The protective mechanism of progesterone on blood-brain barrier in cerebral ischemia in rats

Brain Research Bulletin

Volumn 79, Issue 6, 2009, Pages 426-430

  Wang, Jianping ^a   Jiang, Chao ^a   Li, Xin ^a   Liu, Chunling ^a   Cheng, Ningning ^a   Hao, Yujin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Blood brain barrier; Cerebral ischemia; Claudin5; Matrix metalloproteinase 9; Progesterone; Tumor necrosis factor alpha

Indexed keywords

CLAUDIN 5; GELATINASE B; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DAMAGE; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN WATER; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; BETA-CYCLODEXTRINS; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MATRIX METALLOPROTEINASE 9; MEMBRANE PROTEINS; NEUROPROTECTIVE AGENTS; PROGESTERONE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; WATER;

EID: 67449138379     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.05.018     Document Type: Article

References (40)

1. Abdallah Y., Gligorievski D., and Kasseckert S.A. The role of poly(ADP-ribose) polymerase (PARP) in the autonomous proliferative response of endothelial cells to hypoxia. Cardiovasc Res. 73 (2007) 568-574
2. Begley D.J., and Brightman M.W. Structural and functional aspects of the blood-brain barrier. Prog. Drug Res. 61 (2003) 39-78
3. Botchkina G.I., Meistrell III M.E., and Botchkina I.L. Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol. Med. 3 (1997) 765-781
4. Cunningham L.A., Wetzel M., and Rosenberg G.A. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 50 (2005) 329-339
5. de Vries H.E., Blom-Roosemalen M.C., van Oosten M., de Boer A.G., van Berkel T.J., Breimer D.D., and Kuiper J. The influence of cytokines on the integrity of the blood brain barrier in vitro. J. Neuroimmunol. 64 (2007) 37-43
6. Djebaili M., Hoffman S.W., and Stein D.G. Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex. Neuroscience 123 (2004) 349-359
7. Djebaili M., Guo Q., and Pettus E.H. The neurosteroidsprogesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. J. Neurotrauma 22 (2005) 106-118
8. Dziewulska D., and Mossakowski M.J. Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke. Clin. Neuropathol. 22 (2003) 35-40
9. Frydenlund D.S., Bhardwaj A., Otsuka T., Mylonakou M.N., Yasumura T., and Davidson K.G. Temporary loss of perivasular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 13532-13536
10. Galani R., Hoflhlan S.W., and Stein D.G. Effects of the duration of Progesterone treatment on the resolution of cerebrale edema induced by cortical contusion in rats. Neuroscience 18 (2001) 161-166
11. Gearing A.J., Beckett P., and Christodoulou M. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature 370 (1994) 555-557
12. Gibson C.L., and Murphy S.P. Progestrone enhances functional recovery after middle artery occlusion in male mice. J. Cereb. Blood. Flow Metab. 24 (2004) 805-813
13. Gibson C.L., Constantin D., and Prior M.J. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp. Neurol. 193 (2005) 522-530
14. Goss C.W., Hoffman S.W., and Stein D.G. Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study. Pharmacol. Biochem. Behav. 76 (2003) 231-242
15. Gottschall P.E., and Yu X. Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes. J. Neurochem. 64 (1995) 1513-1520
16. Guo Q., Sayeed I., and Baronne L.M. Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp. Neurol. 198 (2006) 469-478
17. He J., Evans C.O., Hoffman S.W., Oyesiku N.M., and Stein D.G. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp. Neurol. 189 (2004) 404-412
18. Hu Z., Li Y., Fang M., Wai M.S., and Yew D.T. Exogenous progesterone: a potential therapeutic candidate in CNS injury and neurodegeneration. Curr. Med. Chem. 16 (2009) 1418-1425
19. Kumon Y., Kim S.C., and Tompkins P. Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J. Neurosurg. 92 (2000) 848-852
20. Mani S.K., Reyna A.M., Chen J.Z., Mulac-Jericevic B., and Conneely O.M. Differential response of progesterone receptor isoforms in hoemone-dependent and -independent facilitation of female sexual receptivity. Mol. Endocrinol. 20 (2006) 1322-1332
21. Manicone A.M., and McGuire J.K. Matrix metalloproteinases as modulators of inflammation. Semin. Cell. Dev. Biol. 19 (2008) 34-41
22. Meistrell III M.E., Botchkina G.I., and Wang H. Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 8 (1997) 341-348
23. Nawashiro H., Martin D., and Hallenbeck J.M. Neuroprotective effects of TNF binding protein in focal cerebral ischemia. Brain. Res. 778 (1997) 265-271
24. Overall C.M., McQuibban G.A., and Clark-Lewis I. Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics. Biol. Chem. 383 (2002) 1059-1066
25. Roof R.L., Hoffman S.W., and Stein D.G. Progesterone protects against lipid peroxidation following traumatic brain injury in rats. Mol. Chem. Neuropathol. 31 (1997) 1-11
26. Sayeed I., Guo Q., and Hoffman S.W. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Ann. Emerg. Med. 47 (2006) 381-389
27. Sayeed I., Wali B., and Stein D.G. Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor. Neurol. Neurosci. 25 (2007) 151-159
28. Schaeffer V., Meyer L., Patte-Mensah C., Eckert A., and Mensah-Nyagan A.G. Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells. Neurochem. Int. 52 (2008) 948-955
29. Schonbeck U., Mach F., and Libby P. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1 independent pathway of IL-1 beta processing. J. Immunol. 161 (1998) 3340-3346
30. Shen J., Zhang H., and Lin H. Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression. Eur. J. Pharmacol. 558 (2007) 88-95
31. Smith S.S., and Woolley C.S. Cellular and molecular effects of steroid hormones on CNS excitability. Clin. J. Med. Suppl. 2 (2004) S4-10
32. Sternlicht M.D., and Werb Z. How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell. Dev. Biol. 17 (2001) 463-516
33. Svedin P., Hagberg H., and Sävman K. Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia. J. Neurosci. 27 (2007) 1511-1518
34. Tsukita S., and Furuse M. Overcoming barriers in the study of tight junction functions: from occludin to claudin. Genes. Cells. 3 (1998) 569-573
35. Vagnerova K., Koerner I.P., and Hurn P.D. Gender and the injured brain. Anesth. Analg. 107 (2008) 201-214
36. Vincent T., Saikali P., Cayrol R., Roth A.D., Bar-Or A., Prat A., and Antel J.P. Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J. Immunol. 181 (2008) 5730-5737
37. Vizuete M.L., Venero J.L., Vargas C., Ilundáin A.A., Echevarría M., Machado A., and Cano J. Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema. Neurobiol. Dis. 6 (1999) 245-258
38. Weiyan C., Ying Z., Kishio F., Zhen L., Masahiro S., and Ling C. Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacology 55 (2008) 127-138
39. Williams A.J., Dave J.R., and Tortella F.C. Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration. Neurochem. Int. 49 (2006) p106-112
40. Xi G., Hua Y., Keep R.F., Younger J.G., and Hoff J.T. Brain edema after intracerebral hemorrhage: the effects of systemic complement depletion. Acta. Neurochir. Suppl. 81 (2002) 253-256