-
1
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Network, C.G.A.R. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455, 1061-1068.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
Network, C.G.A.R.1
-
2
-
-
77952555038
-
Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma
-
Van Meir, E.G.; Hadjipanayis, C.G.; Norden, A.D.; Shu, H.K.; Wen, P.Y.; Olson, J.J. Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma. CA Cancer J. Clin. 2010, 60, 166-193.
-
(2010)
CA Cancer J. Clin
, vol.60
, pp. 166-193
-
-
van Meir, E.G.1
Hadjipanayis, C.G.2
Norden, A.D.3
Shu, H.K.4
Wen, P.Y.5
Olson, J.J.6
-
3
-
-
78649540362
-
Neuro-oncology is moving!
-
Stupp, R.; Weller, M. 2010: Neuro-oncology is moving! Curr. Opin. Neurol. 2010, 23, 553-555.
-
(2010)
Curr. Opin. Neurol
, vol.2010
, Issue.23
, pp. 553-555
-
-
Stupp, R.1
Weller, M.2
-
4
-
-
78650014126
-
Neuro-oncology: Continuing multidisciplinary progress
-
Nagane, M. Neuro-oncology: Continuing multidisciplinary progress. Lancet Neurol. 2011, 10, 18-20.
-
(2011)
Lancet Neurol
, vol.10
, pp. 18-20
-
-
Nagane, M.1
-
5
-
-
33847336870
-
Molecular targets of glioma invasion
-
Nakada, M.; Nakada, S.; Demuth, T.; Tran, N.L.; Hoelzinger, D.B.; Berens, M.E. Molecular targets of glioma invasion. Cell. Mol. Life Sci. 2007, 64, 458-478.
-
(2007)
Cell. Mol. Life Sci
, vol.64
, pp. 458-478
-
-
Nakada, M.1
Nakada, S.2
Demuth, T.3
Tran, N.L.4
Hoelzinger, D.B.5
Berens, M.E.6
-
6
-
-
62949099350
-
Age as a predictive factor in glioblastomas: Population-based study
-
Kita, D.; Ciernik, I.F.; Vaccarella, S.; Franceschi, S.; Kleihues, P.; Lutolf, U.M.; Ohgaki, H. Age as a predictive factor in glioblastomas: Population-based study. Neuroepidemiology 2009, 33, 17-22.
-
(2009)
Neuroepidemiology
, vol.33
, pp. 17-22
-
-
Kita, D.1
Ciernik, I.F.2
Vaccarella, S.3
Franceschi, S.4
Kleihues, P.5
Lutolf, U.M.6
Ohgaki, H.7
-
7
-
-
58149471244
-
Epidemiology of brain tumors
-
Ohgaki, H. Epidemiology of brain tumors. Methods Mol. Biol. 2009, 472, 323-342.
-
(2009)
Methods Mol. Biol
, vol.472
, pp. 323-342
-
-
Ohgaki, H.1
-
8
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R.; Mason, W.P.; van den Bent, M.J.; Weller, M.; Fisher, B.; Taphoorn, M.J.; Belanger, K.; Brandes, A.A.; Marosi, C.; Bogdahn, U.; et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 2005, 352, 987-996.
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
Weller, M.4
Fisher, B.5
Taphoorn, M.J.6
Belanger, K.7
Brandes, A.A.8
Marosi, C.9
Bogdahn, U.10
-
9
-
-
0027769876
-
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
-
Serrano, M.; Hannon, G.J.; Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366, 704-707.
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano, M.1
Hannon, G.J.2
Beach, D.3
-
10
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr, C.J.; Roberts, J.M. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 1999, 13, 1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
11
-
-
0030070484
-
CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
-
Ueki, K.; Ono, Y.; Henson, J.W.; Efird, J.T.; von Deimling, A.; Louis, D.N. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res. 1996, 56, 150-153.
-
(1996)
Cancer Res
, vol.56
, pp. 150-153
-
-
Ueki, K.1
Ono, Y.2
Henson, J.W.3
Efird, J.T.4
von Deimling, A.5
Louis, D.N.6
-
12
-
-
0030881477
-
Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas
-
Biernat, W.; Tohma, Y.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H. Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol. 1997, 94, 303-309.
-
(1997)
Acta Neuropathol
, vol.94
, pp. 303-309
-
-
Biernat, W.1
Tohma, Y.2
Yonekawa, Y.3
Kleihues, P.4
Ohgaki, H.5
-
13
-
-
0023429079
-
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
-
Wong, A.J.; Bigner, S.H.; Bigner, D.D.; Kinzler, K.W.; Hamilton, S.R.; Vogelstein, B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. USA 1987, 84, 6899-6903.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 6899-6903
-
-
Wong, A.J.1
Bigner, S.H.2
Bigner, D.D.3
Kinzler, K.W.4
Hamilton, S.R.5
Vogelstein, B.6
-
14
-
-
0029401049
-
Platelet-derived growth factor in human glioma
-
Westermark, B.; Heldin, C.H.; Nister, M. Platelet-derived growth factor in human glioma. Glia 1995, 15, 257-263.
-
(1995)
Glia
, vol.15
, pp. 257-263
-
-
Westermark, B.1
Heldin, C.H.2
Nister, M.3
-
15
-
-
0037501724
-
Malignant glioma physiology: Cellular response to hypoxia and its role in tumor progression
-
Brat, D.J.; Mapstone, T.B. Malignant glioma physiology: Cellular response to hypoxia and its role in tumor progression. Ann. Int. Med. 2003, 138, 659-668.
-
(2003)
Ann. Int. Med
, vol.138
, pp. 659-668
-
-
Brat, D.J.1
Mapstone, T.B.2
-
16
-
-
33645732219
-
Molecular pathology of malignant gliomas
-
Louis, D.N. Molecular pathology of malignant gliomas. Annu. Rev. Pathol. 2006, 1, 97-117.
-
(2006)
Annu. Rev. Pathol
, vol.1
, pp. 97-117
-
-
Louis, D.N.1
-
17
-
-
0041737535
-
Molecular mechanisms of glioma invasiveness: The role of proteases
-
Rao, J.S. Molecular mechanisms of glioma invasiveness: The role of proteases. Nat. Rev. Cancer 2003, 3, 489-501.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 489-501
-
-
Rao, J.S.1
-
18
-
-
79951550507
-
Angiogenesis and invasion in glioma
-
Onishi, M.; Ichikawa, T.; Kurozumi, K.; Date, I. Angiogenesis and invasion in glioma. Brain Tumor Pathol. 2011, 28, 13-24.
-
(2011)
Brain Tumor Pathol
, vol.28
, pp. 13-24
-
-
Onishi, M.1
Ichikawa, T.2
Kurozumi, K.3
Date, I.4
-
19
-
-
0034665461
-
P53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
-
Chao, C.; Saito, S.; Kang, J.; Anderson, C.W.; Appella, E.; Xu, Y. P53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J. 2000, 19, 4967-4975.
-
(2000)
EMBO J
, vol.19
, pp. 4967-4975
-
-
Chao, C.1
Saito, S.2
Kang, J.3
Anderson, C.W.4
Appella, E.5
Xu, Y.6
-
20
-
-
22144451105
-
Apoptosis and proliferation: Correlation with p53 in astrocytic tumours
-
Sarkar, C.; Karak, A.K.; Nath, N.; Sharma, M.C.; Mahapatra, A.K.; Chattopadhyay, P.; Sinha, S. Apoptosis and proliferation: Correlation with p53 in astrocytic tumours. J. Neurooncol. 2005, 73, 93-100.
-
(2005)
J. Neurooncol
, vol.73
, pp. 93-100
-
-
Sarkar, C.1
Karak, A.K.2
Nath, N.3
Sharma, M.C.4
Mahapatra, A.K.5
Chattopadhyay, P.6
Sinha, S.7
-
21
-
-
0030838479
-
Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis
-
Gomez-Manzano, C.; Fueyo, J.; Kyritsis, A.P.; McDonnell, T.J.; Steck, P.A.; Levin, V.A.; Yung, W.K. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. J. Natl. Cancer Inst. 1997, 89, 1036-1044.
-
(1997)
J. Natl. Cancer Inst
, vol.89
, pp. 1036-1044
-
-
Gomez-Manzano, C.1
Fueyo, J.2
Kyritsis, A.P.3
McDonnell, T.J.4
Steck, P.A.5
Levin, V.A.6
Yung, W.K.7
-
22
-
-
0034680035
-
Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation
-
Leung, S.Y.; Yuen, S.T.; Chan, T.L.; Chan, A.S.; Ho, J.W.; Kwan, K.; Fan, Y.W.; Hung, K.N.; Chung, L.P.; Wyllie, A.H. Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation. Oncogene 2000, 19, 4079-4083.
-
(2000)
Oncogene
, vol.19
, pp. 4079-4083
-
-
Leung, S.Y.1
Yuen, S.T.2
Chan, T.L.3
Chan, A.S.4
Ho, J.W.5
Kwan, K.6
Fan, Y.W.7
Hung, K.N.8
Chung, L.P.9
Wyllie, A.H.10
-
23
-
-
0028970197
-
The molecular basis of Turcot's syndrome
-
Hamilton, S.R.; Liu, B.; Parsons, R.E.; Papadopoulos, N.; Jen, J.; Powell, S.M.; Krush, A.J.; Berk, T.; Cohen, Z.; Tetu, B.; et al. The molecular basis of Turcot's syndrome. N. Engl. J. Med. 1995, 332, 839-847.
-
(1995)
N. Engl. J. Med
, vol.332
, pp. 839-847
-
-
Hamilton, S.R.1
Liu, B.2
Parsons, R.E.3
Papadopoulos, N.4
Jen, J.5
Powell, S.M.6
Krush, A.J.7
Berk, T.8
Cohen, Z.9
Tetu, B.10
-
24
-
-
0032925147
-
Structural analysis of receptor tyrosine kinases
-
Hubbard, S.R. Structural analysis of receptor tyrosine kinases. Prog. Biophys. Mol. Biol. 1999, 71, 343-358.
-
(1999)
Prog. Biophys. Mol. Biol
, vol.71
, pp. 343-358
-
-
Hubbard, S.R.1
-
25
-
-
20144377465
-
HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells
-
Hirata, A.; Hosoi, F.; Miyagawa, M.; Ueda, S.; Naito, S.; Fujii, T.; Kuwano, M.; Ono, M. HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. Cancer Res. 2005, 65, 4253-4260.
-
(2005)
Cancer Res
, vol.65
, pp. 4253-4260
-
-
Hirata, A.1
Hosoi, F.2
Miyagawa, M.3
Ueda, S.4
Naito, S.5
Fujii, T.6
Kuwano, M.7
Ono, M.8
-
26
-
-
0034789517
-
Receptor tyrosine kinase signalling as a target for cancer intervention strategies
-
Zwick, E.; Bange, J.; Ullrich, A. Receptor tyrosine kinase signalling as a target for cancer intervention strategies. Endocr.-Relat. Cancer 2001, 8, 161-173.
