Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: Importance of the mitochondrial function

Lipids in Health and Disease

Volumn 11, Issue , 2012, Pages

  Martins, Amanda R ^a   Nachbar, Renato T ^a   Gorjao, Renata ^b   Vinolo, Marco A ^a   Festuccia, William T ^a   Lambertucci, Rafael H ^b   Cury Boaventura, Maria F ^b   Silveira, Leonardo R ^a   Curi, Rui ^a   Hirabara, Sandro M ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE CRUZEIRO DO SUL   (Brazil)

Author keywords

Insulin resistance; Mitochondrial dysfunction; Saturated fatty acids; Skeletal muscle

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE I; CERAMIDE; CITRATE SYNTHASE; FATTY ACID; GA BINDING PROTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDIC ACID; PROTEIN KINASE B; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; STRESS ACTIVATED PROTEIN KINASE 1; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

CELL LINE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MITOCHONDRION; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SKELETAL MUSCLE INSULIN RESISTANCE; ANIMAL; BLOOD; DISORDERS OF CARBOHYDRATE METABOLISM; LIPID DIET; METABOLISM; MUSCLE MITOCHONDRION; PATHOLOGY;

ANIMALS; DIET, HIGH-FAT; FATTY ACIDS, NONESTERIFIED; GLUCOSE METABOLISM DISORDERS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDATIVE STRESS;

EID: 84857352823     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-11-30     Document Type: Review

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