The nitric oxide donor LA 419 decreases ischemic brain damage

International Journal of Molecular Medicine

Volumn 19, Issue 2, 2007, Pages 229-236

  Serrano, Julia ^a   Fernández, Ana Patricia ^a   Martínez Murillo, Ricardo ^a   Alonso, David ^b   Rodrigo, José ^a   Salas, Eduardo ^c,d   Mourelle, Marisabel ^c   Martínez, Alfredo ^a  

^a INSTITUTO CAJAL   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c Lacer SA   (Spain)

^d Gendiagexe   (Spain)

Author keywords

Brain ischemia; Inducible nitric oxide synthase; Magnetic resonance imaging; Neuronal nitric oxide synthase; Nitric oxide donor; Nitrotyrosine

Indexed keywords

3 NITROTYROSINE; 3-NITROTYROSINE; CALCIUM; DRUG DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOSORBIDE DINITRATE; LA 419; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE DONOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BRAIN ISCHEMIA; DISEASE MODEL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; RAT; WISTAR RAT;

ANIMALS; BRAIN ISCHEMIA; CALCIUM; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; ISOSORBIDE DINITRATE; MAGNETIC RESONANCE IMAGING; MALE; NEURONS; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; TYROSINE;

EID: 33847718962     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.19.2.229     Document Type: Article

References (43)

1. Mohr JP, Caplan LR, Melski JW, Goldstein RJ, Duncan GW, Kistler JP, Pessin MS and Bleich HL: The Harvard Cooperative Stroke Registry: a prospective registry. Neurology 28: 754-762, 1978.
2. Iadecola C: Mechanisms of cerebral ischemic damage. In: Cerebral Ischemia: Molecular and Cellular Pathophysiology. Walz W (ed). Humana Press, Inc., Totowa, NJ, pp3-36, 1999.
3. Adams H, Adams R, Del ZG and Goldstein LB: Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke 36: 916-923, 2005.
4. Willmot M, Gibson C, Gray L, Murphy S and Bath P: Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: A systematic review. Free Radic Biol Med 39: 412-425, 2005. (Pubitemid 40916222)
5. Bode-Boger SM and Kojda G: Organic nitrates in cardiovascular disease. Cell Mol Biol (Noisy-le-grand) 51: 307-320, 2005.
6. Jones SP and Bolli R: The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol 40: 16-23, 2006.
7. Rodrigo J, Fernandez AP, Serrano J, Peinado MA and Martinez A: The role of free radicals in cerebral hypoxia and ischemia. Free Radic Biol Med 39: 26-50, 2005.
8. Lei B, Adachi N, Nagaro T, Arai T and Koehler RC: Nitric oxide production in the CA1 field of the gerbil hippocampus after transient forebrain ischemia: effects of 7-nitroindazole and NG-nitro-L-arginine methyl ester. Stroke 30: 669-677, 1999.
9. Olesen SP, Moller A, Mordvintcev PI, Busse R and Mulsch A: Regional measurements of NO formed in vivo during brain ischemia. Acta Neurol Scand 95: 219-224, 1997.
10. Togashi H, Mori K, Ueno K, Matsumoto M, Suda N, Saito H and Yoshioka M: Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis. Neurosci Lett 240: 53-57, 1998.
11. Yoshida T, Waeber C, Huang Z and Moskowitz MA: Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion. Neurosci Lett 194: 214-218, 1995.
12. O'Mahony D and Kendall MJ: Nitric oxide in acute ischaemic stroke: a target for neuroprotection. J Neurol Neurosurg Psychiatry 67: 1-3, 1999.
13. Loihl AK, Asensio V, Campbell IL and Murphy S: Expression of nitric oxide synthase (NOS)-2 following permanent focal ischemia and the role of nitric oxide in infarct generation in male, female and NOS-2 gene-deficient mice. Brain Res 830: 155-164, 1999.
14. Sun Y, Carretero OA, Xu J, Rhaleb NE, Wang F, Lin C, Yang JJ, Pagano PJ and Yang XP: Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension. Hypertension 46: 1355-1361, 2005.
15. Huang Z, Huang PL, Ma J, Meng W, Ayata C, Fishman MC and Moskowitz MA: Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab 16: 981-987, 1996.
16. Su J, Tse J, Scholz PM and Weiss HR: Alterations in ventricular myocyte contraction caused by C-type natriuretic peptide and nitric oxide in eNOS-/- mice. J Mol Cell Cardiol 39: 920-928, 2005.
17. Tagami M, Ikeda K, Nara Y, Fujino H, Kubota A, Numano F and Yamori Y: Detailed examination of vascular lesions triggered by an inhibitor of endothelium-derived relaxing factor. Lab Invest 72: 174-182, 1995.
18. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC and Moskowitz MA: Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265: 1883-1885, 1994.
19. Saraiva RM, Minhas KM, Raju SV, Barouch LA, Pitz E, Schuleri KH, Vandegaer K, Li D and Hare JM: Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium. Circulation 112: 3415-3422, 2005.
20. Sampei K, Mandir AS, Asano Y, Wong PC, Traystman RJ, Dawson VL, Dawson TM and Hurn PD: Stroke outcome in double-mutant antioxidant transgenic mice. Stroke 31: 2685-2691, 2000.
21. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I and Hurn PD: Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab 25: 502-512, 2005.
22. Lácer: Derivatives of isosorbid mononitrate as vasodilator agents with reduced tolerance. International Patent. 2005.
23. Vilahur G, Segales E, Casani L and Badimon L: A novel anti-ischemic nitric oxide donor inhibits thrombosis without modifying haemodynamic parameters. Thromb Haemost 91: 1035-1043, 2004.
24. Salas E and Badimón L: Líneas de investigación en el uso terapéutico del óxido nítrico. Rev Esp Cardiol (Suppl) 6: 51A-58A, 2006.
25. Serrano J, Alonso D, Encinas JM, Lopez JC, Fernandez AP, Castro-Blanco S, Fernandez-Vizarra P, Richart A, Bentura ML, Santacana M, Uttenthal LO, Cuttitta F, Rodrigo J and Martinez A: Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat. Neuroscience 109: 717-731, 2002.
26. Alonso D, Serrano J, Rodriguez I, Ruiz-Cabello J, Fernandez AP, Encinas JM, Castro-Blanco S, Bentura ML, Santacana M, Richart A, Fernandez-Vizarra P, Uttenthal LO and Rodrigo J: Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex. J Comp Neurol 443: 183-200, 2002.
27. Rodrigo J, Alonso D, Fernandez AP, Serrano J, Richart A, Lopez JC, Santacana M, Martinez-Murillo R, Bentura ML, Ghiglione M and Uttenthal LO: Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation. Brain Res 909: 20-45, 2001.
28. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
29. Radomski MW, Vallance P, Whitley G, Foxwell N and Moncada S: Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovasc Res 27: 1380-1382, 1993. (Pubitemid 23250924)
30. Haga KK, Gregory LJ, Hicks CA, Ward MA, Beech JS, Bath PW, Williams SC and O'Neill MJ: The neuronal nitric oxide synthase inhibitor, TRIM, as a neuroprotective agent: effects in models of cerebral ischaemia using histological and magnetic resonance imaging techniques. Brain Res 993: 42-53, 2003.
31. Iadecola C, Zhang F and Xu X: Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268: R286-R292, 1995.
32. Cockroft KM, Meistrell M III, Zimmerman GA, Risucci D, Bloom O, Cerami A and Tracey KJ: Cerebroprotective effects of aminoguanidine in a rodent model of stroke. Stroke 27: 1393-1398, 1996.
33. Nagayama M, Zhang F and Iadecola C: Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats. J Cereb Blood Flow Metab 18: 1107-1113, 1998.
34. Cash D, Beech JS, Rayne RC, Bath PM, Meldrum BS and Williams SC: Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain. Brain Res 905: 91-103, 2001.
35. Kuo YR, Wang FS, Jeng SF, Huang HC, Wei FC and Yang KD: Nitrosoglutathione modulation of platelet activation and nitric oxide synthase expression in promotion of flap survival after ischemia/reperfusion injury. J Surg Res 119: 92-99, 2004.
36. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, Dawson TM and Snyder SH: Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 378: 383-386, 1995.
37. Salom JB, Orti M, Centeno JM, Torregrosa G and Alborch E: Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats. Brain Res 865: 149-156, 2000.
38. Zhang R, Zhang L, Zhang Z, Wang Y, Lu M, Lapointe M and Chopp M: A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats. Ann Neurol 50: 602-611, 2001.
39. Coert BA, Anderson RE and Meyer FB: Effects of the nitric oxide donor 3-morpholinosydnonimine (SIN-1) in focal cerebral ischemia dependent on intracellular brain pH. J Neurosurg 97: 914-921, 2002.
40. De AJ, Cardenas A, Moro MA, Leza JC, Lorenzo P, Bosca L and Lizasoain I: Down-regulation of neuronal nitric oxide synthase by nitric oxide after oxygen-glucose deprivation in rat forebrain slices. J Neurochem 72: 248-254, 1999.
41. Ji JY and Diamond SL: Exogenous nitric oxide activates the endothelial glucocorticoid receptor. Biochem Biophys Res Commun 318: 192-197, 2004.
42. Encinas JM, Fernandez AP, Salas E, Castro-Blanco S, Munoz P, Rodrigo J and Serrano J: Nitric oxide synthase and NADPH-diaphorase after acute hypobaric hypoxia in the rat caudate putamen. Exp Neurol 186: 33-45, 2004.
43. Albensi BC, Schweizer MP, Rarick TM and Filloux F: Magnetic resonance imaging of hypoxic-ischemic brain injury in the neonatal rat. Invest Radiol 33: 377-385, 1998.