Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

DMM Disease Models and Mechanisms

Volumn 3, Issue 3-4, 2010, Pages 181-193

  Contreras, Cristina M ^a,b   Akbay, Esra A ^a,b   Gallardo, Teresa D ^a,b   Haynie, J Marshall ^a,b   Sharma, Sreenath ^c   Tagao, Osamu ^d   Bardeesy, Nabeel ^c   Takahashi, Masaya ^d   Settleman, Jeff ^c   Wong, Kwok Kin ^c   Castrillon, Diego H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE LKB1; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; DRUG EFFICACY; ENDOMETRIUM; ENDOMETRIUM CANCER; ESTROGEN RESPONSIVE ELEMENT; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE TARGETING; HETEROZYGOSITY; MALIGNANT TRANSFORMATION; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPRR2F GENE; TRANSGENE; TRANSGENIC MOUSE; TREATMENT RESPONSE; TUMOR GENE; TUMOR REGRESSION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL LINE, TUMOR; CLONING, MOLECULAR; CORNIFIED ENVELOPE PROLINE-RICH PROTEINS; DISEASE MODELS, ANIMAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; ENZYME ACTIVATION; EPITHELIUM; FEMALE; INTEGRASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; ORGAN SPECIFICITY; PENETRANCE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RESPONSE ELEMENTS; SIROLIMUS;

MAMMALIA; MUS;

EID: 77949469320     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.004440     Document Type: Article

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