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Volumn 61, Issue 1, 2009, Pages 47-55

Intramuscular lipid metabolism, insulin action, and obesity

Author keywords

IMCL; Insulin action; Lipid metabolism; Obesity; Skeletal muscle

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A; ACYL COENZYME A; ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; CERAMIDE; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; DIACYLGLYCEROL; FATTY ACID BINDING PROTEIN; FATTY ACID TRANSPORTER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LONG CHAIN FATTY ACYL COENZYME A; MITOCHONDRIAL DNA; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

EID: 61849185113     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.142     Document Type: Review
Times cited : (137)

References (99)
  • 1
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal, K. M., Carroll, M. D., Ogden, C. L., and Johnson, C. L. (2002) Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288, 1723-1727.
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 2
    • 0031445908 scopus 로고    scopus 로고
    • The rising global burden of diabetes and its complications: Estimates and projections to the year 2010
    • Amos, A. F., McCarty, D. J., and Zimmet, P. (1997) The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet. Med. 14 (Suppl. 5), S1-S85.
    • (1997) Diabet. Med. , vol.14 , Issue.SUPPL. 5
    • Amos, A.F.1    McCarty, D.J.2    Zimmet, P.3
  • 3
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., and Felber, J. P. (1981) The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 1000-1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 4
    • 0017077182 scopus 로고
    • Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm
    • Dagenais, G. R., Tancredi, R. G., and Zierler, K. L. (1976) Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J. Clin. Invest. 58, 421-431.
    • (1976) J. Clin. Invest. , vol.58 , pp. 421-431
    • Dagenais, G.R.1    Tancredi, R.G.2    Zierler, K.L.3
  • 5
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • Kelley, D. E., Mokan, M., Simoneau, J. A., and Mandarino, L. J. (1993) Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J. Clin. Invest. 92, 91-98.
    • (1993) J. Clin. Invest. , vol.92 , pp. 91-98
    • Kelley, D.E.1    Mokan, M.2    Simoneau, J.A.3    Mandarino, L.J.4
  • 7
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes, N. D., Cooney, G. J., Camilleri, S., Chisholm, D. J., and Kraegen, E. W. (1997) Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46, 1768-1774.
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 8
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden, G., Chen, X., Ruiz, J., White, J. V., and Rossetti, L. (1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93, 2438-2446.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 9
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani, S. I., Ruderman, N. B., Schmieder, F., and Boden, G. (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51, 2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 10
    • 0013771164 scopus 로고
    • Plasma albumin as an acceptor of free fatty acids
    • Campbell, J., Martucci, A. D., and Green, G. R. (1964) Plasma albumin as an acceptor of free fatty acids. Biochem. J. 93, 183-189.
    • (1964) Biochem. J. , vol.93 , pp. 183-189
    • Campbell, J.1    Martucci, A.D.2    Green, G.R.3
  • 11
    • 0032444832 scopus 로고    scopus 로고
    • Membrane transport of long-chain fatty acids: Evidence for a facilitated process
    • Abumrad, N., Harmon, C., and Ibrahimi, A. (1998) Membrane transport of long-chain fatty acids: evidence for a facilitated process. J. Lipid. Res. 39, 2309-2318.
    • (1998) J. Lipid. Res. , vol.39 , pp. 2309-2318
    • Abumrad, N.1    Harmon, C.2    Ibrahimi, A.3
  • 12
    • 0031921236 scopus 로고    scopus 로고
    • Fatty acid transport: Difficult or easy?
    • Hamilton, J. A. (1998) Fatty acid transport: difficult or easy? J. Lipid. Res. 39, 467-481.
    • (1998) J. Lipid. Res. , vol.39 , pp. 467-481
    • Hamilton, J.A.1
  • 13
    • 0034640498 scopus 로고    scopus 로고
    • Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase
    • Bonen, A., Luiken, J. J., Arumugam, Y., Glatz, J. F., and Tandon, N. N. (2000) Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. J. Biol. Chem. 275, 14501-14508.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14501-14508
    • Bonen, A.1    Luiken, J.J.2    Arumugam, Y.3    Glatz, J.F.4    Tandon, N.N.5
  • 15
    • 0034693232 scopus 로고    scopus 로고
    • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    • Coburn, C. T., Knapp, F. F. Jr., Febbraio, M., Beets, A. L., Silverstein, R. L., and Abumrad, N. A. (2000) Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J. Biol. Chem. 275, 32523-32529.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32523-32529
    • Coburn, C.T.1    Knapp Jr., F.F.2    Febbraio, M.3    Beets, A.L.4    Silverstein, R.L.5    Abumrad, N.A.6
  • 16
    • 2142730490 scopus 로고
    • Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut
    • Schwieterman, W., Sorrentino, D., Potter, B. J., Rand, J., Kiang, C. L., Stump, D., and Berk, P. D. (1988) Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut. Proc. Natl. Acad. Sci. USA 85, 359-363.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 359-363
    • Schwieterman, W.1    Sorrentino, D.2    Potter, B.J.3    Rand, J.4    Kiang, C.L.5    Stump, D.6    Berk, P.D.7
  • 18
    • 0028152492 scopus 로고
    • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
    • Schaffer, J. E., and Lodish, H. F. (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79, 427-436.
