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Volumn 4, Issue 2, 2003, Pages 192-199

Teaching old drugs new tricks: Reincarnating immunosuppressants as antifungal drugs

Author keywords

Aspergillus; Candida albicans; Cryptococcus neoformans; Cyclosporin A; FK 506; Immunophilins; Rapamycin

Indexed keywords

ANTIFUNGAL AGENT; CALCINEURIN INHIBITOR; CYCLOSPORIN A; FENPROPIMORPH; FLUCONAZOLE; IMMUNOSUPPRESSIVE AGENT; L 685818; PYRROLE DERIVATIVE; RAPAMYCIN; TACROLIMUS; TEMSIROLIMUS; TERBINAFINE; UNCLASSIFIED DRUG;

EID: 0344687374     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (67)

References (74)
  • 2
    • 0024959451 scopus 로고
    • Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
    • Takahashi N, Hayano T, Suzuki M: Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature (1989) 337(6206):473-475.
    • (1989) Nature , vol.337 , Issue.6206 , pp. 473-475
    • Takahashi, N.1    Hayano, T.2    Suzuki, M.3
  • 3
    • 0024472603 scopus 로고
    • A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
    • Harding MW, Galat A, Uehling DE, Schreiber SL: A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (1989) 341(6244):758-760.
    • (1989) Nature , vol.341 , Issue.6244 , pp. 758-760
    • Harding, M.W.1    Galat, A.2    Uehling, D.E.3    Schreiber, S.L.4
  • 4
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 66(4):807-815.
    • (1991) Cell , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 5
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J, Movva NR, Hall MN: Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science (1991) 253(5022):905-909.
    • (1991) Science , vol.253 , Issue.5022 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 6
    • 0032823635 scopus 로고    scopus 로고
    • Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action
    • Cardenas ME, Cruz MC, Del Poeta M, Chung N, Perfect JR, Heitman J: Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin Microbiol Rev (1999) 12(4):583-611.
    • (1999) Clin Microbiol Rev , vol.12 , Issue.4 , pp. 583-611
    • Cardenas, M.E.1    Cruz, M.C.2    Del Poeta, M.3    Chung, N.4    Perfect, J.R.5    Heitman, J.6
  • 8
    • 0034774478 scopus 로고    scopus 로고
    • Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
    • note
    • Cruz MC, Goldstein AL, Blankenship J, Del Poeta M, Perfect JR, McCusker JH, Bennani YL, Cardenas ME, Heitman J: Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob Agents Chemother (2001) 45(11):3162-3170. This paper provides a detailed genetic analysis of the action of rapamycin and its analogs on C albicans and C neoformans.
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.11 , pp. 3162-3170
    • Cruz, M.C.1    Goldstein, A.L.2    Blankenship, J.3    Del Poeta, M.4    Perfect, J.R.5    McCusker, J.H.6    Bennani, Y.L.7    Cardenas, M.E.8    Heitman, J.9
  • 9
    • 0037083792 scopus 로고    scopus 로고
    • Calcineurin is essential for survival during membrane stress in Candida albicans
    • note
    • Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, Cardenas ME, Perfect JR, McCusker JH, Heitman J: Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J (2002) 21(4):546-559. This paper provides a detailed genetic analysis of the fungicidal synergism between azoles and calcineurin inhibitors in Candida species highlighting the importance of calcineurin inhibition for synergy.
    • (2002) EMBO J , vol.21 , Issue.4 , pp. 546-559
    • Cruz, M.C.1    Goldstein, A.L.2    Blankenship, J.R.3    Del Poeta, M.4    Davis, D.5    Cardenas, M.E.6    Perfect, J.R.7    McCusker, J.H.8    Heitman, J.9
  • 10
    • 0031028176 scopus 로고    scopus 로고
    • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein
    • Odom A, Poeta MD, Perfect J, Heitman J: The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother (1997) 41(1):156-161.
