-
1
-
-
38049155945
-
Regulation of DNA double-strand break repair pathway choice
-
Shrivastav M., De Haro L.P., and Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18 (2008) 134-147
-
(2008)
Cell Res.
, vol.18
, pp. 134-147
-
-
Shrivastav, M.1
De Haro, L.P.2
Nickoloff, J.A.3
-
2
-
-
0037133699
-
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
-
Allen C., Kurimasa A., Brennemann M.A., Chen D.J., and Nickoloff J.A. DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 3758-3763
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 3758-3763
-
-
Allen, C.1
Kurimasa, A.2
Brennemann, M.A.3
Chen, D.J.4
Nickoloff, J.A.5
-
3
-
-
0142025259
-
Interactive competition between homologous recombination and non-homologous end joining
-
Allen C., Halbrook J., and Nickoloff J.A. Interactive competition between homologous recombination and non-homologous end joining. Mol. Cancer Res. 1 (2003) 913-920
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 913-920
-
-
Allen, C.1
Halbrook, J.2
Nickoloff, J.A.3
-
4
-
-
13444263265
-
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)
-
Convery E., Shin E.K., Ding Q., Wang W., Douglas P., Nickoloff J.A., Lees-Miller S., and Meek K. Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 1345-1350
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 1345-1350
-
-
Convery, E.1
Shin, E.K.2
Ding, Q.3
Wang, W.4
Douglas, P.5
Nickoloff, J.A.6
Lees-Miller, S.7
Meek, K.8
-
5
-
-
28544448011
-
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
-
Cui X., Yu Y., Gupta S., Cho Y.M., Lees-Miller S.P., and Meek K. Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol. Cell. Biol. 25 (2005) 10842-10852
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10842-10852
-
-
Cui, X.1
Yu, Y.2
Gupta, S.3
Cho, Y.M.4
Lees-Miller, S.P.5
Meek, K.6
-
6
-
-
0036682122
-
An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
-
Delacote F., Han M., Stamato T.D., Jasin M., and Lopez B.S. An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res. 30 (2002) 3454-3463
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 3454-3463
-
-
Delacote, F.1
Han, M.2
Stamato, T.D.3
Jasin, M.4
Lopez, B.S.5
-
7
-
-
0035893363
-
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
-
Pierce A.J., Hu P., Han M.G., Ellis N., and Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15 (2001) 3237-3242
-
(2001)
Genes Dev.
, vol.15
, pp. 3237-3242
-
-
Pierce, A.J.1
Hu, P.2
Han, M.G.3
Ellis, N.4
Jasin, M.5
-
8
-
-
0942268167
-
Repair of DNA double strand breaks by non-homologous end joining
-
Lees-Miller S.P., and Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85 (2003) 1161-1173
-
(2003)
Biochimie
, vol.85
, pp. 1161-1173
-
-
Lees-Miller, S.P.1
Meek, K.2
-
9
-
-
0032938747
-
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
-
Kurimasa A., Kumano S., Boubnov N.V., Story M.D., Tung C.S., Peterson S.R., and Chen D.J. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol. Cell. Biol. 19 (1999) 3877-3884
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3877-3884
-
-
Kurimasa, A.1
Kumano, S.2
Boubnov, N.V.3
Story, M.D.4
Tung, C.S.5
Peterson, S.R.6
Chen, D.J.7
-
10
-
-
0033104517
-
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
-
Shao R.G., Cao C.X., Zhang H., Kohn K.W., Wold M.S., and Pommier Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J. 18 (1999) 1397-1406
-
(1999)
EMBO J.