    • (1994) Cell , vol.79 , pp. 427-436
    • Schaffer, J.E.1    Lodish, H.F.2
  • 19
    • 0032555136 scopus 로고    scopus 로고
    • A family of fatty acid transporters conserved from mycobacterium to man
    • Hirsch, D., Stahl, A., and Lodish, H. F. (1998) A family of fatty acid transporters conserved from mycobacterium to man. Proc. Natl. Acad. Sci. USA 95, 8625-8629.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8625-8629
    • Hirsch, D.1    Stahl, A.2    Lodish, H.F.3
  • 20
    • 0034833822 scopus 로고    scopus 로고
    • CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
    • Febbraio, M., Hajjar, D. P., and Silverstein, R. L. (2001) CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J. Clin. Invest. 108, 785-791.
    • (2001) J. Clin. Invest. , vol.108 , pp. 785-791
    • Febbraio, M.1    Hajjar, D.P.2    Silverstein, R.L.3
  • 21
    • 0033516477 scopus 로고    scopus 로고
    • A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    • Febbraio, M., Abumrad, N. A., Hajjar, D. P., Sharma, K., Cheng, W., Pearce, S. F., and Silverstein, R. L. (1999) A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J. Biol. Chem. 274, 19055-19062.
    • (1999) J. Biol. Chem. , vol.274 , pp. 19055-19062
    • Febbraio, M.1    Abumrad, N.A.2    Hajjar, D.P.3    Sharma, K.4    Cheng, W.5    Pearce, S.F.6    Silverstein, R.L.7
  • 23
    • 0037677773 scopus 로고    scopus 로고
    • Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling
    • Luiken, J. J., Coort, S. L., Willems, J., Coumans, W. A., Bonen, A., van der Vusse, G. J., and Glatz, J. F. (2003) Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Diabetes 52, 1627-1634.
    • (2003) Diabetes , vol.52 , pp. 1627-1634
    • Luiken, J.J.1    Coort, S.L.2    Willems, J.3    Coumans, W.A.4    Bonen, A.5    Van Der Vusse, G.J.6    Glatz, J.F.7
  • 24
    • 1842457594 scopus 로고    scopus 로고
    • Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism
    • Clarke, D. C., Miskovic, D., Han, X. X., Calles-Escandon, J., Glatz, J. F., Luiken, J. J., Heikkila, J. J., and Bonen, A. (2004) Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism. Physiol. Genomics 17, 31-37.
    • (2004) Physiol. Genomics , vol.17 , pp. 31-37
    • Clarke, D.C.1    Miskovic, D.2    Han, X.X.3    Calles-Escandon, J.4    Glatz, J.F.5    Luiken, J.J.6    Heikkila, J.J.7    Bonen, A.8
  • 25
    • 33646239182 scopus 로고    scopus 로고
    • FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity
    • Wu, Q., Ortegon, A. M., Tsang, B., Doege, H., Feingold, K. R., and Stahl, A. (2006) FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol. Cell. Biol. 26, 3455-3467.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3455-3467
    • Wu, Q.1    Ortegon, A.M.2    Tsang, B.3    Doege, H.4    Feingold, K.R.5    Stahl, A.6
  • 27
    • 0036291378 scopus 로고    scopus 로고
    • Regulation of fat metabolism in skeletal muscle
    • Jeukendrup, A. E. (2002) Regulation of fat metabolism in skeletal muscle. Ann. NY Acad. Sci. 967, 217-235.
    • (2002) Ann. NY Acad. Sci. , vol.967 , pp. 217-235
    • Jeukendrup, A.E.1
  • 28
    • 33644846005 scopus 로고    scopus 로고
    • Skeletal muscle lipid metabolism in exercise and insulin resistance
    • Kiens, B. (2006) Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol. Rev. 86, 205-243.