    • (1997) Antimicrob Agents Chemother , vol.41 , Issue.1 , pp. 156-161
    • Odom, A.1    Poeta, M.D.2    Perfect, J.3    Heitman, J.4
  • 11
    • 0033986998 scopus 로고    scopus 로고
    • Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin
    • note
    • Cruz MC, Del Poeta M, Wang P, Wenger R, Zenke G, Quesniaux VFJ, Movva NR, Perfect JR, Cardenas ME, Heitman J: Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother (2000) 44(1):143-149. Demonstration of the effectiveness of CsA and less immunossuppressive CsA analogs against C neformans and their mechanism of action.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.1 , pp. 143-149
    • Cruz, M.C.1    Del Poeta, M.2    Wang, P.3    Wenger, R.4    Zenke, G.5    Quesniaux, V.F.J.6    Movva, N.R.7    Perfect, J.R.8    Cardenas, M.E.9    Heitman, J.10
  • 12
    • 0037326390 scopus 로고    scopus 로고
    • Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species
    • Kontoyiannis DP, Lewis RE, Osherov N, Albert ND, May GS: Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species. J Antimicrob Chemother (2003) 51(2):313-316.
    • (2003) J Antimicrob Chemother , vol.51 , Issue.2 , pp. 313-316
    • Kontoyiannis, D.P.1    Lewis, R.E.2    Osherov, N.3    Albert, N.D.4    May, G.S.5
  • 13
    • 0035971180 scopus 로고    scopus 로고
    • The TOR kinases link nutrient sensing to cell growth
    • Rohde J, Heitman J, Cardenas ME: The TOR kinases link nutrient sensing to cell growth. J Biol Chem (2001) 276(13):9583-9586.
    • (2001) J Biol Chem , vol.276 , Issue.13 , pp. 9583-9586
    • Rohde, J.1    Heitman, J.2    Cardenas, M.E.3
  • 14
    • 0016724057 scopus 로고
    • Rapamycin (AY-22989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina C, Kudelski A, Sehgal SN: Rapamycin (AY-22989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (1975) 28(10):721-726.
    • (1975) J Antibiot , vol.28 , Issue.10 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 15
    • 0016713286 scopus 로고
    • Rapamycin (AY-22989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vezina C: Rapamycin (AY-22989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (1975) 28(10):727-732.
    • (1975) J Antibiot , vol.28 , Issue.10 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 16
    • 0018101547 scopus 로고
    • Rapamycin (AY-22989), a new antifungal antibiotic. III. In vitro and in vivo evaluation
    • Baker H, Sidorowicz A, Sehgal SN, Venzina C: Rapamycin (AY-22989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J Antibiot (1978) 31(6):539-545.
    • (1978) J Antibiot , vol.31 , Issue.6 , pp. 539-545
    • Baker, H.1    Sidorowicz, A.2    Sehgal, S.N.3    Venzina, C.4
  • 17
    • 0017362502 scopus 로고
    • Inhibition of the immune response by rapamycin, a new antifungal antibiotic
    • Martel RR, Klicius J, Galet S: Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can J Physiol Pharmacol (1977) 55(1):48-51.
    • (1977) Can J Physiol Pharmacol , vol.55 , Issue.1 , pp. 48-51
    • Martel, R.R.1    Klicius, J.2    Galet, S.3
  • 19
    • 0036707338 scopus 로고    scopus 로고
    • CCI-779 Wyeth
    • Elit L: CCI-779 Wyeth. Curr Opin Investig Drugs (2002) 3(8):1249-1253.
    • (2002) Curr Opin Investig Drugs , vol.3 , Issue.8 , pp. 1249-1253
    • Elit, L.1
  • 21
    • 0027284520 scopus 로고
    • A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase
    • Ocain TD, Longhi D, Steffan RJ, Caccese RG, Sehgal SN: A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase. Biochem Biophys Res Commun (1993) 192(3):1340-1346.
    • (1993) Biochem Biophys Res Commun , vol.192 , Issue.3 , pp. 1340-1346
    • Ocain, T.D.1    Longhi, D.2    Steffan, R.J.3    Caccese, R.G.4    Sehgal, S.N.5
  • 22
    • 0017086114 scopus 로고
    • Comparative study of in vitro and in vivo drug effects on cell-mediated cytotoxicity
    • Borel JF: Comparative study of in vitro and in vivo drug effects on cell-mediated cytotoxicity. Immunology (1976) 31(4):631-641.
