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Volumn 3, Issue 6, 2011, Pages 330-340

The tumor suppressor kinase LKB1: Lessons from mouse models

Author keywords

AMPK; LKB1; mouse model; tumor suppressor

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN;

EID: 83455245205     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjr016     Document Type: Review
Times cited : (54)

References (103)
  • 1
    • 77749233738 scopus 로고    scopus 로고
    • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    • Alexander, A., Cai, S.L., Kim, J., et al. (2010). ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc. Natl Acad. Sci. USA 107, 4153-4158.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 4153-4158
    • Alexander, A.1    Cai, S.L.2    Kim, J.3
  • 2
    • 69949187550 scopus 로고    scopus 로고
    • SADB phosphorylation of gamma-tubulin regulates centrosome duplication
    • Alvarado-Kristensson, M., Rodriguez, M.J., Silio, V., et al. (2009). SADB phosphorylation of gamma-tubulin regulates centrosome duplication. Nat. Cell Biol. 11, 1081-1092.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1081-1092
    • Alvarado-Kristensson, M.1    Rodriguez, M.J.2    Silio, V.3
  • 3
    • 1542777034 scopus 로고    scopus 로고
    • Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
    • Baas, A.F., Kuipers, J., van der Wel, N.N., et al. (2004). Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116, 457-466.
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1    Kuipers, J.2    Van Der Wel, N.N.3
  • 4
    • 0037068461 scopus 로고    scopus 로고
    • Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    • Bardeesy, N., Sinha, M., Hezel, A.F., et al. (2002). Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419, 162-167.
    • (2002) Nature , vol.419 , pp. 162-167
    • Bardeesy, N.1    Sinha, M.2    Hezel, A.F.3
  • 5
    • 34247511497 scopus 로고    scopus 로고
    • LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
    • Barnes, A.P., Lilley, B.N., Pan, Y.A., et al. (2007). LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129, 549-563.
    • (2007) Cell , vol.129 , pp. 549-563
    • Barnes, A.P.1    Lilley, B.N.2    Pan, Y.A.3
  • 6
    • 39149088615 scopus 로고    scopus 로고
    • Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    • Beppu, H., Mwizerwa, O.N., Beppu, Y., et al. (2008). Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene 27, 1063-1070.
    • (2008) Oncogene , vol.27 , pp. 1063-1070
    • Beppu, H.1    Mwizerwa, O.N.2    Beppu, Y.3
  • 7
    • 0842288323 scopus 로고    scopus 로고
    • TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick, N.A., Chytil, A., Plieth, D., et al. (2004). TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303, 848-851.
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3
  • 8
    • 34047265189 scopus 로고    scopus 로고
    • Inactivation of Apc in the mouse prostate causes prostate carcinoma
    • Bruxvoort, K.J., Charbonneau, H.M., Giambernardi, T.A., et al. (2007). Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res. 67, 2490-2496.
    • (2007) Cancer Res. , vol.67 , pp. 2490-2496
    • Bruxvoort, K.J.1    Charbonneau, H.M.2    Giambernardi, T.A.3
  • 9
    • 73849112608 scopus 로고    scopus 로고
    • The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
    • Cao, Y., Li, H., Liu, H., et al. (2010). The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Res. 20, 99-108.
    • (2010) Cell Res. , vol.20 , pp. 99-108
    • Cao, Y.1    Li, H.2    Liu, H.3
  • 10
    • 38849193504 scopus 로고    scopus 로고
    • Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
    • Contreras, C.M., Gurumurthy, S., Haynie, J.M., et al. (2008). Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res. 68, 759-766.
    • (2008) Cancer Res. , vol.68 , pp. 759-766
    • Contreras, C.M.1    Gurumurthy, S.2    Haynie, J.M.3
  • 11
    • 77949469320 scopus 로고    scopus 로고
    • Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
    • Contreras, C.M., Akbay, E.A., Gallardo, T.D., et al. (2010). Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis. Model. Mech. 3, 181-193.
    • (2010) Dis. Model. Mech. , vol.3 , pp. 181-193
    • Contreras, C.M.1    Akbay, E.A.2    Gallardo, T.D.3
  • 12
    • 3042818799 scopus 로고    scopus 로고
    • Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
    • Corradetti, M.N., Inoki, K., Bardeesy, N., et al. (2004). Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18, 1533-1538.
