XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Genes and Development

Volumn 13, Issue 20, 1999, Pages 2633-2638

  Pierce, Andrew J ^a   Johnson, Roger D ^a   Thompson, Larry H ^b   Jasin, Maria ^a  

^a Weill Cornell Medical Center   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Double strand break repair; Gene conversion; Homologous recombination; Mammalian cells; Rad51 related proteins; XRCC3

Indexed keywords

DOUBLE STRANDED DNA; TRANSFERASE;

ARTICLE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FLUORESCENCE; GENETIC RECOMBINATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

ANIMALS; CELL LINE; CRICETINAE; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENE CONVERSION; GENE EXPRESSION; GENETIC COMPLEMENTATION TEST; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; RAD51 RECOMBINASE; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC;

EID: 0033569684     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.20.2633     Document Type: Article

References (40)

1. Baumann, P. and S.C. West. 1998. Role of the human RAD51 protein in homologous recombination and double-stranded-break repair. Trends Biochem. Sci. 23: 247-251.
2. Bishop, D.K., U. Ear, A. Bhattacharyya, C. Calderone, M. Beckett, R.R. Weichselbaum, and A. Shinohara. 1998. Xrcc3 is required for assembly of Rad51 complexes in vivo. J. Biol. Chem. 273: 21482-21488.
3. Caldecott, K. and P. Jego. 1991. Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutat. Res. 255: 111-121.
4. Caldecott, K.W., C.K. McKeown, J.D. Tucker, S. Ljungquist, and L.H. Thompson. 1994. An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Mol. Cell. Biol. 14: 68-76.
5. Colleaux, L., L. d'Auriol, F. Gailbert, and B. Dujon. 1988. Recognition and cleavage site of the intron-encoded omega transposase. Proc. Natl. Acad. Sci. 85: 6022-6026.
6. Donoho, G., M. Jasin, and P. Berg. 1998. Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells. Mol. Cell. Biol. 18: 4070-4078.
7. Elliott, B., C. Richardson, J. Winderbaum, J.A. Nickoloff, and M. Jasin. 1998. Gene conversion tracts from double-strand break repair in mammalian cells. Mol. Cell. Biol. 18: 93-101.
8. Essers, J., R.W. Hendriks, S.M.A. Swagemakers, C. Troelstra, J. de Wit, D. Bootsma, J.H.J. Hoeijmakers, and R. Kanaar. 1997. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell 89: 195-204.
9. Fuller, L.F. and R.B. Painter. 1988. A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication. Mutat. Res. 193: 109-121.
10. Hays, S.L., A.A. Firmenich, and P. Berg. 1995. Complex formation in yeast double-strand break repair: Participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl. Acad. Sci. 92: 6925-6929.
11. Jasin, M. 1996. Genetic manipulation of genomes with rare-cutting endonucleases. Trends Genet. 12: 224-228.
12. Jeggo, P.A. 1998. DNA breakage and repair. Adv. Genet. 38: 185-218.
13. Johnson, R.D. and L.S. Symington. 1995. Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57. Mol. Cell. Biol. 15: 4843-4850.
14. Johnson, R.D., N. Liu, and M. Jasin. 1999. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature 401: 397-399.
15. Jones, N.J., R. Cox, and J. Thacker. 1987. Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells. Mutat. Res. 183: 279-286.
16. Kemp, L.M. and P.A. Jeggo. 1986. Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line. Mutat. Res. 166: 255-263.
17. Kinzler, K.W. and B. Vogelstein. 1997. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386: 761, 763.
18. Liang, F., P.J. Romanienko, D.T. Weaver, P.A. Jeggo, and M. Jasin. 1996. Chromosomal double-strand break repair in Ku80 deficient cells. Proc. Natl. Acad. Sci. 93: 8929-8933.
19. Liang, F., M. Han, P.J. Romanienko, and M. Jasin. 1998. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc. Natl. Acad. Sci. 95: 5172-5177.
20. Lim, D.S. and P. Hasty. 1996. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16: 7133-7143.
21. Liu, N., J.E. Lamerdin, R.S. Tebbs, D. Schild, J.D. Tucker, M.R. Shen, K.W. Brookman, M.J. Siciliano, C.A. Walter, W. Fan, L.S. Narayana et al. 1998. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol. Cell 1: 783-793.
22. Moynahan, M.E., J.W. Chiu, B.H. Koller, and M. Jasin. 1999. Brcal controls homology-directed repair. Mol. Cell. (In press).
23. Muris, D.F., K. Vreeken, A.M. Carr, B.C. Broughton, A.R. Lehmann, P.H. Lohman, and A. Pastink. 1993. Cloning the RAD51 homologue of Schizosaccharomyces pombe. Nucleic Acids Res. 21: 4586-4591.
24. Niwa, H., K. Yamamura, and J.-i. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193-200.
25. Pedone, P.V., R. Ghirlando, G.M. Clore, A.M. Gronenborn, G. Felsenfeld, and J.G. Omichinski. 1996. The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding. Proc. Natl. Acad. Sci. 93: 2822-2826.
26. Petes, T.D., R.E. Malone, and L.S. Symington. 1991. Recombination in yeast. In The molecular and cellular biology of the yeast Saccharomyces: Genome dynamics, protein synthesis, and energetics (ed. J.R. Broach, J.R. Pringle, and E. W. Jones), pp. 407-521. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Richardson, C., M.E. Moynahan, and M. Jasin. 1998. Double-strand break repair by interchromosomal recombination: Suppression of chromosomal translocations. Genes & Dev. 12: 3831-3842.
28. Rijkers, T., J. Van Den Ouweland, B. Morolli, A.G. Rolink, W.M. Baarends, P.P. Van Sloun, P.H. Lohman, and A. Pastink. 1998. Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Mol. Cell. Biol. 18: 6423-6429.
29. Scully, R., J. Chen, A. Plug, Y. Xiao, D. Weaver, J. Feunteun, T. Ashley, and D.M. Livingston. 1997. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88: 265-275.
30. Shinohara, A., H. Ogawa, and T. Ogawa. 1992. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69: 457-470.
31. Sung, P. 1994. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265: 1241-1243.
32. _. 1997a. Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase. J. Biol. Chem. 272: 28194-28197.
33. _. 1997b. Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase. Genes & Dev. 11: 1111-1121.
34. Taccioli, G.E., G. Rathbun, E. Oltz, T. Stamato, P.A. Jeggo, and F.W. Alt. 1993. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260: 207-210.
35. Taghian, D.G. and J.A. Nickoloff. 1997. Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells. Mol. Cell. Biol. 17: 6386-6393.
36. Tebbs, R.S., Y. Zhao, J.D. Tucker, J.B. Scheerer, M.J. Siciliano, M. Hwang, N. Liu, R.J. Legerski, and L.H. Thompson. 1995. Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc. Natl. Acad. Sci. 92: 6354-6358.
37. Thompson, L.H. and P.A. Jeggo. 1995. Nomenclature of human genes involved in ionizing radiation sensitivity. Mutat. Res. 337: 131-134.
38. Thompson, L.H. and D. Schild. 1999. The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81: 87-105.
39. Tsuzuki, T., Y. Fujii, K. Sakumi, Y. Tominaga, K. Nakao, M. Sekiguchi, A. Matsushiro, Y. Yoshimura, and T. Morita. 1996. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. 93: 6236-6340.
40. Ward, J.F. 1995. Radiation mutagenesis: The initial DNA lesions responsible. Radiat. Res. 142: 362-368.