메뉴 건너뛰기




Volumn 32, Issue 3, 2012, Pages 319-336

Current therapeutic strategies to mitigate the eNOS dysfunction in ischaemic stroke

Author keywords

eNOS; Ischaemia; NO; Oxidative stress; Therapeutic strategies

Indexed keywords

ACETYLSALICYLIC ACID; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; BENIDIPINE; CALCIUM CHANNEL BLOCKING AGENT; CILOSTAZOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRIDAMOLE; DIURETIC AGENT; ELLAGIC ACID; ENALAPRIL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LISINOPRIL; MANIDIPINE; NIFEDIPINE; NITRIC OXIDE DONOR; PHOSPHODIESTERASE III INHIBITOR; PIOGLITAZONE; RAMIPRIL; RESVERATROL; S NITROSOGLUTATHIONE; SILDENAFIL; SIMVASTATIN; TELMISARTAN; TETRAHYDROBIOPTERIN; TRANDOLAPRIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZJM 289;

EID: 84859921204     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9777-z     Document Type: Review
Times cited : (47)

References (203)
  • 1
    • 0037335810 scopus 로고    scopus 로고
    • Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: In vitro and in vivo/ex vivo studies
    • DOI 10.1161/01.STR.0000056527.34434.59
    • Aktas B, Utz A, Hoenig-Liedl P, Walter U, Geiger J (2003) Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke 34:764-769 (Pubitemid 36307408)
    • (2003) Stroke , vol.34 , Issue.3 , pp. 764-769
    • Aktas, B.1    Utz, A.2    Hoenig-Liedl, P.3    Walter, U.4    Geiger, J.5
  • 2
    • 42449124177 scopus 로고    scopus 로고
    • Risk factors for ischaemic stroke
    • DOI 10.1111/j.1747-4949.2008.00187.x
    • Allen C, Bayraktutan U (2008) Risk factors for ischaemic stroke. Int J Stroke 3:105-116 (Pubitemid 351566844)
    • (2008) International Journal of Stroke , vol.3 , Issue.2 , pp. 105-116
    • Allen, C.L.1    Bayraktutan, U.2
  • 3
    • 77449152992 scopus 로고    scopus 로고
    • Oxidative stress and its role in the pathogenesis of ischaemic stroke
    • Allen C, Bayraktutan U (2009) Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int J Stroke 4:461-470
    • (2009) Int J Stroke , vol.4 , pp. 461-470
    • Allen, C.1    Bayraktutan, U.2
  • 4
    • 0035073930 scopus 로고    scopus 로고
    • Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice
    • Amin-Hanjani S, Stagliano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA (2001) Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32:980-986
    • (2001) Stroke , vol.32 , pp. 980-986
    • Amin-Hanjani, S.1    Stagliano, N.E.2    Yamada, M.3    Huang, P.L.4    Liao, J.K.5    Moskowitz, M.A.6
  • 5
    • 0033567065 scopus 로고    scopus 로고
    • Enzymatic function of nitric oxide synthases
    • DOI 10.1016/S0008-6363(99)00115-7, PII S0008636399001157
    • Andrew PJ, Mayer B (1999) Enzymatic function of nitric oxide synthases. Cardiovasc Res 43:521-531 (Pubitemid 29369251)
    • (1999) Cardiovascular Research , vol.43 , Issue.3 , pp. 521-531
    • Andrew, P.J.1    Mayer, B.2
  • 6
    • 80052337287 scopus 로고    scopus 로고
    • Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells
    • Epub ahead of print
    • Aoki C, Nakano A, Tanaka S, Yanagi K, Ohta S, Jojima T, Kasai K, Takekawa H, Hirata K, Hattori Y (2010) Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells. Int J Cardiol [Epub ahead of print]
    • (2010) Int J Cardiol
    • Aoki, C.1    Nakano, A.2    Tanaka, S.3    Yanagi, K.4    Ohta, S.5    Jojima, T.6    Kasai, K.7    Takekawa, H.8    Hirata, K.9    Hattori, Y.10
  • 7
    • 33751208892 scopus 로고    scopus 로고
    • Astrocytic-inducible nitric oxide synthase in the ischemic developing human brain
    • DOI 10.1203/01.pdr.0000246226.89215.a6, PII 0000645020061200000007
    • Askalan R, Deveber G, Ho M, Ma J, Hawkins C (2006) Astrocytic-inducible nitric oxide synthase in the ischemic developing human brain. Pediatr Res 60:687-692 (Pubitemid 44789510)
    • (2006) Pediatric Research , vol.60 , Issue.6 , pp. 687-692
    • Askalan, R.1    Deveber, G.2    Ho, M.3    Ma, J.4    Hawkins, C.5
  • 8
    • 0034646421 scopus 로고    scopus 로고
    • Aspirin
    • Awtry EH, Loscalzo J (2000) Aspirin. Circulation 101:1206-1218 (Pubitemid 30146625)
    • (2000) Circulation , vol.101 , Issue.10 , pp. 1206-1218
    • Awtry, E.H.1    Loscalzo, J.2
  • 9
    • 72949090178 scopus 로고    scopus 로고
    • Systematic review: Comparative effectiveness of angiotensin-converting enzyme inhibitors or angiotensin II-receptor blockers for ischemic heart disease
    • Baker WL, Coleman CI, Kluger J, Reinhart KM, Talati R, Quercia R, Phung OJ, White CM (2009) Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors or angiotensin II-receptor blockers for ischemic heart disease. Ann Intern Med 151:861-871
    • (2009) Ann Intern Med , vol.151 , pp. 861-871
    • Baker, W.L.1    Coleman, C.I.2    Kluger, J.3    Reinhart, K.M.4    Talati, R.5    Quercia, R.6    Phung, O.J.7    White, C.M.8
  • 10
    • 13744259397 scopus 로고    scopus 로고
    • Association between hormone replacement therapy and subsequent stroke: A meta-analysis
    • Bath PM, Gray LJ (2005) Association between hormone replacement therapy and subsequent stroke: a meta-analysis. BMJ 330:342
    • (2005) BMJ , vol.330 , pp. 342
    • Bath, P.M.1    Gray, L.J.2
  • 11
    • 70350561899 scopus 로고    scopus 로고
    • Effect of telmisartan on functional outcome, recurrence, and BP in patients with acute mild ischemic stroke: A PRoFESS subgroup analysis
    • for the PRoFESS Study Group
    • Bath PM, Martin RH, Palesch Y, Cotton D, Yusuf S, Sacco R, Diener HC, Toni D, Estol C, Roberts R, for the PRoFESS Study Group (2009) Effect of telmisartan on functional outcome, recurrence, and BP in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis. Stroke 40:3541-3546
    • (2009) Stroke , vol.40 , pp. 3541-3546
    • Bath, P.M.1    Martin, R.H.2    Palesch, Y.3    Cotton, D.4    Yusuf, S.5    Sacco, R.6    Diener, H.C.7    Toni, D.8    Estol, C.9    Roberts, R.10
  • 13
    • 0025854274 scopus 로고
    • The double-edged role of nitric oxide in brain function and superoxide-mediated injury
    • Beckman JS (1991) The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J Dev Physiol 15:53-59
    • (1991) J Dev Physiol , vol.15 , pp. 53-59
    • Beckman, J.S.1
  • 14
    • 0037155132 scopus 로고    scopus 로고
    • Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells
    • DOI 10.1074/jbc.M110508200
    • Begum N, Sandu OA, Ito M, Lohmann SM, Smolenski A (2002) Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J Biol Chem 277:6214-6222 (Pubitemid 34968412)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.8 , pp. 6214-6222
    • Begum, N.1    Sandu, O.A.2    Ito, M.3    Lohmann, S.M.4    Smolenski, A.5
  • 17
    • 0343060358 scopus 로고    scopus 로고
    • Roles of nitric oxide in brain hypoxia-ischemia
    • DOI 10.1016/S0005-2728(99)00030-4, PII S0005272899000304
    • Bolaños JP, Almeida A (1999) Roles of nitric oxide in brain hypoxia-ischemia. Biochim Biophys Acta 1411:415-436 (Pubitemid 29221965)
    • (1999) Biochimica et Biophysica Acta - Bioenergetics , vol.1411 , Issue.2-3 , pp. 415-436
    • Bolanos, J.P.1    Almeida, A.2
  • 19
    • 0031922540 scopus 로고    scopus 로고
    • Pathophysiological assessment of nitric oxide (given as sodium nitroprusside) in acute ischaemic stroke
    • DOI 10.1159/000015842
    • Butterworth RJ, Cluckie A, Jackson SH, Buxton-Thomas M, Bath PM (1998) Pathophysiological assessment of nitric oxide (given as sodium nitroprusside) in acute ischaemic stroke. Cerebrovasc Dis 8:158-165 (Pubitemid 28192817)
    • (1998) Cerebrovascular Diseases , vol.8 , Issue.3 , pp. 158-165
    • Butterworth, R.J.1    Cluckie, A.2    Jackson, S.H.D.3    Buxton-Thomas, M.4    Bath, P.M.W.5
  • 20
    • 47149112183 scopus 로고    scopus 로고
    • Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage
    • Cai W, Zhu Y, Furuya K, Li Z, Sokabe M, Chen L (2008) Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacology 55:127-138
    • (2008) Neuropharmacology , vol.55 , pp. 127-138
    • Cai, W.1    Zhu, Y.2    Furuya, K.3    Li, Z.4    Sokabe, M.5    Chen, L.6
  • 23
    • 0037468581 scopus 로고    scopus 로고
    • Neuroprotective effects of aspirin in patients with acute cerebral infarction
    • DOI 10.1016/S0304-3940(03)00029-6
    • Castillo J, Leira R, Moro MA, Lizasoain I, Serena J, Dávalos A (2003) Neuroprotective effects of aspirin in patients with acute cerebral infarction. Neurosci Lett 339:248-250 (Pubitemid 36299011)
    • (2003) Neuroscience Letters , vol.339 , Issue.3 , pp. 248-250
    • Castillo, J.1    Leira, R.2    Moro, M.A.3    Lizasoain, I.4    Serena, J.5    Davalos, A.6