    • (2004) Genes Dev. , vol.18 , pp. 1533-1538
    • Corradetti, M.N.1    Inoki, K.2    Bardeesy, N.3
  • 13
    • 0030969575 scopus 로고    scopus 로고
    • MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
    • Drewes, G., Ebneth, A., Preuss, U., et al. (1997). MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89, 297-308.
    • (1997) Cell , vol.89 , pp. 297-308
    • Drewes, G.1    Ebneth, A.2    Preuss, U.3
  • 14
    • 0034610730 scopus 로고    scopus 로고
    • Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
    • Esteller, M., Avizienyte, E., Corn, P.G., et al. (2000). Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene 19, 164-168.
    • (2000) Oncogene , vol.19 , pp. 164-168
    • Esteller, M.1    Avizienyte, E.2    Corn, P.G.3
  • 15
    • 0033775035 scopus 로고    scopus 로고
    • An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers
    • Forster, L.F., Defres, S., Goudie, D.R., et al. (2000). An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers. J. Clin. Pathol. 53, 791-793.
    • (2000) J. Clin. Pathol. , vol.53 , pp. 791-793
    • Forster, L.F.1    Defres, S.2    Goudie, D.R.3
  • 16
    • 70349484214 scopus 로고    scopus 로고
    • Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice
    • Fu, A., Ng, A.C., Depatie, C., et al. (2009). Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab. 10, 285-295.
    • (2009) Cell Metab. , vol.10 , pp. 285-295
    • Fu, A.1    Ng, A.C.2    Depatie, C.3
  • 17
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan, B., Hu, J., Jiang, S., et al. (2010). Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468, 701-704.
    • (2010) Nature , vol.468 , pp. 701-704
    • Gan, B.1    Hu, J.2    Jiang, S.3
  • 18
    • 77955092984 scopus 로고    scopus 로고
    • Spectrum of LKB1, EGFR, and KRAS mutations in Chinese lung adenocarcinomas
    • Gao, B., Sun, Y., Zhang, J., et al. (2010). Spectrum of LKB1, EGFR, and KRAS mutations in Chinese lung adenocarcinomas. J. Thorac. Oncol. 5, 1130-1135.
    • (2010) J. Thorac. Oncol. , vol.5 , pp. 1130-1135
    • Gao, B.1    Sun, Y.2    Zhang, J.3
  • 19
  • 20
    • 0034464147 scopus 로고    scopus 로고
    • Very high risk of cancer in familial Peutz-Jeghers syndrome
    • Giardiello, F.M., Brensinger, J.D., Tersmette, A.C., et al. (2000). Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119, 1447-1453.
    • (2000) Gastroenterology , vol.119 , pp. 1447-1453
    • Giardiello, F.M.1    Brensinger, J.D.2    Tersmette, A.C.3
  • 21
    • 70349503932 scopus 로고    scopus 로고
    • LKB1 regulates pancreatic beta cell size, polarity, and function
    • Granot, Z., Swisa, A., Magenheim, J., et al. (2009). LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab. 10, 296-308.
    • (2009) Cell Metab. , vol.10 , pp. 296-308
    • Granot, Z.1    Swisa, A.2    Magenheim, J.3
  • 22
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin, D.A., and Sabatini, D.M. (2007). Defining the role of mTOR in cancer. Cancer Cell 12, 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 23
    • 39149083762 scopus 로고    scopus 로고
    • LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
    • Gurumurthy, S., Hezel, A.F., Sahin, E., et al. (2008). LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res. 68, 55-63.
    • (2008) Cancer Res. , vol.68 , pp. 55-63
    • Gurumurthy, S.1    Hezel, A.F.2    Sahin, E.3
  • 24
    • 78649851511 scopus 로고    scopus 로고
    • The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
    • Gurumurthy, S., Xie, S.Z., Alagesan, B., et al. (2010). The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468, 659-663.
    • (2010) Nature , vol.468 , pp. 659-663
    • Gurumurthy, S.1    Xie, S.Z.2    Alagesan, B.3
  • 25
    • 0038199737 scopus 로고    scopus 로고
    • Management of cellular energy by the AMP-activated protein kinase system
    • Hardie, D.G., Scott, J.W., Pan, D.A., et al. (2003). Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546, 113-120.
    • (2003) FEBS Lett. , vol.546 , pp. 113-120
    • Hardie, D.G.1    Scott, J.W.2    Pan, D.A.3
  • 26
    • 33744782567 scopus 로고    scopus 로고
    • Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
    • Hearle, N., Schumacher, V., Menko, F.H., et al. (2006). Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin. Cancer Res. 12, 3209-3215.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3209-3215
    • Hearle, N.1    Schumacher, V.2    Menko, F.H.3
  • 27
    • 0032495530 scopus 로고    scopus 로고
    • A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
    • Hemminki, A., Markie, D., Tomlinson, I., et al. (1998). A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391, 184-187.
