LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

Biochemical Journal

Volumn 434, Issue 1, 2011, Pages 49-60

  Woods, Angela ^a   Heslegrave, Amanda J ^a   Muckett, Phillip J ^a   Levene, Adam P ^a   Clements, Melanie ^a   Mobberley, Margaret ^b   Ryder, Timothy A ^b   Abu Hayyeh, Shadi ^a   Williamson, Catherine ^a   Goldin, Robert D ^a   Ashworth, Alan ^c   Withers, Dominic J ^a   Carling, David ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

AMP activated protein kinase (AMPK); ATP binding cassette subfamily B; Bile salt export pump (BSEP); Cholestasis; Hyperbilirubinaemia; Member 11 (ABCB11); Polarity

Indexed keywords

ABC TRANSPORTER; BILE ACID; BILE SALT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN KINASE LKB1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID METABOLISM; BILE ACID TRANSPORT; BILE DUCT; BILE SALT EXPORT PUMP; CANALICULAR MEMBRANE INTEGRITY; CELL MEMBRANE; CELL POLARITY; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHOLESTASIS; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; CYTOARCHITECTURE; EMBRYO; ERYTHROCYTE; GENE DELETION; HYPERBILIRUBINEMIA; INTRAHEPATIC BILE DUCT; LIPID METABOLISM; LIPID TRANSPORT; LIVER CELL; LIVER CELL MEMBRANE; LIVER CLEARANCE; LIVER FAILURE; LIVER FUNCTION; LIVER METABOLISM; LIVER STRUCTURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS;

AGING; ANIMALS; BILE ACIDS AND SALTS; BILE CANALICULI; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CHOLESTEROL; LIVER; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES;

MUS;

EID: 78650908575     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101721     Document Type: Article

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