    • (1976) Immunology , vol.31 , Issue.4 , pp. 631-641
    • Borel, J.F.1
  • 23
    • 0023245677 scopus 로고
    • FK506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, physico-chemical and biological characteristics
    • Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H: FK506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, physico-chemical and biological characteristics. J Antibiot (1987) 40(9):1249-1255.
    • (1987) J Antibiot , vol.40 , Issue.9 , pp. 1249-1255
    • Kino, T.1    Hatanaka, H.2    Hashimoto, M.3    Nishiyama, M.4    Goto, T.5    Okuhara, M.6    Kohsaka, M.7    Aoki, H.8    Imanaka, H.9
  • 24
    • 0024844391 scopus 로고
    • Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae
    • Tropschug M, Barthelmess IB, Neupert W: Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae. Nature (1989) 342(6252):953-955.
    • (1989) Nature , vol.342 , Issue.6252 , pp. 953-955
    • Tropschug, M.1    Barthelmess, I.B.2    Neupert, W.3
  • 25
    • 0026619467 scopus 로고
    • Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast
    • Foor F, Parent SA, Morin N, Dahl AM, Ramadan N, Chrebet G, Bostian KA, Nielsen JB: Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast. Nature (1992) 360(6405):682-684.
    • (1992) Nature , vol.360 , Issue.6405 , pp. 682-684
    • Foor, F.1    Parent, S.A.2    Morin, N.3    Dahl, A.M.4    Ramadan, N.5    Chrebet, G.6    Bostian, K.A.7    Nielsen, J.B.8
  • 29
    • 0029852215 scopus 로고    scopus 로고
    • Tacrolimus has antifungal activities against Malassezia furfur isolated from healthy adults and patients with atopic dermatitis
    • Nakagawa H, Etoh T, Yokota Y, Ikeda F, Hatano K, Teratani N, Shimomura K, Mine Y, Amaya T: Tacrolimus has antifungal activities against Malassezia furfur isolated from healthy adults and patients with atopic dermatitis. Clin Drug Invest (1996) 12(6):244-250.
    • (1996) Clin Drug Invest , vol.12 , Issue.6 , pp. 244-250
    • Nakagawa, H.1    Etoh, T.2    Yokota, Y.3    Ikeda, F.4    Hatano, K.5    Teratani, N.6    Shimomura, K.7    Mine, Y.8    Amaya, T.9
  • 31
    • 0027467516 scopus 로고
    • Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis
    • Rotonda J, Burbaum JJ, Chan HK, Marcy AI, Becker JW: Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis. J Biol Chem (1993) 268(11):7607-7609.
    • (1993) J Biol Chem , vol.268 , Issue.11 , pp. 7607-7609
    • Rotonda, J.1    Burbaum, J.J.2    Chan, H.K.3    Marcy, A.I.4    Becker, J.W.5
  • 33
    • 84907131884 scopus 로고
    • Isolation of Cryptococcus neoformans var gattii from an Asian patient in France: Evidence for dormant infection in healthy subjects
    • Dromer F, Ronin O, Dupont B: Isolation of Cryptococcus neoformans var gattii from an Asian patient in France: Evidence for dormant infection in healthy subjects. J Med Vet Mycol (1992) 30(5):395-397.
    • (1992) J Med Vet Mycol , vol.30 , Issue.5 , pp. 395-397
    • Dromer, F.1    Ronin, O.2    Dupont, B.3
  • 34
    • 0032552169 scopus 로고    scopus 로고
    • HIV combination therapy: Partial immune restitution unmasking latent cryptococcal infection
    • Woods ML 2nd, MacGinley R, Eisen DP, Allworth AM: HIV combination therapy: Partial immune restitution unmasking latent cryptococcal infection. AIDS (1998) 12(12):1491-1494.
    • (1998) AIDS , vol.12 , Issue.12 , pp. 1491-1494
    • Woods M.L. II1    MacGinley, R.2    Eisen, D.P.3    Allworth, A.M.4
  • 35
    • 0033971042 scopus 로고    scopus 로고
    • Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression and altered antibody responsiveness to cryptococcal polysaccharide
    • Goldman DL, Lee SC, Mednick AJ, Montella L, Casadevall A: Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression and altered antibody responsiveness to cryptococcal polysaccharide. Infect Immun (2000) 68(2):832-838.