-
(2001)
Endocr.-Relat. Cancer
, vol.8
, pp. 161-173
-
-
Zwick, E.1
Bange, J.2
Ullrich, A.3
-
27
-
-
14644412873
-
Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
-
Heimberger, A.B.; Hlatky, R.; Suki, D.; Yang, D.; Weinberg, J.; Gilbert, M.; Sawaya, R.; Aldape, K. Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin. Cancer Res. 2005, 11, 1462-1466.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 1462-1466
-
-
Heimberger, A.B.1
Hlatky, R.2
Suki, D.3
Yang, D.4
Weinberg, J.5
Gilbert, M.6
Sawaya, R.7
Aldape, K.8
-
28
-
-
0030017885
-
Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
-
discussion 223-214
-
Watanabe, K.; Tachibana, O.; Sata, K.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol. 1996, 6, 217-223 discussion 223-214.
-
(1996)
Brain Pathol
, vol.6
, pp. 217-223
-
-
Watanabe, K.1
Tachibana, O.2
Sata, K.3
Yonekawa, Y.4
Kleihues, P.5
Ohgaki, H.6
-
29
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
-
Fleming, T.P.; Saxena, A.; Clark, W.C.; Robertson, J.T.; Oldfield, E.H.; Aaronson, S.A.; Ali, I.U. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 1992, 52, 4550-4553.
-
(1992)
Cancer Res
, vol.52
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
Robertson, J.T.4
Oldfield, E.H.5
Aaronson, S.A.6
Ali, I.U.7
-
30
-
-
75349091751
-
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
-
Charles, N.; Ozawa, T.; Squatrito, M.; Bleau, A.M.; Brennan, C.W.; Hambardzumyan, D.; Holland, E.C. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010, 6, 141-152.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 141-152
-
-
Charles, N.1
Ozawa, T.2
Squatrito, M.3
Bleau, A.M.4
Brennan, C.W.5
Hambardzumyan, D.6
Holland, E.C.7
-
31
-
-
0028890744
-
The insulin-like growth factor I receptor: A key to tumor growth?
-
Baserga, R. The insulin-like growth factor I receptor: A key to tumor growth? Cancer Res. 1995, 55, 249-252.
-
(1995)
Cancer Res
, vol.55
, pp. 249-252
-
-
Baserga, R.1
-
32
-
-
0028332782
-
Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme
-
Morrison, R.S.; Yamaguchi, F.; Bruner, J.M.; Tang, M.; McKeehan, W.; Berger, M.S. Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme. Cancer Res. 1994, 54, 2794-2799.
-
(1994)
Cancer Res
, vol.54
, pp. 2794-2799
-
-
Morrison, R.S.1
Yamaguchi, F.2
Bruner, J.M.3
Tang, M.4
McKeehan, W.5
Berger, M.S.6
-
33
-
-
0032418232
-
Clinical importance of c-Met protein expression in high grade astrocytic tumors
-
discussion 858-859
-
Hirose, Y.; Kojima, M.; Sagoh, M.; Hayashi, T.; Murakami, H.; Shimazaki, K.; Yoshida, K.; Kawase, T. Clinical importance of c-Met protein expression in high grade astrocytic tumors. Neurol. Med. Chir. (Tokyo) 1998, 38, 851-858; discussion 858-859.
-
(1998)
Neurol. Med. Chir. (Tokyo)
, vol.38
, pp. 851-858
-
-
Hirose, Y.1
Kojima, M.2
Sagoh, M.3
Hayashi, T.4
Murakami, H.5
Shimazaki, K.6
Yoshida, K.7
Kawase, T.8
-
34
-
-
0026576726
-
Insulin-like growth factors and cancer
-
Macaulay, V.M. Insulin-like growth factors and cancer. Br. J. Cancer 1992, 65, 11-320.
-
(1992)
Br. J. Cancer
, vol.65
, pp. 11-320
-
-
Macaulay, V.M.1
-
35
-
-
77957937844
-
Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies
-
Ahluwalia, M.S.; de Groot, J.; Liu, W.M.; Gladson, C.L. Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies. Cancer Lett. 2010, 298, 139-149.
-
(2010)
Cancer Lett
, vol.298
, pp. 139-149
-
-
Ahluwalia, M.S.1
de Groot, J.2
Liu, W.M.3
Gladson, C.L.4
-
36
-
-
0026772431
-
Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
-
Hermanson, M.; Funa, K.; Hartman, M.; Claesson-Welsh, L.; Heldin, C.H.; Westermark, B.; Nister, M. Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 1992, 52, 3213-3219.
-
(1992)
Cancer Res
, vol.52
, pp. 3213-3219
-
-
Hermanson, M.1
Funa, K.2
Hartman, M.3
Claesson-Welsh, L.4
Heldin, C.H.5
Westermark, B.6
Nister, M.7
-
37
-
-
0028865803
-
Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells
-
Murphy, G.M., Jr.; Lee, Y.L.; Jia, X.C.; Yu, A.C.; Majewska, A.; Song, Y.; Schmidt, K.; Eng, L.F. Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. J. Neurochem. 1995, 65, 2716-2724.
-
(1995)
J. Neurochem
, vol.65
, pp. 2716-2724
-
-
Murphy Jr., G.M.1
Lee, Y.L.2
Jia, X.C.3
Yu, A.C.4
Majewska, A.5
Song, Y.6
Schmidt, K.7
Eng, L.F.8
-
38
-
-
0025832177
-
Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor
-
Takahashi, J.A.; Fukumoto, M.; Kozai, Y.; Ito, N.; Oda, Y.; Kikuchi, H.; Hatanaka, M. Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor. FEBS Lett. 1991, 288, 65-71.
-
(1991)
FEBS Lett
, vol.288
, pp. 65-71
-
-
Takahashi, J.A.1
Fukumoto, M.2
Kozai, Y.3
Ito, N.4
Oda, Y.5
Kikuchi, H.6
Hatanaka, M.7
-
39
-
-
0027316295
-
Characterization of insulin-like growth factor 1 in human primary brain tumors
-
Sandberg-Nordqvist, A.C.; Stahlbom, P.A.; Reinecke, M.; Collins, V.P.; von Holst, H.; Sara, V. Characterization of insulin-like growth factor 1 in human primary brain tumors. Cancer Res. 1993, 53, 2475-2478.
-
(1993)
Cancer Res
, vol.53
, pp. 2475-2478
-
-
Sandberg-Nordqvist, A.C.1
Stahlbom, P.A.2
Reinecke, M.3
Collins, V.P.4
von Holst, H.5
Sara, V.6
-
40
-
-
0035865158
-
Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape
-
Platten, M.; Wick, W.; Weller, M. Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape. Microsc. Res. Tech. 2001, 52, 401-410.
-
(2001)
Microsc. Res. Tech
, vol.52
, pp. 401-410
-
-
Platten, M.1
Wick, W.2
Weller, M.3
-
41
-
-
0026026818
-
The GTPase superfamily: Conserved structure and molecular mechanism
-
Bourne, H.R.; Sanders, D.A.; McCormick, F. The GTPase superfamily: Conserved structure and molecular mechanism. Nature 1991, 349, 117-127.
-
(1991)
Nature
, vol.349
, pp. 117-127
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
42
-
-
0032927688
-
The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas
-
Bredel, M.; Pollack, I.F. The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas. Brain Res. Brain Res. Rev. 1999, 29, 232-249.
-
(1999)
Brain Res. Brain Res. Rev
, vol.29
, pp. 232-249
-
-
Bredel, M.1
Pollack, I.F.2
-
43
-
-
0027328191
-
Activin receptor-like kinases: A novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
-
Ten Dijke, P.; Ichijo, H.; Franzen, P.; Schulz, P.; Saras, J.; Toyoshima, H.; Heldin, C.H.; Miyazono, K. Activin receptor-like kinases: A novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene 1993, 8, 2879-2887.
-
(1993)
Oncogene
, vol.8
, pp. 2879-2887
-
-
Ten, D.P.1
Ichijo, H.2
Franzen, P.3
Schulz, P.4
Saras, J.5
Toyoshima, H.6
Heldin, C.H.7
Miyazono, K.8
-
44
-
-
33748058131
-
Frequent alterations in the expression of serine/threonine kinases in human cancers
-
Capra, M.; Nuciforo, P.G.; Confalonieri, S.; Quarto, M.; Bianchi, M.; Nebuloni, M.; Boldorini, R.; Pallotti, F.; Viale, G.; Gishizky, M.L.; et al. Frequent alterations in the expression of serine/threonine kinases in human cancers. Cancer Res. 2006, 66, 8147-8154.
-
(2006)
Cancer Res
, vol.66
, pp. 8147-8154
-
-
Capra, M.1
Nuciforo, P.G.2
Confalonieri, S.3
Quarto, M.4
Bianchi, M.5
Nebuloni, M.6
Boldorini, R.7
Pallotti, F.8
Viale, G.9
Gishizky, M.L.10
-
45
-
-
0035880788
-
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
-
Smith, J.S.; Tachibana, I.; Passe, S.M.; Huntley, B.K.; Borell, T.J.; Iturria, N.; O'Fallon, J.R.; Schaefer, P.L.; Scheithauer, B.W.; James, C.D.; et al. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J. Natl. Cancer Inst. 2001, 93, 1246-1256.
-
(2001)
J. Natl. Cancer Inst
, vol.93
, pp. 1246-1256
-
-
Smith, J.S.1
Tachibana, I.2
Passe, S.M.3
Huntley, B.K.4
Borell, T.J.5
Iturria, N.6
O'Fallon, J.R.7
Schaefer, P.L.8
Scheithauer, B.W.9
James, C.D.10
-
46
-
-
0034020459
-
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
-
Holland, E.C.; Celestino, J.; Dai, C.; Schaefer, L.; Sawaya, R.E.; Fuller, G.N. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. 2000, 25, 55-57.
-
(2000)
Nat. Genet
, vol.25
, pp. 55-57
-
-
Holland, E.C.1
Celestino, J.2
Dai, C.3
Schaefer, L.4
Sawaya, R.E.5
Fuller, G.N.6
-
47
-
-
79954441895
-
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
-
Schindler, G.; Capper, D.; Meyer, J.; Janzarik, W.; Omran, H.; Herold-Mende, C.; Schmieder, K.; Wesseling, P.; Mawrin, C.; Hasselblatt, M. et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011, 121, 397-405.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 397-405
-
-
Schindler, G.1
Capper, D.2
Meyer, J.3
Janzarik, W.4
Omran, H.5
Herold-Mende, C.6
Schmieder, K.7
Wesseling, P.8
Mawrin, C.9
Hasselblatt, M.10
-
48
-
-
16344395995
-
Mutation analysis of B-RAF gene in human gliomas
-
Basto, D.; Trovisco, V.; Lopes, J.M.; Martins, A.; Pardal, F.; Soares, P.; Reis, R.M. Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathol. 2005, 109, 207-210.
