Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 3, 2003, Pages 371-380

  Yamakawa, Haruki ^a   Jezova, Miroslava ^a   Ando, Hiromichi ^a   Saavedra, Juan M ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Angiotensin II receptor types; Brain ischemia; Cerebrovascular regulation; Genetic hypertension; Renin angiotensin system; Stroke

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CIRCULUS ARTERIOSUS; BRAIN ISCHEMIA; COMMON CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIUM CELL; HEMODYNAMIC MONITORING; HYPERTENSION; MALE; MIDDLE CEREBRAL ARTERY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STROKE;

EID: 0037341594     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000047369.05600.03     Document Type: Article

References (48)

1. Amin-Hanjani SH, Stagliano NE, Yamada M. Huang PL, Liao JK, Moskowitz MA (2001) Mevastatin, an HMG CoA-reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32:980-986
2. Arnetić SP, Honig MA, Milner TA, Greco S, ladecola C, Reis DJ (1988) Neuronal and endothelial sites of acetylcholine synthesis and release associated with microvessels in rat cerebral cortex ultrastructural and neurochemical studies. Brain Res 454:11-30
3. Barsotti A, Di Napoli P, Taccardi AA, Spina R, Stuppia L, Palka G. Barbacane RC, De Caterina R, Conti P (2001) MK-954 (losartan potassium) exerts endothelial protective effects against reperfusion injury: evidence of an e-NOS mRNA overexpression after global ischemia. Atherosclerosis 155:53-59
4. Baumbach GL, Heistad DD (1992) Drug-induced changes in mechanics and structure of cerebral arterioles. J Hypertens 10(suppl 6):S137-S140
5. Bederson JB, Pitts LH, Germano SM. Nishimura MC, Davis RL, Bartkowski HM (1986) Evaluation of 2,3.5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304-1308
6. 1 receptor antagonism parallels improved vascular morphology in hypertensive rats. J Am Soc Nephrol 10:S104-S115
7. Briones AM, Alonso MJ, Hernanz R, Miguel M, Salaices M (2002) Alterations of the nitric oxide pathway in cerebral arteries from spontaneously hypertensive rats. J Cardiovasc Pharmacil 39:378-388
8. Cahill PA, Redmond EM. Foster C, Sitzmann JV (1995) Nitric oxide regulates angiotensin 11 receptors in vascular smooth muscle cells. Eur J Pharmacol 288:219-229
9. Chou TC, Yen MH. Chi-Yuan L, Ding YA (1998) Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 31:643-648
10. Cromheeke KM, Kockx MM. De Meyer GRY, Bosmans JM. Bult H, Beelaerts WJF, Vrints CJ, Herman AG (1999) Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques. Cardiovasc Res 43:744-754
11. Eugene JR, Abdallah M. Miglietta M, Vernenkar VV, Pascual R. Briones R, Barnes T, Hager J (1999) Carotid occlusive disease: primary care of patients with or without symptoms, Geriatrics 54:24-26
12. Faraci FM, Heistad DD, Mayhan WG (1987) Role of large arteries in regulation of blood flow to brain stem in cats. J Physiol (Lond) 387:115-123
13. Fujii K, Weno BL, Baumbach GL, Heistad DD (1992) Effect of anti-hypertensive treatment on focal cerebral infarction. Hypertension 19:713-716
14. Gorelick PB (2002) Stroke prevention therapy beyond antithromhotics: unifying mechanisms in ischemic stroke pathogenesis and implications for therapy. An invited review. Stroke 33:862-875
15. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW (1994) Angiotensin 11 stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74:1141-1148
16. Heistad DD. Baumbach GL (1992) Cerebral vascular changes during chronic hypertension: good guys and bad guys, J Hypertens 10:(suppl 7):S71-S75
17. Intengan HD, Schiffrin EL (2001) Vascular remodeling in hypertension roles of apoptosis, inflammation and fibrosis. Hypertension 38:(pt 2):581-587
18. Ito H, Takemori K, Suzuki T (2001) Role of angiotensin II type I receptor in the leucocytes and endothelial cells of brain microvessels in the pathogenesis of hypertensive cerebral injury. J Hypertens 19:591-597
19. 1 antagonist. Stroke 33:2297-2303
20. Kobayashi N, Mori Y, Nakano S, Tsubokou Y, Kobayashi T. Shirataki H, Matsuoka H (2001) TCV-116 stimulates eNOS and caveolin-I expression and improves coronary microvascular remodeling in normotensive and angiotensin II-induced hypertensive rats. Atherosclerosis 158:359-368
