-
1
-
-
13144281703
-
Identification of a gene encoding an acyl CoA:Diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
-
Cases, S., S. J. Smith, Y. W. Zheng, H. M. Myers, S. R. Lear, E. Sande, S. Novak, C. Collins, C. B. Welch, A. J. Lusis, et al. 1998. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA. 95: 13018-13023.
-
(1998)
Proc. Natl. Acad. Sci. USA.
, vol.95
, pp. 13018-13023
-
-
Cases, S.1
Smith, S.J.2
Zheng, Y.W.3
Myers, H.M.4
Lear, S.R.5
Sande, E.6
Novak, S.7
Collins, C.8
Welch, C.B.9
Lusis, A.J.10
-
2
-
-
24744443740
-
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
-
Yen, C. L., M. Monetti, B. J. Burri, and R. V. Farese, Jr. 2005. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J. Lipid Res. 46: 1502-1511.
-
(2005)
J. Lipid Res.
, vol.46
, pp. 1502-1511
-
-
Yen, C.L.1
Monetti, M.2
Burri, B.J.3
Farese Jr., R.V.4
-
3
-
-
0032500641
-
Characterization of two human genes encoding acyl coenzyme A:Cholesterol acyltransferase-related enzymes
-
Oelkers, P., A. Behari, D. Cromley, J. T. Billheimer, and S. L. Sturley. 1998. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273: 26765-26771.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26765-26771
-
-
Oelkers, P.1
Behari, A.2
Cromley, D.3
Billheimer, J.T.4
Sturley, S.L.5
-
4
-
-
34547946930
-
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
-
Choi, C. S., D. B. Savage, A. Kulkarni, X. X. Yu, Z. X. Liu, K. Morino, S. Kim, A. Distefano, V. T. Samuel, S. Neschen, et al. 2007. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282: 22678-22688.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22678-22688
-
-
Choi, C.S.1
Savage, D.B.2
Kulkarni, A.3
Yu, X.X.4
Liu, Z.X.5
Morino, K.6
Kim, S.7
Distefano, A.8
Samuel, V.T.9
Neschen, S.10
-
5
-
-
34249894505
-
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
-
Liu, L., Y. Zhang, N. Chen, X. Shi, B. Tsang, and Y. H. Yu. 2007. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest. 117: 1679-1689.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1679-1689
-
-
Liu, L.1
Zhang, Y.2
Chen, N.3
Shi, X.4
Tsang, B.5
Yu, Y.H.6
-
6
-
-
73649094432
-
DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity
-
Liu, L., X. Shi, K. G. Bharadwaj, S. Ikeda, H. Yamashita, H. Yagyu, J. E. Schaffer, Y. H. Yu, and I. J. Goldberg. 2009. DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. J. Biol. Chem. 284: 36312-36323.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 36312-36323
-
-
Liu, L.1
Shi, X.2
Bharadwaj, K.G.3
Ikeda, S.4
Yamashita, H.5
Yagyu, H.6
Schaffer, J.E.7
Yu, Y.H.8
Goldberg, I.J.9
-
7
-
-
0035217707
-
Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
-
Goodpaster, B. H., J. He, S. Watkins, and D. E. Kelley. 2001. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86: 5755-5761.
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 5755-5761
-
-
Goodpaster, B.H.1
He, J.2
Watkins, S.3
Kelley, D.E.4
-
8
-
-
33745841299
-
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
-
Bruce, C. R., A. B. Thrush, V. A. Mertz, V. Bezaire, A. Chabowski, G. J. Heigenhauser, and D. J. Dyck. 2006. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am. J. Physiol. Endocrinol. Metab. 291: E99-E107.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
-
-
Bruce, C.R.1
Thrush, A.B.2
Mertz, V.A.3
Bezaire, V.4
Chabowski, A.5
Heigenhauser, G.J.6
Dyck, D.J.7
-
9
-
-
77949690002
-
DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation
-
Koliwad, S. K., R. S. Streeper, M. Monetti, I. Cornelissen, L. Chan, K. Terayama, S. Naylor, M. Rao, B. Hubbard, and R. V. Farese, Jr. 2010. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J. Clin. Invest. 120: 756-767.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 756-767
-
-
Koliwad, S.K.1
Streeper, R.S.2
Monetti, M.3
Cornelissen, I.4
Chan, L.5
Terayama, K.6
Naylor, S.7
Rao, M.8
Hubbard, B.9
Farese Jr., R.V.10
-
10
-
-
0034103658
-
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
-
Smith, S. J., S. Cases, D. R. Jensen, H. C. Chen, E. Sande, B. Tow, D. A. Sanan, J. Raber, R. H. Eckel, and R. V. Farese, Jr. 2000. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25: 87-90.
