메뉴 건너뛰기




Volumn 52, Issue 4, 2011, Pages 732-744

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle

Author keywords

Ceramide; Diacylglycerol acyl transferase; Exercise; Heart; Muscle hypertrophy; Peroxisome proliferator activated receptor; Triglyceride

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; DIACYLGLYCEROL ACYLTRANSFERASE 1; FATTY ACID; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN KINASE B; TRIACYLGLYCEROL;

EID: 79953306636     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M011395     Document Type: Article
Times cited : (71)

References (50)
  • 2
    • 24744443740 scopus 로고    scopus 로고
    • The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
    • Yen, C. L., M. Monetti, B. J. Burri, and R. V. Farese, Jr. 2005. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J. Lipid Res. 46: 1502-1511.
    • (2005) J. Lipid Res. , vol.46 , pp. 1502-1511
    • Yen, C.L.1    Monetti, M.2    Burri, B.J.3    Farese Jr., R.V.4
  • 3
    • 0032500641 scopus 로고    scopus 로고
    • Characterization of two human genes encoding acyl coenzyme A:Cholesterol acyltransferase-related enzymes
    • Oelkers, P., A. Behari, D. Cromley, J. T. Billheimer, and S. L. Sturley. 1998. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273: 26765-26771.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26765-26771
    • Oelkers, P.1    Behari, A.2    Cromley, D.3    Billheimer, J.T.4    Sturley, S.L.5
  • 4
    • 34547946930 scopus 로고    scopus 로고
    • Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
    • Choi, C. S., D. B. Savage, A. Kulkarni, X. X. Yu, Z. X. Liu, K. Morino, S. Kim, A. Distefano, V. T. Samuel, S. Neschen, et al. 2007. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282: 22678-22688.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22678-22688
    • Choi, C.S.1    Savage, D.B.2    Kulkarni, A.3    Yu, X.X.4    Liu, Z.X.5    Morino, K.6    Kim, S.7    Distefano, A.8    Samuel, V.T.9    Neschen, S.10
  • 5
    • 34249894505 scopus 로고    scopus 로고
    • Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
    • Liu, L., Y. Zhang, N. Chen, X. Shi, B. Tsang, and Y. H. Yu. 2007. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest. 117: 1679-1689.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1679-1689
    • Liu, L.1    Zhang, Y.2    Chen, N.3    Shi, X.4    Tsang, B.5    Yu, Y.H.6
  • 7
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • Goodpaster, B. H., J. He, S. Watkins, and D. E. Kelley. 2001. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86: 5755-5761.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 11
    • 0038481184 scopus 로고    scopus 로고
    • Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:Diacylglycerol acyltransferase 1
    • Chen, H. C., D. R. Jensen, H. M. Myers, R. H. Eckel, and R. V. Farese, Jr. 2003. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 111: 1715-1722.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1715-1722
    • Chen, H.C.1    Jensen, D.R.2    Myers, H.M.3    Eckel, R.H.4    Farese Jr., R.V.5
  • 16
    • 64349101065 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor
    • Birch, A. M., S. Birtles, L. K. Buckett, P. D. Kemmitt, G. J. Smith, T. J. Smith, A. V. Turnbull, and S. J. Wang. 2009. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J. Med. Chem. 52: 1558-1568.
    • (2009) J. Med. Chem. , vol.52 , pp. 1558-1568
    • Birch, A.M.1    Birtles, S.2    Buckett, L.K.3    Kemmitt, P.D.4    Smith, G.J.5    Smith, T.J.6    Turnbull, A.V.7    Wang, S.J.8
  • 18
    • 34247877577 scopus 로고    scopus 로고
    • The fuzzy logic of physiological cardiac hypertrophy
    • Dorn 2nd, G. W. 2007. The fuzzy logic of physiological cardiac hypertrophy. Hypertension. 49: 962-970.
    • (2007) Hypertension , vol.49 , pp. 962-970
    • Dorn II, G.W.1
  • 19
    • 67651227757 scopus 로고    scopus 로고
    • Changes in muscle mass with mechanical load: Possible cellular mechanisms
    • Spangenburg, E. E. 2009. Changes in muscle mass with mechanical load: possible cellular mechanisms. Appl. Physiol. Nutr. Metab. 34: 328-335.
    • (2009) Appl. Physiol. Nutr. Metab. , vol.34 , pp. 328-335
    • Spangenburg, E.E.1
  • 22
    • 0034467428 scopus 로고    scopus 로고
    • PPAR signaling in the control of cardiac energy metabolism
    • Barger, P. M., and D. P. Kelly. 2000. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc. Med. 10: 238-245.