  • 24
    • 0035942232 scopus 로고    scopus 로고
    • Oxidized LDL inhibits vascular endothelial growth factor - Induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway
    • Chavakis E, Dernbach E, Hermann C, Mondorf U, Zeiher A, Dimmeler S (2001) Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway. Circulation 103:2102-2107 (Pubitemid 32373015)
    • (2001) Circulation , vol.103 , Issue.16 , pp. 2102-2107
    • Chavakis, E.1    Dernbach, E.2    Hermann, C.3    Mondorf, U.F.4    Zeiher, A.M.5    Dimmeler, S.6
  • 25
    • 77954522739 scopus 로고    scopus 로고
    • Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation
    • Chen XN, Xu J, Feng Z, Fan M, Han JY, Yang Z (2010) Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation. Acta Pharmacol Sin 31:813-820
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 813-820
    • Chen, X.N.1    Xu, J.2    Feng, Z.3    Fan, M.4    Han, J.Y.5    Yang, Z.6
  • 26
    • 26444561886 scopus 로고    scopus 로고
    • Neuroprotective effect of simvastatin in stroke: A comparison between adult and neonatal rat models of cerebral ischemia
    • DOI 10.1016/j.neuro.2005.03.009, PII S0161813X05000471, First International Porto Pirgos Conference on Advances in Neuroscience
    • Cimino M, Balduini W, Carloni S, Gelosa P, Guerrini U, Tremoli E, Sironi L (2005) Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia. Neurotoxicology 26:929-933 (Pubitemid 41427533)
    • (2005) NeuroToxicology , vol.26 , Issue.5 , pp. 929-933
    • Cimino, M.1    Balduini, W.2    Carloni, S.3    Gelosa, P.4    Guerrini, U.5    Tremoli, E.6    Sironi, L.7
  • 27
  • 29
    • 77954347313 scopus 로고    scopus 로고
    • Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx
    • Datar R, Kaesemeyer WH, Chandra S, Fulton DJ, Caldwell RW (2010) Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx. Br J Pharmacol 160:1765-1772
    • (2010) Br J Pharmacol , vol.160 , pp. 1765-1772
    • Datar, R.1    Kaesemeyer, W.H.2    Chandra, S.3    Fulton, D.J.4    Caldwell, R.W.5
  • 30
    • 0036141158 scopus 로고    scopus 로고
    • Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation
    • DOI 10.1161/hs0102.101299
    • De Cristóbal J, Cárdenas A, Lizasoain I, Leza JC, Fernández-Tomé P, Lorenzo P, Moro MA (2002) Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation. Stroke 33:261-267 (Pubitemid 34052222)
    • (2002) Stroke , vol.33 , Issue.1 , pp. 261-267
    • De Cristobal, J.1    Cardenas, A.2    Lizasoain, I.3    Leza, J.C.4    Fernandez-Tome, P.5    Lorenzo, P.6    Moro, M.A.7
  • 31
    • 0033979993 scopus 로고    scopus 로고
    • Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
    • del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10:95-112 (Pubitemid 30056398)
    • (2000) Brain Pathology , vol.10 , Issue.1 , pp. 95-112
    • Del, Z.G.1    Ginis, I.2    Hallenbeck, J.M.3    Iadecola, C.4    Wang, X.5    Feuerstein, G.Z.6
  • 32
    • 27944446934 scopus 로고    scopus 로고
    • Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects
    • Demirci B, McKeown PP, Bayraktutan U (2005) Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its BP-lowering effects. J Hypertens 23:2219-2227 (Pubitemid 41666752)
    • (2005) Journal of Hypertension , vol.23 , Issue.12 , pp. 2219-2227
    • Demirci, B.1    McKeown, P.P.2    Bayraktutan, U.3
  • 33
    • 0032885807 scopus 로고    scopus 로고
    • Dual mode of action of dihydropyridine calcium antagonists. A role for nitric oxide
    • DOI 10.2165/00003495-199958030-00002
    • Dhein S, Salameh A, Berkels R, Klaus W (1999) Dual mode of action of dihydropyridine calcium antagonists: a role for nitric oxide. Drugs 58:397-404 (Pubitemid 29427851)
    • (1999) Drugs , vol.58 , Issue.3 , pp. 397-404
    • Dhein, S.1    Salameh, A.2    Berkels, R.3    Klaus, W.4
  • 34
    • 77955515557 scopus 로고    scopus 로고
    • Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions
    • Die J, Wang K, Fan L, Jiang Y, Shi Z (2010) Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions. Brain Res 1346:251-261
    • (2010) Brain Res , vol.1346 , pp. 251-261
    • Die, J.1    Wang, K.2    Fan, L.3    Jiang, Y.4    Shi, Z.5
  • 35
    • 0030297319 scopus 로고    scopus 로고
    • European stroke prevention study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke
    • DOI 10.1016/S0022-510X(96)00308-5, PII S0022510X96003085
    • Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A (1996) European stroke prevention study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143:1-13 (Pubitemid 26402780)
    • (1996) Journal of the Neurological Sciences , vol.143 , Issue.1-2 , pp. 1-13
    • Diener, H.C.1    Cunha, L.2    Forbes, C.3    Sivenius, J.4    Smets, P.5    Lowenthal, A.6
  • 36
    • 3242770664 scopus 로고    scopus 로고
    • Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): Randomised, double-blind, placebo-controlled trial
    • MATCH investigators
    • Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ, MATCH investigators (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364:331-337
    • (2004) Lancet , vol.364 , pp. 331-337
    • Diener, H.C.1    Bogousslavsky, J.2    Brass, L.M.3    Cimminiello, C.4    Csiba, L.5    Kaste, M.6    Leys, D.7    Matias-Guiu, J.8    Rupprecht, H.J.9
  • 37
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 38
    • 0031724864 scopus 로고    scopus 로고
    • Calcium channel blockade enhances nitric oxide synthase expression by cultured endothelial cells
    • Ding Y, Vaziri ND (1998) Calcium channel blockade enhances nitric oxide synthase expression by cultured endothelial cells. Hypertension 32:718-723 (Pubitemid 28480550)
    • (1998) Hypertension , vol.32 , Issue.4 , pp. 718-723
    • Ding, Y.1    Vaziri, N.D.2
  • 39
    • 81855173610 scopus 로고    scopus 로고
    • Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating amp-activated protein kinase
    • Dong Q, Yang Y, Song L, Qian H, Xu Z (2010) Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating amp-activated protein kinase. Int J Cardiol 153:311-316
    • (2010) Int J Cardiol , vol.153 , pp. 311-316
    • Dong, Q.1    Yang, Y.2    Song, L.3    Qian, H.4    Xu, Z.5
  • 41
    • 0031035036 scopus 로고    scopus 로고
    • Oxidative stress during post-hypoxic-ischemic reperfusion in the newborn lamb: The effect of nitric oxide synthesis inhibition
    • Dorrepaal CA, van Bel F, Moison RM, Shadid M, van de Bor M, Steendijk P, Berger HM (1997) Oxidative stress during post-hypoxic-ischemic reperfusion in the newborn lamb: the effect of nitric oxide synthesis inhibition. Pediatr Res 41:321-326 (Pubitemid 27097896)
    • (1997) Pediatric Research , vol.41 , Issue.3 , pp. 321-326
    • Dorrepaal, C.A.1    Van Bel, F.2    Moison, R.M.W.3    Shadid, M.4    Van De, B.M.5    Steendijk, P.6    Berger, H.M.7
  • 42
    • 77954366329 scopus 로고    scopus 로고
    • Effects of suboptimal doses of the AT1 receptor blocker, telmisartan, with the angiotensin-converting enzyme inhibitor, ramipril, on cerebral arterioles in spontaneously hypertensive rat
    • Dupuis F, Vincent JM, Limiñana P, Chillon JM, Capdeville-Atkinson C, Atkinson J (2010) Effects of suboptimal doses of the AT1 receptor blocker, telmisartan, with the angiotensin-converting enzyme inhibitor, ramipril, on cerebral arterioles in spontaneously hypertensive rat. J Hypertens 28:1566-1573
    • (2010) J Hypertens , vol.28 , pp. 1566-1573
    • Dupuis, F.1    Vincent, J.M.2    Limiñana, P.3    Chillon, J.M.4    Capdeville-Atkinson, C.5    Atkinson, J.6
  • 44
    • 0028240615 scopus 로고
    • Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia
    • DOI 10.1016/0006-8993(94)90683-1
    • Endoh M, Maiese K, Wagner J (1994) Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Res 651:92-100 (Pubitemid 24222853)
    • (1994) Brain Research , vol.651 , Issue.1-2 , pp. 92-100
    • Endoh, M.1    Maiese, K.2    Wagner, J.3
  • 45
    • 3042700144 scopus 로고    scopus 로고
    • Medical lipid-regulating therapy: Current evidence, ongoing trials and future developments
    • DOI 10.2165/00003495-200464110-00003
    • Evans M, Roberts A, Davies S, Rees A (2004) Medical lipid-regulating therapy: current evidence, ongoing trials and future developments. Drugs 64:1181-1196 (Pubitemid 38858287)
    • (2004) Drugs , vol.64 , Issue.11 , pp. 1181-1196
    • Evans, M.1    Roberts, A.2    Davies, S.3    Rees, A.4
  • 46
    • 1642324921 scopus 로고    scopus 로고
    • Control of platelet activation by cyclic AMP turnover and cyclic nucleotide phosphodiesterase type-3
    • DOI 10.1016/j.bcp.2003.12.028, PII S0006295204000280
