Neuroprotective effects of progesterone following stroke in aged rats

Behavioural Brain Research

Volumn 209, Issue 1, 2010, Pages 119-122

  Wang, Jianping ^a   Jiang, Chao ^a   Liu, Chunling ^a   Li, Xin ^a   Chen, Ningning ^a   Hao, Yujin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Aged rats; Brain water content; Functional deficits; Infarct volume; Progesterone

Indexed keywords

PROGESTERONE;

AGED; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DIGITAL IMAGING; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FUNCTIONAL ASSESSMENT; IMAGE ANALYSIS; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE; WATER CONTENT;

AGING; ANALYSIS OF VARIANCE; ANIMALS; BRAIN EDEMA; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; MALE; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; STROKE; TETRAZOLIUM SALTS; TIME FACTORS;

EID: 77249145948     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.01.026     Document Type: Article

References (28)

1. Arnold K.G. Cerebral blood flow in geriatrics- a review. Age Ageing 10 1 (1981) 5-9
2. Ayata C., and Ropper A.H. Ischaemic brain oedema. J Clin Neurosci 9 2 (2002) 113-124
3. Buga A.M., Bǎlşeanu A., Popa-Wagner A., and Mogoantǎ L. Strategies to improve post-stroke behavioral recovery in aged subjects. Rom J Morphol Embryol 50 4 (2009) 559-582
4. Betz A.L., and Coester H.C. Effect of steroids on edema and sodium uptake of the brain during focal ischemia in rats. Stroke 21 8 (1990) 1199-1204
5. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., and Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 3 (1986) 472-476
6. Chen J., Chopp M., and Li Y. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 171 (1999) 24-30
7. Cai W., Zhu Y., Furuya K., Li Z., Sokabe M., and Chen L. Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacology 55 2 (2008) 127-138
8. Gibson C.L., Constantin D., Prior M.J., Bath P.M., and Murphy S.P. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 193 2 (2005) 522-530
9. Gibson C.L., Gray L.J., Bath P.M., and Murphy S.P. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 131 Pt2 (2008) 318-328
10. Goss C.W., Hoffman S.W., and Stein D.G. Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study. Pharmacol Biochem Behav 76 2 (2003) 231-242
11. Gibson C.L., and Murphy S.P. Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 24 7 (2004) 805-813
12. Golanov E.V., and Reis D.J. Contribution of cerebral edema to the neuronal salvage elicited by stimulation of cerebellar fastigial nucleus after occlusion of the middle cerebral artery in rat. J Cereb Blood Flow Metab 15 1 (1995) 172-174
13. Guo Q., Sayeed I., Baronne L.M., Hoffman S.W., Guennoun R., and Stein D.G. Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp Neurol 198 2 (2006) 469-478
14. Ginsberg M.D., Watson B.D., Busto R., Yoshida S., Prado R., Nakayama H., et al. Peroxidative damage to cell membranes following cerebral ischemia. A cause of ischemic brain injury?. Neurochem Pathol 9 (1988) 171-193
15. Hoyer S. Ischemia in aged brain. Gerontology 33 3-4 (1987) 203-206
16. Hamm R.J., Pike B.R., O'Dell D.M., Lyeth B.G., and Jenkins L.W. The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J Neurotrauma 11 2 (1994) 187-196
17. Jun He, Chheng-Orn Evans, Stuart W., Hoffman, Nelson M., Oyesiku, et al. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol 189 2 (2004) 404-412
18. Mizoi K., Suzuki J., Imaizumi S., and Yoshimoto T. Development of new cerebral protective agents: the free radical scavengers. Neurol Res 8 2 (1986) 75-80
19. Pitkänen A. Clinical trials in neuroprotection. Idrugs 6 3 (2003) 200-202
20. Siesjö B.K., Agardh C.D., and Bengtsson F. Free radical and brain damage. Cerebrovasc Brain Metab Rev 1 3 (1989) 165-211
21. Sayeed I., Wali B., and Stein D.G. Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 25 2 (2007) 151-159
22. Takaba H., Fukuda K., and Yao H. Substrain differences, gender, and age of spontaneously hypertensive rats critically determine infarct size produced by distal middle cerebral artery occlusion. Cell Mol Neurobiol 24 5 (2004) 589-598
23. Tauheed Ishrat, Iqbal Sayeed, Fahim Atif, and Donald G. Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats. Brain Res 1257 (2009) 94-101
24. Tatlisumak T., Carano R.A., Takano K., Meiler M.R., Li F., Sotak C.H., et al. Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J Neurol Sci 178 2 (2000) 107-113
25. Vandromme M., Melton S.M., and Kerby J.D. Progesterone in traumatic brain injury: time to move on to phase III trials. Crit Care 129 2 (2008) 153
26. Wright D.W., Bauer M.E., Hoffman S.W., and Stein D.G. Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. J Neurotrauma 18 9 (2001) 901-909
27. Yao H., Sadoshima S., Ooboshi H., Sato Y., Uchimura H., and Fujishima M. Age-related vulnerability to cerebral ischemia in spontaneously hypertensive rats. Stroke 22 11 (1991) 1414-1418
28. Zea Longa Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 1 (1989) 84-91