-
(2005)
Acta Neuropathol
, vol.109
, pp. 207-210
-
-
Basto, D.1
Trovisco, V.2
Lopes, J.M.3
Martins, A.4
Pardal, F.5
Soares, P.6
Reis, R.M.7
-
49
-
-
0034604110
-
Role of transforming growth factor beta in human disease
-
Blobe, G.C.; Schiemann, W.P.; Lodish, H.F. Role of transforming growth factor beta in human disease. N. Engl. J. Med. 2000, 342, 1350-1358.
-
(2000)
N. Engl. J. Med
, vol.342
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
50
-
-
33846821916
-
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
-
Bruna, A.; Darken, R.S.; Rojo, F.; Ocana, A.; Penuelas, S.; Arias, A.; Paris, R.; Tortosa, A.; Mora, J.; Baselga, J. et al High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 2007, 11, 147-160.
-
(2007)
Cancer Cell
, vol.11
, pp. 147-160
-
-
Bruna, A.1
Darken, R.S.2
Rojo, F.3
Ocana, A.4
Penuelas, S.5
Arias, A.6
Paris, R.7
Tortosa, A.8
Mora, J.9
Baselga, J.10
-
51
-
-
36949000268
-
NF-kappaB controls growth of glioblastomas/astrocytomas
-
Smith, D.; Shimamura, T.; Barbera, S.; Bejcek, B.E. NF-kappaB controls growth of glioblastomas/astrocytomas. Mol. Cell. Biochem. 2008, 307, 141-147.
-
(2008)
Mol. Cell. Biochem
, vol.307
, pp. 141-147
-
-
Smith, D.1
Shimamura, T.2
Barbera, S.3
Bejcek, B.E.4
-
52
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
Romashkova, J.A.; Makarov, S.S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999, 401, 86-90.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
53
-
-
35949002429
-
Malignant astrocytic glioma: Genetics, biology, and paths to treatment
-
Furnari, F.B.; Fenton, T.; Bachoo, R.M.; Mukasa, A.; Stommel, J.M.; Stegh, A.; Hahn, W.C.; Ligon, K.L.; Louis, D.N.; Brennan, C.; et al. Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev. 2007, 21, 2683-2710.
-
(2007)
Genes Dev
, vol.21
, pp. 2683-2710
-
-
Furnari, F.B.1
Fenton, T.2
Bachoo, R.M.3
Mukasa, A.4
Stommel, J.M.5
Stegh, A.6
Hahn, W.C.7
Ligon, K.L.8
Louis, D.N.9
Brennan, C.10
-
54
-
-
0029397222
-
Angiogenesis in malignant gliomas
-
Plate, K.H.; Risau, W. Angiogenesis in malignant gliomas. Glia 1995, 15, 339-347.
-
(1995)
Glia
, vol.15
, pp. 339-347
-
-
Plate, K.H.1
Risau, W.2
-
55
-
-
0031045279
-
Neovasculature induced by vascular endothelial growth factor is fenestrated
-
Roberts, W.G.; Palade, G.E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res. 1997, 57, 765-772.
-
(1997)
Cancer Res
, vol.57
, pp. 765-772
-
-
Roberts, W.G.1
Palade, G.E.2
-
56
-
-
68849084613
-
Brain angiogenesis in developmental and pathological processes: Therapeutic aspects of vascular endothelial growth factor
-
Shibuya, M. Brain angiogenesis in developmental and pathological processes: Therapeutic aspects of vascular endothelial growth factor. FEBS J. 2009, 276, 4636-4643.
-
(2009)
FEBS J
, vol.276
, pp. 4636-4643
-
-
Shibuya, M.1
-
57
-
-
68049113584
-
Angiogenesis as a therapeutic target in malignant gliomas
-
Chi, A.S.; Sorensen, A.G.; Jain, R.K.; Batchelor, T.T. Angiogenesis as a therapeutic target in malignant gliomas. Oncologist 2009, 14, 621-636.
-
(2009)
Oncologist
, vol.14
, pp. 621-636
-
-
Chi, A.S.1
Sorensen, A.G.2
Jain, R.K.3
Batchelor, T.T.4
-
58
-
-
0037389767
-
Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A
-
Lamszus, K.; Ulbricht, U.; Matschke, J.; Brockmann, M.A.; Fillbrandt, R.; Westphal, M. Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin. Cancer Res. 2003, 9, 1399-1405.
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 1399-1405
-
-
Lamszus, K.1
Ulbricht, U.2
Matschke, J.3
Brockmann, M.A.4
Fillbrandt, R.5
Westphal, M.6
-
59
-
-
0038737156
-
Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma
-
Salmaggi, A.; Eoli, M.; Frigerio, S.; Silvani, A.; Gelati, M.; Corsini, E.; Broggi, G.; Boiardi, A. Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma. J. Neurooncol. 2003, 62, 297-303.
-
(2003)
J. Neurooncol
, vol.62
, pp. 297-303
-
-
Salmaggi, A.1
Eoli, M.2
Frigerio, S.3
Silvani, A.4
Gelati, M.5
Corsini, E.6
Broggi, G.7
Boiardi, A.8
-
60
-
-
0017370183
-
Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
-
Ausprunk, D.H.; Folkman, J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc. Res. 1977, 14, 53-65.
-
(1977)
Microvasc. Res
, vol.14
, pp. 53-65
-
-
Ausprunk, D.H.1
Folkman, J.2
-
61
-
-
0030070486
-
Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro
-
Zagzag, D.; Friedlander, D.R.; Dosik, J.; Chikramane, S.; Chan, W.; Greco, M.A.; Allen, J.C.; Dorovini-Zis, K.; Grumet, M. Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro. Cancer Res. 1996, 56, 182-89.
-
(1996)
Cancer Res
, vol.56
, pp. 182-189
-
-
Zagzag, D.1
Friedlander, D.R.2
Dosik, J.3
Chikramane, S.4
Chan, W.5
Greco, M.A.6
Allen, J.C.7
Dorovini-Zis, K.8
Grumet, M.9
-
62
-
-
67650713544
-
Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas
-
Wong, M.L.; Prawira, A.; Kaye, A.H.; Hovens, C.M. Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas. J. Clin. Neurosci. 2009, 16, 1119-1130.
-
(2009)
J. Clin. Neurosci
, vol.16
, pp. 1119-1130
-
-
Wong, M.L.1
Prawira, A.2
Kaye, A.H.3
Hovens, C.M.4
-
63
-
-
33645821049
-
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
-
Vajkoczy, P.; Knyazev, P.; Kunkel, A.; Capelle, H.H.; Behrndt, S.; von Tengg-Kobligk, H.; Kiessling, F.; Eichelsbacher, U.; Essig, M.; Read, T.A.; et al. Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. Proc. Natl. Acad. Sci. USA 2006, 103, 5799-5804.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5799-5804
-
-
Vajkoczy, P.1
Knyazev, P.2
Kunkel, A.3
Capelle, H.H.4
Behrndt, S.5
von Tengg-Kobligk, H.6
Kiessling, F.7
Eichelsbacher, U.8
Essig, M.9
Read, T.A.10
-
64
-
-
0025147270
-
Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro
-
Lund-Johansen, M.; Bjerkvig, R.; Humphrey, P.A.; Bigner, S.H.; Bigner, D.D.; Laerum, O.D. Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro. Cancer Res. 1990, 50, 6039-6044.
-
(1990)
Cancer Res
, vol.50
, pp. 6039-6044
-
-
Lund-Johansen, M.1
Bjerkvig, R.2
Humphrey, P.A.3
Bigner, S.H.4
Bigner, D.D.5
Laerum, O.D.6
-
65
-
-
0041806539
-
Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2
-
Hu, B.; Guo, P.; Fang, Q.; Tao, H.Q.; Wang, D.; Nagane, M.; Huang, H.J.; Gunji, Y.; Nishikawa, R.; Alitalo, K.; et al. Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc. Natl. Acad. Sci. USA 2003, 100, 8904-8909.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8904-8909
-
-
Hu, B.1
Guo, P.2
Fang, Q.3
Tao, H.Q.4
Wang, D.5
Nagane, M.6
Huang, H.J.7
Gunji, Y.8
Nishikawa, R.9
Alitalo, K.10
-
66
-
-
33645320530
-
Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2
-
Ram, R.; Lorente, G.; Nikolich, K.; Urfer, R.; Foehr, E.; Nagavarapu, U. Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2. J. Neurooncol. 2006, 76, 239-248.
-
(2006)
J. Neurooncol
, vol.76
, pp. 239-248
-
-
Ram, R.1
Lorente, G.2
Nikolich, K.3
Urfer, R.4
Foehr, E.5
Nagavarapu, U.6
-
67
-
-
0030465547
-
Diffuse brain invasion of glioma cells requires beta 1 integrins
-
Paulus, W.; Baur, I.; Beutler, A.S.; Reeves, S.A. Diffuse brain invasion of glioma cells requires beta 1 integrins. Lab. Invest. 1996, 75, 819-826.
-
(1996)
Lab. Invest
, vol.75
, pp. 819-826
-
-
Paulus, W.1
Baur, I.2
Beutler, A.S.3
Reeves, S.A.4
-
68
-
-
0035542984
-
Molecular characterization of cell substratum attachments in human glial tumors relates to prognostic features
-
Belot, N.; Rorive, S.; Doyen, I.; Lefranc, F.; Bruyneel, E.; Dedecker, R.; Micik, S.; Brotchi, J.; Decaestecker, C.; Salmon, I.; et al. Molecular characterization of cell substratum attachments in human glial tumors relates to prognostic features. Glia 2001, 36, 375-390.
-
(2001)
Glia
, vol.36
, pp. 375-390
-
-
Belot, N.1
Rorive, S.2
Doyen, I.3
Lefranc, F.4
Bruyneel, E.5
Dedecker, R.6
Micik, S.7
Brotchi, J.8
Decaestecker, C.9
Salmon, I.10
-
69
-
-
0031594731
-
Integrin alpha3beta1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells
-
Fukushima, Y.; Ohnishi, T.; Arita, N.; Hayakawa, T.; Sekiguchi, K. Integrin alpha3beta1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells. Int. J. Cancer 1998, 76, 63-72.