21. Kruger L, Saporta S, Swanson L, eds (1995) Photographic atlas of the rat brain. New York, NY: Cambridge University Press, pp 1-299
22. Ledingham JM, Laverty R (2000) Basilar artery remodelling in the genetically hypertensive rat: effects of nitric oxide synthase inhibition and treatment with valsartan and enalapril. Clin Pharmacol Physiol 27:642-646
23. Leker RR, Teichner A, Ovadia H, Keshet E, Reinherz E, Ben-Hur T (2001) Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor. Brain Res 909:1-7
24. Li H, Wallerath T, Forstermann U (2002) Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric Oxide 7:132-147
25. Millatt LJ, Abdel-Rahman EM, Siragy HM (1999) Angiotensin 11 and nitric oxide: a question of balance. Regul Pept 81:1-10
26. Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heisted DD (1996) Vascular remodeling. Hypertension 28:505-506
27. 1 receptor mediated contraction of the perfused rat cerebral artery. Neuroendocrinology 5:2278-2280
28. 1 receptors. Brain Res 871:29-38
29. 1, blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke 31:2478-2486
30. Orlowski M, Meister A (1963) γ-Glutamyl-p-nitroanilide: a new convenient substrate for determination and study of L- and D-γ-glutamyltranspeptidase activities. Biochim Biophys Acta 73:679-681
31. Orlowski M. Sessa G, Green JP (1974) γ-Glutamyl transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids. Science 184:66-68
32. Rajagopalan S, Kurz S, Mdnzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide to production via membrane NADH/NADPH oxidase activation. J Clin Invest 97:1916-1923
33. Rudic RD, Sessa WC (1999) Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. Am J Hum Genet 64:673-677
34. Rudic RD, Shesely EG, Maeda N. Smithies O, Segal SS, Sessa WC (1998) Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 101:731-736
35. 1-receptors in the regulation of the cerebral blood flow and brain ischaemia. J Renin Angiotensin Aldosterone Syst 2:S102-S109
36. Samdani AF, Dawson TM, Dawson VL (1997) Nitric oxide synthase in models of focal ischemia. Stroke 28:1283-1288
37. Satoh CH. Fukuda N, Hu W-Y, Nakayama M, Kishioka H, Kanmatsuse K (2001) Role of endogenous angiotensin 11 in the increased expression of growth factors in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Phamacol 37:108-118
38. Schieffer B, Shieffer E, Hilfiker-Kleiner D, Hilfiker A, Kovanen PT, Kaartinen M, Nussberger J, Harringer W, Drexler H (2000) Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques. Circulation 101:1372-1378
39. Stouffer GA, Owens GK (1992) Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta. Circ Res 70:820-828
40. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10:290-295
41. Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) Focal ischemia in the rat. Part I: description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1:53-60
42. Tontsch U, Bauer HC (1989) Isolation, characterization, and long-term cultivation of porcine and murine cerebral capillary endothelial cells. Microvasc Res 37:148-161
43. Tsutsui M, Onoue H, lida Y, Smith L, O'Brien T. Katusic ZS (2000) Effects of recombinant eNOS gene expression on reactivity of small cerebral arteries. Am J Physiol Heart Circ Physiol 278: H420-H427
44. Wu L, lwai M, Nakagami H, Li Z, Chen R, Suzuki J, Akishita M, de Gasparo M. Horiuchi M (2001) Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin aniotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury. Circulation 104:2716-2721
45. Yogo K, Shimokawa H, Funakoshi H. Kandabashi T, Miyata K, Okamoto S, Egashire K, Huang P, Akaike T. Takeshita A (2000) Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice. Arterioscler Thromb Vasc Biol 20:96-100
46. Yoshizumi M, Perrella MA, Burnett JC Jr. Lee ME (1993) Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 73:205-209
47. Zhang H, Chen X, Teng X, Snead C. Catravas JD (1998) Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells. Biochem Pharmacol 55:1873-1880
48. 1 receptor and nitric oxide synthase expression in patients with coronary heart disease. Hypertension 39:(pt 2):634-638