Elevated free fatty acids induce uncoupling protein 3 expression in muscle: A potential explanation for the effect of fasting

Diabetes

Volumn 47, Issue 2, 1998, Pages 298-302

  Weigle, David S ^a   Selfridge, Leah E ^a   Schwartz, Michael W ^a   Seeley, Randy J ^a   Cummings, David E ^a   Havel, Peter J ^c   Kuijper, Joseph L ^b   BeltrandelRio, Hector ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b ZYMOGENETICS INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; FATTY ACID; GLUCOCORTICOID; HEPARIN; LEPTIN; RECOMBINANT PROTEIN; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENERGY EXPENDITURE; FATTY ACID METABOLISM; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SKELETAL MUSCLE; THERMOGENESIS;

EID: 0031915045     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.2.298     Document Type: Article

References (22)

1. Himms-Hagen J: Brown adipose tissue thermogenesis and obesity. Prog Lipid Res 28:67-115, 1989
2. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet 15:269-272, 1997
3. Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LA: Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46:900-906, 1997
4. Gong D-W, He Y, Karas M, Reitman M: Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta 3-adrenergic agonists, and leptin. J Biol Chem 272:24129-24132, 1997
5. Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino J-P: Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408:39-42, 1997
6. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB: UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Com 235:79-82, 1997
7. Zurlo F, Larson K, Bogardus C, Ravussin E: Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 86:1423-1427, 1990
8. Boss O, Samec S, Dulloo A, Seydoux J, Muzzin P, Giacobino J-P: Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold. FEBS Lett 412:111-114, 1997
9. Trayhurn P, Jennings G: Nonshivering thermogenesis and the thermogenic capacity of brown fat in fasted and/or refed mice. Am J Physiol 254:R11-R16, 1988
10. Grande F, Anderson JT, Keys A: Changes of basal metabolic rate in man in semi-starvation and refeeding. J Appl Physiol 12:230-238, 1958
11. Erickson JC, Clegg KE, Palmiter RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-418, 1996
12. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252, 1996
13. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL: Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2070, 1995
14. Barash IA, Cheung CC, Weigle DS, Ren H, Kabigting EB, Kuijper JL, Clifton DK, Steiner RA: Leptin is a metabolic signal to the reproductive system. Endocrinology 137:3144-3147, 1996
15. Zhou Y-T, Shimabukuro M, Koyama K, Lee Y, Wang M-Y, Trieu F, Newgard CB, Unger RH: Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Nat Acad Sci USA 94:6386-6390, 1997
16. Akana SF, Strack AM, Hanson ES, Dallman MF: Regulation of activity in the Hypothalamo-pituitary-adrenal axis is integral to a larger hypothalamic system that determines caloric flow. Endocrinology 135:1125-1134, 1994
17. De Vos P, Saladin R, Auwerx J, Staels B: Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270:15958-15961, 1995
18. Sears IB, MacGinnitie MA, Kovacs LG, Graves RA: Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor γ. Mol Cell Biol 16:3410-3419, 1996
19. Park KS, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Nikoulina SE, Henry RR: PPAR-γ gene expression is elevated in skeletal muscle of obese and type II diabetic subjects. Diabetes 46:1230-1234, 1997
20. Meng HC, Edgren B: Source of plasma free fatty acids in dogs receiving fat emulsion and heparin. Am J Physiol 204:691-695, 1963
21. Zambon A, Hashimoto SI, Brunzell JD: Analysis of techniques to obtain plasma for measurement of levels of free fatty acids. J Lipid Res 34:1021-1028, 1993
22. Jezek P, Hanus J, Semrad C, Garlid KD: Photoactivated azido fatty acid irreversibly inhibits anion and proton transport through the mitochondrial uncoupling protein. J Biol Chem 271:6199-6205, 1996