Induced chromosomal proximity and gene fusions in prostate cancer

Science

Volumn 326, Issue 5957, 2009, Pages 1230-

  Mani, Ram Shankar ^a   Tomlins, Scott A ^a   Callahan, Kaitlin ^a   Ghosh, Aparna ^a   Nyati, Mukesh K ^a   Varambally, Sooryanarayana ^a   Palanisamy, Nallasivam ^a   Chinnalyan, Arul M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; BOLDENONE; DOUBLE STRANDED DNA; ESTROGEN;

ANDROGEN; CANCER; CHROMOSOME; GENE EXPRESSION; GENOMICS;

5' UNTRANSLATED REGION; CANCER CELL; CANCER GENETICS; CARCINOGENESIS; CELL STIMULATION; CELL STRAIN LNCAP; CHROMOSOME 21Q; CHROMOSOME ABERRATION; DNA STRAND BREAKAGE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GENE LOCATION; GENE LOCUS; GENETIC CODE; GENETIC PROCEDURES; HORMONE SENSITIVITY; HUMAN; IN SITU HYBRIDIZATION; INDUCED CHROMOSOMAL PROXIMITY; PRIORITY JOURNAL; PROSTATE CANCER; SHORT SURVEY; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 21; DIHYDROTESTOSTERONE; DNA BREAKS, DOUBLE-STRANDED; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; ONCOGENE FUSION; ONCOGENE PROTEINS, FUSION; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 70849135782     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1178124     Document Type: Short Survey

References (6)

1. J. D. Rowley, Annu. Rev. Genet 32, 495 (1998).
2. S. A. Tomlins et al., Science 310, 644 (2005).
3. Q. Hu et al., Proc. Natl. Acad. Sci. U.S.A 105, 19199 (2008).
4. Materials and methods are available as supporting material on Science Online.
5. M. N. Nikiforova et al., Science 290,138 (2000).
6. This work was supported by NIH grants P50CA69568, R01CA132874, and DOD W81XWH-09-2-0014. A.M.C is a paid consultant to Gen-Probe, Incorporated. A.M.C. and S.A.T. are named as co-inventors on a patent related to gene fusions in prostate cancer that is licensed to Gen-Probe, Incorporated.