    • (2000) Trends Cardiovasc. Med. , vol.10 , pp. 238-245
    • Barger, P.M.1    Kelly, D.P.2
  • 23
    • 20444452139 scopus 로고    scopus 로고
    • Effect of elevated lipid concentrations on human skeletal muscle gene expression
    • Tunstall, R. J., and D. Cameron-Smith. 2005. Effect of elevated lipid concentrations on human skeletal muscle gene expression. Metabolism. 54: 952-959.
    • (2005) Metabolism , vol.54 , pp. 952-959
    • Tunstall, R.J.1    Cameron-Smith, D.2
  • 24
    • 2542610041 scopus 로고    scopus 로고
    • Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:Diacylglycerol acyltransferase 1
    • Chen, H. C., M. Rao, M. P. Sajan, M. Standaert, Y. Kanoh, A. Miura, R. V. Farese, Jr., and R. V. Farese. 2004. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Diabetes. 53: 1445-1451.
    • (2004) Diabetes , vol.53 , pp. 1445-1451
    • Chen, H.C.1    Rao, M.2    Sajan, M.P.3    Standaert, M.4    Kanoh, Y.5    Miura, A.6    Farese Jr., R.V.7    Farese, R.V.8
  • 26
    • 0037341240 scopus 로고    scopus 로고
    • Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle
    • Pilegaard, H., B. Saltin, and P. D. Neufer. 2003. Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle. Diabetes. 52: 657-662.
    • (2003) Diabetes , vol.52 , pp. 657-662
    • Pilegaard, H.1    Saltin, B.2    Neufer, P.D.3
  • 27
    • 68949181550 scopus 로고    scopus 로고
    • Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
    • Villanueva, C. J., M. Monetti, M. Shih, P. Zhou, S. M. Watkins, S. Bhanot, and R. V. Farese, Jr. 2009. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 50: 434-442.
    • (2009) Hepatology , vol.50 , pp. 434-442
    • Villanueva, C.J.1    Monetti, M.2    Shih, M.3    Zhou, P.4    Watkins, S.M.5    Bhanot, S.6    Farese Jr., R.V.7
  • 28
    • 0036828913 scopus 로고    scopus 로고
    • Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:Diacylglycerol acyltransferase 1 in white adipose tissue
    • Chen, H. C., S. J. Stone, P. Zhou, K. K. Buhman, and R. V. Farese, Jr. 2002. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 51: 3189-3195.
    • (2002) Diabetes , vol.51 , pp. 3189-3195
    • Chen, H.C.1    Stone, S.J.2    Zhou, P.3    Buhman, K.K.4    Farese Jr., R.V.5
  • 30
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer, C., D. L. Craig, and T. J. Biden. 1999. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 274: 24202-24210.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 31
    • 0029742924 scopus 로고    scopus 로고
    • Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
    • Avignon, A., K. Yamada, X. Zhou, B. Spencer, O. Cardona, S. Saba-Siddique, L. Galloway, M. L. Standaert, and R. V. Farese. 1996. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Diabetes. 45: 1396-1404.
    • (1996) Diabetes , vol.45 , pp. 1396-1404
    • Avignon, A.1    Yamada, K.2    Zhou, X.3    Spencer, B.4    Cardona, O.5    Saba-Siddique, S.6    Galloway, L.7    Standaert, M.L.8    Farese, R.V.9
  • 32
    • 0030914330 scopus 로고    scopus 로고
    • Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat diet rat
    • Schmitz-Peiffer, C., C. L. Browne, N. D. Oakes, A. Watkinson, D. J. Chisholm, E. W. Kraegen, and T. J. Biden. 1997. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat diet rat. Diabetes. 46: 169-178.
    • (1997) Diabetes , vol.46 , pp. 169-178
    • Schmitz-Peiffer, C.1    Browne, C.L.2    Oakes, N.D.3    Watkinson, A.4    Chisholm, D.J.5    Kraegen, E.W.6    Biden, T.J.7
  • 33
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani, S. I., N. B. Ruderman, F. Schmieder, and G. Boden. 2002. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51: 2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 35
    • 33845401821 scopus 로고    scopus 로고
    • Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
    • Turpin, S. M., G. I. Lancaster, I. Darby, M. A. Febbraio, and M. J. Watt. 2006. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am. J. Physiol. Endocrinol. Metab. 291: E1341-E1350.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Turpin, S.M.1    Lancaster, G.I.2    Darby, I.3    Febbraio, M.A.4    Watt, M.J.5
  • 36
    • 14744304497 scopus 로고    scopus 로고
    • Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice
    • Chen, H. C., and R. V. Farese, Jr. 2005. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 482-486.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 482-486
