Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells

Journal of Vascular Surgery

Volumn 52, Issue 5, 2010, Pages 1290-1300

  Lee, Wen Jane ^a,b   Ou, Hsiu Chung ^c   Hsu, Wen Cheng ^d   Chou, Min Min ^a   Tseng, Jenn Jhy ^a   Hsu, Shih Lan ^a   Tsai, Kun Ling ^c   Sheu, Wayne Huey Herng ^a,e,f,g  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b TUNGHAI UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (China)

^d TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENYLIODONIUM SALT; ELLAGIC ACID; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN GP 91; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 18; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE P38; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN P22; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; VASCULAR CELL ADHESION MOLECULE 1; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; AUTACOID; CATION; CELL ADHESION MOLECULE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE; NOS2A PROTEIN, HUMAN; NOS3 PROTEIN, HUMAN; OLR1 PROTEIN, HUMAN; OXIDIZED LOW DENSITY LIPOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL LINE; PREMEDICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL CULTURE; DOSE RESPONSE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CELL ADHESION MOLECULES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELLAGIC ACID; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPROTEINS, LDL; NADPH OXIDASE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; ONIUM COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 79952111529     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2010.04.085     Document Type: Article

References (40)

1. Aviram M. Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 1993;98:1-9.
2. Shi X, Niimi S, Ohtani T, Machida S. Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor. J Cell Sci 2001;114:1273-82.
3. Chen XP, Xun KL, Wu Q, Zhang TT, Shi JS, Du GH. Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species. Vascul Pharmacol 2007;47:1-9.
4. Vendrov AE, Madamanchi NR, Hakim ZS, Rojas M, Runge MS. Thrombin and NAD(P)H oxidase-mediated regulation of CD44 and BMP4-Id pathway in VSMC, restenosis, and atherosclerosis. Circ Res 2006;98:1254-63.
5. Flaherty JT, Pitt B, Gruber JW, Heuser RR, Rothbaum DA, Burwell LR, et al. Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 1994;89: 1982-91.
6. Kris-Etherton PM, Keen CL. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipidol 2002;13:41-9.
7. de Ancos B, Gonzalez EM, Cano MP. Ellagic acid, vitamin C, and total phenolic contents and radical scavenging capacity affected by freezing and frozen storage in raspberry fruit. J Agric Food Chem 2000;48: 4565-70.
8. Larrosa M, Tomas-Barberan FA, Espin JC. The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem 2006;17:611-25.
9. Singh K, Khanna AK, Visen PK, Chander R. Protective effect of ellagic acid on t-butyl hydroperoxide induced lipid peroxidation in isolated rat hepatocytes. Indian J Exp Biol 1999;37:939-40.
10. Iino T, Tashima K, Umeda M, Ogawa Y, Takeeda M, Takata K, et al. Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion. Life Sci 2002;70:1139-50.
11. Labrecque L, Lamy S, Chapus A, Mihoubi S, Durocher Y, Cass B, et al. Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound. Carcinogenesis 2005;26:821-6.
12. Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate. Eur Urol 2005;47:449-54; discussion 454-5.
13. Yu YM, Chang WC, Wu CH, Chiang SY. Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid. J Nutr Biochem 2005;16:675-81.
14. Takagi A, Sai K, Umemura T, Hasegawa R, Kurokawa Y. Inhibitory effects of vitamin E and ellagic acid on 8-hydroxydeoxyguanosine formation in liver nuclear DNA of rats treated with 2-nitropropane. Cancer Lett 1995;91:139-44.
15. Chang WC, Yu YM, Chiang SY, Tseng CY. Ellagic acid suppresses oxidised low-density lipoprotein-induced aortic smooth muscle cell proliferation: studies on the activation of extracellular signal-regulated kinase 1/2 and proliferating cell nuclear antigen expression. Br J Nutr 2008;99:709-14.
16. Papoutsi Z, Kassi E, Chinou I, Halabalaki M, Skaltsounis LA, Moutsat-sou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr 2008;99:715-22.
17. Yu YM, Wang ZH, Liu CH, Chen CS. Ellagic acid inhibits IL-1beta-induced cell adhesion molecule expression in human umbilical vein endothelial cells. Br J Nutr 2007;97:692-8.
18. Vieira O, Escargueil-Blanc I, Meilhac O, Basile JP, Laranjinha J, Almeida L, et al. Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL. Br J Pharmacol 1998;123:565-73.
19. Kuo WW, Huang CY, Chung JG, Yang SF, Tsai KL, Chiu TH, et al. Crude extracts of solanum lyratum protect endothelial cells against oxidized low-density lipoprotein-induced injury by direct antioxidant action. J Vasc Surg 2009;50:849-60.
20. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-53.
21. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
22. Cross AR, Jones OT. The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J 1986;237: 111-6.
23. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988;141:2407-12.
24. Xu HS, Duan J, Dai S, Wu Y, Sun R, Ren J. Phytoestrogen alpha-zearalanol antagonizes oxidized LDL-induced inhibition of nitric oxide production and stimulation of endothelin-1 release in human umbilical vein endothelial cells. Endocrine 2004;25:235-45.
25. Rueckschloss U, Galle J, Holtz J, Zerkowski HR, Morawietz H. Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coen-zyme A reductase inhibitor therapy. Circulation 2001;104:1767-72.
26. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007;87:245-313.
27. Lubrano V, Baldi S, Ferrannini E, L'Abbate A, Natali A. Role of thromboxane A2 receptor on the effects of oxidized LDL on microvas-cular endothelium nitric oxide, endothelin-1, and IL-6 production. Microcirculation 2008;15:543-53.
28. Chen XP, Zhang TT, DuGH. Lectin-like oxidized low-density lipopro-tein receptor-1, a new promising target for the therapy of atherosclerosis? Cardiovasc Drug Rev 2007;25:146-61.
29. Ghosh S, Baltimore D. Activation in vitro of NF-kappa B by phosphor-ylation of its inhibitor I kappa B. Nature 1990;344:678-82.
30. Urban MB, Schreck R, Baeuerle PA. NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit. Embo J 1991;10:1817-25.
31. Li JM, Shah AM. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol 2004;287:R1014-30.
32. CominaciniL, Pasini AF, Garbin U, DavoliA, Tosetti ML, Campagnola M, et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappa B through an increased production of intracellular reactive oxygen species. J Biol Chem 2000;275:12633-8.
33. Mehta JL, Chen J, Yu F, Li DY. Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endo-thelial cells. Cardiovasc Res 2004;64:243-9.
34. Hamilton TA, Major JA, Armstrong D, Tebo JM. Oxidized LDL modulates activation of NFkappaB in mononuclear phagocytes by altering the degradation if IkappaBs. J Leukoc Biol 1998;64:667-74.
35. Zou MH, Leist M, Ullrich V. Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries. Am J Pathol 1999;154:1359-65.
36. Marshall HE, Merchant K, Stamler JS. Nitrosation and oxidation in the regulation of gene expression. FASEB J 2000;14:1889-900.
37. Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW. p53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett 1999;136: 215-21.
38. Murugan V, Mukherjee K, Maiti K, Mukherjee PK. Enhanced oral bioavailability and antioxidant profile of ellagic acid by phospholipids. J Agric Food Chem 2009;57:4559-65.
39. Mertens-Talcott SU, Talcott ST, Percival SS. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cyto-toxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 2003; 133:2669-74.
40. Seeram NP, Lee R, Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta 2004;348:63-8.