    • (1998) Nature , vol.391 , pp. 184-187
    • Hemminki, A.1    Markie, D.2    Tomlinson, I.3
  • 28
    • 56749176442 scopus 로고    scopus 로고
    • LKB1; linking cell structure and tumor suppression
    • Hezel, A.F., and Bardeesy, N. (2008). LKB1; linking cell structure and tumor suppression. Oncogene 27, 6908-6919.
    • (2008) Oncogene , vol.27 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 29
    • 39749194712 scopus 로고    scopus 로고
    • Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    • Hezel, A.F., Gurumurthy, S., Granot, Z., et al. (2008). Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol. Cell. Biol. 28, 2414-2425.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2414-2425
    • Hezel, A.F.1    Gurumurthy, S.2    Granot, Z.3
  • 30
    • 44449103256 scopus 로고    scopus 로고
    • Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    • Huang, X., Wullschleger, S., Shpiro, N., et al. (2008). Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem. J. 412, 211-221.
    • (2008) Biochem. J. , vol.412 , pp. 211-221
    • Huang, X.1    Wullschleger, S.2    Shpiro, N.3
  • 31
    • 72149093508 scopus 로고    scopus 로고
    • Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction
    • Ikeda, Y., Sato, K., Pimentel, D.R., et al. (2009). Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J. Biol. Chem. 284, 35839-35849.
    • (2009) J. Biol. Chem. , vol.284 , pp. 35839-35849
    • Ikeda, Y.1    Sato, K.2    Pimentel, D.R.3
  • 32
    • 0031974516 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    • Jenne, D.E., Reimann, H., Nezu, J., et al. (1998). Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat. Genet. 18, 38-43.
    • (1998) Nat. Genet. , vol.18 , pp. 38-43
    • Jenne, D.E.1    Reimann, H.2    Nezu, J.3
  • 33
    • 77953808195 scopus 로고    scopus 로고
    • Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function
    • Jessen, N., Koh, H.J., Folmes, C.D., et al. (2010). Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochim. Biophys. Acta 1802, 593-600.
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 593-600
    • Jessen, N.1    Koh, H.J.2    Folmes, C.D.3
  • 34
    • 34547926839 scopus 로고    scopus 로고
    • LKB1 modulates lung cancer differentiation and metastasis
    • Ji, H., Ramsey, M.R., Hayes, D.N., et al. (2007). LKB1 modulates lung cancer differentiation and metastasis. Nature 448, 807-810.
    • (2007) Nature , vol.448 , pp. 807-810
    • Ji, H.1    Ramsey, M.R.2    Hayes, D.N.3
  • 35
    • 0037173013 scopus 로고    scopus 로고
    • Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
    • Jishage, K., Nezu, J., Kawase, Y., et al. (2002). Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc. Natl Acad. Sci. USA 99, 8903-8908.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8903-8908
    • Jishage, K.1    Nezu, J.2    Kawase, Y.3
  • 37
    • 41349114071 scopus 로고    scopus 로고
    • LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
    • Katajisto, P., Vaahtomeri, K., Ekman, N., et al. (2008). LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat. Genet. 40, 455-459.
    • (2008) Nat. Genet. , vol.40 , pp. 455-459
    • Katajisto, P.1    Vaahtomeri, K.2    Ekman, N.3
  • 38
    • 0024284814 scopus 로고
    • Identification of genes required for cytoplasmic localization in early C. elegans embryos
    • Kemphues, K.J., Priess, J.R., Morton, D.G., et al. (1988). Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52, 311-320.
    • (1988) Cell , vol.52 , pp. 311-320
    • Kemphues, K.J.1    Priess, J.R.2    Morton, D.G.3
  • 39
    • 33745578957 scopus 로고    scopus 로고
    • Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
    • Kim, B.G., Li, C., Qiao, W., et al. (2006). Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 441, 1015-1019.
    • (2006) Nature , vol.441 , pp. 1015-1019
    • Kim, B.G.1    Li, C.2    Qiao, W.3
  • 40
    • 13644267037 scopus 로고    scopus 로고
    • Mammalian SAD kinases are required for neuronal polarization
    • Kishi, M., Pan, Y.A., Crump, J.G., et al. (2005). Mammalian SAD kinases are required for neuronal polarization. Science 307, 929-932.