-
(2000)
Nat. Genet.
, vol.25
, pp. 87-90
-
-
Smith, S.J.1
Cases, S.2
Jensen, D.R.3
Chen, H.C.4
Sande, E.5
Tow, B.6
Sanan, D.A.7
Raber, J.8
Eckel, R.H.9
Farese Jr., R.V.10
-
11
-
-
0038481184
-
Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:Diacylglycerol acyltransferase 1
-
Chen, H. C., D. R. Jensen, H. M. Myers, R. H. Eckel, and R. V. Farese, Jr. 2003. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 111: 1715-1722.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1715-1722
-
-
Chen, H.C.1
Jensen, D.R.2
Myers, H.M.3
Eckel, R.H.4
Farese Jr., R.V.5
-
12
-
-
0036228339
-
Increased insulin and leptin sensitivity in mice lacking acyl CoA:Diacylglycerol acyltransferase 1
-
Chen, H. C., S. J. Smith, Z. Ladha, D. R. Jensen, L. D. Ferreira, L. K. Pulawa, J. G. McGuire, R. E. Pitas, R. H. Eckel, and R. V. Farese, Jr. 2002. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 109: 1049-1055.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1049-1055
-
-
Chen, H.C.1
Smith, S.J.2
Ladha, Z.3
Jensen, D.R.4
Ferreira, L.D.5
Pulawa, L.K.6
McGuire, J.G.7
Pitas, R.E.8
Eckel, R.H.9
Farese Jr., R.V.10
-
13
-
-
0032763865
-
Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice
-
Ryder, J. W., Y. Kawano, D. Galuska, R. Fahlman, H. Wallberg-Henriksson, M. J. Charron, and J. R. Zierath. 1999. Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice. FASEB J. 13: 2246-2256.
-
(1999)
FASEB J.
, vol.13
, pp. 2246-2256
-
-
Ryder, J.W.1
Kawano, Y.2
Galuska, D.3
Fahlman, R.4
Wallberg-Henriksson, H.5
Charron, M.J.6
Zierath, J.R.7
-
14
-
-
33646832738
-
Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction
-
Augustus, A. S., J. Buchanan, T. S. Park, K. Hirata, H. L. Noh, J. Sun, S. Homma, J. D'Armiento, E. D. Abel, and I. J. Goldberg. 2006. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J. Biol. Chem. 281: 8716-8723.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8716-8723
-
-
Augustus, A.S.1
Buchanan, J.2
Park, T.S.3
Hirata, K.4
Noh, H.L.5
Sun, J.6
Homma, S.7
D'Armiento, J.8
Abel, E.D.9
Goldberg, I.J.10
-
15
-
-
19444382326
-
Perfusion of hearts with triglyceride-rich particles reproduces the metabolic abnormalities in lipotoxic cardiomyopathy
-
Pillutla, P., Y. C. Hwang, A. Augustus, M. Yokoyama, H. Yagyu, T. P. Johnston, M. Kaneko, R. Ramasamy, and I. J. Goldberg. 2005. Perfusion of hearts with triglyceride-rich particles reproduces the metabolic abnormalities in lipotoxic cardiomyopathy. Am. J. Physiol. Endocrinol. Metab. 288: E1229-E1235.