, vol.18
, pp. 1397-1406
-
-
Shao, R.G.1
Cao, C.X.2
Zhang, H.3
Kohn, K.W.4
Wold, M.S.5
Pommier, Y.6
-
11
-
-
3242886503
-
Role of DNA-PK in the cellular response to DNA double-strand breaks
-
Burma S., and Chen D.J. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair 3 (2004) 909-918
-
(2004)
DNA Repair
, vol.3
, pp. 909-918
-
-
Burma, S.1
Chen, D.J.2
-
12
-
-
0032972734
-
DNA-Dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer
-
Chan D.W., Ye R.Q., Veillette C.J., and Lees-Miller S.P. DNA-Dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Biochemistry 38 (1999) 1819-1828
-
(1999)
Biochemistry
, vol.38
, pp. 1819-1828
-
-
Chan, D.W.1
Ye, R.Q.2
Veillette, C.J.3
Lees-Miller, S.P.4
-
13
-
-
0037166306
-
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation
-
Karmakar P., Piotrowski J., Brosh R.M., Sommers J.A., Miller S.P.L., Cheng W.H., Snowden C.M., Ramsden D.A., and Bohr V.A. Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J. Biol. Chem. 277 (2002) 18291-18302
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18291-18302
-
-
Karmakar, P.1
Piotrowski, J.2
Brosh, R.M.3
Sommers, J.A.4
Miller, S.P.L.5
Cheng, W.H.6
Snowden, C.M.7
Ramsden, D.A.8
Bohr, V.A.9
-
14
-
-
0035851181
-
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase
-
Yannone S.M., Roy S., Chan D.W., Murphy M.B., Huang S.R., Campisi J., and Chen D.J. Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J. Biol. Chem. 276 (2001) 38242-38248
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38242-38248
-
-
Yannone, S.M.1
Roy, S.2
Chan, D.W.3
Murphy, M.B.4
Huang, S.R.5
Campisi, J.6
Chen, D.J.7
-
16
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., and Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421 (2003) 499-506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
17
-
-
0035189448
-
ATM-a key determinant of multiple cellular responses to irradiation
-
Kastan M.B., Lim D.S., Kim S.T., and Yang D. ATM-a key determinant of multiple cellular responses to irradiation. Acta Oncol. 40 (2001) 686-688
-
(2001)
Acta Oncol.
, vol.40
, pp. 686-688
-
-
Kastan, M.B.1
Lim, D.S.2
Kim, S.T.3
Yang, D.4
-
18
-
-
2942687831
-
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
-
Kitagawa R., Bakkenist C.J., McKinnon P.J., and Kastan M.B. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18 (2004) 1423-1438
-
(2004)
Genes Dev.
, vol.18
, pp. 1423-1438
-
-
Kitagawa, R.1
Bakkenist, C.J.2
McKinnon, P.J.3
Kastan, M.B.4
-
19
-
-
0030925565
-
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
-
Baskaran R., Wood L.D., Whitaker L.L., Canman C.E., Morgan S.E., Xu Y., Barlow C., Baltimore D., Wynshaw-Boris A., Kastan M.B., and Wang J.Y. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387 (1997) 516-519
-
(1997)
Nature
, vol.387
, pp. 516-519
-
-
Baskaran, R.1
Wood, L.D.2
Whitaker, L.L.3
Canman, C.E.4
Morgan, S.E.5
Xu, Y.6
Barlow, C.7
Baltimore, D.8
Wynshaw-Boris, A.9
Kastan, M.B.10
Wang, J.Y.11
-
20
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma S., Chen B.P., Murphy M., Kurimasa A., and Chen D.J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276 (2001) 42462-42467
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42462-42467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
Kurimasa, A.4
Chen, D.J.5
-
21
-
-
0030807476
-
Identification of defective illegitimate recombinational repair of oxidatively-induced dna double-strand breaks in ataxia telangiectasia cells
-
Dar M.E., Winters T.A., and Jorgensen T.J. Identification of defective illegitimate recombinational repair of oxidatively-induced dna double-strand breaks in ataxia telangiectasia cells. Mutat. Res. 384 (1997) 169-179
-
(1997)
Mutat. Res.
, vol.384
, pp. 169-179
-
-
Dar, M.E.1
Winters, T.A.2
Jorgensen, T.J.3
-
22
-
-
1642556817
-
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity
-
Kuhne M., Riballo E., Rief N., Rothkamm K., Jeggo P.A., and Lobrich M. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res. 64 (2004) 500-508
-
(2004)
Cancer Res.