    • (2005) Science , vol.307 , pp. 929-932
    • Kishi, M.1    Pan, Y.A.2    Crump, J.G.3
  • 41
    • 33751013309 scopus 로고    scopus 로고
    • Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
    • Koh, H.J., Arnolds, D.E., Fujii, N., et al. (2006). Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol. Cell. Biol. 26, 8217-8227.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 8217-8227
    • Koh, H.J.1    Arnolds, D.E.2    Fujii, N.3
  • 42
    • 77957288749 scopus 로고    scopus 로고
    • Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle
    • Koh, H.J., Toyoda, T., Fujii, N., et al. (2010). Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc. Natl Acad. Sci. USA 107, 15541-15546.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15541-15546
    • Koh, H.J.1    Toyoda, T.2    Fujii, N.3
  • 43
    • 48249102662 scopus 로고    scopus 로고
    • Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients
    • Koivunen, J.P., Kim, J., Lee, J., et al. (2008). Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. Br. J. Cancer 99, 245-252.
    • (2008) Br. J. Cancer , vol.99 , pp. 245-252
    • Koivunen, J.P.1    Kim, J.2    Lee, J.3
  • 44
    • 48249143587 scopus 로고    scopus 로고
    • LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment
    • Londesborough, A., Vaahtomeri, K., Tiainen, M., et al. (2008). LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment. Development 135, 2331-2338.
    • (2008) Development , vol.135 , pp. 2331-2338
    • Londesborough, A.1    Vaahtomeri, K.2    Tiainen, M.3
  • 45
    • 49849087494 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    • Lu, K.H., Wu, W., Dave, B., et al. (2008). Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clin. Cancer Res. 14, 2543-2550.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2543-2550
    • Lu, K.H.1    Wu, W.2    Dave, B.3
  • 46
    • 0037461735 scopus 로고    scopus 로고
    • A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
    • Martin, S.G., and St Johnston, D. (2003). A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421, 379-384.
    • (2003) Nature , vol.421 , pp. 379-384
    • Martin, S.G.1    St Johnston, D.2
  • 47
    • 34748845413 scopus 로고    scopus 로고
    • Prevalence and specificity of LKB1 genetic alterations in lung cancers
    • Matsumoto, S., Iwakawa, R., Takahashi, K., et al. (2007). Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 26, 5911-5918.
    • (2007) Oncogene , vol.26 , pp. 5911-5918
    • Matsumoto, S.1    Iwakawa, R.2    Takahashi, K.3
  • 48
    • 70350436136 scopus 로고    scopus 로고
    • Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
    • McCarthy, A., Lord, C.J., Savage, K., et al. (2009). Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J. Pathol. 219, 306-316.
    • (2009) J. Pathol. , vol.219 , pp. 306-316
    • McCarthy, A.1    Lord, C.J.2    Savage, K.3
  • 49
    • 26444610333 scopus 로고    scopus 로고
    • LKB1 interacts with and phosphorylates PTEN: A functional link between two proteins involved in cancer predisposing syndromes
    • Mehenni, H., Lin-Marq, N., Buchet-Poyau, K., et al. (2005). LKB1 interacts with and phosphorylates PTEN: A functional link between two proteins involved in cancer predisposing syndromes. Hum. Mol. Genet. 14, 2209-2219.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2209-2219
    • Mehenni, H.1    Lin-Marq, N.2    Buchet-Poyau, K.3
  • 50
    • 33745480336 scopus 로고    scopus 로고
    • Cancer risks in LKB1 germline mutation carriers
    • Mehenni, H., Resta, N., Park, J.G., et al. (2006). Cancer risks in LKB1 germline mutation carriers. Gut 55, 984-990.
    • (2006) Gut , vol.55 , pp. 984-990
    • Mehenni, H.1    Resta, N.2    Park, J.G.3
  • 51
    • 0033692749 scopus 로고    scopus 로고
    • Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome
    • Miyaki, M., Iijima, T., Hosono, K., et al. (2000). Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Cancer Res. 60, 6311-6313.
    • (2000) Cancer Res. , vol.60 , pp. 6311-6313
    • Miyaki, M.1    Iijima, T.2    Hosono, K.3
  • 52
    • 0037089467 scopus 로고    scopus 로고
    • Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
    • Miyoshi, H., Nakau, M., Ishikawa, T.O., et al. (2002). Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res. 62, 2261-2266.
