Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions

Brain Research

Volumn 1346, Issue , 2010, Pages 251-261

  Die, Jun ^a   Wang, Kunzheng ^a   Fan, Lihong ^a   Jiang, Yong ^a   Shi, Zhibing ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Neuroprotection; Nitric oxide synthase; Rosuvastatin; Spinal cord ischemia

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MEVALONIC ACID; NEURONAL NITRIC OXIDE SYNTHASE; ROSUVASTATIN; TRIPHENYLTETRAZOLIUM; BIOLOGICAL MARKER; FLUOROBENZENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NEUROPROTECTIVE AGENT; NITRIC OXIDE SYNTHASE; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DESCENDING AORTA; DRUG MECHANISM; ENZYME BLOOD LEVEL; FUNCTIONAL ASSESSMENT; IMMUNOHISTOCHEMISTRY; INFARCTION; ISCHEMIC PRECONDITIONING; MALE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD ISCHEMIA; SPRAGUE DAWLEY RAT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; HINDLIMB; LOCOMOTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; TREATMENT OUTCOME;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; FLUOROBENZENES; HINDLIMB; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFARCTION; ISCHEMIC PRECONDITIONING; LOCOMOTION; MALE; MEVALONIC ACID; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD ISCHEMIA; SULFONAMIDES; TREATMENT OUTCOME;

ANIMALIA; RATTUS;

EID: 77955515557     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.05.068     Document Type: Article

References (49)