, vol.64
, pp. 500-508
-
-
Kuhne, M.1
Riballo, E.2
Rief, N.3
Rothkamm, K.4
Jeggo, P.A.5
Lobrich, M.6
-
23
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci
-
Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C., Recio M.J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A., Jeggo P.A., and Lobrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci. Mol. Cell 16 (2004) 715-724
-
(2004)
Mol. Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
Doherty, A.4
Smith, G.C.5
Recio, M.J.6
Reis, C.7
Dahm, K.8
Fricke, A.9
Krempler, A.10
Parker, A.R.11
Jackson, S.P.12
Gennery, A.13
Jeggo, P.A.14
Lobrich, M.15
-
24
-
-
33747097562
-
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
-
Bredemeyer A.L., Sharma G.G., Huang C.Y., Helmink B.A., Walker L.M., Khor K.C., Nuskey B., Sullivan K.E., Pandita T.K., Bassing C.H., and Sleckman B.P. ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature 442 (2006) 466-470
-
(2006)
Nature
, vol.442
, pp. 466-470
-
-
Bredemeyer, A.L.1
Sharma, G.G.2
Huang, C.Y.3
Helmink, B.A.4
Walker, L.M.5
Khor, K.C.6
Nuskey, B.7
Sullivan, K.E.8
Pandita, T.K.9
Bassing, C.H.10
Sleckman, B.P.11
-
25
-
-
0034141562
-
The controlling role of ATM in homologous recombinational repair of DNA damage
-
Morrison C., Sonoda E., Takao N., Shinohara A., Yamamoto K., and Takeda S. The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J. 19 (2000) 463-471
-
(2000)
EMBO J.
, vol.19
, pp. 463-471
-
-
Morrison, C.1
Sonoda, E.2
Takao, N.3
Shinohara, A.4
Yamamoto, K.5
Takeda, S.6
-
26
-
-
0030048511
-
High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines
-
Luo C.-M., Tang W., Mekeel K.L., DeFrank J.S., Anne P.R., and Powell S.N. High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines. J. Biol. Chem. 271 (1996) 4497-4503
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4497-4503
-
-
Luo, C.-M.1
Tang, W.2
Mekeel, K.L.3
DeFrank, J.S.4
Anne, P.R.5
Powell, S.N.6
-
27
-
-
10944219768
-
Control of sister chromatid recombination by histone H2AX
-
Xie A., Puget N., Shim I., Odate S., Jarzyna I., Bassing C.H., Alt F.W., and Scully R. Control of sister chromatid recombination by histone H2AX. Mol. Cell 16 (2004) 1017-1025
-
(2004)
Mol. Cell
, vol.16
, pp. 1017-1025
-
-
Xie, A.1
Puget, N.2
Shim, I.3
Odate, S.4
Jarzyna, I.5
Bassing, C.H.6
Alt, F.W.7
Scully, R.8
-
28
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff T., O'Driscoll M., Rief N., Iwabuchi K., Lobrich M., and Jeggo P.A. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64 (2004) 2390-2396
-
(2004)
Cancer Res.
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
O'Driscoll, M.2
Rief, N.3
Iwabuchi, K.4
Lobrich, M.5
Jeggo, P.A.6
-
29
-
-
16444384872
-
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM
-
Peng Y., Woods R.G., Beamish H., Ye R., Lees-Miller S.P., Lavin M.F., and Bedford J.S. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 65 (2005) 1670-1677
-
(2005)
Cancer Res.
, vol.65
, pp. 1670-1677
-
-
Peng, Y.1
Woods, R.G.2
Beamish, H.3
Ye, R.4
Lees-Miller, S.P.5
Lavin, M.F.6
Bedford, J.S.7
-
30
-
-
34247507469
-
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
-
Chen B.P., Uematsu N., Kobayashi J., Lerenthal Y., Krempler A., Yajima H., Lobrich M., Shiloh Y., and Chen D.J. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J. Biol. Chem. 282 (2007) 6582-6587
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6582-6587
-
-
Chen, B.P.1
Uematsu, N.2
Kobayashi, J.3
Lerenthal, Y.4
Krempler, A.5
Yajima, H.6
Lobrich, M.7
Shiloh, Y.8
Chen, D.J.9
-
31
-
-
0030009738
-
The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
-
Chan D.W., and Lees-Miller S.P. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol. Chem. 271 (1996) 8936-8941
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8936-8941
-
-
