Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context

Journal of Biological Chemistry

Volumn 286, Issue 49, 2011, Pages 42470-42482

  Gunn, Amanda ^a   Bennardo, Nicole ^a,b   Cheng, Anita ^a   Stark, Jeremy M ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA-DEPENDENT PROTEIN KINASE; DOUBLE STRAND BREAKS; END-USES; ENDONUCLEASES; EXONUCLEASE; HIGHER FREQUENCIES; INDUCIBLE PROMOTER; KINASE ACTIVITY; REPAIR PROTEINS;

AUTOMATIC TELLER MACHINES; CHROMOSOMES; DNA; ENZYMES; INTERNET PROTOCOLS; JOINING; TRANSCRIPTION;

REPAIR;

ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; ENDONUCLEASE; HISTONE H2AX; RAD50 PROTEIN; SCEI PROTEIN; TREX2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CHROMOSOMES; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR ENZYMES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GREEN FLUORESCENT PROTEINS; HISTONES; HUMANS; MICE; MODELS, GENETIC; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 82755183606     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309252     Document Type: Article

References (73)

1. Stratton, M. R. (2011) Science 331, 1553-1558
2. Stephens, P. J., McBride, D. J., Lin, M. L., Varela, I., Pleasance, E. D., Simpson, J. T., Stebbings, L. A., Leroy, C., Edkins, S., Mudie, L. J., Greenman, C. D., Jia, M., Latimer, C., Teague, J. W., Lau, K. W., Burton, J., Quail, M. A., Swerdlow, H., Churcher, C., Natrajan, R., Sieuwerts, A. M., Martens, J. W., Silver, D. P., Langerød, A., Russnes, H. E., Foekens, J. A., Reis-Filho, J. S., van't Veer, L., Richardson, A. L., Børresen-Dale, A. L., Campbell, P. J., Futreal, P. A., and Stratton, M. R. (2009) Nature 462, 1005-1010
3. Mahaney, B. L., Meek, K., and Lees-Miller, S. P. (2009) Biochem. J. 417, 639-650
4. Bredemeyer, A. L., Huang, C. Y., Walker, L. M., Bassing, C. H., and Sleckman, B. P. (2008) J. Immunol. 181, 2620-2625
5. Deriano, L., Stracker, T. H., Baker, A., Petrini, J. H., and Roth, D. B. (2009) Mol. Cell 34, 13-25
6. Helmink, B. A., Bredemeyer, A. L., Lee, B. S., Huang, C. Y., Sharma, G. G., Walker, L. M., Bednarski, J. J., Lee, W. L., Pandita, T. K., Bassing, C. H., and Sleckman, B. P. (2009) J. Exp. Med. 206, 669-679
7. Bennardo, N., and Stark, J. M. (2010) PLoS Genet. 6, e1001194
8. Rahal, E. A., Henricksen, L. A., Li, Y., Williams, R. S., Tainer, J. A., and Dixon, K. (2010) Cell Cycle 9, 2866-2877
9. Shiloh, Y. (2003) Nat. Rev. Cancer 3, 155-168
10. van der Burgt, I., Chrzanowska, K. H., Smeets, D., and Weemaes, C. (1996) J. Med. Genet. 33, 153-156
11. Waltes, R., Kalb, R., Gatei, M., Kijas, A. W., Stumm, M., Sobeck, A., Wieland, B., Varon, R., Lerenthal, Y., Lavin, M. F., Schindler, D., and Dörk, T. (2009) Am. J. Hum. Genet. 84, 605-616
12. van der Burg, M., Ijspeert, H., Verkaik, N. S., Turul, T., Wiegant, W. W., Morotomi-Yano, K., Mari, P. O., Tezcan, I., Chen, D. J., Zdzienicka, M. Z., van Dongen, J. J., and van Gent, D. C. (2009) J. Clin. Invest. 119, 91-98
13. Lieber, M. R. (2010) Annu. Rev. Biochem. 79, 181-211
14. Meek, K., Dang, V., and Lees-Miller, S. P. (2008) Adv. Immunol. 99, 33-58
15. Stracker, T. H., and Petrini, J. H. (2011) Nat. Rev. Mol. Cell Biol. 12, 90-103
16. Abuzeid, W. M., Jiang, X., Shi, G., Wang, H., Paulson, D., Araki, K., Jungreis, D., Carney, J., O'Malley, B. W., Jr., and Li, D. (2009) J. Clin. Invest. 119, 1974-1985
17. Veuger, S. J., Curtin, N. J., Richardson, C. J., Smith, G. C., and Durkacz, B. W. (2003) Cancer Res. 63, 6008-6015