1. S. Amin-Hanjani, N.E. Stagliano, M. Yamada, P.L. Huang, J.K. Liao, and M.A. Moskowitz Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice Stroke 32 2001 980 986
2. D.M. Basso, M.S. Beattie, and J.C. Bresnahan A sensitive and reliable locomotor rating scale for open field testing in rats J. Neurotrauma 12 1995 1 21
3. M.S. Beattie, A.A. Farooqui, and J.C. Bresnahan Review of current evidence for apoptosis after spinal cord injury J. Neurotrauma 17 2000 915 925
4. V. Calabrese, C. Mancuso, M. Calvani, E. Rizzarelli, D.A. Butterfield, and A.M. Stella Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity Nat. Rev. Neurosci. 8 2007 766 775
5. A. Conti, M. Miscusi, S. Cardali, A. Germano, H. Suzuki, S. Cuzzocrea, and F. Tomasello Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation Brain Res. Rev. 54 2007 205 218
6. N.K. Cortas, and N.W. Wakid Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method Clin. Chem. 36 1990 1440 1443
7. M.A. Dery, G. Rousseau, M. Benderdour, and E. Beaumont Atorvastatin prevents early apoptosis after thoracic spinal cord contusion injury and promotes locomotion recovery Neurosci. Lett. 453 2009 73 76
8. P. Di Napoli, A.A. Taccardi, A. Grilli, M.A. De Lutiis, A. Barsotti, M. Felaco, and R. De Caterina Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts Cardiovasc. Res. 66 2005 462 471
9. A. Diaz-Ruiz, A. Ibarra, F. Perez-Severiano, G. Guizar-Sahagun, I. Grijalva, and C. Rios Constitutive and inducible nitric oxide synthase activities after spinal cord contusion in rats Neurosci. Lett. 319 2002 129 132
10. T. Engelhorn, A. Doerfler, G. Heusch, and R. Schulz Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats Neurosci. Lett. 406 2006 92 96
11. O. Feron, C. Dessy, J.P. Desager, and J.L. Balligand Hydroxy- methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance Circulation 103 2001 113 118
12. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
13. Y. Hamada, T. Ikata, S. Katoh, K. Tsuchiya, M. Niwa, Y. Tsutsumishita, and K. Fukuzawa Roles of nitric oxide in compression injury of rat spinal cord Free Radic. Biol. Med. 20 1996 1 9 (Pubitemid 26014315)
14. H.T. Hassoun, R.A. Kozar, B.C. Kone, H.J. Safi, and F.A. Moore Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia reperfusion Surgery 132 2002 369 376
15. T. Hayashi, M. Sakurai, K. Abe, M. Sadahiro, K. Tabayashi, and Y. Itoyama Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia Stroke 29 1998 1007 1012 (discussion 1013)
16. W.H. Hu, F. Li, W.A. Qiang, N. Liu, G.Q. Wang, J. Xiao, J.S. Liu, W.H. Liao, and M.F. Jen Dual role for nitric oxide in dynorphin spinal neurotoxicity J. Neurotrauma 16 1999 85 98
17. P.L. Huang Nitric oxide and cerebral ischemic preconditioning Cell Calcium 36 2004 323 329
18. Z. Huang, P.L. Huang, N. Panahian, T. Dalkara, M.C. Fishman, and M.A. Moskowitz Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase Science 265 1994 1883 1885
19. Z. Huang, P.L. Huang, J. Ma, W. Meng, C. Ayata, M.C. Fishman, and M.A. Moskowitz Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-l-arginine J. Cereb. Blood Flow Metab. 16 1996 981 987
20. K.C. Huang, C.W. Chen, J.C. Chen, and W.W. Lin HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages J. Biomed. Sci. 10 2003 396 405
21. C. Iadecola, F. Zhang, R. Casey, M. Nagayama, and M.E. Ross Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene J. Neurosci. 17 1997 9157 9164
22. J.H. In, E.J. Lee, B.H. Lee, Y.G. Lim, and M.H. Chun Regulation and localization of neuronal nitric oxide synthase in the ischemic rabbit spinal cord Mol. Cells 15 2003 406 411
23. H. Kleinert, A. Pautz, K. Linker, and P.M. Schwarz Regulation of the expression of inducible nitric oxide synthase Eur. J. Pharmacol. 500 2004 255 266
24. K. Kucharova, N. Lukacova, J. Pavel, J. Radonak, M.P. Hefferan, D. Kolesar, M. Kolesarova, M. Marsala, and J. Marsala Spatiotemporal alterations of the NO/NOS neuronal pools following transient abdominal aorta occlusion: morphological and biochemical studies in the rabbit Cell. Mol. Neurobiol. 26 2006 1295 1310
25. U. Laufs, and J.K. Liao Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase J. Biol. Chem. 273 1998 24266 24271
26. U. Laufs, D. Marra, K. Node, and J.K. Liao 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1) J. Biol. Chem. 274 1999 21926 21931