    • (2000) Infect Immun , vol.68 , Issue.2 , pp. 832-838
    • Goldman, D.L.1    Lee, S.C.2    Mednick, A.J.3    Montella, L.4    Casadevall, A.5
  • 36
    • 0035347637 scopus 로고    scopus 로고
    • Cryptococcus neoformans infection in organ transplant recipients: Variables influencing clinical characteristics and outcome
    • Husain S, Wagener MM, Singh N: Cryptococcus neoformans infection in organ transplant recipients: Variables influencing clinical characteristics and outcome. Emerg Infect Dis (2001) 7(3):375-381.
    • (2001) Emerg Infect Dis , vol.7 , Issue.3 , pp. 375-381
    • Husain, S.1    Wagener, M.M.2    Singh, N.3
  • 37
    • 0034881410 scopus 로고    scopus 로고
    • Fungemia in HIV-infected patients: A 12-year study in a tertiary care hospital
    • Garbino J, Kolarova L, Lew D, Hirschel B, Rohner P: Fungemia in HIV-infected patients: A 12-year study in a tertiary care hospital. AIDS Patient Care STDS (2001) 15(8):407-410.
    • (2001) AIDS Patient Care STDS , vol.15 , Issue.8 , pp. 407-410
    • Garbino, J.1    Kolarova, L.2    Lew, D.3    Hirschel, B.4    Rohner, P.5
  • 39
    • 0019948366 scopus 로고
    • Central nervous system infection in the chronically immunosuppressed
    • Hooper DC, Pruitt AA, Rubin RH: Central nervous system infection in the chronically immunosuppressed. Medicine (1982) 61(3):166-188.
    • (1982) Medicine , vol.61 , Issue.3 , pp. 166-188
    • Hooper, D.C.1    Pruitt, A.A.2    Rubin, R.H.3
  • 41
    • 0000103974 scopus 로고    scopus 로고
    • Therapy of cryptococcal meningitis in non-HIV-infected patients
    • Pappas PG: Therapy of cryptococcal meningitis in non-HIV-infected patients. Curr Infect Dis Rep (2001) 3(4):365-370.
    • (2001) Curr Infect Dis Rep , vol.3 , Issue.4 , pp. 365-370
    • Pappas, P.G.1
  • 43
    • 0033043180 scopus 로고    scopus 로고
    • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans
    • note
    • Cruz MC, Cavallo LM, Görlach JM, Cox G, Perfect JR, Cardenas ME, Heitman J: Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol Cell Biol (1999) 19(6):4101-4112. A genetic and molecular examination of the role of Tor and FKBP12 on the activity on rapamycin in C neoformans pointing to a conserved role for these proteins.
    • (1999) Mol Cell Biol , vol.19 , Issue.6 , pp. 4101-4112
    • Cruz, M.C.1    Cavallo, L.M.2    Görlach, J.M.3    Cox, G.4    Perfect, J.R.5    Cardenas, M.E.6    Heitman, J.7
  • 44
    • 0021929967 scopus 로고
    • Effects of cyclosporine in experimental cryptococcal meningitis
    • Perfect JR, Durack DT: Effects of cyclosporine in experimental cryptococcal meningitis. Infect Immun (1985) 50(1):22-26.
    • (1985) Infect Immun , vol.50 , Issue.1 , pp. 22-26
    • Perfect, J.R.1    Durack, D.T.2
  • 45
    • 0023882309 scopus 로고
    • Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model
    • Mody CH, Toews GB, Lipscomb MF: Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model. Infect Immun (1988) 56(1):7-12.
    • (1988) Infect Immun , vol.56 , Issue.1 , pp. 7-12
    • Mody, C.H.1    Toews, G.B.2    Lipscomb, M.F.3
  • 46
    • 0024493070 scopus 로고
    • Treatment of murine cryptococcosis with cyclosporin A in normal and athymic mice
    • Mody CH, Toews GB, Lipscomb MF: Treatment of murine cryptococcosis with cyclosporin A in normal and athymic mice. Am Rev Respir Dis (1989) 139(1):8-13.
