Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

Cell Metabolism

Volumn 10, Issue 4, 2009, Pages 285-295

  Fu, Accalia ^a,b   Ng, Andy Cheuk Him ^a,b   Depatie, Chantal ^a   Wijesekara, Nadeeja ^c   He, Ying ^d   Wang, Gen Sheng ^d   Bardeesy, Nabeel ^e   Scott, Fraser W ^d   Touyz, Rhian M ^d   Wheeler, Michael B ^c   Screaton, Robert A ^a,b  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e HARVARD UNIVERSITY   (United States)

Author keywords

HUMDISEASE

Indexed keywords

GLUCOSE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE LKB1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; GLUCOSE TOLERANCE; HYPERGLYCEMIA; IN VIVO STUDY; INSULIN RELEASE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTECTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; DIETARY FATS; ESTROGEN ANTAGONISTS; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; TAMOXIFEN; TRANSGENES;

MUS;

EID: 70349484214     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.08.008     Document Type: Article

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