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Volumn 10, Issue 1, 2011, Pages 102-110

Chromosome integrity at a double-strand break requires exonuclease 1 and MRX

Author keywords

Chromosome break; Double strand break repair; Exonuclease 1; Fluorescent imaging; MRX

Indexed keywords

DNA; ENDONUCLEASE; EXONUCLEASE; EXONUCLEASE 1; MRE11 PROTEIN; MRX COMPLEX; NUCLEIC ACID BINDING PROTEIN; RAD50 PROTEIN; UNCLASSIFIED DRUG; XRS2 PROTEIN;

EID: 78650413995     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2010.10.004     Document Type: Article
Times cited : (19)

References (41)
  • 1
    • 0037660900 scopus 로고    scopus 로고
    • The role of DNA breaks in genomic instability and tumorigenesis
    • Mills K.D., Ferguson D.O., Alt F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 2003, 194:77-95.
    • (2003) Immunol. Rev. , vol.194 , pp. 77-95
    • Mills, K.D.1    Ferguson, D.O.2    Alt, F.W.3
  • 3
    • 10344240414 scopus 로고    scopus 로고
    • Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex
    • Lobachev K., Vitriol E., Stemple J., Resnick M.A., Bloom K. Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex. Curr. Biol. 2004, 14:2107-2112.
    • (2004) Curr. Biol. , vol.14 , pp. 2107-2112
    • Lobachev, K.1    Vitriol, E.2    Stemple, J.3    Resnick, M.A.4    Bloom, K.5
  • 4
    • 10344225665 scopus 로고    scopus 로고
    • DNA breaks promote genomic instability by impeding proper chromosome segregation
    • Kaye J.A., Melo J.A., Cheung S.K., Vaze M.B., Haber J.E., Toczyski D.P. DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr. Biol. 2004, 14:2096-2106.
    • (2004) Curr. Biol. , vol.14 , pp. 2096-2106
    • Kaye, J.A.1    Melo, J.A.2    Cheung, S.K.3    Vaze, M.B.4    Haber, J.E.5    Toczyski, D.P.6
  • 6
    • 0030461543 scopus 로고    scopus 로고
    • In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition
    • Robinett C.C., Straight A., Li G., Willhelm C., Sudlow G., Murray A., Belmont A.S. In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. J. Cell Biol. 1996, 135:1685-1700.
    • (1996) J. Cell Biol. , vol.135 , pp. 1685-1700
    • Robinett, C.C.1    Straight, A.2    Li, G.3    Willhelm, C.4    Sudlow, G.5    Murray, A.6    Belmont, A.S.7
  • 7
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques F., Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 1999, 63:349-404.
    • (1999) Microbiol. Mol. Biol. Rev. , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 8
    • 0034130841 scopus 로고    scopus 로고
    • EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae
    • Sokolsky T., Alani E. EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae. Genetics 2000, 155:589-599.
    • (2000) Genetics , vol.155 , pp. 589-599
    • Sokolsky, T.1    Alani, E.2
  • 9
    • 0036837137 scopus 로고    scopus 로고
    • Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae
    • Tran P.T., Erdeniz N., Dudley S., Liskay R.M. Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair (Amst) 2002, 1:895-912.
    • (2002) DNA Repair (Amst) , vol.1 , pp. 895-912
    • Tran, P.T.1    Erdeniz, N.2    Dudley, S.3    Liskay, R.M.4
  • 10
    • 70349653553 scopus 로고    scopus 로고
    • RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends
    • Westmoreland J., Ma W., Yan Y., Van Hulle K., Malkova A., Resnick M.A. RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends. PLoS Genet. 2009, 5:e1000656.
    • (2009) PLoS Genet. , vol.5
    • Westmoreland, J.1    Ma, W.2    Yan, Y.3    Van Hulle, K.4    Malkova, A.5    Resnick, M.A.6
  • 12
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • Furuse M., Nagase Y., Tsubouchi H., Murakami-Murofushi K., Shibata T., Ohta K. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 1998, 17:6412-6425.
    • (1998) EMBO J. , vol.17 , pp. 6412-6425
    • Furuse, M.1    Nagase, Y.2    Tsubouchi, H.3    Murakami-Murofushi, K.4    Shibata, T.5    Ohta, K.6
  • 13