-
(1998)
Int. J. Cancer
, vol.76
, pp. 63-72
-
-
Fukushima, Y.1
Ohnishi, T.2
Arita, N.3
Hayakawa, T.4
Sekiguchi, K.5
-
70
-
-
0036144093
-
CD44 expression in human gliomas
-
discussion 35-36
-
Ranuncolo, S.M.; Ladeda, V.; Specterman, S.; Varela, M.; Lastiri, J.; Morandi, A.; Matos, E.; Bal de Kier Joffe, E.; Puricelli, L.; Pallotta, M.G. CD44 expression in human gliomas. J. Surg. Oncol. 2002, 79, 30-35; discussion 35-36.
-
(2002)
J. Surg. Oncol
, vol.79
, pp. 30-35
-
-
Ranuncolo, S.M.1
Ladeda, V.2
Specterman, S.3
Varela, M.4
Lastiri, J.5
Morandi, A.6
Matos, E.7
de Kierjoffe, E.B.8
Puricelli, L.9
Pallotta, M.G.10
-
71
-
-
0033580237
-
CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
-
Okamoto, I.; Kawano, Y.; Tsuiki, H.; Sasaki, J.; Nakao, M.; Matsumoto, M.; Suga, M.; Ando, M.; Nakajima, M.; Saya, H. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene 1999, 18, 1435-1446.
-
(1999)
Oncogene
, vol.18
, pp. 1435-1446
-
-
Okamoto, I.1
Kawano, Y.2
Tsuiki, H.3
Sasaki, J.4
Nakao, M.5
Matsumoto, M.6
Suga, M.7
Ando, M.8
Nakajima, M.9
Saya, H.10
-
72
-
-
0036174344
-
Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors
-
Okamoto, I.; Tsuiki, H.; Kenyon, L.C.; Godwin, A.K.; Emlet, D.R.; Holgado-Madruga, M.; Lanham, I.S.; Joynes, C.J.; Vo, K.T.; Guha, A.; et al. Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors. Am. J. Pathol. 2002, 160, 441-447.
-
(2002)
Am. J. Pathol
, vol.160
, pp. 441-447
-
-
Okamoto, I.1
Tsuiki, H.2
Kenyon, L.C.3
Godwin, A.K.4
Emlet, D.R.5
Holgado-Madruga, M.6
Lanham, I.S.7
Joynes, C.J.8
Vo, K.T.9
Guha, A.10
-
73
-
-
11844256383
-
Mechanism and biological significance of CD44 cleavage
-
Nagano, O.; Saya, H. Mechanism and biological significance of CD44 cleavage. Cancer Sci. 2004, 95, 930-935.
-
(2004)
Cancer Sci
, vol.95
, pp. 930-935
-
-
Nagano, O.1
Saya, H.2
-
74
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S.; Hall, A. Rho GTPases in cell biology. Nature 2002, 420, 629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
75
-
-
8544283078
-
Role of synaptojanin 2 in glioma cell migration and invasion
-
Chuang, Y.Y.; Tran, N.L.; Rusk, N.; Nakada, M.; Berens, M.E.; Symons, M. Role of synaptojanin 2 in glioma cell migration and invasion. Cancer Res. 2004, 64, 8271-8275.
-
(2004)
Cancer Res
, vol.64
, pp. 8271-8275
-
-
Chuang, Y.Y.1
Tran, N.L.2
Rusk, N.3
Nakada, M.4
Berens, M.E.5
Symons, M.6
-
76
-
-
25444528940
-
Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1
-
Salhia, B.; Rutten, F.; Nakada, M.; Beaudry, C.; Berens, M.; Kwan, A.; Rutka, J.T. Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1. Cancer Res. 2005, 65, 8792-8800.
-
(2005)
Cancer Res
, vol.65
, pp. 8792-8800
-
-
Salhia, B.1
Rutten, F.2
Nakada, M.3
Beaudry, C.4
Berens, M.5
Kwan, A.6
Rutka, J.T.7
-
77
-
-
37249066605
-
Uncovering therapeutic targets for glioblastoma: A systems biology approach
-
Huang, P.H.; Cavenee, W.K.; Furnari, F.B.; White, F.M. Uncovering therapeutic targets for glioblastoma: A systems biology approach. Cell Cycle 2007, 6, 2750-2754.
-
(2007)
Cell Cycle
, vol.6
, pp. 2750-2754
-
-
Huang, P.H.1
Cavenee, W.K.2
Furnari, F.B.3
White, F.M.4
-
78
-
-
31544454386
-
Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells
-
Ramnarain, D.B.; Park, S.; Lee, D.Y.; Hatanpaa, K.J.; Scoggin, S.O.; Otu, H.; Libermann, T.A.; Raisanen, J.M.; Ashfaq, R.; Wong, E.T. et al. Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells. Cancer Res. 2006, 66, 867-874.
-
(2006)
Cancer Res
, vol.66
, pp. 867-874
-
-
Ramnarain, D.B.1
Park, S.2
Lee, D.Y.3
Hatanpaa, K.J.4
Scoggin, S.O.5
Otu, H.6
Libermann, T.A.7
Raisanen, J.M.8
Ashfaq, R.9
Wong, E.T.10
-
79
-
-
78649831949
-
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells
-
Sunayama, J.; Matsuda, K.; Sato, A.; Tachibana, K.; Suzuki, K.; Narita, Y.; Shibui, S.; Sakurada, K.; Kayama, T.; Tomiyama, A. et al. Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells 2010, 28, 1930-1939.
-
(2010)
Stem Cells
, vol.28
, pp. 1930-1939
-
-
Sunayama, J.1
Matsuda, K.2
Sato, A.3
Tachibana, K.4
Suzuki, K.5
Narita, Y.6
Shibui, S.7
Sakurada, K.8
Kayama, T.9
Tomiyama, A.10
-
80
-
-
0034766198
-
Glioma cell motility is associated with reduced transcription of proapoptotic and proliferation genes: A cDNA microarray analysis
-
Mariani, L.; Beaudry, C.; McDonough, W.S.; Hoelzinger, D.B.; Demuth, T.; Ross, K.R.; Berens, T.; Coons, S.W.; Watts, G.; Trent, J.M. et al. Glioma cell motility is associated with reduced transcription of proapoptotic and proliferation genes: A cDNA microarray analysis. J. Neurooncol. 2001, 53, 161-176.
-
(2001)
J. Neurooncol
, vol.53
, pp. 161-176
-
-
Mariani, L.1
Beaudry, C.2
McDonough, W.S.3
Hoelzinger, D.B.4
Demuth, T.5
Ross, K.R.6
Berens, T.7
Coons, S.W.8
Watts, G.9
Trent, J.M.10
-
81
-
-
33947381317
-
PIK3CA alterations in primary (de novo) and secondary glioblastomas
-
Kita, D.; Yonekawa, Y.; Weller, M.; Ohgaki, H. PIK3CA alterations in primary (de novo) and secondary glioblastomas. Acta Neuropathol. 2007, 113, 295-302.
-
(2007)
Acta Neuropathol
, vol.113
, pp. 295-302
-
-
Kita, D.1
Yonekawa, Y.2
Weller, M.3
Ohgaki, H.4
-
82
-
-
0022372783
-
Amplification and overexpression of the EGF receptor gene in primary human glioblastomas
-
Libermann, T.A.; Nusbaum, H.R.; Razon, N.; Kris, R.; Lax, I.; Soreq, H.; Whittle, N.; Waterfield, M.D.; Ullrich, A.; Schlessinger, J. Amplification and overexpression of the EGF receptor gene in primary human glioblastomas. J. Cell Sci. Suppl. 1985, 3, 161-172.
-
(1985)
J. Cell Sci. Suppl
, vol.3
, pp. 161-172
-
-
Libermann, T.A.1
Nusbaum, H.R.2
Razon, N.3
Kris, R.4
Lax, I.5
Soreq, H.6
Whittle, N.7
Waterfield, M.D.8
Ullrich, A.9
Schlessinger, J.10
-
83
-
-
0026521394
-
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
-
Ekstrand, A.J.; Sugawa, N.; James, C.D.; Collins, V.P. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc. Natl. Acad. Sci. USA 1992, 89, 4309-4313.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4309-4313
-
-
Ekstrand, A.J.1
Sugawa, N.2
James, C.D.3
Collins, V.P.4
-
84
-
-
4944255253
-
Genetic pathways to glioblastoma: A population-based study
-
Ohgaki, H.; Dessen, P.; Jourde, B.; Horstmann, S.; Nishikawa, T.; Di Patre, P.L.; Burkhard, C.; Schuler, D.; Probst-Hensch, N.M.; Maiorka, P.C. et al. Genetic pathways to glioblastoma: A population-based study. Cancer Res. 2004, 64, 6892-6899.
-
(2004)
Cancer Res
, vol.64
, pp. 6892-6899
-
-
Ohgaki, H.1
Dessen, P.2
Jourde, B.3
Horstmann, S.4
Nishikawa, T.5
di Patre, P.L.6
Burkhard, C.7
Schuler, D.8
Probst-Hensch, N.M.9
Maiorka, P.C.10
-
85
-
-
0023912033
-
Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors
-
Yamazaki, H.; Fukui, Y.; Ueyama, Y.; Tamaoki, N.; Kawamoto, T.; Taniguchi, S.; Shibuya, M. Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors. Mol. Cell. Biol. 1988, 8, 1816-1820.
-
(1988)
Mol. Cell. Biol
, vol.8
, pp. 1816-1820
-
-
Yamazaki, H.1
Fukui, Y.2
Ueyama, Y.3
Tamaoki, N.4
Kawamoto, T.5
Taniguchi, S.6
Shibuya, M.7
-
86
-
-
2442676505
-
Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas
-
Biernat, W.; Huang, H.; Yokoo, H.; Kleihues, P.; Ohgaki, H. Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol. 2004, 14, 131-136.
-
(2004)
Brain Pathol
, vol.14
, pp. 131-136
-
-
Biernat, W.1
Huang, H.2
Yokoo, H.3
Kleihues, P.4
Ohgaki, H.5
-
87
-
-
0032763824
-
Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens
-
Feldkamp, M.M.; Lala, P.; Lau, N.; Roncari, L.; Guha, A. Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens. Neurosurgery 1999, 45, 1442-1453.
-
(1999)
Neurosurgery
, vol.45
, pp. 1442-1453
-
-
Feldkamp, M.M.1
Lala, P.2
Lau, N.3
Roncari, L.4
Guha, A.5
-
88
-
-
0035479296
-
EGFR overexpression and radiation response in glioblastoma multiforme
-
Barker, F.G., 2nd; Simmons, M.L.; Chang, S.M.; Prados, M.D.; Larson, D.A.; Sneed, P.K.; Wara, W.M.; Berger, M.S.; Chen, P.; Israel, M.A. et al. EGFR overexpression and radiation response in glioblastoma multiforme. Int. J. Radiat. Oncol. Biol. Phys. 2001, 51, 410-418.