18. Della-Maria, J., Zhou, Y., Tsai, M. S., Kuhnlein, J., Carney, J. P., Paull, T. T., and Tomkinson, A. E. (2011) J. Biol. Chem. 286, 33845-33853
19. Moreno-Herrero, F., de Jager, M., Dekker, N. H., Kanaar, R., Wyman, C., and Dekker, C. (2005) Nature 437, 440-443
20. Bhaskara, V., Dupré, A., Lengsfeld, B., Hopkins, B. B., Chan, A., Lee, J. H., Zhang, X., Gautier, J., Zakian, V., and Paull, T. T. (2007) Mol. Cell 25, 647-661
21. DeFazio, L. G., Stansel, R. M., Griffith, J. D., and Chu, G. (2002) EMBO J. 21, 3192-3200
22. Hammel, M., Yu, Y., Mahaney, B. L., Cai, B., Ye, R., Phipps, B. M., Rambo, R. P., Hura, G. L., Pelikan, M., So, S., Abolfath, R. M., Chen, D. J., Lees-Miller, S. P., and Tainer, J. A. (2010) J. Biol. Chem. 285, 1414-1423
23. Paull, T. T. (2010) DNA Repair 9, 1283-1291
24. Neal, J. A., Dang, V., Douglas, P., Wold, M. S., Lees-Miller, S. P., and Meek, K. (2011) Mol. Cell. Biol. 31, 1719-1733
25. Shrivastav, M., Miller, C. A., De Haro, L. P., Durant, S. T., Chen, B. P., Chen, D. J., and Nickoloff, J. A. (2009) DNA Repair 8, 920-929
26. Rooney, S., Alt, F. W., Lombard, D., Whitlow, S., Eckersdorff, M., Fleming, J., Fugmann, S., Ferguson, D. O., Schatz, D. G., and Sekiguchi, J. (2003) J. Exp. Med. 197, 553-565
27. Mathas, S., and Misteli, T. (2009) Cell 139, 1047-1049
28. Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B. G., Ohgi, K., Zhang, J., Rose, D. W., Fu, X. D., Glass, C. K., and Rosenfeld, M. G. (2009) Cell 139, 1069-1083
29. Mathas, S., Kreher, S., Meaburn, K. J., Jöhrens, K., Lamprecht, B., Assaf, C., Sterry, W., Kadin, M. E., Daibata, M., Joos, S., Hummel, M., Stein, H., Janz, M., Anagnostopoulos, I., Schrock, E., Misteli, T., and Dörken, B. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 5831-5836
30. Mani, R. S., Tomlins, S. A., Callahan, K., Ghosh, A., Nyati, M. K., Varambally, S., Palanisamy, N., and Chinnaiyan, A. M. (2009) Science 326, 1230
31. Allen, C., Miller, C. A., and Nickoloff, J. A. (2003) DNA Repair 2, 1147-1156
32. Gottipati, P., Cassel, T. N., Savolainen, L., and Helleday, T. (2008) Mol. Cell. Biol. 28, 154-164
33. Xie, A., Puget, N., Shim, I., Odate, S., Jarzyna, I., Bassing, C. H., Alt, F. W., and Scully, R. (2004) Mol. Cell 16, 1017-1025
34. Helmink, B. A., Tubbs, A. T., Dorsett, Y., Bednarski, J. J., Walker, L. M., Feng, Z., Sharma, G. G., McKinnon, P. J., Zhang, J., Bassing, C. H., and Sleckman, B. P. (2011) Nature 469, 245-249
35. Bothmer, A., Robbiani, D. F., Di Virgilio, M., Bunting, S. F., Klein, I. A., Feldhahn, N., Barlow, J., Chen, H. T., Bosque, D., Callen, E., Nussenzweig, A., and Nussenzweig, M. C. (2011) Mol. Cell 42, 319-329
36. Bennardo, N., Cheng, A., Huang, N., and Stark, J. M. (2008) PLoS Genet. 4, e1000110
37. Bennardo, N., Gunn, A., Cheng, A., Hasty, P., and Stark, J. M. (2009) PLoS Genet. 5, e1000683
38. Pierce, A. J., Johnson, R. D., Thompson, L. H., and Jasin, M. (1999) Genes Dev. 13, 2633-2638
39. Stark, J. M., and Jasin, M. (2003) Mol. Cell. Biol. 23, 733-743
40. Palli, S. R., Kapitskaya, M. Z., Kumar, M. B., and Cress, D. E. (2003) Eur. J. Biochem. 270, 1308-1315
41. Bassing, C. H., Chua, K. F., Sekiguchi, J., Suh, H., Whitlow, S. R., Fleming, J. C., Monroe, B. C., Ciccone, D. N., Yan, C., Vlasakova, K., Livingston, D. M., Ferguson, D. O., Scully, R., and Alt, F. W. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 8173-8178
42. Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., and Smith, G. C. (2004) Cancer Res. 64, 9152-9159
43. Chen, M. J., Ma, S. M., Dumitrache, L. C., and Hasty, P. (2007) Nucleic Acids Res. 35, 2682-2694
