Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2

Gastroenterology

Volumn 127, Issue 4, 2004, Pages 1030-1037

  Udd, Lina ^a,b   Katajisto, Pekka ^a,b   Rossi, Derrick J ^a   Lepistö, Anna ^c   Lahesmaa, Anna Maria ^a,b   Ylikorkala, Antti ^a   Järvinen, Heikki J ^c   Ristimäki, Ari P ^a   Mäkelä, Tomi P ^a,b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d BIOMEDICUM HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; DISEASE ASSOCIATION; ENZYME INHIBITION; ENZYME REPRESSION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC DISORDER; MOUSE; NONHUMAN; PEUTZ JEGHERS SYNDROME; PILOT STUDY; PRIORITY JOURNAL; REDUCTION; STOMACH POLYPOSIS;

EID: 5144232989     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.07.059     Document Type: Article

References (40)

1. F.M. Giardiello, J.D. Brensinger, A.C. Tersmette, S.N. Goodman, G.M. Petersen, S.V. Booker, M. Cruz-Correa, J.A. Offerhaus Very high risk of cancer in familial Peutz--Jeghers syndrome Gastroenterology 119 2000 1447 1453
2. A.M. Westerman, M.M. Entius, E. de Baar, P.P. Boor, R. Koole, M.L. van Velthuysen, G.J. Offerhaus, D. Lindhout, F.W. de Rooij, J.H. Wilson Peutz--Jeghers syndrome 78-year follow-up of the original family Lancet 353 1999 1211 1215
3. D.R. McGrath, A.D. Spigelman Preventive measures in Peutz--Jeghers syndrome Fam Cancer 1 2001 123 127
4. A. Hemminki, D. Markie, I. Tomlinson, E. Avizienyte, S. Roth, A. Loukola, G. Bignell, W. Warren, M. Aminoff, P. Hoglund, H. Jarvinen, P. Kristo, K. Pelin, M. Ridanpaa, R. Salovaara, T. Toro, W. Bodmer, S. Olschwang, A.S. Olsen, M.R. Stratton, A. de la Chapelle, L.A. Aaltonen A serine/threonine kinase gene defective in Peutz-Jeghers syndrome Nature 391 1998 184 187
5. W. Lim, N. Hearle, B. Shah, V. Murday, S.V. Hodgson, A. Lucassen, D. Eccles, I. Talbot, K. Neale, A.G. Lim, J. O'Donohue, A. Donaldson, R.C. Macdonald, I.D. Young, M.H. Robinson, P.W. Lee, B.J. Stoodley, I. Tomlinson, D. Alderson, A.G. Holbrook, S. Vyas, E.T. Swarbrick, A.A. Lewis, R.K. Phillips, R.S. Houlston Further observations on LKB1/STK11 status and cancer risk in Peutz--Jeghers syndrome Br J Cancer 89 2003 308 313
6. S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, T.P. Makela, D.R. Alessi, D.G. Hardie Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade J Biol 2 2003 28
7. J.M. Lizcano, O. Goransson, R. Toth, M. Deak, N.A. Morrice, J. Boudeau, S.A. Hawley, L. Udd, T.P. Makela, D.G. Hardie, D.R. Alessi LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 EMBO J 23 2004 833 843
8. S.G. Martin, D. St Johnston A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity Nature 421 2003 379 384
9. A.F. Baas, J. Kuipers, N.N. van der Wel, E. Batlle, H.K. Koerten, P.J. Peters, H.C. Clevers Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD Cell 116 2004 457 466
10. M. Tiainen, A. Ylikorkala, T.P. Makela Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest Proc Natl Acad Sci U S A 96 1999 9248 9251
11. A. Ylikorkala, D.J. Rossi, N. Korsisaari, K. Luukko, K. Alitalo, M. Henkemeyer, T.P. Makela Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice Science 293 2001 1323 1326
12. N. Bardeesy, M. Sinha, A.F. Hezel, S. Signoretti, N.A. Hathaway, N.E. Sharpless, M. Loda, D.R. Carrasco, R.A. DePinho Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation Nature 419 2002 162 167
13. H. Miyoshi, M. Nakau, T.O. Ishikawa, M.F. Seldin, M. Oshima, M.M. Taketo Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice Cancer Res 62 2002 2261 2266
14. D.J. Rossi, A. Ylikorkala, N. Korsisaari, R. Salovaara, K. Luukko, V. Launonen, M. Henkemeyer, A. Ristimaki, L.A. Aaltonen, T.P. Makela Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis Proc Natl Acad Sci U S A 99 2002 12327 12332
15. K. Jishage, J. Nezu, Y. Kawase, T. Iwata, M. Watanabe, A. Miyoshi, A. Ose, K. Habu, T. Kake, N. Kamada, O. Ueda, M. Kinoshita, D.E. Jenne, M. Shimane, H. Suzuki Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis Proc Natl Acad Sci U S A 99 2002 8903 8908
16. S.B. Gruber, M.M. Entius, G.M. Petersen, S.J. Laken, P.A. Longo, R. Boyer, A.M. Levin, U.J. Mujumdar, J.M. Trent, K.W. Kinzler, B. Vogelstein, S.R. Hamilton, M.H. Polymeropoulos, G.J. Offerhaus, F.M. Giardiello Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome Cancer Res 58 1998 5267 5270