-
(2001)
Int. J. Radiat. Oncol. Biol. Phys
, vol.51
, pp. 410-418
-
-
Barker II, F.G.1
Simmons, M.L.2
Chang, S.M.3
Prados, M.D.4
Larson, D.A.5
Sneed, P.K.6
Wara, W.M.7
Berger, M.S.8
Chen, P.9
Israel, M.A.10
-
89
-
-
0142188691
-
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
-
Shinojima, N.; Tada, K.; Shiraishi, S.; Kamiryo, T.; Kochi, M.; Nakamura, H.; Makino, K.; Saya, H.; Hirano, H.; Kuratsu, J. et al. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res. 2003, 63, 6962-6970.
-
(2003)
Cancer Res
, vol.63
, pp. 6962-6970
-
-
Shinojima, N.1
Tada, K.2
Shiraishi, S.3
Kamiryo, T.4
Kochi, M.5
Nakamura, H.6
Makino, K.7
Saya, H.8
Hirano, H.9
Kuratsu, J.10
-
90
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak, R.G.; Hoadley, K.A.; Purdom, E.; Wang, V.; Qi, Y.; Wilkerson, M.D.; Miller, C.R.; Ding, L.; Golub, T.; Mesirov, J.P. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010, 17, 98-110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
Wang, V.4
Qi, Y.5
Wilkerson, M.D.6
Miller, C.R.7
Ding, L.8
Golub, T.9
Mesirov, J.P.10
-
91
-
-
4644238311
-
EGFR mutations and sensitivity to gefitinib
-
author reply 1260-1261
-
Rich, J.N.; Rasheed, B.K.; Yan, H. EGFR mutations and sensitivity to gefitinib. N. Engl. J. Med. 2004, 351, 1260-1261; author reply 1260-1261.
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 1260-1261
-
-
Rich, J.N.1
Rasheed, B.K.2
Yan, H.3
-
92
-
-
21444450373
-
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
-
Haas-Kogan, D.A.; Prados, M.D.; Tihan, T.; Eberhard, D.A.; Jelluma, N.; Arvold, N.D.; Baumber, R.; Lamborn, K.R.; Kapadia, A.; Malec, M. et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J. Natl. Cancer Inst. 2005, 97, 880-887.
-
(2005)
J. Natl. Cancer Inst
, vol.97
, pp. 880-887
-
-
Haas-Kogan, D.A.1
Prados, M.D.2
Tihan, T.3
Eberhard, D.A.4
Jelluma, N.5
Arvold, N.D.6
Baumber, R.7
Lamborn, K.R.8
Kapadia, A.9
Malec, M.10
-
93
-
-
62449150719
-
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
-
van den Bent, M.J.; Brandes, A.A.; Rampling, R.; Kouwenhoven, M.C.; Kros, J.M.; Carpentier, A.F.; Clement, P.M.; Frenay, M.; Campone, M.; Baurain, J.F. et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J. Clin. Oncol. 2009, 27, 1268-1274.
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 1268-1274
-
-
van den Bent, M.J.1
Brandes, A.A.2
Rampling, R.3
Kouwenhoven, M.C.4
Kros, J.M.5
Carpentier, A.F.6
Clement, P.M.7
Frenay, M.8
Campone, M.9
Baurain, J.F.10
-
94
-
-
0028911678
-
Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
-
Guha, A.; Dashner, K.; Black, P.M.; Wagner, J.A.; Stiles, C.D. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int. J. Cancer 1995, 60, 168-173.
-
(1995)
Int. J. Cancer
, vol.60
, pp. 168-173
-
-
Guha, A.1
Dashner, K.2
Black, P.M.3
Wagner, J.A.4
Stiles, C.D.5
-
95
-
-
0036645057
-
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
-
Lokker, N.A.; Sullivan, C.M.; Hollenbach, S.J.; Israel, M.A.; Giese, N.A. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 2002, 62, 3729-3735.
-
(2002)
Cancer Res
, vol.62
, pp. 3729-3735
-
-
Lokker, N.A.1
Sullivan, C.M.2
Hollenbach, S.J.3
Israel, M.A.4
Giese, N.A.5
-
96
-
-
33644830094
-
Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
-
Reardon, D.A.; Egorin, M.J.; Quinn, J.A.; Rich, J.N.; Gururangan, S.; Vredenburgh, J.J.; Desjardins, A.; Sathornsumetee, S.; Provenzale, J.M.; Herndon, J.E., 2nd.; et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J. lin. Oncol. 2005, 23, 9359-9368.
-
(2005)
J. Lin. Oncol
, vol.23
, pp. 9359-9368
-
-
Reardon, D.A.1
Egorin, M.J.2
Quinn, J.A.3
Rich, J.N.4
Gururangan, S.5
Vredenburgh, J.J.6
Desjardins, A.7
Sathornsumetee, S.8
Provenzale, J.M.9
Herndon II, J.E.10
-
97
-
-
71649102124
-
Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
-
Reardon, D.A.; Dresemann, G.; Taillibert, S.; Campone, M.; van den Bent, M.; Clement, P.; Blomquist, E.; Gordower, L.; Schultz, H.; Raizer, J. et al. Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br. J. Cancer 2009, 101, 1995-2004.
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1995-2004
-
-
Reardon, D.A.1
Dresemann, G.2
Taillibert, S.3
Campone, M.4
van den Bent, M.5
Clement, P.6
Blomquist, E.7
Gordower, L.8
Schultz, H.9
Raizer, J.10
-
98
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco, I.; Sawyers, C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2, 489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
99
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels, Y.; Wang, Z.; Bardelli, A.; Silliman, N.; Ptak, J.; Szabo, S.; Yan, H.; Gazdar, A.; Powell, S.M.; Riggins, G.J. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304, 554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
-
100
-
-
2342632542
-
Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment
-
Workman, P. Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment. Biochem. Soc. Trans. 2004, 32, 393-396.
-
(2004)
Biochem. Soc. Trans
, vol.32
, pp. 393-396
-
-
Workman, P.1
-
101
-
-
3643119742
-
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
-
Furnari, F.B.; Huang, H.J.; Cavenee, W.K. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res. 1998, 58, 5002-5008.
-
(1998)
Cancer Res
, vol.58
, pp. 5002-5008
-
-
Furnari, F.B.1
Huang, H.J.2
Cavenee, W.K.3
-
102
-
-
0038615946
-
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo
-
Choe, G.; Horvath, S.; Cloughesy, T.F.; Crosby, K.; Seligson, D.; Palotie, A.; Inge, L.; Smith, B.L.; Sawyers, C.L.; Mischel, P.S. Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res. 2003, 63, 2742-2746.
-
(2003)
Cancer Res
, vol.63
, pp. 2742-2746
-
-
Choe, G.1
Horvath, S.2
Cloughesy, T.F.3
Crosby, K.4
Seligson, D.5
Palotie, A.6
Inge, L.7
Smith, B.L.8
Sawyers, C.L.9
Mischel, P.S.10
-
103
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J.; Yen, C.; Liaw, D.; Podsypanina, K.; Bose, S.; Wang, S.I.; Puc, J.; Miliaresis, C.; Rodgers, L.; McCombie, R. et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275, 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
-
104
-
-
0031840405
-
PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas
-
Tohma, Y.; Gratas, C.; Biernat, W.; Peraud, A.; Fukuda, M.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H. PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. J. Neuropathol. Exp. Neurol. 1998, 57, 684-689.
-
(1998)
J. Neuropathol. Exp. Neurol
, vol.57
, pp. 684-689
-
-
Tohma, Y.1
Gratas, C.2
Biernat, W.3
Peraud, A.4
Fukuda, M.5
Yonekawa, Y.6
Kleihues, P.7
Ohgaki, H.8
-
105
-
-
0032558822
-
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
-
Haas-Kogan, D.; Shalev, N.; Wong, M.; Mills, G.; Yount, G.; Stokoe, D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol. 1998, 8, 1195-1198.
-
(1998)
Curr. Biol
, vol.8
, pp. 1195-1198
-
-
Haas-Kogan, D.1
Shalev, N.2
Wong, M.3
Mills, G.4
Yount, G.5
Stokoe, D.6
-
106
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff, I.K.; Wang, M.Y.; Vivanco, I.; Haas-Kogan, D.A.; Zhu, S.; Dia, E.Q.; Lu, K.V.; Yoshimoto, K.; Huang, J.H.; Chute, D.J. et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 2005, 353, 2012-2024.
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
Haas-Kogan, D.A.4
Zhu, S.5
Dia, E.Q.6
Lu, K.V.7
Yoshimoto, K.8
Huang, J.H.9
Chute, D.J.10
-
107
-
-
66249107937
-
Absence of AKT1 mutations in glioblastoma
-
Bleeker, F.E.; Lamba, S.; Zanon, C.; van Tilborg, A.A.; Leenstra, S.; Troost, D.; Hulsebos, T.; Vandertop, W.P.; Bardelli, A. Absence of AKT1 mutations in glioblastoma. PLoS One 2009, 4, e5638.
-
(2009)
PLoS One
, vol.4
-
-
Bleeker, F.E.1
Lamba, S.2
Zanon, C.3
van Tilborg, A.A.4
Leenstra, S.5
Troost, D.6
Hulsebos, T.7
Vandertop, W.P.8
Bardelli, A.9
-
108
-
-
60349088457
-
Perifosine: Update on a novel Akt inhibitor
-
Gills, J.J.; Dennis, P.A. Perifosine: Update on a novel Akt inhibitor. Curr. Oncol. Rep. 2009, 11, 102-110.
-
(2009)
Curr. Oncol. Rep
, vol.11
, pp. 102-110
-
-
Gills, J.J.1
Dennis, P.A.2
-
109
-
-
21044431575
-
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
-
Chang, S.M.; Wen, P.; Cloughesy, T.; Greenberg, H.; Schiff, D.; Conrad, C.; Fink, K.; Robins, H.I.; De Angelis, L.; Raizer, J. et al. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest. New Drugs 2005, 23, 357-361.
-
(2005)
Invest. New Drugs
, vol.23
, pp. 357-361
-
-
Chang, S.M.1
Wen, P.2
Cloughesy, T.3
Greenberg, H.4
Schiff, D.5
Conrad, C.6
Fink, K.7
Robins, H.I.8
de Angelis, L.9
Raizer, J.10
-
110
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis, E.; Buckner, J.C.; Maurer, M.J.; Kreisberg, J.I.; Ballman, K.; Boni, J.; Peralba, J.M.; Jenkins, R.B.; Dakhil, S.R.; Morton, R.F. et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study. J. Clin. Oncol. 2005, 23, 5294-5304.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
Kreisberg, J.I.4
Ballman, K.5
Boni, J.6
Peralba, J.M.7
Jenkins, R.B.8
Dakhil, S.R.9
Morton, R.F.10
-
111
-
-
0029397307
-
The p53 gene and its role in human brain tumors
-
Bogler, O.; Huang, H.J.; Kleihues, P.; Cavenee, W.K. The p53 gene and its role in human brain tumors. Glia 1995, 15, 308-327.
-
(1995)
Glia
, vol.15
, pp. 308-327
-
-
Bogler, O.1
Huang, H.J.2
Kleihues, P.3
Cavenee, W.K.4
-
112
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
Harper, J.W.; Adami, G.R.; Wei, N.; Keyomarsi, K.; Elledge, S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75, 805-816.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
113
-
-
0032169516
-
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
-
Stott, F.J.; Bates, S.; James, M.C.; McConnell, B.B.; Starborg, M.; Brookes, S.; Palmero, I.; Ryan, K.; Hara, E.; Vousden, K.H. et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J. 1998, 17, 5001-5014.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
McConnell, B.B.4
Starborg, M.5
Brookes, S.6
Palmero, I.7
Ryan, K.8
Hara, E.9
Vousden, K.H.10
-
114
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner, J.D.; Kinzler, K.W.; Meltzer, P.S.; George, D.L.; Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992, 358, 80-83.
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
115
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat, M.H.; Jones, S.N.; Vousden, K.H. Regulation of p53 stability by Mdm2. Nature 1997, 387, 299-303.
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
116
-
-
0028049474
-
Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
-
Barak, Y.; Gottlieb, E.; Juven-Gershon, T.; Oren, M. Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 1994, 8, 1739-1749.
-
(1994)
Genes Dev
, vol.8
, pp. 1739-1749
-
-
Barak, Y.1
Gottlieb, E.2
Juven-Gershon, T.3
Oren, M.4
-
117
-
-
0029131447
-
A functional p53-responsive intronic promoter is contained within the human mdm2 gene
-
Zauberman, A.; Flusberg, D.; Haupt, Y.; Barak, Y.; Oren, M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 1995, 23, 2584-2592.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2584-2592
-
-
Zauberman, A.1
Flusberg, D.2
Haupt, Y.3
Barak, Y.4
Oren, M.5
-
118
-
-
0028982932
-
A novel p16INK4A transcript
-
Mao, L.; Merlo, A.; Bedi, G.; Shapiro, G.I.; Edwards, C.D.; Rollins, B.J.; Sidransky, D. A novel p16INK4A transcript. Cancer Res. 1995, 55, 2995-2997.
-
(1995)
Cancer Res
, vol.55
, pp. 2995-2997
-
-
Mao, L.1
Merlo, A.2
Bedi, G.3
Shapiro, G.I.4
Edwards, C.D.5
Rollins, B.J.6
Sidransky, D.7
-
119
-
-
0032493350
-
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
-
Kamijo, T.; Weber, J.D.; Zambetti, G.; Zindy, F.; Roussel, M.F.; Sherr, C.J. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. USA 1998, 95, 8292-8297.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8292-8297
-
-
Kamijo, T.1
Weber, J.D.2
Zambetti, G.3
Zindy, F.4
Roussel, M.F.5
Sherr, C.J.6
-
120
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang, Y.; Xiong, Y.; Yarbrough, W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998, 92, 725-734.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
121
-
-
70449711757
-
Genetic alterations and signaling pathways in the evolution of gliomas
-
Ohgaki, H.; Kleihues, P. Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci. 2009, 100, 2235-2241.
-
(2009)
Cancer Sci
, vol.100
, pp. 2235-2241
-
-
Ohgaki, H.1
Kleihues, P.2
-
122
-
-
70349653793
-
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
-
Nobusawa, S.; Watanabe, T.; Kleihues, P.; Ohgaki, H. IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin. Cancer Res. 2009, 15, 6002-6007.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 6002-6007
-
-
Nobusawa, S.1
Watanabe, T.2
Kleihues, P.3
Ohgaki, H.4
-
123
-
-
65349150503
-
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
-
Watanabe, T.; Nobusawa, S.; Kleihues, P.; Ohgaki, H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am. J. Pathol. 2009, 174, 1149-1153.
-
(2009)
Am. J. Pathol
, vol.174
, pp. 1149-1153
-
-
Watanabe, T.1
Nobusawa, S.2
Kleihues, P.3
Ohgaki, H.4
-
124
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H.; Parsons, D.W.; Jin, G.; McLendon, R.; Rasheed, B.A.; Yuan, W.; Kos, I.; Batinic-Haberle, I.; Jones, S.; Riggins, G.J. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 2009, 360, 765-773.
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
Kos, I.7
Batinic-Haberle, I.8
Jones, S.9
Riggins, G.J.10
-
125
-
-
67349220062
-
Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome
-
Watanabe, T.; Vital, A.; Nobusawa, S.; Kleihues, P.; Ohgaki, H. Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome. Acta Neuropathol. 2009, 117, 653-656.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 653-656
-
-
Watanabe, T.1
Vital, A.2
Nobusawa, S.3
Kleihues, P.4
Ohgaki, H.5
-
126
-
-
78650682939
-
Isocitrate dehydrogenase-1 mutations: A fundamentally new understanding of diffuse glioma
-
Kloosterhof, N.K.; Bralten, L.B.; Dubbink, H.J.; French, P.J.; van den Bent, M.J. Isocitrate dehydrogenase-1 mutations: A fundamentally new understanding of diffuse glioma? Lancet Oncol. 2011, 12, 83-91.
-
(2011)
Lancet Oncol
, vol.12
, pp. 83-91
-
-
Kloosterhof, N.K.1
Bralten, L.B.2
Dubbink, H.J.3
French, P.J.4
van den Bent, M.J.5
-
127
-
-
0030917734
-
Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies
-
Watanabe, K.; Sato, K.; Biernat, W.; Tachibana, O.; von Ammon, K.; Ogata, N.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H. Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies. Clin. Cancer Res. 1997, 3, 523-530.
-
(1997)
Clin. Cancer Res
, vol.3
, pp. 523-530
-
-
Watanabe, K.1
Sato, K.2
Biernat, W.3
Tachibana, O.4
von Ammon, K.5
Ogata, N.6
Yonekawa, Y.7
Kleihues, P.8
Ohgaki, H.9
-
128
-
-
34250877865
-
Genetic pathways to primary and secondary glioblastoma
-
Ohgaki, H.; Kleihues, P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 2007, 170, 1445-1453.
-
(2007)
Am. J. Pathol
, vol.170
, pp. 1445-1453
-
-
Ohgaki, H.1
Kleihues, P.2
-
129
-
-
0027196974
-
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
-
Reifenberger, G.; Liu, L.; Ichimura, K.; Schmidt, E.E.; Collins, V.P. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 1993, 53, 2736-2739.
-
(1993)
Cancer Res
, vol.53
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
Schmidt, E.E.4
Collins, V.P.5
-
130
-
-
0034649787
-
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
-
Ichimura, K.; Bolin, M.B.; Goike, H.M.; Schmidt, E.E.; Moshref, A.; Collins, V.P. Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res. 2000, 60, 417-424.
-
(2000)
Cancer Res
, vol.60
, pp. 417-424
-
-
Ichimura, K.1
Bolin, M.B.2
Goike, H.M.3
Schmidt, E.E.4
Moshref, A.5
Collins, V.P.6
-
131
-
-
0034745338
-
P14arf deletion and methylation in genetic pathways to glioblastomas
-
Nakamura, M.; Watanabe, T.; Klangby, U.; Asker, C.; Wiman, K.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H. P14arf deletion and methylation in genetic pathways to glioblastomas. Brain Pathol. 2001, 11, 159-168.
-
(2001)
Brain Pathol
, vol.11
, pp. 159-168
-
-
Nakamura, M.1
Watanabe, T.2
Klangby, U.3
Asker, C.4
Wiman, K.5
Yonekawa, Y.6
Kleihues, P.7
Ohgaki, H.8
-
132
-
-
78650014447
-
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas
-
Squatrito, M.; Brennan, C.W.; Helmy, K.; Huse, J.T.; Petrini, J.H.; Holland, E.C. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell 2010, 18, 619-629.
-
(2010)
Cancer Cell
, vol.18
, pp. 619-629
-
-
Squatrito, M.1
Brennan, C.W.2
Helmy, K.3
Huse, J.T.4
Petrini, J.H.5
Holland, E.C.6
-
133
-
-
0035313706
-
DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
-
Durocher, D.; Jackson, S.P. DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme? Curr. Opin. Cell Biol. 2001, 13, 225-231.
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 225-231
-
-
Durocher, D.1
Jackson, S.P.2
-
134
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. ATM and related protein kinases: Safeguarding genome integrity. Nat. Rev. Cancer 2003, 3, 155-168.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
135
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek, J.; Lukas, J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003, 3, 421-429.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
136
-
-
68249126215
-
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
-
Stracker, T.H.; Usui, T.; Petrini, J.H. Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) 2009, 8, 1047-1054.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1047-1054
-
-
Stracker, T.H.1
Usui, T.2
Petrini, J.H.3
-
137
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao, A.; Kong, Y.Y.; Matsuoka, S.; Wakeham, A.; Ruland, J.; Yoshida, H.; Liu, D.; Elledge, S.J.; Mak, T.W. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000, 287, 1824-1827.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
Yoshida, H.6
Liu, D.7
Elledge, S.J.8
Mak, T.W.9
-
138
-
-
0036724625
-
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
-
Hirao, A.; Cheung, A.; Duncan, G.; Girard, P.M.; Elia, A.J.; Wakeham, A.; Okada, H.; Sarkissian, T.; Wong, J.A.; Sakai, T. et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol. Cell. Biol. 2002, 22, 6521-6532.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 6521-6532
-
-
Hirao, A.1
Cheung, A.2
Duncan, G.3
Girard, P.M.4
Elia, A.J.5
Wakeham, A.6
Okada, H.7
Sarkissian, T.8
Wong, J.A.9
Sakai, T.10
-
139
-
-
0034277902
-
Mutation analysis of the hCHK2 gene in primary human malignant gliomas
-
Ino, Y.; Wahrer, D.C.; Bell, D.W.; Haber, D.A.; Louis, D.N. Mutation analysis of the hCHK2 gene in primary human malignant gliomas. Neurogenetics 2000, 3, 45-46.
-
(2000)
Neurogenetics
, vol.3
, pp. 45-46
-
-
Ino, Y.1
Wahrer, D.C.2
Bell, D.W.3
Haber, D.A.4
Louis, D.N.5
-
140
-
-
23944501100
-
CHEK2 mutations in primary glioblastomas
-
Sallinen, S.L.; Ikonen, T.; Haapasalo, H.; Schleutker, J. CHEK2 mutations in primary glioblastomas. J. Neurooncol. 2005, 74, 93-95.
-
(2005)
J. Neurooncol
, vol.74
, pp. 93-95
-
-
Sallinen, S.L.1
Ikonen, T.2
Haapasalo, H.3
Schleutker, J.4
-
141
-
-
0028652269
-
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
-
Schmidt, E.E.; Ichimura, K.; Reifenberger, G.; Collins, V.P. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res. 1994, 54, 6321-6324.
-
(1994)
Cancer Res
, vol.54
, pp. 6321-6324
-
-
Schmidt, E.E.1
Ichimura, K.2
Reifenberger, G.3
Collins, V.P.4
-
142
-
-
0027978368
-
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2
-
Reifenberger, G.; Reifenberger, J.; Ichimura, K.; Meltzer, P.S.; Collins, V.P. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res. 1994, 54, 4299-4303.
-
(1994)
Cancer Res
, vol.54
, pp. 4299-4303
-
-
Reifenberger, G.1
Reifenberger, J.2
Ichimura, K.3
Meltzer, P.S.4
Collins, V.P.5
-
143
-
-
0028986612
-
Loss of P16INK4 expression is frequent in high grade gliomas
-
Nishikawa, R.; Furnari, F.B.; Lin, H.; Arap, W.; Berger, M.S.; Cavenee, W.K.; Su Huang, H.J. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995, 55, 1941-1945.
-
(1995)
Cancer Res
, vol.55
, pp. 1941-1945
-
-
Nishikawa, R.1
Furnari, F.B.2
Lin, H.3
Arap, W.4
Berger, M.S.5
Cavenee, W.K.6
Su, H.H.J.7
-
144
-
-
0031906358
-
Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas
-
Burns, K.L.; Ueki, K.; Jhung, S.L.; Koh, J.; Louis, D.N. Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas. J. Neuropathol. Exp. Neurol. 1998, 57, 122-130.
-
(1998)
J. Neuropathol. Exp. Neurol
, vol.57
, pp. 122-130
-
-
Burns, K.L.1
Ueki, K.2
Jhung, S.L.3
Koh, J.4
Louis, D.N.5
-
145
-
-
0030797470
-
Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme
-
Hayashi, Y.; Ueki, K.; Waha, A.; Wiestler, O.D.; Louis, D.N.; von Deimling, A. Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol. 1997, 7, 871-875.
-
(1997)
Brain Pathol
, vol.7
, pp. 871-875
-
-
Hayashi, Y.1
Ueki, K.2
Waha, A.3
Wiestler, O.D.4
Louis, D.N.5
von Deimling, A.6
-
146
-
-
1842330265
-
Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas
-
Hegi, M.E.; zur Hausen, A.; Ruedi, D.; Malin, G.; Kleihues, P. Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas. Int. J. Cancer 1997, 73, 57-63.
-
(1997)
Int. J. Cancer
, vol.73
, pp. 57-63
-
-
Hegi, M.E.1
Zur, H.A.2
Ruedi, D.3
Malin, G.4
Kleihues, P.5
-
147
-
-
33947098325
-
Recent developments in neurofibromatosis type 1
-
Lee, M.J.; Stephenson, D.A. Recent developments in neurofibromatosis type 1. Curr. Opin. Neurol. 2007, 20, 135-141.
-
(2007)
Curr. Opin. Neurol
, vol.20
, pp. 135-141
-
-
Lee, M.J.1
Stephenson, D.A.2
-
148
-
-
76549123056
-
Neurofibromatosis Type 1 and tumorigenesis: Molecular mechanisms and therapeutic implications
-
Gottfried, O.N.; Viskochil, D.H.; Couldwell, W.T. Neurofibromatosis Type 1 and tumorigenesis: Molecular mechanisms and therapeutic implications. Neurosurg. Focus 2010, 28, E8.
-
(2010)
Neurosurg. Focus
, vol.28
-
-
Gottfried, O.N.1
Viskochil, D.H.2
Couldwell, W.T.3
-
149
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos, J.L. Ras oncogenes in human cancer: A review. Cancer Res. 1989, 49, 4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
150
-
-
0037805547
-
RAS oncogenes: The first 30 years
-
Malumbres, M.; Barbacid, M. RAS oncogenes: The first 30 years. Nat. Rev. Cancer 2003, 3, 459-465.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
151
-
-
0031465906
-
Proliferation of human malignant astrocytomas is dependent on Ras activation
-
Guha, A.; Feldkamp, M.M.; Lau, N.; Boss, G.; Pawson, A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 1997, 15, 2755-2765.
-
(1997)
Oncogene
, vol.15
, pp. 2755-2765
-
-
Guha, A.1
Feldkamp, M.M.2
Lau, N.3
Boss, G.4
Pawson, A.5
-
152
-
-
66949147222
-
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
-
Sievert, A.J.; Jackson, E.M.; Gai, X.; Hakonarson, H.; Judkins, A.R.; Resnick, A.C.; Sutton, L.N.; Storm, P.B.; Shaikh, T.H.; Biegel, J.A. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathol. 2009, 19, 449-458.
-
(2009)
Brain Pathol
, vol.19
, pp. 449-458
-
-
Sievert, A.J.1
Jackson, E.M.2
Gai, X.3
Hakonarson, H.4
Judkins, A.R.5
Resnick, A.C.6
Sutton, L.N.7
Storm, P.B.8
Shaikh, T.H.9
Biegel, J.A.10
-
153
-
-
23944515326
-
Intracellular signal transduction pathway proteins as targets for cancer therapy
-
Adjei, A.A.; Hidalgo, M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J. Clin. Oncol. 2005, 23, 5386-5403.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 5386-5403
-
-
Adjei, A.A.1
Hidalgo, M.2
-
154
-
-
0038278706
-
Mitogenic signaling cascades in glial tumors
-
discussion 1434-1425
-
Kapoor, G.S.; O'Rourke, D.M. Mitogenic signaling cascades in glial tumors. Neurosurgery 2003, 52, 1425-1434; discussion 1434-1425.
-
(2003)
Neurosurgery
, vol.52
, pp. 1425-1434
-
-
Kapoor, G.S.1
O'Rourke, D.M.2
-
155
-
-
29644442764
-
Receptor tyrosine kinase signaling in gliomagenesis: Pathobiology and therapeutic approaches
-
Kapoor, G.S.; O'Rourke, D.M. Receptor tyrosine kinase signaling in gliomagenesis: Pathobiology and therapeutic approaches. Cancer Biol. Ther. 2003, 2, 330-342.
-
(2003)
Cancer Biol. Ther
, vol.2
, pp. 330-342
-
-
Kapoor, G.S.1
O'Rourke, D.M.2
-
156
-
-
77954341696
-
Survival signalling and apoptosis resistance in glioblastomas: Opportunities for targeted therapeutics
-
Krakstad, C.; Chekenya, M. Survival signalling and apoptosis resistance in glioblastomas: Opportunities for targeted therapeutics. Mol. Cancer 2010, 9, 135.
-
(2010)
Mol. Cancer
, vol.9
, pp. 135
-
-
Krakstad, C.1
Chekenya, M.2
-
157
-
-
0036737914
-
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
-
Ignatova, T.N.; Kukekov, V.G.; Laywell, E.D.; Suslov, O.N.; Vrionis, F.D.; Steindler, D.A. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002, 39, 193-206.
-
(2002)
Glia
, vol.39
, pp. 193-206
-
-
Ignatova, T.N.1
Kukekov, V.G.2
Laywell, E.D.3
Suslov, O.N.4
Vrionis, F.D.5
Steindler, D.A.6
-
158
-
-
0344735881
-
Cancerous stem cells can arise from pediatric brain tumors
-
Hemmati, H.D.; Nakano, I.; Lazareff, J.A.; Masterman-Smith, M.; Geschwind, D.H.; Bronner-Fraser, M.; Kornblum, H.I. Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl. Acad. Sci. USA 2003, 100, 15178-15183.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 15178-15183
-
-
Hemmati, H.D.1
Nakano, I.2
Lazareff, J.A.3
Masterman-Smith, M.4
Geschwind, D.H.5
Bronner-Fraser, M.6
Kornblum, H.I.7
-
159
-
-
4944250781
-
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
-
Galli, R.; Binda, E.; Orfanelli, U.; Cipelletti, B.; Gritti, A.; De Vitis, S.; Fiocco, R.; Foroni, C.; Dimeco, F.; Vescovi, A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004, 64, 7011-7021.
-
(2004)
Cancer Res
, vol.64
, pp. 7011-7021
-
-
Galli, R.1
Binda, E.2
Orfanelli, U.3
Cipelletti, B.4
Gritti, A.5
de Vitis, S.6
Fiocco, R.7
Foroni, C.8
Dimeco, F.9
Vescovi, A.10
-
160
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh, S.K.; Hawkins, C.; Clarke, I.D.; Squire, J.A.; Bayani, J.; Hide, T.; Henkelman, R.M.; Cusimano, M.D.; Dirks, P.B. Identification of human brain tumour initiating cells. Nature 2004, 432, 396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
Squire, J.A.4
Bayani, J.5
Hide, T.6
Henkelman, R.M.7
Cusimano, M.D.8
Dirks, P.B.9
-
161
-
-
23944445606
-
Neural stem cells and the origin of gliomas
-
Sanai, N.; Alvarez-Buylla, A.; Berger, M.S. Neural stem cells and the origin of gliomas. N. Engl. J. Med. 2005, 353, 811-822.
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 811-822
-
-
Sanai, N.1
Alvarez-Buylla, A.2
Berger, M.S.3
-
162
-
-
33745880884
-
PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
-
Jackson, E.L.; Garcia-Verdugo, J.M.; Gil-Perotin, S.; Roy, M.; Quinones-Hinojosa, A.; VandenBerg, S.; Alvarez-Buylla, A. PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 2006, 51, 187-199.
-
(2006)
Neuron
, vol.51
, pp. 187-199
-
-
Jackson, E.L.1
Garcia-Verdugo, J.M.2
Gil-Perotin, S.3
Roy, M.4
Quinones-Hinojosa, A.5
Vandenberg, S.6
Alvarez-Buylla, A.7
-
163
-
-
35348837163
-
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
-
Bar, E.E.; Chaudhry, A.; Lin, A.; Fan, X.; Schreck, K.; Matsui, W.; Piccirillo, S.; Vescovi, A.L.; DiMeco, F.; Olivi, A. et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 2007, 25, 2524-2533.