    • (2002) Cancer Res. , vol.62 , pp. 2261-2266
    • Miyoshi, H.1    Nakau, M.2    Ishikawa, T.O.3
  • 53
    • 71049143563 scopus 로고    scopus 로고
    • Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/2 mice
    • Miyoshi, H., Deguchi, A., Nakau, M., et al. (2009). Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/2 mice. Cancer Sci. 100, 2046-2053.
    • (2009) Cancer Sci. , vol.100 , pp. 2046-2053
    • Miyoshi, H.1    Deguchi, A.2    Nakau, M.3
  • 54
    • 77955488036 scopus 로고    scopus 로고
    • LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    • Morton, J.P., Jamieson, N.B., Karim, S.A., et al. (2010). LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology 139, 586-597.
    • (2010) Gastroenterology , vol.139 , pp. 586-597
    • Morton, J.P.1    Jamieson, N.B.2    Karim, S.A.3
  • 55
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada, D., Saunders, T.L., and Morrison, S.J. (2010). Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468, 653-658.
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 56
    • 0037102428 scopus 로고    scopus 로고
    • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
    • Nakau, M., Miyoshi, H., Seldin, M.F., et al. (2002). Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res. 62, 4549-4553.
    • (2002) Cancer Res. , vol.62 , pp. 4549-4553
    • Nakau, M.1    Miyoshi, H.2    Seldin, M.F.3
  • 57
    • 77954601017 scopus 로고    scopus 로고
    • LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis
    • Ohashi, K., Ouchi, N., Higuchi, A., et al. (2010). LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J. Biol. Chem. 285, 22291-22298.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22291-22298
    • Ohashi, K.1    Ouchi, N.2    Higuchi, A.3
  • 58
    • 35548952703 scopus 로고    scopus 로고
    • Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
    • Partanen, J.I., Nieminen, A.I., Mäkelä, T.P., et al. (2007). Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc. Natl Acad. Sci. USA 104, 14694-14699.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 14694-14699
    • Partanen, J.I.1    Nieminen, A.I.2    Mäkelä, T.P.3
  • 59
    • 42049113832 scopus 로고    scopus 로고
    • Lkb1 deficiency causes prostate neoplasia in the mouse
    • Pearson, H.B., McCarthy, A., Collins, C.M., et al. (2008). Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res. 68, 2223-2232.
    • (2008) Cancer Res. , vol.68 , pp. 2223-2232
    • Pearson, H.B.1    McCarthy, A.2    Collins, C.M.3
  • 60
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumor stroma
    • Pietras, K., and Ostman, A. (2010). Hallmarks of cancer: Interactions with the tumor stroma. Exp. Cell Res. 316, 1324-1331.
    • (2010) Exp. Cell Res. , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 61
    • 56549107692 scopus 로고    scopus 로고
    • Osteogenic tumours in Lkb1-deficient mice
    • Robinson, J., Nye, E., Stamp, G., et al. (2008). Osteogenic tumours in Lkb1-deficient mice. Exp. Mol. Pathol. 85, 223-226.
    • (2008) Exp. Mol. Pathol. , vol.85 , pp. 223-226
    • Robinson, J.1    Nye, E.2    Stamp, G.3
  • 62
    • 0037125996 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
    • Rossi, D.J., Ylikorkala, A., Korsisaari, N., et al. (2002). Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc. Natl Acad. Sci. USA 99, 12327-12332.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12327-12332
    • Rossi, D.J.1    Ylikorkala, A.2    Korsisaari, N.3
  • 63
    • 0038107613 scopus 로고    scopus 로고
    • Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
    • Sahin, F., Maitra, A., Argani, P., et al. (2003). Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod. Pathol. 16, 686-691.
    • (2003) Mod. Pathol. , vol.16 , pp. 686-691
    • Sahin, F.1    Maitra, A.2    Argani, P.3
  • 64
    • 20044370885 scopus 로고    scopus 로고
    • Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
    • Sakamoto, K., McCarthy, A., Smith, D., et al. (2005). Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 24, 1810-1820.
    • (2005) EMBO J. , vol.24 , pp. 1810-1820
    • Sakamoto, K.1    McCarthy, A.2    Smith, D.3
  • 65
    • 33646420605 scopus 로고    scopus 로고
    • Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1
    • Sakamoto, K., Zarrinpashneh, E., Budas, G.R., et al. (2006). Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am. J. Physiol. Endocrinol. Metab. 290, E780-E788.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Sakamoto, K.1    Zarrinpashneh, E.2    Budas, G.R.3
  • 66
    • 0036645286 scopus 로고    scopus 로고
    • Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
    • Sanchez-Cespedes, M., Parrella, P., Esteller, M., et al. (2002). Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 62, 3659-3662.