    • Feijge MA, Ansink K, Vanschoonbeek K, Heemskerk JW (2004) Control of platelet activation by cyclic AMP turnover and cyclic nucleotide phosphodiesterase type-3. Biochem Pharmacol 67:1559-1567 (Pubitemid 38388218)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.8 , pp. 1559-1567
    • Feijge, M.A.H.1    Ansink, K.2    Vanschoonbeek, K.3    Heemskerk, J.W.M.4
  • 48
    • 0030860260 scopus 로고    scopus 로고
    • Soluble macrophage factors trigger apoptosis in cultured hippocampal neurons
    • DOI 10.1016/S0306-4522(97)00078-X, PII S030645229700078X
    • Flavin MP, Coughlin K, Ho LT (1997) Soluble macrophage factors trigger apoptosis in cultured hippocampal neurons. Neuroscience 80:437-448 (Pubitemid 27334593)
    • (1997) Neuroscience , vol.80 , Issue.2 , pp. 437-448
    • Flavin, M.P.1    Coughlin, K.2    Ho, L.T.3
  • 49
    • 0035827676 scopus 로고    scopus 로고
    • Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity
    • Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R (2001) Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 88:E68-E75
    • (2001) Circ Res , vol.88
    • Fleming, I.1    Fisslthaler, B.2    Dimmeler, S.3    Kemp, B.E.4    Busse, R.5
  • 51
    • 0031317919 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular endothelium of rat hippocampus after ischemia: Evidence and significance
    • Gajkowska B, Mossakowski MJ (1997) Endothelial nitric oxide synthase in vascular endothelium of rat hippocampus after ischemia: evidence and significance. Folia Neuropathol 35: 171-180 (Pubitemid 127533692)
    • (1997) Folia Neuropathologica , vol.35 , Issue.3 , pp. 171-180
    • Gajkowska, B.1    Mossakowski, M.J.2
  • 53
    • 33750879820 scopus 로고    scopus 로고
    • Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries
    • Geary GG, Krause DN, Duckles SP (1998) Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am J Physiol 275:H292-H300
    • (1998) Am J Physiol , vol.275
    • Geary, G.G.1    Krause, D.N.2    Duckles, S.P.3
  • 55
    • 0037319355 scopus 로고    scopus 로고
    • Withdrawal of statin treatment abrogates stroke protection in mice
    • DOI 10.1161/01.STR.0000054055.28435.BF
    • Gertz K, Laufs U, Lindauer U, Nickenig G, Böhm M, Dirnagl U, Endres M (2003) Withdrawal of statin treatment abrogates stroke protection in mice. Stroke 34:551-557 (Pubitemid 36206363)
    • (2003) Stroke , vol.34 , Issue.2 , pp. 551-557
    • Gertz, K.1    Laufs, U.2    Lindauer, U.3    Nickenig, G.4    Bohm, M.5    Dirnagl, U.6    Endres, M.7
  • 56
    • 3042773856 scopus 로고    scopus 로고
    • Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice
    • Gibson CL, Murphy SP (2004) Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 24:805-813 (Pubitemid 38880226)
    • (2004) Journal of Cerebral Blood Flow and Metabolism , vol.24 , Issue.7 , pp. 805-813
    • Gibson, C.L.1    Murphy, S.P.2
  • 57
    • 18144409121 scopus 로고    scopus 로고
    • Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
    • DOI 10.1016/j.expneurol.2005.01.009
    • Gibson CL, Constantin D, Prior MJ, Bath PM, Murphy SP (2005) Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 193:522-530 (Pubitemid 40616199)
    • (2005) Experimental Neurology , vol.193 , Issue.2 , pp. 522-530
    • Gibson, C.L.1    Constantin, D.2    Prior, M.J.W.3    Bath, P.M.W.4    Murphy, S.P.5
  • 59
    • 0029799831 scopus 로고    scopus 로고
    • Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation
    • DOI 10.1126/science.274.5291.1383
    • Grilli M, Pizzi M, Memo M, Spano P (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274:1383-1385 (Pubitemid 26391464)
    • (1996) Science , vol.274 , Issue.5291 , pp. 1383-1385
    • Grilli, M.1    Pizzi, M.2    Memo, M.3    Spano, P.4
  • 60
    • 24144494527 scopus 로고    scopus 로고
    • The physiology and pathophysiology of nitric oxide in the brain
    • DOI 10.1016/j.pneurobio.2005.06.001, PII S030100820500064X
    • Guix FX, Uribesalgo I, Coma M, Muñoz FJ (2005) The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol 76:126-152 (Pubitemid 41242885)
    • (2005) Progress in Neurobiology , vol.76 , Issue.2 , pp. 126-152
    • Guix, F.X.1    Uribesalgo, I.2    Coma, M.3    Munoz, F.J.4
  • 61
    • 33646596912 scopus 로고    scopus 로고
    • Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomised controlled trial
    • ESPRIT Study Group
    • Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A, ESPRIT Study Group (2006) Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 367:1665-1673
    • (2006) Lancet , vol.367 , pp. 1665-1673
    • Halkes, P.H.1    Van Gijn, J.2    Kappelle, L.J.3    Koudstaal, P.J.4    Algra, A.5
  • 63
    • 0020636637 scopus 로고
    • Mechanism of action of dipyridamole
    • Harker LA, Kadatz RA (1983) Mechanism of action of dipyridamole. Thromb Res Suppl 4:39-46 (Pubitemid 13078094)
    • (1983) Thrombosis Research , vol.30 , Issue.SUPPL. 4 , pp. 39-46
    • Harker, L.A.1    Kadatz, R.A.2
  • 64
    • 0035844241 scopus 로고    scopus 로고
    • Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation
    • Harris MB, Ju H, Venema VJ, Liang H, Zou R, Michell BJ, Chen ZP, Kemp BE, Venema RC (2001) Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem 276:16587-16591
    • (2001) J Biol Chem , vol.276 , pp. 16587-16591
    • Harris, M.B.1    Ju, H.2    Venema, V.J.3    Liang, H.4    Zou, R.5    Michell, B.J.6    Chen, Z.P.7    Kemp, B.E.8    Venema, R.C.9
  • 65
    • 33750369864 scopus 로고    scopus 로고
    • Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A- and phosphatidylinositol 3-kinase/Akt-dependent mechanism
    • DOI 10.1016/j.atherosclerosis.2006.01.022, PII S0021915006000505
    • Hashimoto A, Miyakoda G, Hirose Y, Mori T (2006) Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A- and phosphatidylinositol 3-kinase/Akt-dependent mechanism. Atherosclerosis 189:350-357 (Pubitemid 44634499)
    • (2006) Atherosclerosis , vol.189 , Issue.2 , pp. 350-357
    • Hashimoto, A.1    Miyakoda, G.2    Hirose, Y.3    Mori, T.4
  • 66
    • 75149115336 scopus 로고    scopus 로고
    • Effects of a calcium-channel blocker (CV159) on hepatic ischemia/reperfusion injury in rats: Evaluation with selective NO/pO2 electrodes and an electron paramagnetic resonance spin-trapping method
    • Hataji K, Watanabe T, Oowada S, Nagaya M, Kamibayashi M, Murakami E, Kawakami H, Ishiuchi A, Kumai T, Nakano H, Kobayashi S, Otsubo T (2010) Effects of a calcium-channel blocker (CV159) on hepatic ischemia/reperfusion injury in rats: evaluation with selective NO/pO2 electrodes and an electron paramagnetic resonance spin-trapping method. Biol Pharm Bull 33:77-83
    • (2010) Biol Pharm Bull , vol.33 , pp. 77-83
    • Hataji, K.1    Watanabe, T.2    Oowada, S.3    Nagaya, M.4    Kamibayashi, M.5    Murakami, E.6    Kawakami, H.7    Ishiuchi, A.8    Kumai, T.9    Nakano, H.10    Kobayashi, S.11    Otsubo, T.12
  • 67
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57:173-185 (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 69
    • 68349088090 scopus 로고    scopus 로고
    • Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia
    • Haynes RL, Folkerth RD, Trachtenberg FL, Volpe JJ, Kinney HC (2009) Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia. Acta Neuropathol 118:391-399
    • (2009) Acta Neuropathol , vol.118 , pp. 391-399
    • Haynes, R.L.1    Folkerth, R.D.2    Trachtenberg, F.L.3    Volpe, J.J.4    Kinney, H.C.5
  • 70
    • 33747190923 scopus 로고    scopus 로고
    • Effects of thiazide diuretics on the gene expression of endothelial nitric oxide synthase and endothelin-1 in the spontaneous hypertensive rats
    • He Y, Yan J-t, Tu R-h, Wang P-h, Wang D-w (2006) Effects of thiazide diuretics on the gene expression of endothelial nitric oxide synthase and endothelin-1 in the spontaneous hypertensive rats. Zhongguo Yaolixue Tongbao 22:552-555 (Pubitemid 44229533)
    • (2006) Chinese Pharmacological Bulletin , vol.22 , Issue.5 , pp. 552-555
    • He, Y.1    Yan, J.-T.2    Tu, R.-H.3    Wang, P.-H.4    Wang, D.-W.5
  • 71
    • 4744365177 scopus 로고    scopus 로고
    • Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: Counteracting role of arginase
    • DOI 10.1096/fj.03-0115fje
    • Hein TW, Zhang C, Wang W, Chang CI, Thengchaisri N, Kuo L (2003) Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase. FASEB J 17:2328-2330 (Pubitemid 39561482)
    • (2003) FASEB Journal , vol.17 , Issue.15 , pp. 2328-2330
    • Hein, T.W.1    Zhang, C.2    Wang, W.3    Chang, C.-I.4    Thengchaisri, N.5    Kuo, L.6
  • 72
    • 0022919535 scopus 로고