    • (1989) Am Rev Respir Dis , vol.139 , Issue.1 , pp. 8-13
    • Mody, C.H.1    Toews, G.B.2    Lipscomb, M.F.3
  • 47
    • 0031008864 scopus 로고    scopus 로고
    • Calcineurin is required for virulence of Cryptococcus neoformans
    • Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J: Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J (1997) 16(10):2576-2589.
    • (1997) EMBO J , vol.16 , Issue.10 , pp. 2576-2589
    • Odom, A.1    Muir, S.2    Lim, E.3    Toffaletti, D.L.4    Perfect, J.5    Heitman, J.6
  • 48
    • 0032841468 scopus 로고    scopus 로고
    • Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans
    • Arndt C, Cruz MC, Cardenas ME, Heitman J: Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology (1999) 145(Pt 8):1989-2000.
    • (1999) Microbiology , vol.145 , Issue.PART 8 , pp. 1989-2000
    • Arndt, C.1    Cruz, M.C.2    Cardenas, M.E.3    Heitman, J.4
  • 49
    • 0034959767 scopus 로고    scopus 로고
    • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans
    • Wang P, Cardenas ME, Cox GM, Perfect JR, Heitman J: Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. EMBO Rep (2001) 2(6):511-518.
    • (2001) EMBO Rep , vol.2 , Issue.6 , pp. 511-518
    • Wang, P.1    Cardenas, M.E.2    Cox, G.M.3    Perfect, J.R.4    Heitman, J.5
  • 50
    • 0035114113 scopus 로고    scopus 로고
    • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans
    • Fox DS, Cruz MC, Sia RA, Ke H, Cox GM, Cardenas ME, Heitman J: Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol Microbiol (2001) 39(4):835-849.
    • (2001) Mol Microbiol , vol.39 , Issue.4 , pp. 835-849
    • Fox, D.S.1    Cruz, M.C.2    Sia, R.A.3    Ke, H.4    Cox, G.M.5    Cardenas, M.E.6    Heitman, J.7
  • 51
    • 0033998663 scopus 로고    scopus 로고
    • Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743873) with calcineurin inhibitors FK506 and L-685818 against Cryptococcus neoformans
    • note
    • Del Poeta M, Cruz MC, Cardenas ME, Perfect JR, Heitman J: Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743873) with calcineurin inhibitors FK506 and L-685818 against Cryptococcus neoformans. Antimicrob Agents Chemother (2000) 44(3):739-746. This paper explores the synergism between FK-506 and L-685818 with currently used antifungal drugs, including azoles, pneumocandins and the vacuola proton-translocating-ATPase inhibitor bafilomycin against C neoformans.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.3 , pp. 739-746
    • Del Poeta, M.1    Cruz, M.C.2    Cardenas, M.E.3    Perfect, J.R.4    Heitman, J.5
  • 53
    • 0027511893 scopus 로고
    • Secular trends in the epidemiology of nosocomial fungal injections in the United States, 1980-1990. National Nosocomial Infections Surveillance System
    • Beck-Sague CM, Jarvis WR: Secular trends in the epidemiology of nosocomial fungal injections in the United States, 1980-1990. National Nosocomial Infections Surveillance System. J Infect Dis (1993) 167(5):1247-1251.
    • (1993) J Infect Dis , vol.167 , Issue.5 , pp. 1247-1251
    • Beck-Sague, C.M.1    Jarvis, W.R.2
  • 54
    • 0036205767 scopus 로고    scopus 로고
    • Caspofungin: An echinocandin antifungal agent
    • Stone EA, Fung HB, Kirschenbaum HL: Caspofungin: An echinocandin antifungal agent. Clin Ther (2002) 24(3):351-377.
    • (2002) Clin Ther , vol.24 , Issue.3 , pp. 351-377
    • Stone, E.A.1    Fung, H.B.2    Kirschenbaum, H.L.3
  • 55
    • 0036178410 scopus 로고    scopus 로고
    • Amphotericin B: Spectrum and resistance
    • Ellis D: Amphotericin B: Spectrum and resistance. J Antimicrob Chemother (2002) 49(Suppl 1):7-10.