    • (2002) Cancer Res. , vol.62 , pp. 3659-3662
    • Sanchez-Cespedes, M.1    Parrella, P.2    Esteller, M.3
  • 67
    • 0035184065 scopus 로고    scopus 로고
    • STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
    • Sato, N., Rosty, C., Jansen, M., et al. (2001). STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am. J. Pathol. 159, 2017-2022.
    • (2001) Am. J. Pathol. , vol.159 , pp. 2017-2022
    • Sato, N.1    Rosty, C.2    Jansen, M.3
  • 68
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford, D.B., and Shaw, R.J. (2009). The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression. Nat. Rev. Cancer 9, 563-575.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 69
    • 67650480092 scopus 로고    scopus 로고
    • MTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
    • Shackelford, D.B., Vasquez, D.S., Corbeil, J., et al. (2009). mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc. Natl Acad. Sci. USA 106, 11137-11142.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 11137-11142
    • Shackelford, D.B.1    Vasquez, D.S.2    Corbeil, J.3
  • 70
    • 3142594193 scopus 로고    scopus 로고
    • The LKB1 tumor suppressor negatively regulates mTOR signaling
    • Shaw, R.J., Bardeesy, N., Manning, B.D., et al. (2004). The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6, 91-99.
    • (2004) Cancer Cell , vol.6 , pp. 91-99
    • Shaw, R.J.1    Bardeesy, N.2    Manning, B.D.3
  • 71
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw, R.J., Lamia, K.A., Vasquez, D., et al. (2005). The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642-1646.
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3
  • 72
    • 34247478454 scopus 로고    scopus 로고
    • LKB1/STRAD promotes axon initiation during neuronal polarization
    • Shelly, M., Cancedda, L., Heilshorn, S., et al. (2007). LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 129, 565-577.
    • (2007) Cell , vol.129 , pp. 565-577
    • Shelly, M.1    Cancedda, L.2    Heilshorn, S.3
  • 73
    • 0034660862 scopus 로고    scopus 로고
    • Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: An implication for mutator phenotype and breast cancer pathogenesis
    • Shen, C.Y., Yu, J.C., Lo, Y.L., et al. (2000). Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: An implication for mutator phenotype and breast cancer pathogenesis. Cancer Res. 60, 3884-3892.
    • (2000) Cancer Res. , vol.60 , pp. 3884-3892
    • Shen, C.Y.1    Yu, J.C.2    Lo, Y.L.3
  • 74
    • 59249096211 scopus 로고    scopus 로고
    • Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine
    • Shorning, B.Y., Zabkiewicz, J., McCarthy, A., et al. (2009). Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PloS One 4, e4264.
    • (2009) PloS One , vol.4
    • Shorning, B.Y.1    Zabkiewicz, J.2    McCarthy, A.3
  • 75
    • 79251614530 scopus 로고    scopus 로고
    • Lkb1 and pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder
    • Shorning, B.Y., Griffiths, D., and Clarke, A.R. (2011). Lkb1 and pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PloS One 6, e16209.
    • (2011) PloS One , vol.6
    • Shorning, B.Y.1    Griffiths, D.2    Clarke, A.R.3
  • 76
    • 0042090214 scopus 로고    scopus 로고
    • Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
    • Spicer, J., Rayter, S., Young, N., et al. (2003). Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22, 4752-4756.
    • (2003) Oncogene , vol.22 , pp. 4752-4756
    • Spicer, J.1    Rayter, S.2    Young, N.3
  • 77
    • 10944227282 scopus 로고    scopus 로고
    • Tau phosphorylation: Physiological and pathological consequences
    • Stoothoff, W.H., and Johnson, G.V. (2005). Tau phosphorylation: Physiological and pathological consequences. Biochim. Biophys. Acta 1739, 280-297.
    • (2005) Biochim. Biophys. Acta , vol.1739 , pp. 280-297
    • Stoothoff, W.H.1    Johnson, G.V.2
  • 78
    • 65249093808 scopus 로고    scopus 로고
    • Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma
    • Strazisar, M., Mlakar, V., Rott, T., et al. (2009). Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma. Cancer Invest. 27, 407-416.