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
-
-
Pillutla, P.1
Hwang, Y.C.2
Augustus, A.3
Yokoyama, M.4
Yagyu, H.5
Johnston, T.P.6
Kaneko, M.7
Ramasamy, R.8
Goldberg, I.J.9
-
16
-
-
64349101065
-
Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor
-
Birch, A. M., S. Birtles, L. K. Buckett, P. D. Kemmitt, G. J. Smith, T. J. Smith, A. V. Turnbull, and S. J. Wang. 2009. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J. Med. Chem. 52: 1558-1568.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1558-1568
-
-
Birch, A.M.1
Birtles, S.2
Buckett, L.K.3
Kemmitt, P.D.4
Smith, G.J.5
Smith, T.J.6
Turnbull, A.V.7
Wang, S.J.8
-
18
-
-
34247877577
-
The fuzzy logic of physiological cardiac hypertrophy
-
Dorn 2nd, G. W. 2007. The fuzzy logic of physiological cardiac hypertrophy. Hypertension. 49: 962-970.
-
(2007)
Hypertension
, vol.49
, pp. 962-970
-
-
Dorn II, G.W.1
-
19
-
-
67651227757
-
Changes in muscle mass with mechanical load: Possible cellular mechanisms
-
Spangenburg, E. E. 2009. Changes in muscle mass with mechanical load: possible cellular mechanisms. Appl. Physiol. Nutr. Metab. 34: 328-335.
-
(2009)
Appl. Physiol. Nutr. Metab.
, vol.34
, pp. 328-335
-
-
Spangenburg, E.E.1
-
20
-
-
0036839504
-
Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training
-
Iemitsu, M., T. Miyauchi, S. Maeda, T. Tanabe, M. Takanashi, Y. Irukayama-Tomobe, S. Sakai, H. Ohmori, M. Matsuda, and I. Yamaguchi. 2002. Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training. Am. J. Physiol. Heart Circ. Physiol. 283: H1750-H1760.
-
(2002)
Am. J. Physiol. Heart Circ. Physiol.
, vol.283
-
-
Iemitsu, M.1
Miyauchi, T.2
Maeda, S.3
Tanabe, T.4
Takanashi, M.5
Irukayama-Tomobe, Y.6
Sakai, S.7
Ohmori, H.8
Matsuda, M.9
Yamaguchi, I.10
-
21
-
-
63849228324
-
Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
-
Alsted, T. J., L. Nybo, M. Schweiger, C. Fledelius, P. Jacobsen, R. Zimmermann, R. Zechner, and B. Kiens. 2009. Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training. Am. J. Physiol. Endocrinol. Metab. 296: E445-E453.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Alsted, T.J.1
Nybo, L.2
Schweiger, M.3
Fledelius, C.4
Jacobsen, P.5
Zimmermann, R.6
Zechner, R.7
Kiens, B.8
-
22
-
-
0034467428
-
PPAR signaling in the control of cardiac energy metabolism
-
Barger, P. M., and D. P. Kelly. 2000. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc. Med. 10: 238-245.
-
(2000)
Trends Cardiovasc. Med.
, vol.10
, pp. 238-245
-
-
Barger, P.M.1
Kelly, D.P.2
-
23
-
-
20444452139
-
Effect of elevated lipid concentrations on human skeletal muscle gene expression
-
Tunstall, R. J., and D. Cameron-Smith. 2005. Effect of elevated lipid concentrations on human skeletal muscle gene expression. Metabolism. 54: 952-959.
-
(2005)
Metabolism
, vol.54
, pp. 952-959
-
-
Tunstall, R.J.1
Cameron-Smith, D.2
-
24
-
-
2542610041
-
Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:Diacylglycerol acyltransferase 1
-
Chen, H. C., M. Rao, M. P. Sajan, M. Standaert, Y. Kanoh, A. Miura, R. V. Farese, Jr., and R. V. Farese. 2004. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Diabetes. 53: 1445-1451.