Chan, D.W.1
Lees-Miller, S.P.2
-
32
-
-
0033583204
-
The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
-
Calsou P., Frit P., Humbert O., Muller C., Chen D.J., and Salles B. The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA. J. Biol. Chem. 274 (1999) 7848-7856
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7848-7856
-
-
Calsou, P.1
Frit, P.2
Humbert, O.3
Muller, C.4
Chen, D.J.5
Salles, B.6
-
33
-
-
0037159220
-
The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
-
Merkle D., Douglas P., Moorhead G.B.G., Leonenko Z., Yu Y., Cramb D., Bazett-Jones D.P., and Lees-Miller S.P. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 41 (2002) 12706-12714
-
(2002)
Biochemistry
, vol.41
, pp. 12706-12714
-
-
Merkle, D.1
Douglas, P.2
Moorhead, G.B.G.3
Leonenko, Z.4
Yu, Y.5
Cramb, D.6
Bazett-Jones, D.P.7
Lees-Miller, S.P.8
-
34
-
-
0035374588
-
Protein phosphatases regulate DNA-dependent protein kinase activity
-
Douglas P., Moorhead G.B.G., Ye R.Q., and Lees-Miller S.P. Protein phosphatases regulate DNA-dependent protein kinase activity. J. Biol. Chem. 276 (2001) 18992-18998
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18992-18998
-
-
Douglas, P.1
Moorhead, G.B.G.2
Ye, R.Q.3
Lees-Miller, S.P.4
-
35
-
-
0043133778
-
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
-
Ding Q., Reddy Y.V., Wang W., Woods T., Douglas P., Ramsden D.A., Lees-Miller S.P., and Meek K. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol. Cell. Biol. 23 (2003) 5836-5848
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5836-5848
-
-
Ding, Q.1
Reddy, Y.V.2
Wang, W.3
Woods, T.4
Douglas, P.5
Ramsden, D.A.6
Lees-Miller, S.P.7
Meek, K.8
-
36
-
-
4043073590
-
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
-
Block W.D., Yu Y., Merkle D., Gifford J.L., Ding Q., Meek K., and Lees-Miller S.P. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res. 32 (2004) 4351-4357
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 4351-4357
-
-
Block, W.D.1
Yu, Y.2
Merkle, D.3
Gifford, J.L.4
Ding, Q.5
Meek, K.6
Lees-Miller, S.P.7
-
37
-
-
4544295689
-
Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends
-
Reddy Y.V., Ding Q., Lees-Miller S.P., Meek K., and Ramsden D.A. Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J. Biol. Chem. 279 (2004) 39408-39413
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 39408-39413
-
-
Reddy, Y.V.1
Ding, Q.2
Lees-Miller, S.P.3
Meek, K.4
Ramsden, D.A.5
-
38
-
-
0037106180
-
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
-
Chan D.W., Chen B.P.-C., Prithivirasingh S., Kurimasa A., Story M.D., Qin J., and Chen D.J. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 16 (2002) 2333-2338
-
(2002)
Genes Dev.
, vol.16
, pp. 2333-2338
-
-
Chan, D.W.1
Chen, B.P.-C.2
Prithivirasingh, S.3
Kurimasa, A.4
Story, M.D.5
Qin, J.6
Chen, D.J.7
-
39
-
-
34248231265
-
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
-
Meek K., Douglas P., Cui X., Ding Q., and Lees-Miller S.P. trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Mol. Cell. Biol. 27 (2007) 3881-3890
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3881-3890
-
-
Meek, K.1
Douglas, P.2
Cui, X.3
Ding, Q.4
Lees-Miller, S.P.5
-
40
-
-
34547636294
-
Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
-
Povirk L.F., Zhou R.Z., Ramsden D.A., Lees-Miller S.P., and Valerie K. Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Res. 35 (2007) 3869-3878
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 3869-3878
-
-
Povirk, L.F.1
Zhou, R.Z.2
Ramsden, D.A.3
Lees-Miller, S.P.4
Valerie, K.5
-
42
-
-
0036468807
-
Genome architecture, rearrangements and genomic disorders
-
Stankiewicz P., and Lupski J.R. Genome architecture, rearrangements and genomic disorders. Trends Genet. 18 (2002) 74-82
-
(2002)
Trends Genet.