    • (2006) Physiol. Rev. , vol.86 , pp. 205-243
    • Kiens, B.1
  • 29
    • 34047223522 scopus 로고    scopus 로고
    • Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification
    • Bruce, C. R., Brolin, C., Turner, N., Cleasby, M. E., van der Leij, F. R., Cooney, G. J., and Kraegen, E. W. (2007) Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification. Am. J. Physiol. Endocrinol. Metab. 292, E1231-E1237.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292
    • Bruce, C.R.1    Brolin, C.2    Turner, N.3    Cleasby, M.E.4    Van Der Leij, F.R.5    Cooney, G.J.6    Kraegen, E.W.7
  • 30
    • 0030893631 scopus 로고    scopus 로고
    • Effect of endurance training on fatty acid metabolism: Local adaptations
    • Kiens, B. (1997) Effect of endurance training on fatty acid metabolism: local adaptations. Med. Sci. Sports Exerc. 29, 640-645.
    • (1997) Med. Sci. Sports Exerc. , vol.29 , pp. 640-645
    • Kiens, B.1
  • 31
    • 0031059829 scopus 로고    scopus 로고
    • Fasting increases plasma membrane fatty acid-binding protein (FABP(PM)) in red skeletal muscle
    • Turcotte, L. P., Srivastava, A. K., and Chiasson, J. L. (1997) Fasting increases plasma membrane fatty acid-binding protein (FABP(PM)) in red skeletal muscle. Mol. Cell. Biochem. 166, 153-158.
    • (1997) Mol. Cell. Biochem. , vol.166 , pp. 153-158
    • Turcotte, L.P.1    Srivastava, A.K.2    Chiasson, J.L.3
  • 32
    • 2942715349 scopus 로고    scopus 로고
    • Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle
    • Roepstorff, C., Helge, J. W., Vistisen, B., and Kiens, B. (2004) Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle. Proc. Nutr. Soc. 63, 239-244.
    • (2004) Proc. Nutr. Soc. , vol.63 , pp. 239-244
    • Roepstorff, C.1    Helge, J.W.2    Vistisen, B.3    Kiens, B.4
  • 34
    • 0032752951 scopus 로고    scopus 로고
    • Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
    • Simoneau, J. A., Veerkamp, J. H., Turcotte, L. P., and Kelley, D. E. (1999) Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J. 13, 2051-2060.
    • (1999) FASEB J. , vol.13 , pp. 2051-2060
    • Simoneau, J.A.1    Veerkamp, J.H.2    Turcotte, L.P.3    Kelley, D.E.4
  • 35
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    • Bonen, A., Parolin, M. L., Steinberg, G. R., Calles-Escandon, J., Tandon, N. N., Glatz, J. F., Luiken, J. J., Heigenhauser, G. J., and Dyck, D. J. (2004) Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 18, 1144-1146.
    • (2004) FASEB J. , vol.18 , pp. 1144-1146
    • Bonen, A.1    Parolin, M.L.2    Steinberg, G.R.3    Calles-Escandon, J.4    Tandon, N.N.5    Glatz, J.F.6    Luiken, J.J.7    Heigenhauser, G.J.8    Dyck, D.J.9
  • 37
    • 0030740621 scopus 로고    scopus 로고
    • Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
    • Simoneau, J. A., and Kelley, D. E. (1997) Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J. Appl. Physiol. 83, 166-171.
    • (1997) J. Appl. Physiol. , vol.83 , pp. 166-171
    • Simoneau, J.A.1    Kelley, D.E.2
  • 38
    • 3042551249 scopus 로고    scopus 로고
    • Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation
    • Perdomo, G., Commerford, S. R., Richard, A. M., Adams, S. H., Corkey, B. E., O'Doherty, R. M., and Brown, N. F. (2004) Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J. Biol. Chem. 279, 27177-27186.
    • (2004) J. Biol. Chem. , vol.279 , pp. 27177-27186
    • Perdomo, G.1    Commerford, S.R.2    Richard, A.M.3    Adams, S.H.4    Corkey, B.E.5    O'Doherty, R.M.6    Brown, N.F.7
  • 41
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley, D. E., He, J., Menshikova, E. V., and Ritov, V. B. (2002) Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 44
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley, D. E., Goodpaster, B., Wing, R. R., and Simoneau, J. A. (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. 277, E1130-E1141.