-
(2004)
Diabetes
, vol.53
, pp. 1445-1451
-
-
Chen, H.C.1
Rao, M.2
Sajan, M.P.3
Standaert, M.4
Kanoh, Y.5
Miura, A.6
Farese Jr., R.V.7
Farese, R.V.8
-
25
-
-
0035658527
-
Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet
-
Peters, S. J., R. A. Harris, P. Wu, T. L. Pehleman, G. J. Heigenhauser, and L. L. Spriet. 2001. Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet. Am. J. Physiol. Endocrinol. Metab. 281: E1151-E1158.
-
(2001)
Am. J. Physiol. Endocrinol. Metab.
, vol.281
-
-
Peters, S.J.1
Harris, R.A.2
Wu, P.3
Pehleman, T.L.4
Heigenhauser, G.J.5
Spriet, L.L.6
-
26
-
-
0037341240
-
Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle
-
Pilegaard, H., B. Saltin, and P. D. Neufer. 2003. Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle. Diabetes. 52: 657-662.
-
(2003)
Diabetes
, vol.52
, pp. 657-662
-
-
Pilegaard, H.1
Saltin, B.2
Neufer, P.D.3
-
27
-
-
68949181550
-
Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
-
Villanueva, C. J., M. Monetti, M. Shih, P. Zhou, S. M. Watkins, S. Bhanot, and R. V. Farese, Jr. 2009. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 50: 434-442.
-
(2009)
Hepatology
, vol.50
, pp. 434-442
-
-
Villanueva, C.J.1
Monetti, M.2
Shih, M.3
Zhou, P.4
Watkins, S.M.5
Bhanot, S.6
Farese Jr., R.V.7
-
28
-
-
0036828913
-
Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:Diacylglycerol acyltransferase 1 in white adipose tissue
-
Chen, H. C., S. J. Stone, P. Zhou, K. K. Buhman, and R. V. Farese, Jr. 2002. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 51: 3189-3195.
-
(2002)
Diabetes
, vol.51
, pp. 3189-3195
-
-
Chen, H.C.1
Stone, S.J.2
Zhou, P.3
Buhman, K.K.4
Farese Jr., R.V.5
-
29
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland, W. L., J. T. Brozinick, L. P. Wang, E. D. Hawkins, K. M. Sargent, Y. Liu, K. Narra, K. L. Hoehn, T. A. Knotts, A. Siesky, et al. 2007. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5: 167-179.
-
(2007)
Cell Metab.
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
Hawkins, E.D.4
Sargent, K.M.5
Liu, Y.6
Narra, K.7
Hoehn, K.L.8
Knotts, T.A.9
Siesky, A.10
-
30
-
-
0033588253
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
Schmitz-Peiffer, C., D. L. Craig, and T. J. Biden. 1999. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 274: 24202-24210.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24202-24210
-
-
Schmitz-Peiffer, C.1
Craig, D.L.2
Biden, T.J.3
-
31
-
-
0029742924
-
Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
-
Avignon, A., K. Yamada, X. Zhou, B. Spencer, O. Cardona, S. Saba-Siddique, L. Galloway, M. L. Standaert, and R. V. Farese. 1996. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Diabetes. 45: 1396-1404.
-
(1996)
Diabetes
, vol.45
, pp. 1396-1404
-
-
Avignon, A.1
Yamada, K.2
Zhou, X.3
Spencer, B.4
Cardona, O.5
Saba-Siddique, S.6
Galloway, L.7
Standaert, M.L.8
Farese, R.V.9
-
32
-
-
0030914330
-
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat diet rat
-
Schmitz-Peiffer, C., C. L. Browne, N. D. Oakes, A. Watkinson, D. J. Chisholm, E. W. Kraegen, and T. J. Biden. 1997. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat diet rat. Diabetes. 46: 169-178.
-
(1997)
Diabetes
, vol.46
, pp. 169-178
-
-
Schmitz-Peiffer, C.1
Browne, C.L.2
Oakes, N.D.3
Watkinson, A.4
Chisholm, D.J.5
Kraegen, E.W.6
Biden, T.J.7
-
33
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
-
Itani, S. I., N. B. Ruderman, F. Schmieder, and G. Boden. 2002. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51: 2005-2011.