    • Chen, H.C.1    Farese Jr., R.V.2
  • 37
    • 70849136098 scopus 로고    scopus 로고
    • Pathogenesis and pathophysiology of the cardiometabolic syndrome
    • Kirk, E. P., and S. Klein. 2009. Pathogenesis and pathophysiology of the cardiometabolic syndrome. J. Clin. Hypertens. (Greenwich). 11: 761-765.
    • (2009) J. Clin. Hypertens. (Greenwich). , vol.11 , pp. 761-765
    • Kirk, E.P.1    Klein, S.2
  • 38
    • 2942746793 scopus 로고    scopus 로고
    • The role of acyl-CoA: Diacylglycerol acyltransferase (DGAT) in energy metabolism
    • Yu, Y. H., and H. N. Ginsberg. 2004. The role of acyl-CoA: diacylglycerol acyltransferase (DGAT) in energy metabolism. Ann. Med. 36: 252-261.
    • (2004) Ann. Med. , vol.36 , pp. 252-261
    • Yu, Y.H.1    Ginsberg, H.N.2
  • 39
    • 0034693232 scopus 로고    scopus 로고
    • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    • Coburn, C. T., F. F. Knapp, Jr., M. Febbraio, A. L. Beets, R. L. Silverstein, and N. A. Abumrad. 2000. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J. Biol. Chem. 275: 32523-32529.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32523-32529
    • Coburn, C.T.1    Knapp Jr., F.F.2    Febbraio, M.3    Beets, A.L.4    Silverstein, R.L.5    Abumrad, N.A.6
  • 40
    • 34548119860 scopus 로고    scopus 로고
    • Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress
    • Luptak, I., J. Yan, L. Cui, M. Jain, R. Liao, and R. Tian. 2007. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 116: 901-909.
    • (2007) Circulation , vol.116 , pp. 901-909
    • Luptak, I.1    Yan, J.2    Cui, L.3    Jain, M.4    Liao, R.5    Tian, R.6
  • 41
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • Baron, A. D., G. Brechtel, P. Wallace, and S. V. Edelman. 1988. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am. J. Physiol. 255: E769-E774.
    • (1988) Am. J. Physiol. , vol.255
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 42
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • Summers, S. A., L. A. Garza, H. Zhou, and M. J. Birnbaum. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18: 5457-5464.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 43
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke, J., and J. D. Molkentin. 2006. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7: 589-600.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 44
    • 24144490615 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver
    • Park, S. Y., Y. R. Cho, B. N. Finck, H. J. Kim, T. Higashimori, E. G. Hong, M. K. Lee, C. Danton, S. Deshmukh, G. W. Cline, et al. 2005. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes. 54: 2514-2524.
    • (2005) Diabetes , vol.54 , pp. 2514-2524
    • Park, S.Y.1    Cho, Y.R.2    Finck, B.N.3    Kim, H.J.4    Higashimori, T.5    Hong, E.G.6    Lee, M.K.7    Danton, C.8    Deshmukh, S.9    Cline, G.W.10
  • 47
    • 0032530765 scopus 로고    scopus 로고
    • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha- Deficient mice
    • Djouadi, F., C. J. Weinheimer, J. E. Saffitz, C. Pitchford, J. Bastin, F. J. Gonzalez, and D. P. Kelly. 1998. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha- deficient mice. J. Clin. Invest. 102: 1083-1091.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1083-1091
    • Djouadi, F.1    Weinheimer, C.J.2    Saffitz, J.E.3    Pitchford, C.4    Bastin, J.5    Gonzalez, F.J.6    Kelly, D.P.7
  • 48
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng, L., G. Ding, Q. Qin, Y. Huang, W. Lewis, N. He, R. M. Evans, M. D. Schneider, F. A. Brako, Y. Xiao, et al. 2004. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med. 10: 1245-1250.
    • (2004) Nat. Med. , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5    He, N.6    Evans, R.M.7    Schneider, M.D.8    Brako, F.A.9    Xiao, Y.10
  • 50
    • 68149098866 scopus 로고    scopus 로고
    • Identification of a physiologically relevant endogenous ligand for PPARalpha in liver
    • Chakravarthy, M. V., I. J. Lodhi, L. Yin, R. R. Malapaka, H. E. Xu, J. Turk, and C. F. Semenkovich. 2009. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 138: 476-488.
    • (2009) Cell , vol.138 , pp. 476-488
    • Chakravarthy, M.V.1    Lodhi, I.J.2    Yin, L.3    Malapaka, R.R.4    Xu, H.E.5    Turk, J.6    Semenkovich, C.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.