27. U. Laufs, M. Endres, N. Stagliano, S. Amin-Hanjani, D.S. Chui, S.X. Yang, T. Simoncini, M. Yamada, E. Rabkin, P.G. Allen, P.L. Huang, M. Bohm, F.J. Schoen, M.A. Moskowitz, and J.K. Liao Neuroprotection mediated by changes in the endothelial actin cytoskeleton J. Clin. Invest. 106 2000 15 24
28. U. Laufs, K. Gertz, U. Dirnagl, M. Bohm, G. Nickenig, and M. Endres Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice Brain Res. 942 2002 23 30
29. M.E. Mackey, Y. Wu, R. Hu, J.A. DeMaro, M.F. Jacquin, G.K. Kanellopoulos, C.Y. Hsu, and N.T. Kouchoukos Cell death suggestive of apoptosis after spinal cord ischemia in rabbits Stroke 28 1997 2012 2017 (Pubitemid 27459012)
30. M. Matsumoto, Y. Iida, H. Wakamatsu, K. Ohtake, K. Nakakimura, L. Xiong, and T. Sakabe The effects of N(G)-nitro-l-arginine-methyl ester on neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits Anesth. Analg. 89 1999 696 702
31. F. McTaggart, L. Buckett, R. Davidson, G. Holdgate, A. McCormick, D. Schneck, G. Smith, and M. Warwick Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Am. J. Cardiol. 87 2001 28B 32B
32. Y. Naito, K. Katada, T. Takagi, H. Tsuboi, M. Kuroda, O. Handa, S. Kokura, N. Yoshida, H. Ichikawa, and T. Yoshikawa Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein World J. Gastroenterol. 12 2006 2024 2030
33. T. Nemoto, T. Sekikawa, T. Suzuki, H. Moriya, and H. Nakaya Inhibition of nitric oxide synthesis accelerates the recovery of polysynaptic reflex potentials after transient spinal cord ischemia in cats Naunyn. Schmiedebergs Arch. Pharmacol. 355 1997 447 451
34. M. Niwa, S. Inao, M. Takayasu, T. Kawai, Y. Kajita, T. Nihashi, R. Kabeya, T. Sugimoto, and J. Yoshida Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats Neurol. Med. Chir. (Tokyo) 41 2001 63 72 (discussion 72-63)
35. K. Pahan, F.G. Sheikh, A.M. Namboodiri, and I. Singh Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages J. Clin. Invest. 100 1997 2671 2679
36. N. Panahian, T. Yoshida, P.L. Huang, E.T. Hedley-Whyte, T. Dalkara, M.C. Fishman, and M.A. Moskowitz Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase Neuroscience 72 1996 343 354
37. R. Pannu, E. Barbosa, A.K. Singh, and I. Singh Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats J. Neurosci. Res. 79 2005 340 350
38. D.D. Pearse, K. Chatzipanteli, A.E. Marcillo, M.B. Bunge, and W.D. Dietrich Comparison of iNOS inhibition by antisense and pharmacological inhibitors after spinal cord injury J. Neuropathol. Exp. Neurol. 62 2003 1096 1107
39. Y. Rikitake, and J.K. Liao Rho GTPases, statins, and nitric oxide Circ. Res. 97 2005 1232 1235
40. A.F. Samdani, T.M. Dawson, and V.L. Dawson Nitric oxide synthase in models of focal ischemia Stroke 28 1997 1283 1288
41. C. Santoscoy, C. Rios, R.E. Franco-Bourland, E. Hong, G. Bravo, G. Rojas, and G. Guizar-Sahagun Lipid peroxidation by nitric oxide supplements after spinal cord injury: effect of antioxidants in rats Neurosci. Lett. 330 2002 94 98
42. K. Stepien, M. Tomaszewski, and S.J. Czuczwar Neuroprotective properties of statins Pharmacol. Rep. 57 2005 561 569
43. Y. Taira, and M. Marsala Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat Stroke 27 1996 1850 1858
44. C.J. Vaughan, and N. Delanty Neuroprotective properties of statins in cerebral ischemia and stroke Stroke 30 1999 1969 1973
45. Y. Wang, S.Z. Lin, A.L. Chiou, L.R. Williams, and B.J. Hoffer Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex J. Neurosci. 17 1997 4341 4348
46. M. Yamada, Z. Huang, T. Dalkara, M. Endres, U. Laufs, C. Waeber, P.L. Huang, J.K. Liao, and M.A. Moskowitz Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by l-arginine after chronic statin treatment J. Cereb. Blood Flow Metab. 20 2000 709 717
47. T. Yoshida, V. Limmroth, K. Irikura, and M.A. Moskowitz The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels J. Cereb. Blood Flow Metab. 14 1994 924 929
48. F. Zhang, R.M. Casey, M.E. Ross, and C. Iadecola Aminoguanidine ameliorates and l-arginine worsens brain damage from intraluminal middle cerebral artery occlusion Stroke 27 1996 317 323
49. Y. Zhou, Y.N. Zhao, E.B. Yang, E.A. Ling, Y. Wang, M.M. Hassouna, and P. Mack Induction of neuronal and inducible nitric oxide synthase in the motoneurons of spinal cord following transient abdominal aorta occlusion in rats J. Surg. Res. 87 1999 185 193