17. M. Miyaki, T. Iijima, K. Hosono, R. Ishii, M. Yasuno, T. Mori, M. Toi, T. Hishima, N. Shitara, K. Tamura, J. Utsunomiya, N. Kobayashi, T. Kuroki, T. Iwama Somatic mutations of LKB1 and β-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome Cancer Res 60 2000 6311 6313
18. M.M. Entius, J.J. Keller, A.M. Westerman, B.P. van Rees, M.L. van Velthuysen, A.F. de Goeij, J.H. Wilson, F.M. Giardiello, G.J. Offerhaus Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome J Clin Pathol 54 2001 126 131
19. M. Nakau, H. Miyoshi, M.F. Seldin, M. Imamura, M. Oshima, M.M. Taketo Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice Cancer Res 62 2002 4549 4553
20. M. Sanchez-Cespedes, P. Parrella, M. Esteller, S. Nomoto, B. Trink, J.M. Engles, W.H. Westra, J.G. Herman, D. Sidransky Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung Cancer Res 62 2002 3659 3662
21. C.J. Kim, Y.G. Cho, J.Y. Park, T.Y. Kim, J.H. Lee, H.S. Kim, J.W. Lee, Y.H. Song, S.W. Nam, S.H. Lee, N.J. Yoo, J.Y. Lee, W.S. Park Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas Eur J Cancer 40 2004 136 141
22. F. Sahin, A. Maitra, P. Argani, N. Sato, N. Maehara, E. Montgomery, M. Goggins, R.H. Hruban, G.H. Su Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms Mod Pathol 16 2003 686 691
23. T.J. McGarrity, L.P. Peiffer, C.I. Amos, M.L. Frazier, M.G. Ward, M.K. Howett Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome Am J Gastroenterol 98 2003 671 678
24. W.W. De Leng, A.M. Westerman, M.A. Weterman, F.W. De Rooij, H. Dekken Hv, A.F. De Goeij, S.B. Gruber, J.H. Wilson, G.J. Offerhaus, F.M. Giardiello, J.J. Keller Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas Clin Cancer Res 9 2003 3065 3072
25. C. Wei, C.I. Amos, A. Rashid, M. Sabripour, L. Nations, T.J. McGarrity, M.L. Frazier Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome J Histochem Cytochem 51 2003 1665 1672
26. H. Takeda, H. Miyoshi, Y. Tamai, M. Oshima, M.M. Taketo Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas Br J Cancer 90 2004 701 704
27. R.A. Gupta, R.N. Dubois Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 Nat Rev Cancer 1 2001 11 21
28. J.E. Dinchuk, B.D. Car, R.J. Focht, J.J. Johnston, B.D. Jaffee, M.B. Covington, N.R. Contel, V.M. Eng, R.J. Collins, P.M. Czerniak, S.A. Gorry, J.M. Trzaskos Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II Nature 378 1995 406 409
29. H. Seno, M. Oshima, T.O. Ishikawa, H. Oshima, K. Takaku, T. Chiba, S. Narumiya, M.M. Taketo Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps Cancer Res 62 2002 506 511
30. S. Grosch, I. Tegeder, E. Niederberger, L. Brautigam, G. Geisslinger COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib FASEB J 15 2001 2742 2744
31. V. Jendrossek, R. Handrick, C. Belka Celecoxib activates a novel mitochondrial apoptosis signaling pathway FASEB J 17 2003 1547 1549
32. P.J. Hu, J. Yu, Z.R. Zeng, W.K. Leung, H.L. Lin, B.D. Tang, A.H. Bai, J.J. Sung Chemoprevention of gastric cancer by celecoxib in rats Gut 53 2004 195 200
33. K.M. Leahy, R.L. Ornberg, Y. Wang, B.S. Zweifel, A.T. Koki, J.L. Masferrer Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo Cancer Res 62 2002 625 631
34. R. Yamazaki, N. Kusunoki, T. Matsuzaki, S. Hashimoto, S. Kawai Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells FEBS Lett 531 2002 278 284
35. J.J. Deeks, L.A. Smith, M.D. Bradley Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis systematic review of randomised controlled trials BMJ 325 2002 619
36. I.P. Tomlinson, R.S. Houlston Peutz-Jeghers syndrome J Med Genet 34 1997 1007 1011
37. G. Oberhuber, M. Stolte Gastric polyps an update of their pathology and biological significance Virchows Arch 437 2000 581 590
38. H. Takeda, M. Sonoshita, H. Oshima, K. Sugihara, P.C. Chulada, R. Langenbach, M. Oshima, M.M. Taketo Cooperation of cyclooxy genase 1 and cyclooxygenase 2 in intestinal polyposis Cancer Res 63 2003 4872 4877
39. G. Steinbach, P.M. Lynch, R.K. Phillips, M.H. Wallace, E. Hawk, G.B. Gordon, N. Wakabayashi, B. Saunders, Y. Shen, T. Fujimura, L.K. Su, B. Levin The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis N Engl J Med 342 2000 1946 1952
40. R.K. Phillips, M.H. Wallace, P.M. Lynch, E. Hawk, G.B. Gordon, B.P. Saunders, N. Wakabayashi, Y. Shen, S. Zimmerman, L. Godio, M. Rodrigues-Bigas, L.K. Su, J. Sherman, G. Kelloff, B. Levin, G. Steinbach A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis Gut 50 2002 857 860