    • (2009) Cancer Invest. , vol.27 , pp. 407-416
    • Strazisar, M.1    Mlakar, V.2    Rott, T.3
  • 79
    • 0032984141 scopus 로고    scopus 로고
    • Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
    • Su, G.H., Hruban, R.H., Bansal, R.K., et al. (1999). Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am. J. Pathol. 154, 1835-1840.
    • (1999) Am. J. Pathol. , vol.154 , pp. 1835-1840
    • Su, G.H.1    Hruban, R.H.2    Bansal, R.K.3
  • 80
    • 77952587385 scopus 로고    scopus 로고
    • LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo
    • Sun, G., Tarasov, A.I., McGinty, J.A., et al. (2010a). LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am. J. Physiol. Endocrinol. Metab. 298, E1261-E1273.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298
    • Sun, G.1    Tarasov, A.I.2    McGinty, J.A.3
  • 81
    • 77952095690 scopus 로고    scopus 로고
    • Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
    • Sun, G., Tarasov, A.I., McGinty, J.A., et al. (2010b). Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.Diabetologia 53, 924-936.
    • (2010) Diabetologia , vol.53 , pp. 924-936
    • Sun, G.1    Tarasov, A.I.2    McGinty, J.A.3
  • 82
    • 79952331147 scopus 로고    scopus 로고
    • RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis
    • Sun, G., Reynolds, R., Leclerc, I., et al. (2011). RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis. Dis. Model. Mech. 4, 193-202.
    • (2011) Dis. Model. Mech. , vol.4 , pp. 193-202
    • Sun, G.1    Reynolds, R.2    Leclerc, I.3
  • 83
    • 33645022897 scopus 로고    scopus 로고
    • Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/2p532/2 compound mutant mice
    • Takeda, H., Miyoshi, H., Kojima, Y., et al. (2006). Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/2p532/2 compound mutant mice. Oncogene 25, 1816-1820.
    • (2006) Oncogene , vol.25 , pp. 1816-1820
    • Takeda, H.1    Miyoshi, H.2    Kojima, Y.3
  • 84
    • 74249122511 scopus 로고    scopus 로고
    • LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
    • Tamas, P., Macintyre, A., Finlay, D., et al. (2010). LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells. Eur. J. Immunol. 40, 242-253.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 242-253
    • Tamas, P.1    Macintyre, A.2    Finlay, D.3
  • 85
    • 70350510924 scopus 로고    scopus 로고
    • Pten in stromal fibroblasts suppresses mammary epithelial tumours
    • Trimboli, A.J., Cantemir-Stone, C.Z., Li, F., et al. (2009). Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature 461, 1084-1091.
    • (2009) Nature , vol.461 , pp. 1084-1091
    • Trimboli, A.J.1    Cantemir-Stone, C.Z.2    Li, F.3
  • 86
    • 5144232989 scopus 로고    scopus 로고
    • Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2
    • Udd, L., Katajisto, P., Rossi, D.J., et al. (2004). Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Gastroenterology 127, 1030-1037.
    • (2004) Gastroenterology , vol.127 , pp. 1030-1037
    • Udd, L.1    Katajisto, P.2    Rossi, D.J.3
  • 87
    • 77952033717 scopus 로고    scopus 로고
    • Impaired gastric gland differentiation in Peutz-Jeghers syndrome
    • Udd, L., Katajisto, P., Kyyronen, M., et al. (2010). Impaired gastric gland differentiation in Peutz-Jeghers syndrome. Am. J. Pathol. 176, 2467-2476.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2467-2476
    • Udd, L.1    Katajisto, P.2    Kyyronen, M.3
  • 88
    • 79953248896 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor suppression by LKB1
    • Vaahtomeri, K., and Mäkelä, T.P. (2011). Molecular mechanisms of tumor suppression by LKB1. FEBS Lett. 585, 944-951.
    • (2011) FEBS Lett. , vol.585 , pp. 944-951
    • Vaahtomeri, K.1    Mäkelä, T.P.2
  • 89
    • 59149102643 scopus 로고    scopus 로고
    • Lkb1 is required for TGFbeta-mediated myofibroblast differentiation
    • Vaahtomeri, K., Ventela, E., Laajanen, K., et al. (2008). Lkb1 is required for TGFbeta-mediated myofibroblast differentiation. J. Cell Sci. 121, 3531-3540.
    • (2008) J. Cell Sci. , vol.121 , pp. 3531-3540
    • Vaahtomeri, K.1    Ventela, E.2    Laajanen, K.3
  • 90
    • 79551564565 scopus 로고    scopus 로고
    • An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers
    • Vallenius, T., Vaahtomeri, K., Kovac, B., et al. (2010). An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. J. Cell Sci. 124, 384-393.
