Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 25, Issue 4, 2005, Pages 421-426

  Littleton Kearney, Marguerite T ^a   Klaus, Judy A ^a   Hurn, Patricia D ^b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chronic hormone treatment; Conjugated equine estrogens; Medroxyprogesterone; Stroke

Indexed keywords

CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN PERFUSION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HORMONAL THERAPY; NEUROPROTECTION; NONHUMAN; OVARIECTOMY; POSTMENOPAUSE; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; BLOOD PRESSURE; BRAIN; CEREBRAL CORTEX; CEREBRAL INFARCTION; CEREBROVASCULAR ACCIDENT; ESTROGENS, CONJUGATED (USP); FEMALE; INFUSIONS, PARENTERAL; INJECTIONS, SUBCUTANEOUS; MEDROXYPROGESTERONE; MIDDLE CEREBRAL ARTERY; NEOSTRIATUM; NEUROPROTECTIVE AGENTS; OVARIECTOMY; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 17044361906     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600052     Document Type: Article

References (32)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-65
2. Anderson GL, Limacher M, Assaf AR, Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B, Chlebowski R, Curb D, Gass M, Hays J, Heiss G, Hendrix S, Howard BV, Hsia J, Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, Lane D, Langer RD, Lasser N, Lewis CE, Manson J, Margolis K, Ockene J, O'Sullivan MJ, Phillips L, Prentice RL, Ritenbaugh C, Robbins J, Rossouw JE, Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S, Women's Health Initiative Steering Committee (2004) Effects of conjugated, equine estrogen in postmenopausal women with hysterectomy - the women's health initiative randomized controlled trial. JAMA 291:1701-12
3. Bhavnani BR (2003) Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's. J Steroid Biochem Mol Biol 85:473-82
4. Bramlett HM, Dietrich WD (2001) Neuropathological protection after traumatic brain injury in intact female rats versus males or ovariectomized females. J Neurotrauma 18:891-900
5. Butcher RL, Collins WE, Fugo NW (1974) Plasma concentrations of LH, FSH, prolactin, progesterone and estradiol-17β throughout the 4-day estrous cycle of the rat. Endocrinology 94:1704-8
6. Ciriza I, Azcoitia I, Garcia-Segura LM (2004) Reduced progesterone metabolites protect rat hippocampal - neurones from kainic acid excitotoxicity in vivo. J Neuroendocrinol 16:58-63
7. Gibson CL, Murphy SP (2004) Progesterone enhances functional recovery after middle cerebral occlusion in male mice. J Cereb Blood Flow Met 24:805-13
8. Hall ED, Pazara KE, Linseman KL (1991) Sex-differences in postischemic neuronal necrosis in gerbils. J Cereb Blood Flow Metab 11:292-8
9. Hattori K, Lee H, Purn PD, Crain BJ, Traystman RJ, DeVries AC (2000) Cognitive deficits after focal ischemia in mice. Stroke 31:1939-44
10. Herkert O, Kuhl H, Sandow J, Busse R, Schini-Kerth VB (2001) Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor. Circulation 104:2826-31
11. Hurn PD, Brass LM (2003) Estrogen and stroke: A balanced analysis. Stroke 34:338-41
12. Mimura N, Kobayashi K, Nakamura Y, Shimada N, Hosokawa M, Chiba K (2003) Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo. Life Sci 73:3201-12
13. Murphy SJ, Littleton-Kearney MT, Hurn PD (2002) Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats. J Cereb Blood Flow Metab 22:1181-8
14. Nilsen J, Brinton RD (2002a) Impact of progestins on neural effects of estradiol: synergy by progesterone and antagonism by medroxyprogesterone acetate. Neurobiol Aging 23:S122
15. Nilsen J, Brinton RD (2002b) Impact of progestins on estradiol potentiation of the glutamate calcium response. Neuroreport 13:825-30
16. Palmon SC, Williams MJ, Littleton-Kearney MT, Traystman RJ, Kosk-Kosicka D, Hurn PD (1998) Estrogen increases cGMP in selected brain regions and in cerebral microvessels. J Cereb Blood Flow Metab 18:1248-52
17. Pazol K, Wilson ME, Wallen K (2004) Medroxyprogesterone acetate antagonizes the effect of estrogen treatment on social and sexual behavior in female macaques. J Clin Endocrinol Metab 89:2998-3006
18. Pelligrino DA, Santizo R, Baughman VL, Wang Q (1998) Cerebral vasodilating capacity during forebrain ischemia: effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport 9:3285-91
19. Reglodi D, Tamas A, Lengvari I (2002) Examination of sensorimotor performance following meddle cerebral occlusion in rats. Brain Res Bull 59:459-66
20. Rogers DC, Campbeall, Stretton JL, Mackay KB (1997) Correlation between motor impairment and infarct volume after permanent and transient middle cerebral occlusion in the rat. Stroke 28:2060-6
21. Roof RL, Hall ED (2000) Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in rats. J Neurotrauma 2000; 17:1155-69
22. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J, Writing Group for the Women's Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-33
23. Rusa R, Alkayed NJ, Crain BJ, Rusa R, Alkayed NJ, Crain BJ, Traystman RJ, Kimes AS, London ED, Klaus JA, Hurn PD (1999) 17Beta-estradiol reduces stroke injury in estrogen-deficient female animals. Stroke 30:1665-9
24. Stein DG, Hoffman SW (2003) Concepts of CNS plasticity in the context of brain damage and repair. J Head Trauma Rehabil 18:317-41
25. Stein DG (2001) Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? Trends Neurosci 24:386-91
26. Toung JK, Traystman RJ, Hurn PD (1998) Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 29:1666-70
27. Toung TJK, Chen WY, Littleton-Kearney MT, Hurn PD, Murphy SJ (2004) Effects of combined estrogen and progesterone on brain infarction size in reproductively senescent female rats. J Cereb Blood Flow Metab 24:1160-6
28. Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI (2001) A clinical trial of estrogen-replacement therapy after ischemic stroke. N Engl J Med 345:1243-9
29. Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, Kotchen T, Curb JD, Black H, Rossouw JE, Aragaki A, Safford M, Stein E, Laowattana S, Mysiw WJ, WHI Investigators (2003) Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA 289:2673-84
30. Wright DW, Bauer ME, Hoffman SW, Stein DG (2001) Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. J Neurotrauma 18:901-9
31. Xing DQ, Miller A, Novak L, Rocha R, Chen YF, Oparil S (2004) Estradiol and progestins differentially modulate leukocyte infiltration after vascular injury. Circulation 109:234-41
32. Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW (1998) Effects of gender and estradiol treatment on focal brain ischemia. Brain Res 784:321-4