    • (1999) Am. J. Physiol. , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 47
  • 51
    • 34247098939 scopus 로고    scopus 로고
    • Primary cell cultures in the study of human muscle metabolism
    • Berggren, J. R., Tanner, C. J., and Houmard, J. A. (2007) Primary cell cultures in the study of human muscle metabolism. Exerc. Sport Sci. Rev. 35, 56-61.
    • (2007) Exerc. Sport Sci. Rev. , vol.35 , pp. 56-61
    • Berggren, J.R.1    Tanner, C.J.2    Houmard, J.A.3
  • 55
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Roden, M., and Shulman, G. I. (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42, 113-116.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3    DiPietro, L.4    Vogel, S.M.5    Rothman, D.L.6    Roden, M.7    Shulman, G.I.8
  • 56
    • 0035149738 scopus 로고    scopus 로고
    • Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
    • Dobbins, R. L., Szczepaniak, L. S., Bentley, B., Esser, V., Myhill, J., and McGarry, J. D. (2001) Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 50, 123-130.
    • (2001) Diabetes , vol.50 , pp. 123-130
    • Dobbins, R.L.1    Szczepaniak, L.S.2    Bentley, B.3    Esser, V.4    Myhill, J.5    McGarry, J.D.6
  • 57
    • 0032960890 scopus 로고    scopus 로고
    • Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
    • Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., and Haring, H. U. (1999) Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48, 1113-1119.
    • (1999) Diabetes , vol.48 , pp. 1113-1119
    • Jacob, S.1    Machann, J.2    Rett, K.3    Brechtel, K.4    Volk, A.5    Renn, W.6    Maerker, E.7    Matthaei, S.8    Schick, F.9    Claussen, C.D.10    Haring, H.U.11
  • 58
    • 37549054706 scopus 로고    scopus 로고
    • Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients
    • Jazet, I. M., Schaart, G., Gastaldelli, A., Ferrannini, E., Hesselink, M. K., Schrauwen, P., Romijn, J. A., Maassen, J. A., Pijl, H., Ouwens, D. M., and Meinders, A. E. (2008) Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia 51, 309-319.
    • (2008) Diabetologia , vol.51 , pp. 309-319
    • Jazet, I.M.1    Schaart, G.2    Gastaldelli, A.3    Ferrannini, E.4    Hesselink, M.K.5    Schrauwen, P.6    Romijn, J.A.7    Maassen, J.A.8    Pijl, H.9    Ouwens, D.M.10    Meinders, A.E.11
  • 61
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • Goodpaster, B. H., He, J., Watkins, S., and Kelley, D. E. (2001) Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86, 5755-5761.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 62
    • 34249915334 scopus 로고    scopus 로고
    • Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance
    • Schenk, S., and Horowitz, J. F. (2007) Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J. Clin. Invest. 117, 1690-1698.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1690-1698
    • Schenk, S.1    Horowitz, J.F.2
  • 63
    • 0018846846 scopus 로고
    • Enzymes of glycerolipid synthesis in eukaryotes
    • Bell, R. M., and Coleman, R. A. (1980) Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49, 459-487.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 459-487
    • Bell, R.M.1    Coleman, R.A.2
  • 64
    • 0030175841 scopus 로고    scopus 로고
    • Biosynthesis of triacylglycerols
    • Lehner, R. and Kuksis, A. (1996) Biosynthesis of triacylglycerols. Prog. Lipid. Res. 35, 169-201.
    • (1996) Prog. Lipid. Res. , vol.35 , pp. 169-201
    • Lehner, R.1    Kuksis, A.2
  • 65
    • 0347993103 scopus 로고    scopus 로고
    • Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts
    • Bagnato, C., and Igal, R. A. (2003) Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. J. Biol. Chem. 278, 52203-52211.
    • (2003) J. Biol. Chem. , vol.278 , pp. 52203-52211
    • Bagnato, C.1    Igal, R.A.2
  • 66
    • 34249894505 scopus 로고    scopus 로고
    • Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
    • Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., and Yu, Y. H. (2007) Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest. 117, 1679-1689.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1679-1689
    • Liu, L.1    Zhang, Y.2    Chen, N.3    Shi, X.4    Tsang, B.5    Yu, Y.H.6
  • 67
    • 33750906573 scopus 로고    scopus 로고
    • Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
    • Pinnamaneni, S. K., Southgate, R. J., Febbraio, M. A., and Watt, M. J. (2006) Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia 49, 3027-3037.
