Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels

Stroke

Volumn 30, Issue 10, 1999, Pages 2186-2190

  McNeill, Anne Marie ^a   Kim, Nancy ^a   Duckles, Sue P ^a   Krause, Diana N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cerebral vessels; Estrogens; Gender; Nitric oxide synthase; Rats

Indexed keywords

ESTROGEN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN BLOOD VESSEL; CASTRATION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; IMMUNOBLOTTING; LONG TERM CARE; MALE; NEUROPROTECTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROKE; SUBCUTANEOUS DRUG ADMINISTRATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0032860804     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.10.2186     Document Type: Article

References (25)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD. Gender-linked brain injury in experimental stroke. Stroke. 1998;29: 159-165; comment 166.
2. Toung TJ, Traystman RJ, Hurn PD. Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke. 1998;29:1666-1670.
3. Stagliano N, Dietrich W, Prado R, Green E, Busto R. The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat. Brain Res. 1997;759:32-40.
4. Geary GG, Krause DN, Duckles SP. Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am J Physiol. 1998;275:H292-H300.
5. Geary GG, Krause DN, Duckles SP. Estrogen and testosterone influence myogenic tone in male rat cerebral arteries. Soc Neurosci Abstracts. 1998;24:873. Abstract.
6. Joo F. The blood-brain barrier in vitro: ten years of research on microvessels isolated from the brain. Neurochem Int. 1985;7:1-25.
7. Albert DJ, Jonik RH, Walsh ML. Aggression by ovariectomized female rats: combined testosterone/estrogen implants support the development of hormone-dependent aggression. Physiol Behav. 1990;47:825-830.
8. Garcia-Villalon AL, Krause DN, Ehlert FJ, Duckles SP. Heterogeneity of muscarinic receptor subtypes in cerebral blood vessels. J Pharmacol Exp Ther. 1991;258:304-310.
9. Estrada C, Hamel E, Krause DN. Biochemical evidence for cholinergic innervation of intracerebral blood vessels. Brain Res. 1983;266:261-270.
10. MacRitchie AN, Jun SS, Chen Z, German Z, Yuhanna IS, Sherman TS, Shaul PW. Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium. Circ Res. 1997;81: 355-362.
11. Hayashi T, Yamada K, Esaki T, Mutoh E, Iguchi A. Effect of estrogen on isoforms of nitric oxide synthase: possible mechanism of antiatherosclerotic effect of estrogen. Gerontology, 1997;43:24-34.
12. Kleinert H, Wallerath T, Euchenhofer C, Ihrig-Biedert I, Li H. Forstermann U. Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension. 1998;31:582-588.
13. Goetz RM, Morano I, Calovini T, Studer R, Holtz J. Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy. Biochem Biophys Res Commun. 1994;205:905-910.
14. Alfie J, Lugones L, Belardo A, Tutzer M, Galarza CR, Waisman GD, Camera MI. Hemodynamic effects of transdermal estradiol alone and combined with norethisterone acetate. Maturitas. 1997;27:163-169.
15. Gerhard M, Walsh BW, Tawakol A, Haley EA, Creager SJ, Seely EW, Ganz P, Creager MA. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation. 1998;98:1158-1163.
16. Cicinelli E, Ignarro LJ, Lograno M, Galantino P, Balzano G, Schonauer LM. Circulating levels of nitric oxide in fertile women in relation to the menstrual cycle. Fertil Steril. 1996;66:1036-1038.
17. Hashimoto M, Akishita M, Eto M, Ishikawa M, Kozaki K, Toba K, Sagara Y, Taketani Y, Orimo H, Ouchi Y. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation. 1995;92:3431-3435.
18. Sudhir K, Chou TM, Messina LM, Hutchison SJ, Korach KS, Chatterjee K, Rubanyi GM. Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet. 1997;349:1146-1147.
19. Cicinelli E, Ignarro LJ, Lograno M, Matteo G, Falco N, Schonauer LM. Acute effects of transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women. Fertil Steril. 1997;67:63-66.
20. Komesaroff PA, Black CV, Westerman RA. A novel, nongenomic action of estrogen on the cardiovascular system. J Clin Endocrinol Metab. 1998;83:2313-2316.
21. Caulin-Glaser T, Garcia-Cardena G, Sarrel P, Sessa WC, Bender JR. 17 Beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997;81: 885-892.
22. Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM. Estradiol protects against ischemic injury. J Cereb Blood Flow Metab. 1998;18:1253-1258.
23. Palmon SC, Williams MJ, Littleton-Kearney MT, Traystman RJ, Kosk-Kosicka D, Hurn PD. Estrogen increases cGMP in selected brain regions and in cerebral microvessels. J Cereb Blood Flow Metab. 1998;18: 1248-1252.
24. Berman KF, Schmidt PJ, Rubinow DR, Danaceau MA, Van Horn JD, Esposito G, Ostrem JL, Weinberger DR. Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Proc Natl Acad Sci U S A. 1997;94:8836-8841.
25. Ramsay B, Johnson MR, Leone AM, Steer PJ. The effect of exogenous oestrogen on nitric oxide production in women: a placebo controlled crossover study. Br J Obstet Gynaecol. 1995;102:417-419.