    • Inhibition of platelet aggregation in whole blood by dipyridamole and aspirin
    • DOI 10.1016/0049-3848(86)90297-5
    • Heptinstall S, Fox S, Crawford J, Hawkins M (1986) Inhibition of platelet aggregation in whole blood by dipyridamole and aspirin. Thromb Res 42:215-223 (Pubitemid 16073427)
    • (1986) Thrombosis Research , vol.42 , Issue.2 , pp. 215-223
    • Heptinstall, S.1    Fox, S.2    Crawford, J.3    Hawkins, M.4
  • 73
    • 0035140193 scopus 로고    scopus 로고
    • Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle
    • Higaki Y, Hirshman MF, Fujii N, Goodyear LJ (2001) Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes 50:241-247 (Pubitemid 32127278)
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 241-247
    • Higaki, Y.1    Hirshman, M.F.2    Fujii, N.3    Goodyear, L.J.4
  • 74
    • 0036174890 scopus 로고    scopus 로고
    • The biochemistry and physiology of S-nitrosothiols
    • Hogg N (2002) The biochemistry and physiology of S-nitrosothiols. Annu Rev Pharmacol Toxicol 42:585-600
    • (2002) Annu Rev Pharmacol Toxicol , vol.42 , pp. 585-600
    • Hogg, N.1
  • 75
    • 77950648451 scopus 로고    scopus 로고
    • Combination therapy with olmesartan and azelnidipine improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice
    • Hosoya M, Ohashi J, Sawada A, Takaki A, Shimokawa H (2010) Combination therapy with olmesartan and azelnidipine improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice. Circ J 74:798-806
    • (2010) Circ J , vol.74 , pp. 798-806
    • Hosoya, M.1    Ohashi, J.2    Sawada, A.3    Takaki, A.4    Shimokawa, H.5
  • 76
    • 3342877609 scopus 로고    scopus 로고
    • Nitric oxide and cerebral ischemic preconditioning
    • Huang PL (2004) Nitric oxide and cerebral ischemic preconditioning. Cell Calcium 36:323-329
    • (2004) Cell Calcium , vol.36 , pp. 323-329
    • Huang, P.L.1
  • 79
    • 63349089474 scopus 로고    scopus 로고
    • Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats
    • Ishrat T, Sayeed I, Atif F, Stein DG (2009) Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats. Brain Res 1257:94-101
    • (2009) Brain Res , vol.1257 , pp. 94-101
    • Ishrat, T.1    Sayeed, I.2    Atif, F.3    Stein, D.G.4
  • 80
    • 77957780905 scopus 로고    scopus 로고
    • Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
    • Ishrat T, Sayeed I, Atif F, Hua F, Stein DG (2010) Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases. Exp Neurol 226:183-190
    • (2010) Exp Neurol , vol.226 , pp. 183-190
    • Ishrat, T.1    Sayeed, I.2    Atif, F.3    Hua, F.4    Stein, D.G.5
  • 81
    • 0036713880 scopus 로고    scopus 로고
    • 1 antagonist
    • DOI 10.1161/01.STR.0000027274.03779.F3
    • Ito T, Yamakawa H, Bregonzio C, Terrón JA, Falcón-Neri A, Saavedra JM (2002) Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist. Stroke 33:2297-2303 (Pubitemid 35014646)
    • (2002) Stroke , vol.33 , Issue.9 , pp. 2297-2303
    • Ito, T.1    Yamakawa, H.2    Bregonzio, C.3    Terron, J.A.4    Falcon-Neri, A.5    Saavedra, J.M.6
  • 82
    • 34548259920 scopus 로고    scopus 로고
    • Fate of disseminated dead neurons in the cortical ischemic penumbra: Ultrastructure indicating a novel scavenger mechanism of microglia and astrocytes
    • DOI 10.1161/STROKEAHA.107.484394, PII 0000767020070900000031
    • Ito U, Nagasao J, Kawakami E, Oyanagi K (2007) Fate of disseminated dead neurons in the cortical ischemic penumbra: ultrastructure indicating a novel scavenger mechanism of microglia and astrocytes. Stroke 38:2577-2583 (Pubitemid 47329640)
    • (2007) Stroke , vol.38 , Issue.9 , pp. 2577-2583
    • Ito, U.1    Nagasao, J.2    Kawakami, E.3    Oyanagi, K.4
  • 83
    • 77958462484 scopus 로고    scopus 로고
    • Atorvastatin upregulates nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats
    • Ito D, Ito O, Mori N, Muroya Y, Cao PY, Takashima K, Kanazawa M, Kohzuki M (2010) Atorvastatin upregulates nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats. J Hypertens 28:2278-2288
    • (2010) J Hypertens , vol.28 , pp. 2278-2288
    • Ito, D.1    Ito, O.2    Mori, N.3    Muroya, Y.4    Cao, P.Y.5    Takashima, K.6    Kanazawa, M.7    Kohzuki, M.8
  • 84
    • 79952318766 scopus 로고    scopus 로고
    • Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAKSTAT and JNK stress kinase pathways
    • Lond
    • Kacimi R, Giffard RG, Yenari MA (2011) Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAKSTAT and JNK stress kinase pathways. J Inflamm (Lond) 8:7
    • (2011) J Inflamm , vol.8 , pp. 7
    • Kacimi, R.1    Giffard, R.G.2    Yenari, M.A.3
  • 87
    • 0037058825 scopus 로고    scopus 로고
    • S-Nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty
    • DOI 10.1161/01.CIR.0000041251.07332.28
    • Kaposzta Z, Clifton A, Molloy J, Martin JF, Markus HS (2002) S-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty. Circulation 106:3057-3062 (Pubitemid 35440288)
    • (2002) Circulation , vol.106 , Issue.24 , pp. 3057-3062
    • Kaposzta, Z.1    Clifton, A.2    Molloy, J.3    Martin, J.F.4    Markus, H.S.5
  • 89
    • 17344371804 scopus 로고    scopus 로고
    • Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
    • Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, Mattson MP (1998) Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 18:687-697 (Pubitemid 28041905)
    • (1998) Journal of Neuroscience , vol.18 , Issue.2 , pp. 687-697
    • Keller, J.N.1    Kindy, M.S.2    Holtsberg, F.W.3    St., C.D.K.4    Yen, H.-C.5    Germeyer, A.6    Steiner, S.M.7    Bruce-Keller, A.J.8    Hutchins, J.B.9    Mattson, M.P.10
  • 90
    • 78751642044 scopus 로고    scopus 로고
    • Anti-angiogenic and anti-mitotic effects of aspirin in hypoxia-reoxygenation modulation of LOX-1-NADPH oxidase axis as potential mechanism
    • Khaidakov M, Szwedo J, Mitra S, Ayyadevara S, Dobretsov M, Lu J, Mehta JL (2010) Anti-angiogenic and anti-mitotic effects of aspirin in hypoxia-reoxygenation modulation of LOX-1-NADPH oxidase axis as potential mechanism. J Cardiovasc Pharmacol 56:635-641
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 635-641
    • Khaidakov, M.1    Szwedo, J.2    Mitra, S.3    Ayyadevara, S.4    Dobretsov, M.5    Lu, J.6    Mehta, J.L.7
  • 92
    • 33746861531 scopus 로고    scopus 로고
    • Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke
    • DOI 10.1016/j.niox.2006.01.008, PII S1089860306000267
    • Khan M, Jatana M, Elango C, Paintlia AS, Singh AK, Singh I (2006) Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke. Nitric Oxide 15:114-124 (Pubitemid 44175884)
    • (2006) Nitric Oxide - Biology and Chemistry , vol.15 , Issue.2 , pp. 114-124
    • Khan, M.1    Jatana, M.2    Elango, C.3    Singh, P.A.4    Singh, A.K.5    Singh, I.6
  • 95
    • 44549084372 scopus 로고    scopus 로고
    • Vascular cell signaling by membrane estrogen receptors
    • Kim KH, Moriarty K, Bender JR (2008b) Vascular cell signaling by membrane estrogen receptors. Steroids 73:864-869
    • (2008) Steroids , vol.73 , pp. 864-869
    • Kim, K.H.1    Moriarty, K.2    Bender, J.R.3
  • 96
    • 33645822083 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts
    • DOI 10.1161/01.HYP.0000203148.42892.7a, PII 0000426820060400000014
    • Kobayashi N, Yoshida K, Nakano S, Ohno T, Honda T, Tsubokou Y, Matsuoka H (2006) Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts. Hypertension 47:671-679 (Pubitemid 43740237)
    • (2006) Hypertension , vol.47 , Issue.4 , pp. 671-679
    • Kobayashi, N.1    Yoshida, K.2    Nakano, S.3    Ohno, T.4    Honda, T.5    Tsubokou, Y.6    Matsuoka, H.7
  • 97
    • 75449094099 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker telmisartan reduces cerebral infarct volume and peri-infarct cytosolic phospholipase A(2) level in experimental stroke
    • Kobayashi T, Kawamata T, Shibata N, Okada Y, Kobayashi M, Hori T (2009) Angiotensin II type 1 receptor blocker telmisartan reduces cerebral infarct volume and peri-infarct cytosolic phospholipase A(2) level in experimental stroke. J Neurotrauma 26:2355-2364
    • (2009) J Neurotrauma , vol.26 , pp. 2355-2364
    • Kobayashi, T.1    Kawamata, T.2    Shibata, N.3    Okada, Y.4    Kobayashi, M.5    Hori, T.6
  • 98
    • 0029119169 scopus 로고
    • Aspirin as a free radical scavenger: Consequences for therapy of cerebrovascular ischemia
    • Kuhn W, Müller T, Bttner T, Gerlach M (1995) Aspirin as a free radical scavenger: consequences for therapy of cerebrovascular ischemia. Stroke 26:1959-1960
    • (1995) Stroke , vol.26 , pp. 1959-1960
    • Kuhn, W.1    Müller, T.2    Bttner, T.3    Gerlach, M.4
  • 100
