Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

Diabetologia

Volumn 53, Issue 5, 2010, Pages 924-936

  Sun, G ^a   Tarasov, A I ^a   McGinty, J ^a   McDonald, A ^a   Da Silva Xavier, G ^a   Gorman, T ^b   Marley, A ^b   French, P M ^a   Parker, H ^c   Gribble, F ^c   Reimann, F ^c   Prendiville, O ^d   Carzaniga, R ^a   Viollet, B ^e,f   Leclerc, I ^a   Rutter, G A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d CHARING CROSS HOSPITAL   (United Kingdom)

^e INSTITUT COCHIN   (France)

^f INSERM   (France)

Author keywords

AMPK; Beta cell; Insulin secretion; Islet; Knockout; RIP.Cre

Indexed keywords

CALCIUM ION; CATECHOLAMINE DERIVATIVE; CRE RECOMBINASE; GENE PRODUCT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA2; INSULIN; RAT INSULIN PROMOTER 2 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CELL GRANULE; CELL MEMBRANE POTENTIAL; CELL STRUCTURE; CELL VOLUME; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FOOD INTAKE; GLUCOSE TOLERANCE; HYPOTHALAMUS; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; MALE; MOUSE; NERVE CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

AMP-ACTIVATED PROTEIN KINASES; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIETARY FATS; EATING; ELECTROPHYSIOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPOTHALAMUS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; NEURONS; PROMOTER REGIONS, GENETIC; RATS;

EID: 77952095690     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1692-1     Document Type: Article

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