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
34
-
-
8544244084
-
PKC-theta knockout mice are protected from fat-induced insulin resistance
-
Kim, J. K., J. J. Fillmore, M. J. Sunshine, B. Albrecht, T. Higashimori, D. W. Kim, Z. X. Liu, T. J. Soos, G. W. Cline, W. R. O'Brien, et al. 2004. PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114: 823-827.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
Fillmore, J.J.2
Sunshine, M.J.3
Albrecht, B.4
Higashimori, T.5
Kim, D.W.6
Liu, Z.X.7
Soos, T.J.8
Cline, G.W.9
O'Brien, W.R.10
-
35
-
-
33845401821
-
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
-
Turpin, S. M., G. I. Lancaster, I. Darby, M. A. Febbraio, and M. J. Watt. 2006. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am. J. Physiol. Endocrinol. Metab. 291: E1341-E1350.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
-
-
Turpin, S.M.1
Lancaster, G.I.2
Darby, I.3
Febbraio, M.A.4
Watt, M.J.5
-
36
-
-
14744304497
-
Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice
-
Chen, H. C., and R. V. Farese, Jr. 2005. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 482-486.
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 482-486
-
-
Chen, H.C.1
Farese Jr., R.V.2
-
37
-
-
70849136098
-
Pathogenesis and pathophysiology of the cardiometabolic syndrome
-
Kirk, E. P., and S. Klein. 2009. Pathogenesis and pathophysiology of the cardiometabolic syndrome. J. Clin. Hypertens. (Greenwich). 11: 761-765.
-
(2009)
J. Clin. Hypertens. (Greenwich).
, vol.11
, pp. 761-765
-
-
Kirk, E.P.1
Klein, S.2
-
38
-
-
2942746793
-
The role of acyl-CoA: Diacylglycerol acyltransferase (DGAT) in energy metabolism
-
Yu, Y. H., and H. N. Ginsberg. 2004. The role of acyl-CoA: diacylglycerol acyltransferase (DGAT) in energy metabolism. Ann. Med. 36: 252-261.
-
(2004)
Ann. Med.
, vol.36
, pp. 252-261
-
-
Yu, Y.H.1
Ginsberg, H.N.2
-
39
-
-
0034693232
-
Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
-
Coburn, C. T., F. F. Knapp, Jr., M. Febbraio, A. L. Beets, R. L. Silverstein, and N. A. Abumrad. 2000. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J. Biol. Chem. 275: 32523-32529.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32523-32529
-
-
Coburn, C.T.1
Knapp Jr., F.F.2
Febbraio, M.3
Beets, A.L.4
Silverstein, R.L.5
Abumrad, N.A.6
-
40
-
-
34548119860
-
Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress
-
Luptak, I., J. Yan, L. Cui, M. Jain, R. Liao, and R. Tian. 2007. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 116: 901-909.
-
(2007)
Circulation
, vol.116
, pp. 901-909
-
-
Luptak, I.1
Yan, J.2
Cui, L.3
Jain, M.4
Liao, R.5
Tian, R.6
-
41
-
-
0024237258
-
Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
-
Baron, A. D., G. Brechtel, P. Wallace, and S. V. Edelman. 1988. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am. J. Physiol. 255: E769-E774.
-
(1988)
Am. J. Physiol.
, vol.255
-
-
Baron, A.D.1
Brechtel, G.2
Wallace, P.3
Edelman, S.V.4
-
42
-
-
0031841949
-
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
-
Summers, S. A., L. A. Garza, H. Zhou, and M. J. Birnbaum. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18: 5457-5464.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5457-5464
-
-
Summers, S.A.1
Garza, L.A.2
Zhou, H.3
Birnbaum, M.J.4
-
43
-
-
33748323383
-
Regulation of cardiac hypertrophy by intracellular signalling pathways
-
Heineke, J., and J. D. Molkentin. 2006. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7: 589-600.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 589-600
-
-
Heineke, J.1
Molkentin, J.D.2
-
44
-
-
24144490615
-
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver
-
Park, S. Y., Y. R. Cho, B. N. Finck, H. J. Kim, T. Higashimori, E. G. Hong, M. K. Lee, C. Danton, S. Deshmukh, G. W. Cline, et al. 2005. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes. 54: 2514-2524.
