Antiangiogenic and antimitotic effects of aspirin in hypoxia-reoxygenation modulation of the LOX-1-NADPH oxidase axis as a potential mechanism

Journal of Cardiovascular Pharmacology

Volumn 56, Issue 6, 2010, Pages 635-641

  Khaidakov, Magomed ^a   Szwedo, Jacob ^a   Mitra, Sona ^a   Ayyadevara, Srinivas ^a   Dobretsov, Maxim ^a   Lu, Jingjun ^a   Mehta, Jawahar L ^a  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Angiogenesis; Endothelium; Gene expression; Hypoxia reoxygenation; Nitric oxide

Indexed keywords

ACETYLSALICYLIC ACID; BETA CATENIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN P120; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; VASCULAR ENDOTHELIAL CADHERIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL HYPOXIA; CELL JUNCTION; CELL MEMBRANE; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOSIS; PRIORITY JOURNAL; REOXYGENATION; TRANSCRIPTION INITIATION; UPREGULATION;

ANGIOGENESIS INHIBITORS; ANTIMITOTIC AGENTS; ASPIRIN; CELL HYPOXIA; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR JUNCTIONS; NADPH OXIDASE; OXYGEN; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION;

EID: 78751642044     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181f801e4     Document Type: Article

References (27)

1. Herrmann J, Lerman LO, Mukhopadhyay D, et al. Angiogenesis in atherogenesis. Arterioscler Thromb Vasc Biol. 2006;26:1948-1957.
2. Dass CR, Choong PF. Cancer angiogenesis: targeting the heel of Achilles. J Drug Target. 2008;6:449-454.
3. Hu C, Chen J, Dandapat A, et al. LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice. J Mol Cell Cardiol. 2008;44: 76-83.
4. Dandapat A, Hu C, Sun L, et al. Small concentrations of oxLDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway. Arterioscler Thromb Vasc Biol. 2007;27: 2435-2442. (Pubitemid 350203961)
5. Hu C, Dandapat A, Mehta JL. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50:952-957. (Pubitemid 350287540)
6. Toyoda K. Pharmacotherapy for the secondary prevention of stroke. Drugs. 2009;69:633-647.
7. Khan Q, Mehta JL. Relevance of platelet-independent effects of aspirin to its salutary effect in atherosclerosis-related events. J Atheroscler Thromb. 2005;12:185-190.
8. Keirsebilck A, Bonné S, Staes K, et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics. 1998;50:129-146.
9. Dobretsov M, Romanovsky D. 〉Clock-scan〉 protocol for image analysis. Am J Physiol Cell Physiol. 2006;291:C869-C879.
10. Taddei A, Giampietro C, Conti A, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin- 5. Nat. Cell Biol. 2008;10:923-934.
11. Bedel A, Nègre-Salvayre A, Heeneman S, et al. E-cadherin/beta- catenin/ T-cell factor pathway is involved in smooth muscle cell proliferation elicited by oxidized low-density lipoprotein. Circ Res. 2008;103: 694-701.
12. Mann B, Gelos M, Siedow A, et al. Target genes of beta-catenin-T cellfactor/ lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A. 1999;96:1603-1608.
13. Wassermann S, Scheel SK, Hiendlmeyer E, et al. p16INK4a is a betacatenin target gene and indicates low survival in human colorectal tumors. Gastroenterology. 2009;136:196-205.
14. Borthwick GM, Johnson AS, Partington M, et al. Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism. FASEB J. 2006;12:2009-2016.
15. Pearce HR, Kalia N, Bardhan KD, et al. Effects of aspirin and indomethacin on endothelial cell proliferation in vitro. J Gastroenterol Hepatol. 2003;18:1180-1187.
16. Xiao K, Garner J, Buckley KM, et al. p120-Catenin regulates clathrindependent endocytosis of VE-cadherin. Mol Biol Cell. 2005;16: 5141-5151.
17. Lu Z, Ghosh S, Wang Z, et al. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell. 2003;4: 499-515.
18. Bryant DM, Kerr MC, Hammond LA, et al. EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci. 2007;120:1818-1828.
19. Gavard J, Gutkind JS. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol. 2006;8:1223-1234.
20. Li D, Mehta JL. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol. 2000;20: 1116-1122.
21. Li D, Mehta JL. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation. 2000; 101:2889-2895.
22. Nagase M, Ando K, Nagase T, et al. Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium. Biochem Biophys Res Commun. 2001;281:720-725.
23. Petry A, Weitnauer M, Görlach A. Receptor activation of NADPH oxidases. Antioxid Redox Signal. 2010;13:467-487.
24. Mehta JL, Chen J, Yu F, et al. Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells. Cardiovasc Res. 2004;64:243-249.
25. van Wetering S, van Buul JD, Quik S, et al. Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci. 2002;115:1837-1846.
26. Predescu D, Predescu S, Shimizu J, et al. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol. 2005;289:L371-L381.
27. Jin HG, Yamashita H, Nagano Y, et al. Hypoxia-induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression. Neurosci Lett. 2006;408:62-67.