    • (2002) J Antimicrob Chemother , vol.49 , Issue.SUPPL. 1 , pp. 7-10
    • Ellis, D.1
  • 56
    • 0032216576 scopus 로고    scopus 로고
    • Synergic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains
    • note
    • Maesaki S, Marichal P, Hossain MA, Sanglard D, Vanden Bossche H, Kohno S: Synergic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains. J Antimicrob Chemother (1998) 42(6):747-753. First report of synergy between FK-506 and fluconazole or itraconazole against C albicans.
    • (1998) J Antimicrob Chemother , vol.42 , Issue.6 , pp. 747-753
    • Maesaki, S.1    Marichal, P.2    Hossain, M.A.3    Sanglard, D.4    Vanden Bossche, H.5    Kohno, S.6
  • 57
    • 0033836026 scopus 로고    scopus 로고
    • Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans
    • note
    • Marchetti O, Moreillon P, Glauser MP, Bille J, Sanglard D: Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans. Antimicrob Agents Chemother (2000) 44(9):2373-2381. First report of antifungal synergy between CsA and fluconazole.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.9 , pp. 2373-2381
    • Marchetti, O.1    Moreillon, P.2    Glauser, M.P.3    Bille, J.4    Sanglard, D.5
  • 58
    • 0033751965 scopus 로고    scopus 로고
    • Fluconazole plus cyclosporine: A fungicidal combination effective against experimental endocarditis due to Candida albicans
    • note
    • Marchetti O, Entenza JM, Sanglard D, Bille J, Glauser MP, Moreillon P: Fluconazole plus cyclosporine: A fungicidal combination effective against experimental endocarditis due to Candida albicans. Antimicrob Agents Chemother (2000) 44(11):2932-2938. In vivo evidence for the utility of the synergy between azoles and calcineurin inhibitors in a rat model of endocarditis.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.11 , pp. 2932-2938
    • Marchetti, O.1    Entenza, J.M.2    Sanglard, D.3    Bille, J.4    Glauser, M.P.5    Moreillon, P.6
  • 59
    • 0036032124 scopus 로고    scopus 로고
    • Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling
    • Edlind T, Smith L, Henry K, Katiyar S, Nickels J: Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. Mol Microbiol (2002) 46(1):257-268.
    • (2002) Mol Microbiol , vol.46 , Issue.1 , pp. 257-268
    • Edlind, T.1    Smith, L.2    Henry, K.3    Katiyar, S.4    Nickels, J.5
  • 60
    • 0037093384 scopus 로고    scopus 로고
    • Essential role of calcineurin in response to endoplasmic reticulum stress
    • Bonilla M, Nastase KK, Cunningham KW: Essential role of calcineurin in response to endoplasmic reticulum stress. EMBO J (2002) 21(10):2343-2353.
    • (2002) EMBO J , vol.21 , Issue.10 , pp. 2343-2353
    • Bonilla, M.1    Nastase, K.K.2    Cunningham, K.W.3
  • 61
    • 0345489076 scopus 로고    scopus 로고
    • Erogosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors in Candida albicans, Candida glabrata and Candida krusei
    • in press
    • Onyewu C, Blankenship JR, Poeta MD, Heitman J: Erogosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors in Candida albicans, Candida glabrata and Candida krusei. Antimicrob Agents Chemother (2003) 47: in press.
    • (2003) Antimicrob Agents Chemother , vol.47
    • Onyewu, C.1    Blankenship, J.R.2    Poeta, M.D.3    Heitman, J.4
  • 62
    • 0029739907 scopus 로고    scopus 로고
    • Trends in the postmortem epidemiology of invasive fungal infections at a university hospital
    • Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K: Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J Infect (1996) 33(1):23-32.
    • (1996) J Infect , vol.33 , Issue.1 , pp. 23-32
    • Groll, A.H.1    Shah, P.M.2    Mentzel, C.3    Schneider, M.4    Just-Nuebling, G.5    Huebner, K.6
  • 63
    • 0031893513 scopus 로고    scopus 로고
    • Invasive aspergillosis
    • Denning DW: Invasive aspergillosis. Clin Infect Dis (1998) 26(4):781-803.
