Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

British Journal of Cancer

Volumn 99, Issue 2, 2008, Pages 245-252

  Koivunen, J P ^a,b   Kim, J ^c,d   Lee, J ^c,d   Rogers, A M ^b   Park, J O ^a,b   Zhao, X ^b   Naoki, K ^b   Okamoto, I ^e   Nakagawa, K ^e   Yeap, B Y ^f   Meyerson, M ^a,b,g,h   Wong, K K ^a,b,h   Richards, W G ^h   Sugarbaker, D J ^h   Johnson, B E ^a,b,h   Janne P A ^a,b,h  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Samsung Medical Center   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e KINKI UNIVERSITY   (Japan)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Carcinoma; EGFR; KRAS; LKB1; Mutation; Non small cell lung

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE LKB1; BRAF PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, HUMAN;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; ADULT; ARTICLE; ASIAN; CANCER PATIENT; CANCER STAGING; CAUCASIAN; CONTROLLED STUDY; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SCREENING; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KOREA; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MUTATION RATE; MUTATIONAL ANALYSIS; ONCOGENE K RAS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING; SQUAMOUS CELL CARCINOMA; TUMOR GENE; TUMOR SUPPRESSOR GENE; UNITED STATES; ENZYMOLOGY; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; LUNG TUMOR; MUTATION; ONCOGENE RAS; PATHOLOGY; TUMOR CELL LINE;

ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENES, RAS; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUNG NEOPLASMS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS B-RAF; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 48249102662     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604469     Document Type: Article

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