    • (2010) J. Cell Sci. , vol.124 , pp. 384-393
    • Vallenius, T.1    Vaahtomeri, K.2    Kovac, B.3
  • 91
    • 77953230425 scopus 로고    scopus 로고
    • High cancer risk in Peutz-Jeghers syndrome: A systematic review and surveillance recommendations
    • Author reply 1265
    • van Lier, M.G., Wagner, A., Mathus-Vliegen, E.M., et al. (2010). High cancer risk in Peutz-Jeghers syndrome: A systematic review and surveillance recommendations. Am. J. Gastroenterol. 105, 1258-1264; author reply 1265.
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 1258-1264
    • Van Lier, M.G.1    Wagner, A.2    Mathus-Vliegen, E.M.3
  • 92
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang, S., Gao, J., Lei, Q., et al. (2003). Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4, 209-221.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3
  • 93
    • 29244474612 scopus 로고    scopus 로고
    • Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
    • Wei, C., Amos, C.I., Stephens, L.C., et al. (2005). Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res. 65, 11297-11303.
    • (2005) Cancer Res. , vol.65 , pp. 11297-11303
    • Wei, C.1    Amos, C.I.2    Stephens, L.C.3
  • 94
    • 64549113040 scopus 로고    scopus 로고
    • Somatic LKB1 mutations promote cervical cancer progression
    • Wingo, S.N., Gallardo, T.D., Akbay, E.A., et al. (2009). Somatic LKB1 mutations promote cervical cancer progression. PloS One 4, e5137.
    • (2009) PloS One , vol.4
    • Wingo, S.N.1    Gallardo, T.D.2    Akbay, E.A.3
  • 95
    • 78650908575 scopus 로고    scopus 로고
    • LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice
    • Woods, A., Heslegrave, A.J., Muckett, P.J., et al. (2011). LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. Biochem. J. 434, 49-60.
    • (2011) Biochem. J. , vol.434 , pp. 49-60
    • Woods, A.1    Heslegrave, A.J.2    Muckett, P.J.3
  • 96
    • 67650083087 scopus 로고    scopus 로고
    • Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis
    • Xie, Z., Dong, Y., Zhang, J., et al. (2009). Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. Mol. Cell. Biol. 29, 3582-3596.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3582-3596
    • Xie, Z.1    Dong, Y.2    Zhang, J.3
  • 97
    • 4644309913 scopus 로고    scopus 로고
    • High-resolution 19p13.2-13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity
    • Yang, T.L., Su, Y.R., Huang, C.S., et al. (2004). High-resolution 19p13.2-13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity. Genes Chromosomes Cancer 41, 250-256.
    • (2004) Genes Chromosomes Cancer , vol.41 , pp. 250-256
    • Yang, T.L.1    Su, Y.R.2    Huang, C.S.3
  • 98
    • 0038498340 scopus 로고    scopus 로고
    • Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome
    • Yee, N.S., Furth, E.E., and Pack, M. (2003). Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome. Cancer Biol. Ther. 2, 38-47.
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 38-47
    • Yee, N.S.1    Furth, E.E.2    Pack, M.3
  • 99
    • 0035903028 scopus 로고    scopus 로고
    • Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
    • Ylikorkala, A., Rossi, D.J., Korsisaari, N., et al. (2001). Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293, 1323-1326.
    • (2001) Science , vol.293 , pp. 1323-1326
    • Ylikorkala, A.1    Rossi, D.J.2    Korsisaari, N.3
  • 100
    • 77953653569 scopus 로고    scopus 로고
    • New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion
    • Zagorska, A., Deak, M., Campbell, D.G., et al. (2010). New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci. Signal. 3, ra25.
    • (2010) Sci. Signal. , vol.3
    • Zagorska, A.1    Deak, M.2    Campbell, D.G.3
  • 101
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou, G., Myers, R., Li, Y., et al. (2001). Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167-1174.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 102
    • 66149129259 scopus 로고    scopus 로고
    • Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
    • Zhou, J., Huang, W., Tao, R., et al. (2009). Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene 28, 1993-2002.
    • (2009) Oncogene , vol.28 , pp. 1993-2002
    • Zhou, J.1    Huang, W.2    Tao, R.3
  • 103
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R., Efeyan, A., and Sabatini, D.M. (2011). mTOR: From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


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