    • (1998) Clin Infect Dis , vol.26 , Issue.4 , pp. 781-803
    • Denning, D.W.1
  • 64
    • 0029811772 scopus 로고    scopus 로고
    • Therapeutic outcome in invasive aspergillosis
    • Denning DW: Therapeutic outcome in invasive aspergillosis. Clin Infect Dis (1996) 23(3):608-615.
    • (1996) Clin Infect Dis , vol.23 , Issue.3 , pp. 608-615
    • Denning, D.W.1
  • 65
    • 0031728895 scopus 로고    scopus 로고
    • An EORTC multicentre prospective survey of invasive aspergillosis in haematological patients: Diagnosis and therapeutic outcome. EORTC Invasive Fungal Infections Cooperative Group
    • Denning DW, Marinus A, Cohen J, Spence D, Herbrecht R, Pagano L, Kibbler C, Kcrmery V, Offner F, Cordonnier C, Jehn U et al: An EORTC multicentre prospective survey of invasive aspergillosis in haematological patients: Diagnosis and therapeutic outcome. EORTC Invasive Fungal Infections Cooperative Group. J Infect (1998) 37(2):173-180.
    • (1998) J Infect , vol.37 , Issue.2 , pp. 173-180
    • Denning, D.W.1    Marinus, A.2    Cohen, J.3    Spence, D.4    Herbrecht, R.5    Pagano, L.6    Kibbler, C.7    Kcrmery, V.8    Offner, F.9    Cordonnier, C.10    Jehn, U.11
  • 67
    • 0036532203 scopus 로고    scopus 로고
    • Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    • Marr KA, Carter RA, Crippa F, Wald A, Corey L: Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin Infect Dis (2002) 34(7):909-917.
    • (2002) Clin Infect Dis , vol.34 , Issue.7 , pp. 909-917
    • Marr, K.A.1    Carter, R.A.2    Crippa, F.3    Wald, A.4    Corey, L.5
  • 68
    • 0028234434 scopus 로고
    • The antimicrobial activities of cyclosporine, FK506 and rapamycin
    • High KP: The antimicrobial activities of cyclosporine, FK506 and rapamycin. Transplantation (1994) 57(12):1689-1700.
    • (1994) Transplantation , vol.57 , Issue.12 , pp. 1689-1700
    • High, K.P.1
  • 69
    • 0031024618 scopus 로고    scopus 로고
    • Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin)
    • High KP, Washburn RG: Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). J Infect Dis (1997) 175(1):222-225.
    • (1997) J Infect Dis , vol.175 , Issue.1 , pp. 222-225
    • High, K.P.1    Washburn, R.G.2
  • 72
    • 0029842109 scopus 로고    scopus 로고
    • Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    • Choi J, Chen J, Schreiber SL, Clardy J: Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 273(5272):239-242.
    • (1996) Science , vol.273 , Issue.5272 , pp. 239-242
    • Choi, J.1    Chen, J.2    Schreiber, S.L.3    Clardy, J.4
  • 73
    • 0037108767 scopus 로고    scopus 로고
    • Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
    • note
    • Jin L, Harrison SC: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci USA (2002) 99(21):13522-13526. This paper shows the crystal structure of calcineurin-cyclosporin-cyclophilin complex with detailed structural comparisons to unbound calcineurin and unbound prodrug.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.21 , pp. 13522-13526
    • Jin, L.1    Harrison, S.C.2
  • 74
    • 0037126026 scopus 로고    scopus 로고
    • Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
    • note
    • Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proc Natl Acad Sci USA (2002) 99(19):12037-12042. Crystal structure of calcineurin-cyclosporin-cyclophilin complex with detailed structural comparisons to unbound calcineurin, unbound prodrug, calcineurin in complex with FKBP12-FK506 and comparisons of CsA to analogs with implications for calcineurin and cyclophilin binding.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.19 , pp. 12037-12042
    • Huai, Q.1    Kim, H.Y.2    Liu, Y.3    Zhao, Y.4    Mondragon, A.5    Liu, J.O.6    Ke, H.7


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