-
(2005)
Diabetes
, vol.54
, pp. 2514-2524
-
-
Park, S.Y.1
Cho, Y.R.2
Finck, B.N.3
Kim, H.J.4
Higashimori, T.5
Hong, E.G.6
Lee, M.K.7
Danton, C.8
Deshmukh, S.9
Cline, G.W.10
-
45
-
-
34948910262
-
Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice
-
Son, N. H., T. S. Park, H. Yamashita, M. Yokoyama, L. A. Huggins, K. Okajima, S. Homma, M. J. Szabolcs, L. S. Huang, and I. J. Goldberg. 2007. Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. J. Clin. Invest. 117: 2791-2801.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2791-2801
-
-
Son, N.H.1
Park, T.S.2
Yamashita, H.3
Yokoyama, M.4
Huggins, L.A.5
Okajima, K.6
Homma, S.7
Szabolcs, M.J.8
Huang, L.S.9
Goldberg, I.J.10
-
46
-
-
36849068108
-
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart
-
Burkart, E. M., N. Sambandam, X. Han, R. W. Gross, M. Courtois, C. M. Gierasch, K. Shoghi, M. J. Welch, and D. P. Kelly. 2007. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J. Clin. Invest. 117: 3930-3939.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3930-3939
-
-
Burkart, E.M.1
Sambandam, N.2
Han, X.3
Gross, R.W.4
Courtois, M.5
Gierasch, C.M.6
Shoghi, K.7
Welch, M.J.8
Kelly, D.P.9
-
47
-
-
0032530765
-
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha- Deficient mice
-
Djouadi, F., C. J. Weinheimer, J. E. Saffitz, C. Pitchford, J. Bastin, F. J. Gonzalez, and D. P. Kelly. 1998. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha- deficient mice. J. Clin. Invest. 102: 1083-1091.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1083-1091
-
-
Djouadi, F.1
Weinheimer, C.J.2
Saffitz, J.E.3
Pitchford, C.4
Bastin, J.5
Gonzalez, F.J.6
Kelly, D.P.7
-
48
-
-
9144262378
-
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
-
Cheng, L., G. Ding, Q. Qin, Y. Huang, W. Lewis, N. He, R. M. Evans, M. D. Schneider, F. A. Brako, Y. Xiao, et al. 2004. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med. 10: 1245-1250.
-
(2004)
Nat. Med.
, vol.10
, pp. 1245-1250
-
-
Cheng, L.1
Ding, G.2
Qin, Q.3
Huang, Y.4
Lewis, W.5
He, N.6
Evans, R.M.7
Schneider, M.D.8
Brako, F.A.9
Xiao, Y.10
-
49
-
-
0033213637
-
PPAR gamma is required for placental, cardiac, and adipose tissue development
-
Barak, Y., M. C. Nelson, E. S. Ong, Y. Z. Jones, P. Ruiz-Lozano, K. R. Chien, A. Koder, and R. M. Evans. 1999. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell. 4: 585-595.
-
(1999)
Mol. Cell.
, vol.4
, pp. 585-595
-
-
Barak, Y.1
Nelson, M.C.2
Ong, E.S.3
Jones, Y.Z.4
Ruiz-Lozano, P.5
Chien, K.R.6
Koder, A.7
Evans, R.M.8
-
50
-
-
68149098866
-
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver
-
Chakravarthy, M. V., I. J. Lodhi, L. Yin, R. R. Malapaka, H. E. Xu, J. Turk, and C. F. Semenkovich. 2009. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 138: 476-488.
-
(2009)
Cell
, vol.138
, pp. 476-488
-
-
Chakravarthy, M.V.1
Lodhi, I.J.2
Yin, L.3
Malapaka, R.R.4
Xu, H.E.5
Turk, J.6
Semenkovich, C.F.7
|