    • (2006) Diabetologia , vol.49 , pp. 3027-3037
    • Pinnamaneni, S.K.1    Southgate, R.J.2    Febbraio, M.A.3    Watt, M.J.4
  • 69
    • 0026539998 scopus 로고
    • Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat
    • Folli, F., Saad, M. J., Backer, J. M., and Kahn, C. R. (1992) Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J. Biol. Chem. 267, 22171-22177.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22171-22177
    • Folli, F.1    Saad, M.J.2    Backer, J.M.3    Kahn, C.R.4
  • 70
    • 29244462334 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose transport
    • Chang, L., Chiang, S. H., and Saltiel, A. R. (2004) Insulin signaling and the regulation of glucose transport. Mol. Med. 10, 65-71.
    • (2004) Mol. Med. , vol.10 , pp. 65-71
    • Chang, L.1    Chiang, S.H.2    Saltiel, A.R.3
  • 71
    • 34547570876 scopus 로고    scopus 로고
    • Effects of endurance exercise training on insulin signaling in human skeletal muscle: Interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160
    • Frosig, C., Rose, A. J., Treebak, J. T., Kiens, B., Richter, E. A., and Wojtaszewski, J. F. (2007) Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. Diabetes 56, 2093-2102.
    • (2007) Diabetes , vol.56 , pp. 2093-2102
    • Frosig, C.1    Rose, A.J.2    Treebak, J.T.3    Kiens, B.4    Richter, E.A.5    Wojtaszewski, J.F.6
  • 72
    • 33845998942 scopus 로고    scopus 로고
    • AS160 regulates insulin- And contraction-stimulated glucose uptake in mouse skeletal muscle
    • Kramer, H. F., Witczak, C. A., Taylor, E. B., Fujii, N., Hirshman, M. F., and Goodyear, L. J. (2006) AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J. Biol. Chem. 281, 31478-31485.
    • (2006) J. Biol. Chem. , vol.281 , pp. 31478-31485
    • Kramer, H.F.1    Witczak, C.A.2    Taylor, E.B.3    Fujii, N.4    Hirshman, M.F.5    Goodyear, L.J.6
  • 73
    • 0033861608 scopus 로고    scopus 로고
    • Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity
    • Itani, S. I., Zhou, Q., Pories, W. J., MacDonald, K. G., and Dohm, G. L. (2000) Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49, 1353-1358. (Pubitemid 30624237)
    • (2000) Diabetes , vol.49 , Issue.8 , pp. 1353-1358
    • Itani, S.I.1    Zhou, Q.2    Pories, W.J.3    MacDonald, K.G.4    Dohm, G.L.5
  • 74
    • 0028811653 scopus 로고
    • Protein kinase C: Structure, function, and regulation
    • Newton, A. C. (1995) Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270, 28495-28498.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28495-28498
    • Newton, A.C.1
  • 76
    • 0036295566 scopus 로고    scopus 로고
    • Protein kinase C and lipid-induced insulin resistance in skeletal muscle
    • Schmitz-Peiffer, C. (2002) Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Ann. NY Acad. Sci. 967, 146-157.
    • (2002) Ann. NY Acad. Sci. , vol.967 , pp. 146-157
    • Schmitz-Peiffer, C.1
  • 78
    • 0023683874 scopus 로고
    • An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
    • Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S. M., Elton, C. W., and Caro, J. F. (1988) An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82, 486-494.
    • (1988) J. Clin. Invest. , vol.82 , pp. 486-494
    • Dohm, G.L.1    Tapscott, E.B.2    Pories, W.J.3    Dabbs, D.J.4    Flickinger, E.G.5    Meelheim, D.6    Fushiki, T.7    Atkinson, S.M.8    Elton, C.W.9    Caro, J.F.10
  • 79
    • 0031753812 scopus 로고    scopus 로고
    • Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
    • Chalkley, S. M., Hettiarachchi, M., Chisholm, D. J., and Kraegen, E. W. (1998) Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat. Metabolism 47, 1121-1126.
    • (1998) Metabolism , vol.47 , pp. 1121-1126
    • Chalkley, S.M.1    Hettiarachchi, M.2    Chisholm, D.J.3    Kraegen, E.W.4
  • 80
    • 33644695097 scopus 로고    scopus 로고
    • Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients
    • Bajaj, M., Suraamornkul, S., Romanelli, A., Cline, G. W., Mandarino, L. J., Shulman, G. I., and DeFronzo, R. A. (2005) Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes 54, 3148-3153.