    • 2442463320 scopus 로고    scopus 로고
    • Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells
    • Lewis L.K., Storici F., Van Komen S., Calero S., Sung P., Resnick M.A. Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 2004, 166:1701-1713.
    • (2004) Genetics , vol.166 , pp. 1701-1713
    • Lewis, L.K.1    Storici, F.2    Van Komen, S.3    Calero, S.4    Sung, P.5    Resnick, M.A.6
  • 14
    • 33645119826 scopus 로고    scopus 로고
    • Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity
    • Krogh B.O., Llorente B., Lam A., Symington L.S. Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics 2005, 171:1561-1570.
    • (2005) Genetics , vol.171 , pp. 1561-1570
    • Krogh, B.O.1    Llorente, B.2    Lam, A.3    Symington, L.S.4
  • 15
    • 0037169325 scopus 로고    scopus 로고
    • The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
    • Lobachev K.S., Gordenin D.A., Resnick M.A. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 2002, 108:183-193.
    • (2002) Cell , vol.108 , pp. 183-193
    • Lobachev, K.S.1    Gordenin, D.A.2    Resnick, M.A.3
  • 16
    • 33644691699 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends
    • Clerici M., Mantiero D., Lucchini G., Longhese M.P. The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends. J. Biol. Chem. 2005, 280:38631-38638.
    • (2005) J. Biol. Chem. , vol.280 , pp. 38631-38638
    • Clerici, M.1    Mantiero, D.2    Lucchini, G.3    Longhese, M.P.4
  • 17
    • 36248942617 scopus 로고    scopus 로고
    • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
    • Lengsfeld B.M., Rattray A.J., Bhaskara V., Ghirlando R., Paull T.T. Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol. Cell. 2007, 28:638-651.
    • (2007) Mol. Cell. , vol.28 , pp. 638-651
    • Lengsfeld, B.M.1    Rattray, A.J.2    Bhaskara, V.3    Ghirlando, R.4    Paull, T.T.5
  • 18
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    • Martin S.G., Laroche T., Suka N., Grunstein M., Gasser S.M. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 1999, 97:621-633.
    • (1999) Cell , vol.97 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 19
    • 47949092912 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations
    • Lee K., Zhang Y., Lee S.E. Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations. Nature 2008, 454:543-546.
    • (2008) Nature , vol.454 , pp. 543-546
    • Lee, K.1    Zhang, Y.2    Lee, S.E.3
  • 20
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z., Chung W.H., Shim E.Y., Lee S.E., Ira G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 2008, 134:981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 21
    • 77449086623 scopus 로고    scopus 로고
    • DNA resection in eukaryotes: deciding how to fix the break
    • Huertas P. DNA resection in eukaryotes: deciding how to fix the break. Nat. Struct. Mol. Biol. 2010, 17:11-16.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 11-16
    • Huertas, P.1
  • 22
    • 0032588388 scopus 로고    scopus 로고
    • The 3'→5' exonucleases of DNA polymerases delta and epsilon and the 5'→3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae
    • Tran H.T., Gordenin D.A., Resnick M.A. The 3'→5' exonucleases of DNA polymerases delta and epsilon and the 5'→3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae. Mol. Cell Biol. 1999, 19:2000-2007.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 2000-2007
    • Tran, H.T.1    Gordenin, D.A.2    Resnick, M.A.3
  • 24
    • 0036682516 scopus 로고    scopus 로고
    • EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants
    • Maringele L, Lydall D. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants. Genes Dev. 2002, 16:1919-1933.
    • (2002) Genes Dev. , vol.16 , pp. 1919-1933
    • Maringele, L.1    Lydall, D.2
  • 25
    • 2442520305 scopus 로고    scopus 로고
    • EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae
    • Bertuch A.A., Lundblad V. EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. Genetics 2004, 166:1651-1659.
    • (2004) Genetics , vol.166 , pp. 1651-1659
    • Bertuch, A.A.1    Lundblad, V.2
  • 26
    • 5144219712 scopus 로고    scopus 로고
    • Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
    • Zubko M.K., Guillard S., Lydall D. Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics 2004, 168:103-115.
    • (2004) Genetics , vol.168 , pp. 103-115
    • Zubko, M.K.1    Guillard, S.2    Lydall, D.3
  • 27
    • 0033580940 scopus 로고    scopus 로고
    • Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance
    • Qiu J., Qian Y., Chen V., Guan M.X., Shen B. Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance. J. Biol. Chem. 1999, 274:17893-17900.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17893-17900
    • Qiu, J.1    Qian, Y.2    Chen, V.3    Guan, M.X.4    Shen, B.5
  • 28
    • 0037066720 scopus 로고    scopus 로고
    • Human exonuclease I is required for 5' and 3' mismatch repair
    • Genschel J, Bazemore L.R., Modrich P. Human exonuclease I is required for 5' and 3' mismatch repair. J. Biol. Chem. 2002, 277:13302-13311.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13302-13311
    • Genschel, J.1    Bazemore, L.R.2    Modrich, P.3
  • 30
    • 0037593470 scopus 로고    scopus 로고
    • The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein
    • Sharma S., Sommers J.A., Driscoll H.C., Uzdilla L., Wilson T.M., Brosh R.M. The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J. Biol. Chem. 2003, 278:23487-23496.
    • (2003) J. Biol. Chem. , vol.278 , pp. 23487-23496
    • Sharma, S.1    Sommers, J.A.2    Driscoll, H.C.3    Uzdilla, L.4    Wilson, T.M.5    Brosh, R.M.6
  • 31
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs1 and BLM promote DNA double-strand break resection
    • Gravel S., Chapman J.R., Magill C., Jackson S.P. DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev. 2008, 22:2767-2772.
    • (2008) Genes Dev. , vol.22 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 32
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou E.P., Symington L.S. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 2008, 455:770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 33
    • 35348980174 scopus 로고    scopus 로고
    • A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair
    • Tran P.T., Fey J.P., Erdeniz N., Gellon L., Boiteux S., Liskay R.M. A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair. DNA Repair (Amst) 2007, 6:1572-1583.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 1572-1583
    • Tran, P.T.1    Fey, J.P.2    Erdeniz, N.3    Gellon, L.4    Boiteux, S.5    Liskay, R.M.6
  • 34
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 1999, 146:905-916.
    • (1999) J. Cell Biol. , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 37
    • 41149112015 scopus 로고    scopus 로고
    • Beyond the code: the mechanical properties of DNA as they relate to mitosis
    • Bloom K.S. Beyond the code: the mechanical properties of DNA as they relate to mitosis. Chromosoma 2008, 117:103-110.
    • (2008) Chromosoma , vol.117 , pp. 103-110
    • Bloom, K.S.1
  • 38
    • 75749132899 scopus 로고    scopus 로고
    • Towards building a chromosome segregation machine
    • Bloom K., Joglekar A. Towards building a chromosome segregation machine. Nature 2010, 463:446-456.
    • (2010) Nature , vol.463 , pp. 446-456
    • Bloom, K.1    Joglekar, A.2
  • 41
    • 78650417983 scopus 로고    scopus 로고
    • Characterizing resection at random and unique chromosome and telomere ends, Method. Protocol., in press.
    • W. Ma, J. Westmoreland, W. Nakai, A. Malkova, M.A. Resnick, Characterizing resection at random and unique chromosome and telomere ends, Method. Protocol., in press.
    • Ma, W.1    Westmoreland, J.2    Nakai, W.3    Malkova, A.4    Resnick, M.A.5


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