, vol.18
, pp. 74-82
-
-
Stankiewicz, P.1
Lupski, J.R.2
-
43
-
-
0029993727
-
Active and inactive protein kinases: structural basis for regulation
-
Johnson L.N., Noble M.E., and Owen D.J. Active and inactive protein kinases: structural basis for regulation. Cell 85 (1996) 149-158
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.2
Owen, D.J.3
-
44
-
-
0030779879
-
Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells
-
Taghian D.G., and Nickoloff J.A. Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells. Mol. Cell. Biol. 17 (1997) 6386-6393
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6386-6393
-
-
Taghian, D.G.1
Nickoloff, J.A.2
-
45
-
-
14044251525
-
The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair
-
Lu H., Guo X., Meng X., Liu J., Wray J., Allen C., Nickoloff J.A., and Shen Z. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol. Cell. Biol. 25 (2005) 1949-1957
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 1949-1957
-
-
Lu, H.1
Guo, X.2
Meng, X.3
Liu, J.4
Wray, J.5
Allen, C.6
Nickoloff, J.A.7
Shen, Z.8
-
46
-
-
2542456982
-
The mutagenic potential of a single DNA double-strand break is not influenced by transcription
-
Allen C., Miller C.A., and Nickoloff J.A. The mutagenic potential of a single DNA double-strand break is not influenced by transcription. DNA Repair 2 (2003) 1147-1156
-
(2003)
DNA Repair
, vol.2
, pp. 1147-1156
-
-
Allen, C.1
Miller, C.A.2
Nickoloff, J.A.3
-
47
-
-
0012173355
-
Recombination: mechanisms and roles in tumorigenesis
-
Bertino J.R. (Ed), Elsevier Science (USA), San Diego
-
Nickoloff J.A. Recombination: mechanisms and roles in tumorigenesis. In: Bertino J.R. (Ed). Encyclopedia of Cancer. Second ed. (2002), Elsevier Science (USA), San Diego 49-59
-
(2002)
Encyclopedia of Cancer. Second ed.
, pp. 49-59
-
-
Nickoloff, J.A.1
-
48
-
-
2342618116
-
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
-
Block W.D., Yu Y., and Lees-Miller S.P. Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res. 32 (2004) 997-1005
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 997-1005
-
-
Block, W.D.1
Yu, Y.2
Lees-Miller, S.P.3
-
49
-
-
0032743082
-
The contribution of homologous recombination in preserving genome integrity in mammalian cells
-
Thompson L.H., and Schild D. The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81 (1999) 87-105
-
(1999)
Biochimie
, vol.81
, pp. 87-105
-
-
Thompson, L.H.1
Schild, D.2
-
50
-
-
38549146496
-
Interstrand crosslink repair: can XPF-ERCC1 be let off the hook?
-
Bergstralh D.T., and Sekelsky J. Interstrand crosslink repair: can XPF-ERCC1 be let off the hook?. Trends Genet. 24 (2008) 70-76
-
(2008)
Trends Genet.
, vol.24
, pp. 70-76
-
-
Bergstralh, D.T.1
Sekelsky, J.2
-
51
-
-
0036141394
-
Elevated levels of Rad51 recombination protein in tumor cells
-
Raderschall E., Stout K., Freier S., Suckow V., Schweiger S., and Haaf T. Elevated levels of Rad51 recombination protein in tumor cells. Cancer Res. 62 (2002) 219-225
-
(2002)
Cancer Res.
, vol.62
, pp. 219-225
-
-
Raderschall, E.1
Stout, K.2
Freier, S.3
Suckow, V.4
Schweiger, S.5
Haaf, T.6
-
52
-
-
33845406168
-
The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation
-
Fung C.W., Fortin G.S., Peterson S.E., and Symington L.S. The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation. Mol. Cell. Biol. 26 (2006) 9544-9554
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 9544-9554
-
-
Fung, C.W.1
Fortin, G.S.2
Peterson, S.E.3
Symington, L.S.4
-
53
-
-
0035105999
-
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
-
Davies A.A., Masson J.Y., McLlwraith M.J., Stasiak A.Z., Stasiak A., Venkitaraman A.R., and West S.C. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol. Cell 7 (2001) 273-282
-
(2001)
Mol. Cell
, vol.7
, pp. 273-282
-
-
Davies, A.A.1
Masson, J.Y.2
McLlwraith, M.J.3
Stasiak, A.Z.4
Stasiak, A.5
Venkitaraman, A.R.6
West, S.C.7
-
54
-
-
0036864703
-
Rad54, a Swi2/Snf2-like recombinational repair protein, disassembles Rad51:dsDNA filaments
-
Solinger J.A., Kiianitsa K., and Heyer W.D. Rad54, a Swi2/Snf2-like recombinational repair protein, disassembles Rad51:dsDNA filaments. Mol. Cell 10 (2002) 1175-1188
-
(2002)
Mol. Cell
, vol.10
, pp. 1175-1188
-
-
Solinger, J.A.1
Kiianitsa, K.2
Heyer, W.D.3
-
56
-
-
34247477667
-
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
-
Uematsu N., Weterings E., Yano K., Morotomi-Yano K., Jakob B., Taucher-Scholz G., Mari P.O., van Gent D.C., Chen B.P., and Chen D.J. Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J. Cell Biol. 177 (2007) 219-229
-
(2007)
