RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 16, 2005, Pages 5820-5825

  Harper, Scott Q ^a,b   Staber, Patrick D ^a,b   He, Xiaohua ^a,b   Eliason, Steven L ^a,b   Martins, Inês H ^a,b   Mao, Qinwen ^a,b   Yang, Linda ^c   Kotin, Robert M ^c   Paulson, Henry L ^a,b   Davidson, Beverly L ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Gene therapy; Nanomedicine; Short hairpin RNAs; Triplet repeat diseases

Indexed keywords

HUNTINGTIN; MESSENGER RNA; POLYGLUTAMINE; SHORT HAIRPIN RNA; UBIQUINONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CODON; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE SILENCING; GENE THERAPY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MOTOR DYSFUNCTION; MOUSE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; HUNTINGTON DISEASE; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RNA INTERFERENCE;

EID: 20244378556     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501507102     Document Type: Article

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