Olsen, Anna L ^a   Carter, Emma E ^a   Barber, Robert D ^a   Baban, Dilair F ^a   Kingsman, Susan M ^a   Kingsman, Alan J ^a   O'Malley, Karen ^b   Mitrophanous, Kyriacos A ^a  

^a OXFORD BIOMEDICA UK LTD   (United Kingdom)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS GLYCOPROTEIN; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; EQUINE INFECTIOUS ANEMIA VIRUS; GASTROCNEMIUS MUSCLE; GENE TARGETING; GENE THERAPY; GENETIC CODE; GENETIC TRANSDUCTION; HIPPOCAMPUS; IMMUNE RESPONSE; INJECTION; LENTIVIRINAE; LUMBAR SPINAL CORD; MARKER GENE; MOTONEURON; MUSCLE CELL; NERVOUS SYSTEM; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RABIES VIRUS; RAT; RETROGRADE NERVE FIBER TRANSPORT; SPINAL CORD; SUBSTANTIA NIGRA; VESICULAR STOMATITIS VIRUS; VIRUS ENVELOPE;

ANIMALIA; EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS; LENTIVIRUS; RABIES VIRUS; RNA VIRUSES; VESICULAR STOMATITIS VIRUS;

EID: 0034781791     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.19.2109     Document Type: Article

References (74)

1. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
2. Stable gene transfer to the nervous system using a non-primate lentiviral vector
3. Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors
4. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
5. High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells
6. Production and concentration of pseudotyped HIV-1-based gene transfer vectors
7. Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1
8. Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo
9. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
10. CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses
11. Specific patterns of defective HSV-1 gene transfer in the adult central nervous system: Implications for gene targeting
12. Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo
13. Retrograde transport of intact poliovirus through the axon via the fast transport system
14. Neuron to neuron transmission of herpes simplex virus. Transport of virus from skin to brainstem nuclei
15. The pathogenesis of rabies and other lyssaviral infections: Recent studies
16. Retrograde axonal transport
17. Tetanus toxin: Direct evidence for retrograde intraaxonal transport
18. The mechanisms of fast and slow transport in neurons: Identification and characterization of the new kinesin superfamily motors
19. A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons
20. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus
21. Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies
22. Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor
23. Adenovirus-mediated transfer of the neurotrophin-3 gene into skeletal muscle of pmn mice: Therapeutic effects and mechanisms of action
24. Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system
25. IAP family proteins delay motoneuron cell death in vivo
26. Gene delivery to spinal motor neurons
27. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
28. Recent biochemical studies of the dopamine transporter-a CNS drug target
29. Neurotransmitters in the basal ganglia
30. Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors
31. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique
32. Afferents to the hippocampus of the rat studied with the method of retrograde transport of horseradish peroxidase
33. Development and survival of rat embryonic mesencephalic dopaminergic neurones in serum-free, antioxidant-rich primary cultures
34. Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors
35. Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease
36. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2
37. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
38. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
39. Expression of a functional foreign gene in adult mammalian brain following in vivo transfer via a herpes simplex virus type 1 defective viral vector
40. Expression of the lacZ reporter gene in the rat basal forebrain, hippocampus, and nigrostriatal pathway using a nonreplicating herpes simplex vector
41. Characterization of promoter function and cell-type-specific expression from viral vectors in the nervous system
42. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector
43. Evidence for an intraaxonal transport of fixed and street rabies virus
44. Characterization of saturable binding sites for rabies virus
45. The earliest events in vesicular stomatitis virus infection of the murine olfactory neuroepithelium and entry of the central nervous system
46. Experimental rabies in skunks: Immunofluorescence light and electron microscopic studies
47. Axonal transport of rabies virus in the central nervous system of the rat
48. Inhibition of the transport of rabies virus in the central nervous system
49. Spread and pathogenic characteristics of a G-deficient rabies virus recombinant: An in vitro and in vivo study
50. Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus
51. The neural cell adhesion molecule is a receptor for rabies virus
52. Rabies virus binding to an acetylcholine receptor α-subunit peptide
53. Evidence from the anti-idiotypic network that the acetylcholine receptor is a rabies virus receptor
54. Rabies virus binding to the nicotinic acetylcholine receptor α subunit demonstrated by virus overlay protein binding assay
55. Inhibition of VSV binding and infectivity by phosphatidylserine: Is phosphatidylserine a VSV-binding site?
56. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons
57. Experimental rabies virus infection of p75 neurotrophin receptor-deficient mice
58. Retrograde axonal transport of herpes simplex virus: Evidence for a single mechanism and a role for tegument
59. Adenovirus gene transfer causes inflammation in the brain
60. Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain
61. Potential and limitations of a γ 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS
62. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
63. Characterization of infectious molecular clones of equine infectious anaemia virus
64. The design, production, safety, evaluation and clinical applications of non-primate lentiviral vectors
65. A Rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimised HIV-1 gag-pol gene
66. Staging and dissection of rat embryos
67. κ-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons
68. Estimation of nuclear populations from microtome sections
69. Organization of the basal ganglia: The importance of axonal collateralization
70. Axonal arborizations of a magnocellular basal nucleus input and their relation to the neurons in the thalamic reticular nucleus of rats
71. The topical organization of the afferents to the caudatoputamen of the rat. A horseradish peroxidase study
72. Anatomical organization of the parahippocampal-hippocampal network
73. The basic, somatic and emotional components of the motor system in mammals
74. Neural networks that co-ordinate locomotion and body orientation in lamprey