J. Cell Biol.
, vol.177
, pp. 219-229
-
-
Uematsu, N.1
Weterings, E.2
Yano, K.3
Morotomi-Yano, K.4
Jakob, B.5
Taucher-Scholz, G.6
Mari, P.O.7
van Gent, D.C.8
Chen, B.P.9
Chen, D.J.10
-
57
-
-
0033199892
-
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
-
Sarkaria J.N., Busby E.C., Tibbetts R.S., Roos P., Taya Y., Karnitz L.M., and Abraham R.T. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 59 (1999) 4375-4382
-
(1999)
Cancer Res.
, vol.59
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Busby, E.C.2
Tibbetts, R.S.3
Roos, P.4
Taya, Y.5
Karnitz, L.M.6
Abraham, R.T.7
-
58
-
-
0034616329
-
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
-
Zhou B.B., Chaturvedi P., Spring K., Scott S.P., Johanson R.A., Mishra R., Mattern M.R., Winkler J.D., and Khanna K.K. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. J. Biol. Chem. 275 (2000) 10342-10348
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10342-10348
-
-
Zhou, B.B.1
Chaturvedi, P.2
Spring, K.3
Scott, S.P.4
Johanson, R.A.5
Mishra, R.6
Mattern, M.R.7
Winkler, J.D.8
Khanna, K.K.9
-
59
-
-
1242317867
-
Caffeine inhibits homology directed repair of I-SceI induced DNA double-strand breaks
-
Wang H., Boecker W., Wang H., Wang X., Guan J., Thompson L.H., Nickoloff J.A., and Iliakis G. Caffeine inhibits homology directed repair of I-SceI induced DNA double-strand breaks. Oncogene 23 (2004) 824-834
-
(2004)
Oncogene
, vol.23
, pp. 824-834
-
-
Wang, H.1
Boecker, W.2
Wang, H.3
Wang, X.4
Guan, J.5
Thompson, L.H.6
Nickoloff, J.A.7
Iliakis, G.8
-
60
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
Hickson I., Zhao Y., Richardson C.J., Green S.J., Martin N.M., Orr A.I., Reaper P.M., Jackson S.P., Curtin N.J., and Smith G.C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64 (2004) 9152-9159
-
(2004)
Cancer Res.
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C.J.3
Green, S.J.4
Martin, N.M.5
Orr, A.I.6
Reaper, P.M.7
Jackson, S.P.8
Curtin, N.J.9
Smith, G.C.10
-
61
-
-
33745310473
-
Small molecule-based reversible reprogramming of cellular lifespan
-
Won J., Kim M., Kim N., Ahn J.H., Lee W.G., Kim S.S., Chang K.Y., Yi Y.W., and Kim T.K. Small molecule-based reversible reprogramming of cellular lifespan. Nat. Chem. Biol. 2 (2006) 369-374
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 369-374
-
-
Won, J.1
Kim, M.2
Kim, N.3
Ahn, J.H.4
Lee, W.G.5
Kim, S.S.6
Chang, K.Y.7
Yi, Y.W.8
Kim, T.K.9
-
62
-
-
2242484657
-
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
-
Douglas P., Sapkota G.P., Morrice N., Yu Y.P., Goodarzi A.A., Merkle D., Meek K., Alessi D.R., and Lees-Miller S.P. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem. J. 368 (2002) 243-251
-
(2002)
Biochem. J.
