Somatic mutations of LKB1 and β-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome

Cancer Research

Volumn 60, Issue 22, 2000, Pages 6311-6313

  Miyaki, Michiko ^a,d   Iijima, Takeru ^a,d   Hosono, Keiko ^a   Ishii, Reiko ^a   Yasuno, Masamichi ^a   Mori, Takeo ^a   Toi, Masakazu ^a   Hishima, Tsunekazu ^a   Shitara, Nobuyuki ^a   Tamura, Kazuo ^b,d   Utsunomiya, Joji ^b   Kobayashi, Naoyuki ^c   Iwama, Takeo ^e  

^a TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d SHOWA UNIVERSITY   (Japan)

^e SASAKI INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

ARTICLE; GASTROINTESTINAL POLYPOSIS; GENE INACTIVATION; GENE MUTATION; HAMARTOMA; HUMAN; HUMAN TISSUE; INTESTINE CARCINOMA; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL;

ADENOMA; BETA CATENIN; CARCINOMA; CYTOSKELETAL PROTEINS; GASTROINTESTINAL NEOPLASMS; GERM-LINE MUTATION; HAMARTOMA; HUMANS; LOSS OF HETEROZYGOSITY; MUTATION; PEUTZ-JEGHERS SYNDROME; PROTEIN-SERINE-THREONINE KINASES; TRANS-ACTIVATORS;

EID: 0033692749     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. A very remarkable case of familial polyposis of mucous membrane of intestinal tract and nasopharynx accompanied by peculiar pigmentations of skin and mucous membrane
2. Generalized intestinal polyps and melanin spots of the oral mucosa, lips and digits. A syndrome of diagnostic significance
3. Increased risk of cancer in the Peutz-Jeghers syndrome
4. Cancer and the Peutz-Jeghers syndrome
5. The Peutz-Jeghers syndrome and malignant tumor
6. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
7. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
8. Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): Report of a case and review of the literature
9. Peutz-Jeghers syndrome with adenomas and adenocarcinomas in colonic polyps
10. Peutz-Jeghers polyposis associated with carcinoma of the digestive organs: Report of three cases and review of the literature
11. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
12. Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome
13. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors
14. Characteristics of somatic mutation of adenomatous polyposis coli gene in colorectal tumors
15. β-Catenin mutations in human prostate cancer
16. Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and nonfamilial adenomatous polyposis patients
17. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p
18. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
19. β-Catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas