Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

Nature

Volumn 454, Issue 7203, 2008, Pages 543-546

  Lee, Kihoon ^a   Zhang, Yu ^a   Lee, Sang Eun ^a  

^a University of Texas Health Science Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; HISTONE H2AX; PROTEIN DUN1; PROTEIN KINASE; PROTEIN SAE2; PROTEIN TEL1;

CANCER; CHROMOSOME; YEAST;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CARCINOGENESIS; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; GENE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; TELOMERE; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 47949092912     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07054     Document Type: Article

References (30)

1. Zhang, Y. & Rowley, J. D. Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair 5, 1282-1297 (2006).
2. Lieber, M. R., Yu, K. & Raghavan, S. C. Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair 5, 1234-1245 (2006).
3. Putnam, C. D., Pennaneach, V. & Kolodner, R. D. Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype. Mol. Cell. Biol. 25, 7226-7238 (2005).
4. Myung, K., Datta, A. & Kolodner, R. D. Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell 104, 397-408 (2001).
5. Haber, J. E. Transpositions and translocations induced by site-specific double-strand breaks in budding yeast. DNA Repair 5, 998-1009 (2006).
6. Haber, J. E. & Leung, W. Y. Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends. Proc. Natl Acad. Sci. USA 93, 13949-13954 (1996).
7. Khanna, K. K. Cancer risk and the ATM gene: a continuing debate. J. Natl Cancer Inst. 92, 795-802 (2000).
8. Greenwell, P. W. et al. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82, 823-829 (1995).
9. Usui, T., Ogawa, H. & Petrini, J. H. A. DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7, 1255-1266 (2001).
10. Chakhparonian, M., Faucher, D. & Wellinger, R. J. A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance. Curr. Genet. 48, 310-322 (2005).
11. Ritchie, K. B., Mallory, J. C. & Petes, T. D. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 6065-6075 (1999).
12. Nyberg, K. A., Michelson, R. J., Putnam, C. W. & Weinert, T. A. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36, 617-656 (2002).
13. Zhao, X., Muller, E. G. & Rothstein, R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2, 329-340 (1998).
14. Clerici, M., Mantiero, D., Lucchini, G. & Longhese, M. P. The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends. J. Biol. Chem. 280, 38631-38638 (2005).
15. Kim, H. S. et al. Functional interactions between Sae2 and the Mre11 complex. Genetics 178, 711-723 (2008).
16. Moreau, S., Ferguson, J. R. & Symington, L. S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19, 556-566 (1999).
17. Alani, E., Padmore, R. & Kleckner, N. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61, 419-436 (1990).
18. Bashkirov, V. I., Bashkirova, E. V., Haghnazari, E. & Heyer, W. D. Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Mol. Cell. Biol. 23, 1441-1452 (2003).
19. Mallory, J. C. et al. Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. DNA Repair 2, 1041-1064 (2003).
20. Shroff, R. et al. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr. Biol. 14, 1703-1711 (2004).
21. Baroni, E., Viscardi, V., Cartagena-Lirola, H., Lucchini, G. & Longhese, M. P. The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol. Cell. Biol. 24, 4151-4165 (2004).
22. Ira, G. et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431, 1011-1017 (2004).
23. van Attikum, H., Fritsch, O. & Gasser, S. M. Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks. EMBO J. 26, 4113-4125 (2007).
24. Kaye, J. A. et al. DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr. Biol. 14, 2096-2106 (2004).
25. Lobachev, K., Vitriol, E., Stemple, J., Resnick, M. A. & Bloom, K. Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex. Curr. Biol. 14, 2107-2112 (2004).
26. Bassing, C. H. & Alt, F. W. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3, 149-153 (2004).
27. Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922-927 (2002).
28. Petrini, J. H. The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12, 293-296 (2000).
29. Unal, E. et al. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol. Cell 16, 991-1002 (2004).
30. Shim, E. Y. et al. RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatin. Mol. Cell. Biol. 27, 1602-1613 (2007).