Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 5, 2008, Pages

  Robinson, Katherine A ^a   Buse, Maria G ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b CSB 823 ^*  (United States)

Author keywords

Mammalian target of rapamycin Complex 1; Phosphatase and tensin homolog deleted on chromosome 10; Phosphatidylinositol 3,4,5 trisphosphate; Protein kinase B; Rapamycin

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; MANGANESE SUPEROXIDE DISMUTASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; S6 KINASE; UNCOUPLING PROTEIN 1; ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE TRANSPORTER; GREEN FLUORESCENT PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; ION CHANNEL; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; MTORC1 PROTEIN, MOUSE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL; PROTEIN KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SUPEROXIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ADIPOCYTE; ANIMAL; BIOSYNTHESIS; BIOTRANSFORMATION; DRUG EFFECT; ELECTROPORATION; GENETICS; LIPID METABOLISM; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOCYTES; ANIMALS; BIOTRANSFORMATION; BLOTTING, WESTERN; ELECTROPORATION; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; GREEN FLUORESCENT PROTEINS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; ION CHANNELS; LIPID METABOLISM; MICE; MITOCHONDRIAL PROTEINS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN KINASES; PTEN PHOSPHOHYDROLASE; SUPEROXIDES; TRANSCRIPTION FACTORS;

EID: 45549092417     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00644.2007     Document Type: Article

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