44. Tsai, C. J., Kim, S. A., and Chu, G. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 7851-7856
45. Williams, G. J., Lees-Miller, S. P., and Tainer, J. A. (2010) DNA Repair 9, 1299-1306
46. Rogakou, E. P., Boon, C., Redon, C., and Bonner, W. M. (1999) J. Cell Biol. 146, 905-916
47. Yuan, J., Adamski, R., and Chen, J. (2010) FEBS Lett. 584, 3717-3724
48. Yin, B., Savic, V., Juntilla, M. M., Bredemeyer, A. L., Yang-Iott, K. S., Helmink, B. A., Koretzky, G. A., Sleckman, B. P., and Bassing, C. H. (2009) J. Exp. Med. 206, 2625-2639
49. Stark, J. M., Hu, P., Pierce, A. J., Moynahan, M. E., Ellis, N., and Jasin, M. (2002) J. Biol. Chem. 277, 20185-20194
50. Sung, P., Krejci, L., Van Komen, S., and Sehorn, M. G. (2003) J. Biol. Chem. 278, 42729-42732
51. Kass, E. M., and Jasin, M. (2010) FEBS Lett. 584, 3703-3708
52. Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., and Jasin, M. (2004) Mol. Cell. Biol. 24, 9305-9316
53. Golding, S. E., Rosenberg, E., Khalil, A., McEwen, A., Holmes, M., Neill, S., Povirk, L. F., and Valerie, K. (2004) J. Biol. Chem. 279, 15402-15410
54. Allen, C., Halbrook, J., and Nickoloff, J. A. (2003) Mol. Cancer Res. 1, 913-920
55. Niwa, H., Yamamura, K., and Miyazaki, J. (1991) Gene 108, 193-199
56. Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., and Greenberg, R. A. (2010) Cell 141, 970-981
57. Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., and Jeggo, P. A. (2008) Mol. Cell 31, 167-177
58. Uematsu, N., Weterings, E., Yano, K., Morotomi-Yano, K., Jakob, B., Taucher-Scholz, G., Mari, P. O., van Gent, D. C., Chen, B. P., and Chen, D. J. (2007) J. Cell Biol. 177, 219-229
59. Davis, A. J., So, S., and Chen, D. J. (2010) Cell Cycle 9, 2529-2536
60. Weterings, E., Verkaik, N. S., Brüggenwirth, H. T., Hoeijmakers, J. H., and van Gent, D. C. (2003) Nucleic Acids Res. 31, 7238-7246
61. Dobbs, T. A., Tainer, J. A., and Lees-Miller, S. P. (2010) DNA Repair 9, 1307-1314
62. Gapud, E. J., and Sleckman, B. P. (2011) Cell Cycle 10, 1928-1935
63. Nakai, W., Westmoreland, J., Yeh, E., Bloom, K., and Resnick, M. A. (2011) DNA Repair 10, 102-110
64. Lee, K., Zhang, Y., and Lee, S. E. (2008) Nature 454, 543-546
65. Yang, Y. G., Saidi, A., Frappart, P. O., Min, W., Barrucand, C., Dumon-Jones, V., Michelon, J., Herceg, Z., and Wang, Z. Q. (2006) EMBO J. 25, 5527-5538
66. Fattah, F., Lee, E. H., Weisensel, N., Wang, Y., Lichter, N., and Hendrickson, E. A. (2010) PLoS Genet. 6, e1000855
67. Franco, S., Gostissa, M., Zha, S., Lombard, D. B., Murphy, M. M., Zarrin, A. A., Yan, C., Tepsuporn, S., Morales, J. C., Adams, M. M., Lou, Z., Bassing, C. H., Manis, J. P., Chen, J., Carpenter, P. B., and Alt, F. W. (2006) Mol. Cell 21, 201-214
68. Zha, S., Sekiguchi, J., Brush, J. W., Bassing, C. H., and Alt, F. W. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 9302-9306
69. Weinstock, D. M., Elliott, B., and Jasin, M. (2006) Blood 107, 777-780
70. Bassing, C. H., Suh, H., Ferguson, D. O., Chua, K. F., Manis, J., Eckersdorff, M., Gleason, M., Bronson, R., Lee, C., and Alt, F. W. (2003) Cell 114, 359-370
71. Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M. C., Guan, A., Hesley, J. A., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., Meyer, T., and Cimprich, K. A. (2009) Mol. Cell 35, 228-239
72. Gan, W., Guan, Z., Liu, J., Gui, T., Shen, K., Manley, J. L., and Li, X. (2011) Genes Dev. 25, 2041-2056
73. Xu, Y., and Price, B. D. (2011) Cell Cycle 10, 261-267