    • 3342965181 scopus 로고    scopus 로고
    • Effect of sodium nitroprusside on ischemia-reperfusion injuries of the rat liver
    • Kuroki I, Miyazaki T, Mizukami I, Matsumoto N, Matsumoto I (2004) Effect of sodium nitroprusside on ischemia-reperfusion injuries of the rat liver. Hepatogastroenterology 51:1404-1407 (Pubitemid 38987493)
    • (2004) Hepato-Gastroenterology , vol.51 , Issue.59 , pp. 1404-1407
    • Kuroki, K.1    Miyazaki, T.2    Mizukami, S.3    Matsumoto, N.4    Matsumoto, I.5
  • 102
    • 0037189048 scopus 로고    scopus 로고
    • Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice
    • DOI 10.1016/S0006-8993(02)02649-5, PII S0006899302026495
    • Laufs U, Gertz K, Dirnagl U, Böhm M, Nickenig G, Endres M (2002) Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res 942:23-30 (Pubitemid 34597065)
    • (2002) Brain Research , vol.942 , Issue.1-2 , pp. 23-30
    • Laufs, U.1    Gertz, K.2    Dirnagl, U.3    Bohm, M.4    Nickenig, G.5    Endres, M.6
  • 103
    • 79952111529 scopus 로고    scopus 로고
    • Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells
    • Lee W, Ou H, Hsu W, Chou M, Tseng J, Hsu S, Tsai K, Sheu W (2010) Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. J Vasc Surg 52:1290-1300
    • (2010) J Vasc Surg , vol.52 , pp. 1290-1300
    • Lee, W.1    Ou, H.2    Hsu, W.3    Chou, M.4    Tseng, J.5    Hsu, S.6    Tsai, K.7    Sheu, W.8
  • 104
    • 70349693951 scopus 로고    scopus 로고
    • Simvastatin increases the activity of endothelial nitric oxide synthase via enhancing phosphorylation
    • Li X, Wang P, Xu X, Wang Y, Xia Y, Wang D (2009) Simvastatin increases the activity of endothelial nitric oxide synthase via enhancing phosphorylation. J Huazhong Univ Sci Technol Med Sci 29:286-290
    • (2009) J Huazhong Univ Sci Technol Med Sci , vol.29 , pp. 286-290
    • Li, X.1    Wang, P.2    Xu, X.3    Wang, Y.4    Xia, Y.5    Wang, D.6
  • 106
    • 17044361906 scopus 로고    scopus 로고
    • Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat
    • Littleton-Kearney MT, Klaus JA, Hurn PD (2005b) Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat. J Cereb Blood Flow Metab 25:421-426
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 421-426
    • Littleton-Kearney, M.T.1    Klaus, J.A.2    Hurn, P.D.3
  • 107
    • 9644272471 scopus 로고    scopus 로고
    • Molecular mechanisms responsible for microglia-derived protection of Sprague-Dawley rat brain cells during in vitro ischemia
    • DOI 10.1016/j.neulet.2004.10.004, PII S0304394004012510
    • Lu YZ, Lin CH, Cheng FC, Hsueh CM (2005) Molecular mechanisms responsible for microglia-derived protection of Sprague-Dawley rat brain cells during in vitro ischemia. Neurosci Lett 373:159-164 (Pubitemid 39572981)
    • (2005) Neuroscience Letters , vol.373 , Issue.2 , pp. 159-164
    • Lu, Y.-Z.1    Lin, C.-H.2    Cheng, F.-C.3    Hsueh, C.-M.4
  • 108
    • 33748562106 scopus 로고    scopus 로고
    • Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha
    • DOI 10.1016/j.bcp.2006.06.038, PII S0006295206003972
    • Lu DY, Liou HC, Tang CH, Fu WM (2006) Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem Pharmacol 72:992-1000 (Pubitemid 44374459)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.8 , pp. 992-1000
    • Lu, D.-Y.1    Liou, H.-C.2    Tang, C.-H.3    Fu, W.-M.4
  • 109
    • 31044433868 scopus 로고    scopus 로고
    • Effects of low-dose aspirin on blood pressure and endothelial function of treated hypertensive hypercholesterolaemic subjects
    • DOI 10.1038/sj.jhh.1001910, PII 1001910
    • Magen E, Viskoper JR, Mishal J, Priluk R, London D, Yosefy C (2005) Effects of low-dose aspirin on BP and endothelial function of treated hypertensive hypercholesterolaemic subjects. J Hum Hypertens 19:667-673 (Pubitemid 43118088)
    • (2005) Journal of Human Hypertension , vol.19 , Issue.9 , pp. 667-673
    • Magen, E.1    Viskoper, J.R.2    Mishal, J.3    Priluk, R.4    London, D.5    Yosefy, C.6
  • 113
    • 1342282244 scopus 로고    scopus 로고
    • A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma
    • McKay A, Leung BP, McInnes IB, Thomson NC, Liew FY (2004) A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol 172:2903-2908 (Pubitemid 38263676)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 2903-2908
    • McKay, A.1    Leung, B.P.2    McInnes, I.B.3    Thomson, N.C.4    Liew, F.Y.5
  • 114
    • 0032860804 scopus 로고    scopus 로고
    • Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels
    • McNeill AM, Kim N, Duckles SP, Krause DN, Kontos HA (1999) Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke 30:2186-2190 (Pubitemid 29473269)
    • (1999) Stroke , vol.30 , Issue.10 , pp. 2186-2190
    • McNeill, A.M.1    Kim, N.2    Duckles, S.P.3    Krause, D.N.4
  • 115
    • 0036284248 scopus 로고    scopus 로고
    • Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: Effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone
    • DOI 10.1161/01.STR.0000016325.54374.93
    • McNeill AM, Zhang C, Stanczyk FZ, Duckles SP, Krause DN (2002) Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone. Stroke 33:1685-1691 (Pubitemid 34619979)
    • (2002) Stroke , vol.33 , Issue.6 , pp. 1685-1691
    • McNeill, A.M.1    Zhang, C.2    Stanczyk, F.Z.3    Duckles, S.P.4    Krause, D.N.5
  • 116
    • 0026793984 scopus 로고
    • Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning
    • Miura T, Ogawa T, Iwamoto T, Shimamoto K, Iimura O (1992) Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning. Circulation 86:979-985
    • (1992) Circulation , vol.86 , pp. 979-985
    • Miura, T.1    Ogawa, T.2    Iwamoto, T.3    Shimamoto, K.4    Iimura, O.5
  • 117
    • 0028180199 scopus 로고
    • L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat
    • Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T (1994) L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 25:429-435
    • (1994) Stroke , vol.25 , pp. 429-435
    • Morikawa, E.1    Moskowitz, M.A.2    Huang, Z.3    Yoshida, T.4    Irikura, K.5    Dalkara, T.6
  • 119
    • 0035979669 scopus 로고    scopus 로고
    • Endothelium-dependent relaxation by cilostazol, a phosphodiesteras III inhibitor, on rat thoracic aorta
    • DOI 10.1016/S0024-3205(01)01258-9, PII S0024320501012589
    • Nakamura T, Houchi H, Minami A, Sakamoto S, Tsuchiya K, Niwa Y, Minakuchi K, Nakaya Y (2001) Endothelium-dependent relaxation by cilostazol, a phosphodiesteras III inhibitor, on rat thoracic aorta. Life Sci 69:1709-1715 (Pubitemid 32785280)
    • (2001) Life Sciences , vol.69 , Issue.15 , pp. 1709-1715
    • Nakamura, T.1    Houchi, H.2    Minami, A.3    Sakamoto, S.4    Tsuchiya, K.5    Niwa, Y.6    Minakuchi, K.7    Nakaya, Y.8
  • 120
    • 78049468275 scopus 로고    scopus 로고
    • Renin-angiotensin system blockade safely reduces BP in patients with minor ischemic stroke during the acute phase
    • Nakamura T, Tsutsumi Y, Shimizu Y, Uchiyama S (2010) Renin-angiotensin system blockade safely reduces BP in patients with minor ischemic stroke during the acute phase. J Stroke Cerebrovasc Dis 19:435-440
    • (2010) J Stroke Cerebrovasc Dis , vol.19 , pp. 435-440
    • Nakamura, T.1    Tsutsumi, Y.2    Shimizu, Y.3    Uchiyama, S.4
  • 122
    • 67649861869 scopus 로고    scopus 로고
    • Combination treatment with normobaric hyperoxia and cilostazol protects mice against focal cerebral ischemia-induced neuronal damage better than each treatment alone
    • Nonaka Y, Koumura A, Hyakkoku K, Shimazawa M, Yoshimura S, Iwama T, Hara H (2009) Combination treatment with normobaric hyperoxia and cilostazol protects mice against focal cerebral ischemia-induced neuronal damage better than each treatment alone. J Pharmacol Exp Ther 330:13-22
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 13-22
    • Nonaka, Y.1    Koumura, A.2    Hyakkoku, K.3    Shimazawa, M.4    Yoshimura, S.5    Iwama, T.6    Hara, H.7
  • 123
    • 77955984016 scopus 로고    scopus 로고
    • Equine estrogens impair nitric oxide production and endothelial nitric oxide synthase transcription in human endothelial cells compared with the natural 17{beta}-estradiol
    • Novensa L, Selent J, Pastor M, Sandberg K, Heras M, Dantas AP (2010) Equine estrogens impair nitric oxide production and endothelial nitric oxide synthase transcription in human endothelial cells compared with the natural 17{beta}-estradiol. Hypertension 56:405-411
    • (2010) Hypertension , vol.56 , pp. 405-411
    • Novensa, L.1    Selent, J.2    Pastor, M.3    Sandberg, K.4    Heras, M.5    Dantas, A.P.6
  • 124
    • 0030886440 scopus 로고    scopus 로고
    • Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet
    • Numagami Y, Zubrow AB, Mishra OP, Delivoria-Papadopoulos M (1997) Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet. J Neurochem 69:1542-1547 (Pubitemid 27406955)
    • (1997) Journal of Neurochemistry , vol.69 , Issue.4 , pp. 1542-1547
    • Numagami, Y.1    Zubrow, A.B.2    Mishra, O.P.3    Delivoria-Papadopoulos, M.4
  • 125
    • 77951499518 scopus 로고    scopus 로고
    • Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells
    • Oh YT, Lee JY, Lee J, Lee JH, Kim JE, Ha J, Kang I (2010) Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells. Neurosci Lett 474:148-153
    • (2010) Neurosci Lett , vol.474 , pp. 148-153
    • Oh, Y.T.1    Lee, J.Y.2    Lee, J.3    Lee, J.H.4    Kim, J.E.5    Ha, J.6    Kang, I.7
  • 127
    • 51649106480 scopus 로고    scopus 로고
    • Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
    • Ota H, Eto M, Kano MR, Ogawa S, Iijima K, Akishita M, Ouchi Y (2008) Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol 28:1634-1639
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1634-1639
    • Ota, H.1    Eto, M.2    Kano, M.R.3    Ogawa, S.4    Iijima, K.5    Akishita, M.6    Ouchi, Y.7
  • 128
    • 0034904647 scopus 로고    scopus 로고
    • Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-kappaB binding to its recognition sequence
    • DOI 10.1016/S0021-9150(01)00431-2, PII S0021915001004312
    • Otsuki M, Saito H, Xu X, Sumitani S, Kouhara H, Kurabayashi M, Kasayama S (2001) Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-kappaB binding to its recognition sequence. Atherosclerosis 158:121-128 (Pubitemid 32735475)
    • (2001) Atherosclerosis , vol.158 , Issue.1 , pp. 121-128
    • Otsuki, M.1    Saito, H.2    Xu, X.3    Sumitani, S.4    Kouhara, H.5    Kurabayashi, M.6    Kasayama, S.7
  • 129
    • 77956945020 scopus 로고    scopus 로고
    • Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
    • Ou H, Lee W, Lee S, Huang C, Chiu T, Tsai K, Hsu W, Sheu W (2010) Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicol Appl Pharmacol 248:134-143
    • (2010) Toxicol Appl Pharmacol , vol.248 , pp. 134-143
    • Ou, H.1    Lee, W.2    Lee, S.3    Huang, C.4    Chiu, T.5    Tsai, K.6    Hsu, W.7    Sheu, W.8
  • 130
    • 40449114156 scopus 로고    scopus 로고
    • Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483
    • DOI 10.1017/S0007114507837421, PII S0007114507837421
    • Papoutsi Z, Kassi E, Chinou I, Halabalaki M, Skaltsounis L, Moutsatsou P (2008) Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr 99:715-722 (Pubitemid 351351624)
    • (2008) British Journal of Nutrition , vol.99 , Issue.4 , pp. 715-722
    • Papoutsi, Z.1    Kassi, E.2    Chinou, I.3    Halabalaki, M.4    Skaltsounis, L.A.5    Moutsatsou, P.6
  • 131
    • 55949087619 scopus 로고    scopus 로고
    • Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats
    • Pari L, Sivasankari R (2008) Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol 22:395-401
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 395-401
    • Pari, L.1    Sivasankari, R.2
  • 132
    • 14344254509 scopus 로고    scopus 로고
    • Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation
    • Park SY, Lee JH, Kim YK, Kim CD, Rhim BY, Lee WS, Hong KW (2005) Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation. J Pharmacol Exp Ther 312:1241-1248
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 1241-1248
    • Park, S.Y.1    Lee, J.H.2    Kim, Y.K.3    Kim, C.D.4    Rhim, B.Y.5    Lee, W.S.6    Hong, K.W.7
  • 137
    • 57149121456 scopus 로고    scopus 로고
    • Controlling hypertension and hypotension immediately post-stroke (CHHIPS): A randomised, placebo-controlled, double-blind pilot trial
    • Potter JF, Robinson TG, Ford GA, Mistri A, James M, Chernova J, Jagger C (2009) Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial. Lancet Neurol 8:48-56
    • (2009) Lancet Neurol , vol.8 , pp. 48-56
    • Potter, J.F.1    Robinson, T.G.2    Ford, G.A.3    Mistri, A.4    James, M.5    Chernova, J.6    Jagger, C.7
  • 140
    • 0032771861 scopus 로고    scopus 로고
    • Improvement of endothelial function with the fixed low-dose perindopril-indapamide combination
    • Richard V, Thuillez C (1999) Improvement of endothelial function with the fixed low-dose perindopril-indapamide combination. Eur Heart J Suppl 1:L38-L43 (Pubitemid 29348593)
    • (1999) European Heart Journal, Supplement , vol.1 , Issue.L
    • Richard, V.1    Thuillez, C.2
  • 141
    • 0036176869 scopus 로고    scopus 로고
    • Potential therapeutic uses for S-nitrosothiols
    • DOI 10.1042/CS20010207
    • Richardson G, Benjamin N (2002) Potential therapeutic uses for S-nitrosothiols. Clin Sci (Lond) 102:99-105 (Pubitemid 34177806)
    • (2002) Clinical Science , vol.102 , Issue.1 , pp. 99-105
    • Richardson, G.1    Benjamin, N.2
  • 144
    • 77954310801 scopus 로고    scopus 로고
    • Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress
    • Rossi J, Rouleau L, Tardif JC, Leask RL (2010) Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress. Life Sci 87:92-99
    • (2010) Life Sci , vol.87 , pp. 92-99
    • Rossi, J.1    Rouleau, L.2    Tardif, J.C.3    Leask, R.L.4
  • 146
    • 0034717216 scopus 로고    scopus 로고
    • Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats
    • DOI 10.1016/S0006-8993(00)02095-3, PII S0006899300020953
    • Salom JB, Ortí M, Centeno JM, Torregrosa G, Alborch E (2000) Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats. Brain Res 865:149-156 (Pubitemid 30255992)
    • (2000) Brain Research , vol.865 , Issue.2 , pp. 149-156
    • Salom, J.B.1    Orti, M.2    Centeno, J.M.3    Torregrosa, G.4    Alborch, E.5
  • 148
    • 49749127056 scopus 로고    scopus 로고
    • Association between hormone replacement therapy and subsequent arterial and venous vascular events: A meta-analysis
    • Sare GM, Gray LJ, Bath PM (2008) Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis. Eur Heart J 29:2031-2041
    • (2008) Eur Heart J , vol.29 , pp. 2031-2041
    • Sare, G.M.1    Gray, L.J.2    Bath, P.M.3
  • 149
    • 33645002699 scopus 로고    scopus 로고
    • Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    • Sayeed I, Guo Q, Hoffman SW, Stein DG (2006) Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Ann Emerg Med 47:381-389
    • (2006) Ann Emerg Med , vol.47 , pp. 381-389
    • Sayeed, I.1    Guo, Q.2    Hoffman, S.W.3    Stein, D.G.4
  • 150
    • 34548089961 scopus 로고    scopus 로고
    • Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    • Sayeed I, Wali B, Stein DG (2007) Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 25:151-159 (Pubitemid 47290443)
    • (2007) Restorative Neurology and Neuroscience , vol.25 , Issue.2 , pp. 151-159
    • Sayeed, I.1    Wali, B.2    Stein, D.G.3
  • 151
    • 65549085735 scopus 로고    scopus 로고
    • Understanding the PRoFESS study for secondary stroke prevention
    • Schneck MJ (2009) Understanding the PRoFESS study for secondary stroke prevention. Curr Treat Options Cardiovasc Med 11:221-231
    • (2009) Curr Treat Options Cardiovasc Med , vol.11 , pp. 221-231
    • Schneck, M.J.1
  • 153
    • 78651066239 scopus 로고    scopus 로고
    • Effects of aggrenox and aspirin on plasma endothelial nitric oxide synthase and oxidised low-density lipoproteins in patients after ischaemic stroke. The AGgrenox versus aspirin therapy evaluation (AGATE) biomarker substudy
    • Serebruany V, Sani Y, Eisert C, Schevchuck A, Fong A, Hanley D (2011) Effects of aggrenox and aspirin on plasma endothelial nitric oxide synthase and oxidised low-density lipoproteins in patients after ischaemic stroke. The AGgrenox versus aspirin therapy evaluation (AGATE) biomarker substudy. Thromb Haemost 105:81-87
    • (2011) Thromb Haemost , vol.105 , pp. 81-87
    • Serebruany, V.1    Sani, Y.2    Eisert, C.3    Schevchuck, A.4    Fong, A.5    Hanley, D.6
  • 155
    • 45149097380 scopus 로고    scopus 로고
    • Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion
    • DOI 10.1159/000126927
    • Seujange Y, Eiam-Ong S, Tirawatnapong T (2008) Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion. Am J Nephrol 28:692-700 (Pubitemid 351832458)
    • (2008) American Journal of Nephrology , vol.28 , Issue.4 , pp. 692-700
    • Seujange, Y.1    Eiam-Ong, S.2    Tirawatnapong, T.3    Eiam-Ong, S.4
  • 156
    • 0026704175 scopus 로고
    • Prostaglandin endoperoxide synthase. The aspirin acetylation region
    • Shimokawa T, Smith WL (1992) Prostaglandin endoperoxide synthase. The aspirin acetylation region. J Biol Chem 267:12387-12392
