Effects of thiazide diuretics on the gene expression of endothelial nitric oxide synthase and endothelin-1 in the spontaneous hypertensive rats

Chinese Pharmacological Bulletin

Volumn 22, Issue 5, 2006, Pages 552-555

  He, Yan ^a   Yan, Jiang Tao ^a   Tu, Rong Hui ^a   Wang, Pei Hua ^a   Wang, Dao Wen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Endothelial nitric oxide synthase; Endothelin 1; Hydrochlorothiazide; Indapamide

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; HYDROCHLOROTHIAZIDE; INDAPAMIDE; THIAZIDE DIURETIC AGENT;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION;

EID: 33747190923     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Chobanian A V, Bakris G L, Black H B, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure[J]. JAMA, 2003, 289:2560-73.
2. Conway J, Lauwers P. The hemodynamic and hypotensive effects of long-term therapy with chlorothiazide[J]. Circulation, 1960, 21:21-7.
3. Van Brummelen P, Man in't Veld A J, Schalekamp M A. Hemodynamic changes during long-term thiazide treatment of essential hypertension in responders and nonresponders[J]. Clin Pharmacol Ther, 1980,279:328-36.
4. Vardan S, Mookherjee S, Warner R, et al. Systolic hypertension in the elderly: hemodynamic response to long-term thiazide diuretic therapy and its side effects[J]. JAMA, 1983,250:2807-13.
5. Turner S T, Chapman A B, Schwartz G L, et al. Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide[J]. Am J Hypertens, 2003,16(10):834-9.
6. Campbell W B, Harder D R. Prologue: EDHF-what is it[J]? Am J Physiol Heart Circ Physiol, 2001,280:2413-6.
7. De Gennaro Colonna V, Rossoni G, Rigamonti A, et al. Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats[J]. Eur J Pharmacol, 2002,450:61-6.
8. Newaz M A, Yousefipour Z, Nawal N, et al. Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol[J]. J Physiol Pharmacol, 2003,54:319-27.
9. Hirooka Y, Sakai K, Kishi T, et al. Enhanced depressor response to endothelial nitric oxide synthase gene transfer into the nucleus tractus solitarii of spontaneously hypertensive rats[J]. Hypertens Res, 2003,26:325-31.
10. Ferro C J, Webb D J. Endothelial dysfunction and hypertension [J]. Drugs, 1997,53:30-41.
11. Touyz R M, Schiffrin E L. Role of endothelin in human hypertension[J]. Can J Physiol Pharmacol, 2003,81:533-41.
12. Ergul A. Endothelin-1 and endothelin receptor antagonists as potential cardiovascular therapeutic agents[J]. Pharmacotherapy, 2002,22:54-65.