    • (2005) Diabetes , vol.54 , pp. 3148-3153
    • Bajaj, M.1    Suraamornkul, S.2    Romanelli, A.3    Cline, G.W.4    Mandarino, L.J.5    Shulman, G.I.6    DeFronzo, R.A.7
  • 82
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun, Y. A., and Obeid, L. M. (2002) The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277, 25847-25850.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 83
    • 0025283928 scopus 로고
    • An update of the enzymology and regulation of sphingomyelin metabolism
    • Merrill, A. H. Jr., and Jones, D. D. (1990) An update of the enzymology and regulation of sphingomyelin metabolism. Biochim. Biophys. Acta 1044, 1-12.
    • (1990) Biochim. Biophys. Acta , vol.1044 , pp. 1-12
    • Merrill Jr., A.H.1    Jones, D.D.2
  • 85
    • 0025123408 scopus 로고
    • 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo
    • Turinsky, J., O'Sullivan, D. M., and Bayly, B. P. (1990) 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J. Biol. Chem. 265, 16880-16885.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16880-16885
    • Turinsky, J.1    O'Sullivan, D.M.2    Bayly, B.P.3
  • 88
    • 34147145049 scopus 로고    scopus 로고
    • Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects
    • Serlie, M. J., Meijer, A. J., Groener, J. E., Duran, M., Endert, E., Fliers, E., Aerts, J. M., and Sauerwein, H. P. (2007) Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. J. Clin. Endocrinol. Metab. 92, 1524-1529.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1524-1529
    • Serlie, M.J.1    Meijer, A.J.2    Groener, J.E.3    Duran, M.4    Endert, E.5    Fliers, E.6    Aerts, J.M.7    Sauerwein, H.P.8
  • 90
    • 0035133331 scopus 로고    scopus 로고
    • Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
    • Hajduch, E., Balendran, A., Batty, I. H., Litherland, G. J., Blair, A. S., Downes, C. P., and Hundal, H. S. (2001) Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia 44, 173-183.
    • (2001) Diabetologia , vol.44 , pp. 173-183
    • Hajduch, E.1    Balendran, A.2    Batty, I.H.3    Litherland, G.J.4    Blair, A.S.5    Downes, C.P.6    Hundal, H.S.7
  • 91
    • 0142164965 scopus 로고    scopus 로고
    • Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
    • Chavez, J. A., and Summers, S. A. (2003) Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419, 101-109.
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 101-109
    • Chavez, J.A.1    Summers, S.A.2
  • 92
    • 44749085396 scopus 로고    scopus 로고
    • Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
    • Skovbro, M., Baranowski, M., Skov-Jensen, C., Flint, A., Dela, F., Gorski, J., and Helge, J. W. (2008) Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. Diabetologia 51, 1253-1260.
    • (2008) Diabetologia , vol.51 , pp. 1253-1260
    • Skovbro, M.1    Baranowski, M.2    Skov-Jensen, C.3    Flint, A.4    Dela, F.5    Gorski, J.6    Helge, J.W.7
  • 94
    • 42949084209 scopus 로고    scopus 로고
    • Muscular diacylglycerol metabolism and insulin resistance
    • Timmers, S., Schrauwen, P., and de Vogel, J. (2008) Muscular diacylglycerol metabolism and insulin resistance. Physiol. Behav. 94, 242-251.
    • (2008) Physiol. Behav. , vol.94 , pp. 242-251
    • Timmers, S.1    Schrauwen, P.2    De Vogel, J.3
  • 95
    • 0026335117 scopus 로고
    • 1,2-Diacylglycerol and ceramide levels in rat liver and skeletal muscle in vivo
    • Turinsky, J., Bayly, B. P., and O'Sullivan, D. M. (1991) 1,2-Diacylglycerol and ceramide levels in rat liver and skeletal muscle in vivo. Am. J. Physiol. 261, E620-E627.
    • (1991) Am. J. Physiol. , vol.261
    • Turinsky, J.1    Bayly, B.P.2    O'Sullivan, D.M.3
  • 96
    • 0035340548 scopus 로고    scopus 로고
    • Increased protein kinase C theta in skeletal muscle of diabetic patients
    • Itani, S. I., Pories, W. J., Macdonald, K. G., and Dohm, G. L. (2001) Increased protein kinase C theta in skeletal muscle of diabetic patients. Metabolism 50, 553-557.
    • (2001) Metabolism , vol.50 , pp. 553-557
    • Itani, S.I.1    Pories, W.J.2    Macdonald, K.G.3    Dohm, G.L.4


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