    • (1992) J Biol Chem , vol.267 , pp. 12387-12392
    • Shimokawa, T.1    Smith, W.L.2
  • 160
    • 67249152098 scopus 로고    scopus 로고
    • Panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia
    • Son HY, Han HS, Jung HW, Park YK (2009) Panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia. J Pharmacol Sci 109:368-379
    • (2009) J Pharmacol Sci , vol.109 , pp. 368-379
    • Son, H.Y.1    Han, H.S.2    Jung, H.W.3    Park, Y.K.4
  • 161
    • 67651146363 scopus 로고    scopus 로고
    • Inflammatory cytokines in vascular dysfunction and vascular disease
    • Sprague AH, Khalil RA (2009) Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 78:539-552
    • (2009) Biochem Pharmacol , vol.78 , pp. 539-552
    • Sprague, A.H.1    Khalil, R.A.2
  • 162
    • 0030805143 scopus 로고    scopus 로고
    • The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat
    • DOI 10.1016/S0006-8993(97)00200-X, PII S000689939700200X
    • Stagliano NE, Dietrich WD, Prado R, Green EJ, Busto R (1997) The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat. Brain Res 759:32-40 (Pubitemid 27286341)
    • (1997) Brain Research , vol.759 , Issue.1 , pp. 32-40
    • Stagliano, N.E.1    Dietrich, W.D.2    Prado, R.3    Green, E.J.4    Busto, R.5
  • 163
    • 0032930417 scopus 로고    scopus 로고
    • Mammalian nitric oxide synthases
    • Stuehr D (1999) Mammalian nitric oxide synthases. Biochim Biophys Acta 1411:217-230
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 217-230
    • Stuehr, D.1
  • 164
    • 0038458980 scopus 로고    scopus 로고
    • Statins as potential therapeutic agents in neuroinflammatory disorders
    • DOI 10.1097/00019052-200306000-00021
    • Stüve O, Youssef S, Steinman L, Zamvil SS (2003) Statins as potential therapeutic agents in neuroinflammatory disorders. Curr Opin Neurol 16:393-401 (Pubitemid 36688309)
    • (2003) Current Opinion in Neurology , vol.16 , Issue.3 , pp. 393-401
    • Stuve, O.1    Youssef, S.2    Steinman, L.3    Zamvil, S.S.4
  • 165
    • 0030693948 scopus 로고    scopus 로고
    • Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients
    • Taddei S, Virdis A, Ghiadoni L, Uleri S, Magagna A, Salvetti A (1997) Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients. Hypertension 30:1606-1612 (Pubitemid 27528112)
    • (1997) Hypertension , vol.30 , Issue.6 , pp. 1606-1612
    • Taddei, S.1    Virdis, A.2    Ghiadoni, L.3    Uleri, S.4    Magagna, A.5    Salvetti, A.6
  • 166
    • 0035100975 scopus 로고    scopus 로고
    • Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension
    • Taddei S, Virdis A, Ghiadoni L, Magagna A, Favilla S, Pompella A, Salvetti A (2001) Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension 37:943-948 (Pubitemid 32221618)
    • (2001) Hypertension , vol.37 , Issue.3 , pp. 943-948
    • Taddei, S.1    Virdis, A.2    Ghiadoni, L.3    Magagna, A.4    Favilla, S.5    Pompella, A.6    Salvetti, A.7
  • 167
    • 67649661839 scopus 로고    scopus 로고
    • Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats
    • Tamura T, Jamous MA, Kitazato KT, Yagi K, Tada Y, Uno M, Nagahiro S (2009) Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats. J Hypertens 27:1284-1292
    • (2009) J Hypertens , vol.27 , pp. 1284-1292
    • Tamura, T.1    Jamous, M.A.2    Kitazato, K.T.3    Yagi, K.4    Tada, Y.5    Uno, M.6    Nagahiro, S.7
  • 169
    • 33646488692 scopus 로고    scopus 로고
    • Aldosterone antagonism improves endothelial-dependent vasorelaxation in heart failure via upregulation of endothelial nitric oxide synthase production
    • Thai HM, Do BQ, Tran TD, Gaballa MA, Goldman S (2006) Aldosterone antagonism improves endothelial-dependent vasorelaxation in heart failure via upregulation of endothelial nitric oxide synthase production. J Card Fail 12:240-245
    • (2006) J Card Fail , vol.12 , pp. 240-245
    • Thai, H.M.1    Do, B.Q.2    Tran, T.D.3    Gaballa, M.A.4    Goldman, S.5
  • 170
    • 0033027409 scopus 로고    scopus 로고
    • Safety of intrathecal sodium nitroprusside for the treatment and prevention of refractory cerebral vasospasm and ischemia in humans
    • Thomas JE, Rosenwasser RH, Armonda RA, Harrop J, Mitchell W, Galaria I (1999) Safety of intrathecal sodium nitroprusside for the treatment and prevention of refractory cerebral vasospasm and ischemia in humans. Stroke 30:1409-1416 (Pubitemid 29296069)
    • (1999) Stroke , vol.30 , Issue.7 , pp. 1409-1416
    • Thomas, J.E.1    Rosenwasser, R.H.2    Armonda, R.A.3    Harrop, J.4    Mitchell, W.5    Galaria, I.6
  • 171
    • 0037114872 scopus 로고    scopus 로고
    • Meta-analysis of results from eight randomized, placebo-controlled trials on the effect of cilostazol on patients with intermittent claudication
    • DOI 10.1016/S0002-9149(02)02869-2, PII S0002914902028692
    • Thompson PD, Zimet R, Forbes WP, Zhang P (2002) Meta-analysis of results from eight randomized, placebo-controlled trials on the effect of cilostazol on patients with intermittent claudication. Am J Cardiol 90:1314-1319 (Pubitemid 35449476)
    • (2002) American Journal of Cardiology , vol.90 , Issue.12 , pp. 1314-1319
    • Thompson, P.D.1    Zimet, R.2    Forbes, W.P.3    Zhang, P.4
  • 172
    • 27744458898 scopus 로고    scopus 로고
    • G-nitro-L-arginine methyl ester-induced hypertensive rat aorta: Vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine
    • DOI 10.1291/hypres.28.689
    • Toba H, Nakagawa Y, Miki S, Shimizu T, Yoshimura A, Inoue R, Asayama J, Kobara M, Nakata T (2005) Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta: vasoprotective effects beyond the BP-lowering effects of amlodipine and manidipine. Hypertens Res 28:689-700 (Pubitemid 41601043)
    • (2005) Hypertension Research , vol.28 , Issue.8 , pp. 689-700
    • Toba, H.1    Nakagawa, Y.2    Miki, S.3    Shimizu, T.4    Yoshimura, A.5    Inoue, R.6    Asayama, J.7    Kobara, M.8    Nakata, T.9
  • 173
    • 38549179477 scopus 로고    scopus 로고
    • Comparison of the effect of simvastatin, spironolactone and L-arginine on endothelial function of aorta in hereditary hypertriglyceridemic rats
    • Török J, L'upták I, Matúsková J, Pechánová O, Zicha J, Kunes J, Simko F (2007) Comparison of the effect of simvastatin, spironolactone and L-arginine on endothelial function of aorta in hereditary hypertriglyceridemic rats. Physiol Res 56(Suppl 2):S33-S40
    • (2007) Physiol Res , vol.56 , Issue.SUPPL. 2
    • Török, J.1    L'Upták, I.2    Matúsková, J.3    Pechánová, O.4    Zicha, J.5    Kunes, J.6    Simko, F.7
  • 174
    • 0242694051 scopus 로고    scopus 로고
    • Enalapril Prevents Impaired Nitric Oxide Synthase-Dependent Dilatation of Cerebral Arterioles in Diabetic Rats
    • DOI 10.1161/01.STR.0000092121.62649.DC
    • Trauernicht AK, Sun H, Patel KP, Mayhan WG (2003) Enalapril prevents impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in diabetic rats. Stroke 34:2698-2703 (Pubitemid 37392770)
    • (2003) Stroke , vol.34 , Issue.11 , pp. 2698-2703
    • Trauernicht, A.K.1    Sun, H.2    Patel, K.P.3    Mayhan, W.G.4
  • 175
    • 77953302292 scopus 로고    scopus 로고
    • Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver
    • Trocha M, Merwid-Lad A, Szuba A, Chlebda E, Pieśniewska M, Sozański T, Szelag A (2010) Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver. Pharmacol Rep 62:343-351
    • (2010) Pharmacol Rep , vol.62 , pp. 343-351
    • Trocha, M.1    Merwid-Lad, A.2    Szuba, A.3    Chlebda, E.4    Pieśniewska, M.5    Sozański, T.6    Szelag, A.7
  • 176
    • 30644480429 scopus 로고    scopus 로고
    • Tumor necrosis factor beta but not interleukin 1beta mediates neuroprotection in response to acute nitric oxide excitotoxicity
    • DOI 10.1523/JNEUROSCI.4032-05.2006
    • Turrin NP, Rivest S (2006) Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci 26:143-151 (Pubitemid 43089527)
    • (2006) Journal of Neuroscience , vol.26 , Issue.1 , pp. 143-151
    • Turrin, N.P.1    Rivest, S.2
  • 180
    • 2542472417 scopus 로고    scopus 로고
    • Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits
    • DOI 10.1097/00005344-200406000-00003
    • Wang N, Minatoguchi S, Chen XH, Arai M, Uno Y, Lu C, Misao Y, Nagai H, Takemura G, Fujiwara H (2004) Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits. J Cardiovasc Pharmacol 43:747-757 (Pubitemid 38679595)
    • (2004) Journal of Cardiovascular Pharmacology , vol.43 , Issue.6 , pp. 747-757
    • Wang, N.1    Minatoguchi, S.2    Chen, X.-H.3    Arai, M.4    Uno, Y.5    Lu, C.6    Misao, Y.7    Nagai, H.8    Takemura, G.9    Fujiwara, H.10
