Simvastatin increases the activity of endothelial nitric oxide synthase via enhancing phosphorylation

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 29, Issue 3, 2009, Pages 286-290

  Li, Xiaoxia ^a   Wang, Peihua ^a   Xu, Xizhen ^a   Wang, Yong ^a   Xia, Yong ^b   Wang, Daowen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Endothelial cells; Nitric oxide synthase; Phosphorylation; Simvastatin

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NOS3 PROTEIN, HUMAN; SIMVASTATIN;

ARTICLE; CELL LINE; CYTOLOGY; ENZYMOLOGY; EPITHELIUM CELL; HUMAN; KIDNEY; METABOLISM; PHOSPHORYLATION;

CELL LINE; EPITHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KIDNEY; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; SIMVASTATIN;

EID: 70349693951     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-009-0304-0     Document Type: Article

References (24)

1. V. Randriamboavonjy I. Fleming 2005 Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there? Pharmacol Rep 57 Suppl 59 65
2. O. Feron J.L. Balligand 2006 Caveolins and the regulation of endothelial nitric oxide synthase in the heart Cardiovasc Res 69 4 788 797
3. U. Forstermann T. Munzel 2006 Endothelial nitric oxide synthase in vascular disease: from marvel to menace Circulation 113 13 1708 1714
4. Z. Yang X.F. Ming 2006 Recent advances in understanding endothelial dysfunction in atherosclerosis Clin Med Res 4 1 53 65
5. C. Urbich S. Dimmeler 2005 Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitors Kidney Int 67 5 1672 1676
6. H. Wang L. Lin J. Jiang, et al. 2003 Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways J Pharmacol Exp Ther 307 2 753 764
7. M. Paciaroni M. Hennerici G. Agnelli, et al. 2007 Statins and stroke prevention Cerebrovasc Dis 24 2-3 170 182
8. T. Yamada K. Node T. Mine, et al. 2007 Long-term effect of atorvastatin on neurohumoral activation and cardiac function in patients with chronic heart failure: A prospective randomized controlled study Am Heart J 153 6 1055.e1 8
9. U. Laufs F. Custodis M. Böhm 2006 HMG-CoA reductase inhibitors in chronic heart failure: potential mechanisms of benefit and risk Drugs 66 2 145 154
10. J.H. Martin H. Krum 2007 Statins and clinical outcomes in heart failure Clin Sci (Lond) 113 3 119 127 (Pubitemid 47237908)
11. A.M. Lefer B. Campbell Y.K. Shin, et al. 1999 Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts Circulation 100 2 178 184
12. S.S. Abraham J.C. Osorio S. Homma, et al. 2004 Simvastatin preserves cardiac function in genetically determined cardiomyopathy J Cardiovasc Pharmacol 43 3 454 461
13. Y. Kureishi Z. Luo I. Shiojima, et al. 2000 The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 8 1004 1010
14. P. Di Napoli A.A. Taccardi A. Grilli, et al. 2005 Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts Cardiovasc Res 66 3 462 471
15. J.P. Cooke 2003 NO and angiogenesis Atheroscler Suppl 4 4 53 60
16. L. Kalinowski L.W. Dobrucki V. Brovkovych, et al. 2002 Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin Circulation 105 8 933 938
17. U. Laufs J.K. Liao 1998 Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase J Biol Chem 273 37 24 266 24 271
18. Y. Rikitake J.K. Liao 2005 Rho GTPases, statins, and nitric oxide Circ Res 97 12 1232 1235
19. M. Essig G. Nguyen D. Prie, et al. 1998 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells: Role of geranylgeranylation and Rho proteins Circ Res 83 7 683 690
20. U. Laufs D. Marra K. Node, et al. 1999 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1) J Biol Chem 274 31 21 926 21 931
21. Y. Xia V.L. Dawson T.M. Dawson, et al. 1996 Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury PNAS 93 13 6770 6774
22. S. Ramasamy S. Parthasarathyb D.G. Harrison 1998 Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid J Lipid Res 89 268 276
23. Y.C. Boo G. Sorescu N. Boyd, et al. 2002 Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at ser1179 by akt-independent mechanisms. Role of protein kinase A J Biol Chem 277 5 3388 3396
24. M.B. Harris H. Ju V.J. Venema, et al. 2001 Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation J Biol Chem 276 19 16 587 16 591