, vol.368
, pp. 243-251
-
-
Douglas, P.1
Sapkota, G.P.2
Morrice, N.3
Yu, Y.P.4
Goodarzi, A.A.5
Merkle, D.6
Meek, K.7
Alessi, D.R.8
Lees-Miller, S.P.9
-
63
-
-
17644384427
-
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
-
Chen B.P., Chan D.W., Kobayashi J., Burma S., Asaithamby A., Morotomi-Yano K., Botvinick E., Qin J., and Chen D.J. Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J. Biol. Chem. 280 (2005) 14709-14715
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14709-14715
-
-
Chen, B.P.1
Chan, D.W.2
Kobayashi, J.3
Burma, S.4
Asaithamby, A.5
Morotomi-Yano, K.6
Botvinick, E.7
Qin, J.8
Chen, D.J.9
-
64
-
-
0032574750
-
Homology-directed repair is a major double-strand break repair pathway in mammalian cells
-
Liang F., Han M.G., Romanienko P.J., and Jasin M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 5172-5177
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 5172-5177
-
-
Liang, F.1
Han, M.G.2
Romanienko, P.J.3
Jasin, M.4
-
65
-
-
23744447715
-
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
-
Kim J.S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M., and Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 170 (2005) 341-347
-
(2005)
J. Cell Biol.
, vol.170
, pp. 341-347
-
-
Kim, J.S.1
Krasieva, T.B.2
Kurumizaka, H.3
Chen, D.J.4
Taylor, A.M.5
Yokomori, K.6
-
66
-
-
9744284973
-
ATM is required for the cellular response to thymidine induced replication fork stress
-
Bolderson E., Scorah J., Helleday T., Smythe C., and Meuth M. ATM is required for the cellular response to thymidine induced replication fork stress. Hum. Mol. Genet. 13 (2004) 2937-2945
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 2937-2945
-
-
Bolderson, E.1
Scorah, J.2
Helleday, T.3
Smythe, C.4
Meuth, M.5
-
67
-
-
34548496891
-
Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions
-
Sakamoto S., Iijima K., Mochizuki D., Nakamura K., Teshigawara K., Kobayashi J., Matsuura S., Tauchi H., and Komatsu K. Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions. Oncogene 26 (2007) 6002-6009
-
(2007)
Oncogene
, vol.26
, pp. 6002-6009
-
-
Sakamoto, S.1
Iijima, K.2
Mochizuki, D.3
Nakamura, K.4
Teshigawara, K.5
Kobayashi, J.6
Matsuura, S.7
Tauchi, H.8
Komatsu, K.9
-
68
-
-
33646106590
-
γH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes
-
Stucki M., and Jackson S.P. γH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair 5 (2006) 534-543
-
(2006)
DNA Repair
, vol.5
, pp. 534-543
-
-
Stucki, M.1
Jackson, S.P.2
-
69
-
-
23344434844
-
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage
-
Barchi M., Mahadevaiah S., Di Giacomo M., Baudat F., de Rooij D.G., Burgoyne P.S., Jasin M., and Keeney S. Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol. Cell. Biol. 25 (2005) 7203-7215
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7203-7215
-
-
Barchi, M.1
Mahadevaiah, S.2
Di Giacomo, M.3
Baudat, F.4
de Rooij, D.G.5
Burgoyne, P.S.6
Jasin, M.7
Keeney, S.8
-
70
-
-
17844372453
-
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
-
Traven A., and Heierhorst J. SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins. Bioessays 27 (2005) 397-407
-
(2005)
Bioessays
, vol.27
, pp. 397-407
-
-
Traven, A.1
Heierhorst, J.2
-
71
-
-
0037427194
-
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells
-
Yuan S.S., Chang H.L., and Lee E.Y. Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells. Mutat. Res. 525 (2003) 85-92
-
(2003)
Mutat. Res.
, vol.525
, pp. 85-92
-
-
Yuan, S.S.1
Chang, H.L.2
Lee, E.Y.3
-
72
-
-
0030764691
-
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
-
Maser R.S., Monsen K.J., Nelms B.E., and Petrini J.H.J. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell. Biol. 17 (1997) 6087-6096
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6087-6096
-
-
Maser, R.S.1
Monsen, K.J.2
Nelms, B.E.3
Petrini, J.H.J.4
-
73
-
-
0030945148
-
Functional interaction between DNA-PK and c-Abl in response to DNA damage
-
Kharbanda S., Pandey P., Jin S., Inoue S., Bharti A., Yuan Z.M., Weichselbaum R., Weaver D., and Kufe D. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386 (1997) 732-735
-
(1997)
Nature
, vol.386
, pp. 732-735
-
-
Kharbanda, S.1
Pandey, P.2
Jin, S.3
Inoue, S.4
Bharti, A.5
Yuan, Z.M.6
Weichselbaum, R.7
Weaver, D.8
Kufe, D.9
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