  • 181
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • DOI 10.1016/j.jneuroim.2006.11.014, PII S0165572806004693, Inflammation, Neurodegeneration and Neuroprotection in the Central Nervous System
    • Wang Q, Tang XN, Yenari MA (2007) The inflammatory response in stroke. J Neuroimmunol 184:53-68 (Pubitemid 46365991)
    • (2007) Journal of Neuroimmunology , vol.184 , Issue.1-2 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 182
    • 67449138379 scopus 로고    scopus 로고
    • The protective mechanism of progesterone on blood-brain barrier in cerebral ischemia in rats
    • Wang J, Jiang C, Li X, Liu C, Cheng N, Hao Y (2009) The protective mechanism of progesterone on blood-brain barrier in cerebral ischemia in rats. Brain Res Bull 79:426-430
    • (2009) Brain Res Bull , vol.79 , pp. 426-430
    • Wang, J.1    Jiang, C.2    Li, X.3    Liu, C.4    Cheng, N.5    Hao, Y.6
  • 183
    • 77249145948 scopus 로고    scopus 로고
    • Neuroprotective effects of progesterone following stroke in aged rats
    • Wang J, Jiang C, Liu C, Li X, Chen N, Hao Y (2010) Neuroprotective effects of progesterone following stroke in aged rats. Behav Brain Res 209:119-122
    • (2010) Behav Brain Res , vol.209 , pp. 119-122
    • Wang, J.1    Jiang, C.2    Liu, C.3    Li, X.4    Chen, N.5    Hao, Y.6
  • 184
    • 15944376243 scopus 로고    scopus 로고
    • A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow
    • DOI 10.1016/j.niox.2005.01.003
    • Willmot M, Gray L, Gibson C, Murphy S, Bath PM (2005) A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow. Nitric Oxide 12:141-149 (Pubitemid 40432134)
    • (2005) Nitric Oxide - Biology and Chemistry , vol.12 , Issue.3 , pp. 141-149
    • Willmot, M.1    Gray, L.2    Gibson, C.3    Murphy, S.4    Bath, P.M.W.5
  • 185
    • 0037369529 scopus 로고    scopus 로고
    • Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme a reductase inhibitor is mediated by endothelial nitric oxide synthase
    • DOI 10.1097/00005344-200303000-00017
    • Wolfrum S, Grimm M, Heidbreder M, Dendorfer A, Katus HA, Liao JK, Richardt G (2003) Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase. J Cardiovasc Pharmacol 41:474-480 (Pubitemid 36255308)
    • (2003) Journal of Cardiovascular Pharmacology , vol.41 , Issue.3 , pp. 474-480
    • Wolfrum, S.1    Grimm, M.2    Heidbreder, M.3    Dendorfer, A.4    Katus, H.A.5    Liao, J.K.6    Richardt, G.7
  • 186
    • 0029121104 scopus 로고
    • Microglia as a unique cellular target in the treatment of stroke: Potential neurotoxic mediators produced by activated microglia
    • Wood PL (1995) Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol Res 17:242-248
    • (1995) Neurol Res , vol.17 , pp. 242-248
    • Wood, P.L.1
  • 189
    • 0037341594 scopus 로고    scopus 로고
    • 1 receptor inhibition
    • Yamakawa H, Jezova M, Ando H, Saavedra JM (2003) Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition. J Cereb Blood Flow Metab 23:371-380 (Pubitemid 36307581)
    • (2003) Journal of Cerebral Blood Flow and Metabolism , vol.23 , Issue.3 , pp. 371-380
    • Yamakawa, H.1    Jezova, M.2    Ando, H.3    Saavedra, J.M.4
  • 191
    • 0035123687 scopus 로고    scopus 로고
    • A calcium channel blocker, benidipine, inhibits intimal thickening in the carotid artery of mice by increasing nitric oxide production
    • DOI 10.1097/00004872-200103000-00013
    • Yamashita T, Kawashima S, Ozaki M, Rikitake Y, Hirase T, Inoue N, Hirata K, Yokoyama M (2001) A calcium channel blocker, benidipine, inhibits intimal thickening in the carotid artery of mice by increasing nitric oxide production. J Hypertens 19:451-458 (Pubitemid 32195381)
    • (2001) Journal of Hypertension , vol.19 , Issue.3 , pp. 451-458
    • Yamashita, T.1    Kawashima, S.2    Ozaki, M.3    Rikitake, Y.4    Hirase, T.5    Inoue, N.6    Hirata, K.-I.7    Yokoyama, M.8
  • 192
    • 0032808884 scopus 로고    scopus 로고
    • Endothelial nitric oxide gene knockout mice: Cardiac phenotypes and the effect of angiotensin-converting enzyme inhibitor on myocardial ischemia/reperfusion injury
    • Yang XP, Liu YH, Shesely EG, Bulagannawar M, Liu F, Carretero OA (1999) Endothelial nitric oxide gene knockout mice: cardiac phenotypes and the effect of angiotensin-converting enzyme inhibitor on myocardial ischemia/reperfusion injury. Hypertension 34:24-30 (Pubitemid 29325714)
    • (1999) Hypertension , vol.34 , Issue.1 , pp. 24-30
    • Yang, X.-P.1    Liu, Y.-H.2    Shesely, E.G.3    Bulagannawar, M.4    Liu, F.5    Carretero, O.A.6
  • 193
    • 4344702044 scopus 로고    scopus 로고
    • Relationship between S100beta and GFAP expression in astrocytes during infarction and glial scar formation after mild transient ischemia
    • DOI 10.1016/j.brainres.2004.06.015, PII S0006899304009357
    • Yasuda Y, Tateishi N, Shimoda T, Satoh S, Ogitani E, Fujita S (2004) Relationship between S100beta and GFAP expression in astrocytes during infarction and glial scar formation after mild transient ischemia. Brain Res 1021:20-31 (Pubitemid 39158653)
    • (2004) Brain Research , vol.1021 , Issue.1 , pp. 20-31
    • Yasuda, Y.1    Tateishi, N.2    Shimoda, T.3    Satoh, S.4    Ogitani, E.5    Fujita, S.6
  • 196
    • 79958699276 scopus 로고    scopus 로고
    • Dipyridamole with low-dose aspirin augments the infarct size-limiting effects of simvastatin
    • Ye Y, Long B, Qian J, Perez-Polo JR, Birnbaum Y (2011) Dipyridamole with low-dose aspirin augments the infarct size-limiting effects of simvastatin. Cardiovasc Drugs Ther 24:391-399
    • (2011) Cardiovasc Drugs Ther , vol.24 , pp. 391-399
    • Ye, Y.1    Long, B.2    Qian, J.3    Perez-Polo, J.R.4    Birnbaum, Y.5
  • 198
    • 33645799230 scopus 로고    scopus 로고
    • Microglia potentiate damage to blood-brain barrier constituents: Improvement by minocycline in vivo and in vitro
    • Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG (2006) Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke 37:1087-1093
    • (2006) Stroke , vol.37 , pp. 1087-1093
    • Yenari, M.A.1    Xu, L.2    Tang, X.N.3    Qiao, Y.4    Giffard, R.G.5
  • 199
    • 33845965679 scopus 로고    scopus 로고
    • Progestins overcome inhibition of platelet aggregation by endothelial cells by down-regulating endothelial NO synthase via glucocorticoid receptors
    • DOI 10.1096/fj.06-6840com
    • Zerr-Fouineau M, Chataigneau M, Blot C, Schini-Kerth VB (2007) Progestins overcome inhibition of platelet aggregation by endothelial cells by down-regulating endothelial NO synthase via glucocorticoid receptors. FASEB J 21:265-273 (Pubitemid 46052565)
    • (2007) FASEB Journal , vol.21 , Issue.1 , pp. 265-273
    • Zerr-Fouineau, M.1    Chataigneau, M.2    Blot, C.3    Schini-Kerth, V.B.4
  • 200
    • 0031912146 scopus 로고    scopus 로고
    • Amlodipine releases nitric oxide from canine coronary microvessels: An unexpected mechanism of action of a calcium channel-blocking agent
    • Zhang X, Hintze TH (1998) Amlodipine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel-blocking agent. Circulation 97:576-580 (Pubitemid 28090687)
    • (1998) Circulation , vol.97 , Issue.6 , pp. 576-580
    • Zhang, X.1    Hintze, T.H.2
  • 201
    • 0027761945 scopus 로고
    • Inhibition of liver microsomal cytochrome p450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid
    • Zhang Z, Hamilton S, Stewart C, Strother A, Teel R (1993) Inhibition of liver microsomal cytochrome P450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid. Anticancer Res 13:2341-2346 (Pubitemid 24036373)
    • (1993) Anticancer Research , vol.13 , Issue.6 A , pp. 2341-2346
    • Zhang, Z.1    Hamilton, S.M.2    Stewart, C.3    Strother, A.4    Teel, R.W.5
  • 202
    • 0028140030 scopus 로고
    • Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: Evidence that nitric oxide is beneficial in the early stages of cerebral ischemia
    • Zhang F, White JG, Iadecola C (1994) Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 14:217-226 (Pubitemid 24064434)
    • (1994) Journal of Cerebral Blood Flow and Metabolism , vol.14 , Issue.2 , pp. 217-226
    • Zhang, F.1    White, J.G.2    Iadecola, C.3
  • 203
    • 77649144513 scopus 로고    scopus 로고
    • ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats
    • Zhuang P, Ji H, Zhang YH, Min ZL, Ni QG, You R (2010) ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats. Clin Exp Pharmacol Physiol 37:e121-e127
    • (2010) Clin Exp Pharmacol Physiol , vol.37
    • Zhuang, P.1    Ji, H.2    Zhang, Y.H.3    Min, Z.L.4    Ni, Q.G.5    You, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.