-
(2007)
Stem Cells
, vol.25
, pp. 2524-2533
-
-
Bar, E.E.1
Chaudhry, A.2
Lin, A.3
Fan, X.4
Schreck, K.5
Matsui, W.6
Piccirillo, S.7
Vescovi, A.L.8
Dimeco, F.9
Olivi, A.10
-
164
-
-
67650727135
-
BMI1 sustains human glioblastoma multiforme stem cell renewal
-
Abdouh, M.; Facchino, S.; Chatoo, W.; Balasingam, V.; Ferreira, J.; Bernier, G. BMI1 sustains human glioblastoma multiforme stem cell renewal. J. Neurosci. 2009, 29, 8884-8896.
-
(2009)
J. Neurosci
, vol.29
, pp. 8884-8896
-
-
Abdouh, M.1
Facchino, S.2
Chatoo, W.3
Balasingam, V.4
Ferreira, J.5
Bernier, G.6
-
165
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas, S.; Rand, M.D.; Lake, R.J. Notch signaling: Cell fate control and signal integration in development. Science 1999, 284, 770-776.
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
166
-
-
33747513134
-
Notch signalling regulates stem cell numbers in vitro and in vivo
-
Androutsellis-Theotokis, A.; Leker, R.R.; Soldner, F.; Hoeppner, D.J.; Ravin, R.; Poser, S.W.; Rueger, M.A.; Bae, S.K.; Kittappa, R.; McKay, R.D. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 2006, 442, 823-826.
-
(2006)
Nature
, vol.442
, pp. 823-826
-
-
Androutsellis-Theotokis, A.1
Leker, R.R.2
Soldner, F.3
Hoeppner, D.J.4
Ravin, R.5
Poser, S.W.6
Rueger, M.A.7
Bae, S.K.8
Kittappa, R.9
McKay, R.D.10
-
167
-
-
75349105363
-
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
-
Fan, X.; Khaki, L.; Zhu, T.S.; Soules, M.E.; Talsma, C.E.; Gul, N.; Koh, C.; Zhang, J.; Li, Y.M.; Maciaczyk, J. et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010, 28, 5-16.
-
(2010)
Stem Cells
, vol.28
, pp. 5-16
-
-
Fan, X.1
Khaki, L.2
Zhu, T.S.3
Soules, M.E.4
Talsma, C.E.5
Gul, N.6
Koh, C.7
Zhang, J.8
Li, Y.M.9
Maciaczyk, J.10
-
168
-
-
37349067098
-
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
-
Lee, J.; Son, M.J.; Woolard, K.; Donin, N.M.; Li, A.; Cheng, C.H.; Kotliarova, S.; Kotliarov, Y.; Walling, J.; Ahn, S. et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008, 13, 69-80.
-
(2008)
Cancer Cell
, vol.13
, pp. 69-80
-
-
Lee, J.1
Son, M.J.2
Woolard, K.3
Donin, N.M.4
Li, A.5
Cheng, C.H.6
Kotliarova, S.7
Kotliarov, Y.8
Walling, J.9
Ahn, S.10
-
169
-
-
17644368573
-
Interleukin-6: From basic science to medicine-40 years in immunology
-
Kishimoto, T. Interleukin-6: From basic science to medicine-40 years in immunology. Annu. Rev. Immunol. 2005, 23, 1-21.
-
(2005)
Annu. Rev. Immunol
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
170
-
-
2442657786
-
IL-6 is required for glioma development in a mouse model
-
Weissenberger, J.; Loeffler, S.; Kappeler, A.; Kopf, M.; Lukes, A.; Afanasieva, T.A.; Aguzzi, A.; Weis, J. IL-6 is required for glioma development in a mouse model. Oncogene 2004, 23, 3308-3316.
-
(2004)
Oncogene
, vol.23
, pp. 3308-3316
-
-
Weissenberger, J.1
Loeffler, S.2
Kappeler, A.3
Kopf, M.4
Lukes, A.5
Afanasieva, T.A.6
Aguzzi, A.7
Weis, J.8
-
171
-
-
49749129612
-
JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment
-
Su, Y.; Li, G.; Zhang, X.; Gu, J.; Zhang, C.; Tian, Z.; Zhang, J. JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment. Cancer Biol. Ther. 2008, 7, 1243-1249.
-
(2008)
Cancer Biol. Ther
, vol.7
, pp. 1243-1249
-
-
Su, Y.1
Li, G.2
Zhang, X.3
Gu, J.4
Zhang, C.5
Tian, Z.6
Zhang, J.7
-
172
-
-
0033517123
-
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
-
Matsuda, T.; Nakamura, T.; Nakao, K.; Arai, T.; Katsuki, M.; Heike, T.; Yokota, T. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J. 1999, 18, 4261-4269.
-
(1999)
EMBO J
, vol.18
, pp. 4261-4269
-
-
Matsuda, T.1
Nakamura, T.2
Nakao, K.3
Arai, T.4
Katsuki, M.5
Heike, T.6
Yokota, T.7
-
173
-
-
77649100933
-
Targeting A20 decreases glioma stem cell survival and tumor growth
-
Hjelmeland, A.B.; Wu, Q.; Wickman, S.; Eyler, C.; Heddleston, J.; Shi, Q.; Lathia, J.D.; Macswords, J.; Lee, J.; McLendon, R.E.; et al. Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol. 2010, 8, e1000319.
-
(2010)
PLoS Biol
, vol.8
-
-
Hjelmeland, A.B.1
Wu, Q.2
Wickman, S.3
Eyler, C.4
Heddleston, J.5
Shi, Q.6
Lathia, J.D.7
Macswords, J.8
Lee, J.9
McLendon, R.E.10
-
174
-
-
33646743584
-
Development of NG2 neural progenitor cells requires Olig gene function
-
Ligon, K.L.; Kesari, S.; Kitada, M.; Sun, T.; Arnett, H.A.; Alberta, J.A.; Anderson, D.J.; Stiles, C.D.; Rowitch, D.H. Development of NG2 neural progenitor cells requires Olig gene function. Proc. Natl. Acad. Sci. USA 2006, 103, 7853-7858.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 7853-7858
-
-
Ligon, K.L.1
Kesari, S.2
Kitada, M.3
Sun, T.4
Arnett, H.A.5
Alberta, J.A.6
Anderson, D.J.7
Stiles, C.D.8
Rowitch, D.H.9
-
175
-
-
33846815345
-
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
-
Ligon, K.L.; Huillard, E.; Mehta, S.; Kesari, S.; Liu, H.; Alberta, J.A.; Bachoo, R.M.; Kane, M.; Louis, D.N.; Depinho, R.A. et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 2007, 53, 503-517.
-
(2007)
Neuron
, vol.53
, pp. 503-517
-
-
Ligon, K.L.1
Huillard, E.2
Mehta, S.3
Kesari, S.4
Liu, H.5
Alberta, J.A.6
Bachoo, R.M.7
Kane, M.8
Louis, D.N.9
Depinho, R.A.10
-
176
-
-
73049104551
-
An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation
-
Wurdak, H.; Zhu, S.; Romero, A.; Lorger, M.; Watson, J.; Chiang, C.Y.; Zhang, J.; Natu, V.S.; Lairson, L.L.; Walker, J.R. et al. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell 2010, 6, 37-47.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 37-47
-
-
Wurdak, H.1
Zhu, S.2
Romero, A.3
Lorger, M.4
Watson, J.5
Chiang, C.Y.6
Zhang, J.7
Natu, V.S.8
Lairson, L.L.9
Walker, J.R.10
-
177
-
-
35148900227
-
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas
-
Corsten, M.F.; Miranda, R.; Kasmieh, R.; Krichevsky, A.M.; Weissleder, R.; Shah, K. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res. 2007, 67, 8994-9000.
-
(2007)
Cancer Res
, vol.67
, pp. 8994-9000
-
-
Corsten, M.F.1
Miranda, R.2
Kasmieh, R.3
Krichevsky, A.M.4
Weissleder, R.5
Shah, K.6
-
178
-
-
72849108572
-
The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors
-
Kefas, B.; Comeau, L.; Floyd, D.H.; Seleverstov, O.; Godlewski, J.; Schmittgen, T.; Jiang, J.; diPierro, C.G.; Li, Y.; Chiocca, E.A. et al. The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J. Neurosci. 2009, 29, 15161-15168.
-
(2009)
J. Neurosci
, vol.29
, pp. 15161-15168
-
-
Kefas, B.1
Comeau, L.2
Floyd, D.H.3
Seleverstov, O.4
Godlewski, J.5
Schmittgen, T.6
Jiang, J.7
Dipierro, C.G.8
Li, Y.9
Chiocca, E.A.10
-
179
-
-
77953498262
-
Microrna-34a is tumor suppressive in brain tumors and glioma stem cells
-
Guessous, F.; Zhang, Y.; Kofman, A.; Catania, A.; Li, Y.; Schiff, D.; Purow, B.; Abounader, R. Microrna-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 2010, 9, 1031-1036.
-
(2010)
Cell Cycle
, vol.9
, pp. 1031-1036
-
-
Guessous, F.1
Zhang, Y.2
Kofman, A.3
Catania, A.4
Li, Y.5
Schiff, D.6
Purow, B.7
Abounader, R.8
-
180
-
-
67649099677
-
Antiangiogenic strategies for treatment of malignant gliomas
-
Chi, A.S.; Norden, A.D.; Wen, P.Y. Antiangiogenic strategies for treatment of malignant gliomas. Neurotherapeutics 2009, 6, 513-526.
-
(2009)
Neurotherapeutics
, vol.6
, pp. 513-526
-
-
Chi, A.S.1
Norden, A.D.2
Wen, P.Y.3
-
181
-
-
55849130720
-
Novel anti-angiogenic therapies for malignant gliomas
-
Norden, A.D.; Drappatz, J.; Wen, P.Y. Novel anti-angiogenic therapies for malignant gliomas. Lancet Neurol. 2008, 7, 1152-1160.
-
(2008)
Lancet Neurol
, vol.7
, pp. 1152-1160
-
-
Norden, A.D.1
Drappatz, J.2
Wen, P.Y.3
-
182
-
-
33947732977
-
Angiogenesis: An organizing principle for drug discovery?
-
Folkman, J. Angiogenesis: An organizing principle for drug discovery? Nat. Rev. Drug Discov. 2007, 6, 273-286.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
183
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
Vredenburgh, J.J.; Desjardins, A.; Herndon, J.E., 2nd; Marcello, J.; Reardon, D.A.; Quinn, J.A.; Rich, J.N.; Sathornsumetee, S.; Gururangan, S.; Sampson, J. et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J. Clin. Oncol. 2007, 25, 4722-4729.
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon II, J.E.3
Marcello, J.4
Reardon, D.A.5
Quinn, J.A.6
Rich, J.N.7
Sathornsumetee, S.8
Gururangan, S.9
Sampson, J.10
-
184
-
-
75449088610
-
FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
-
Cohen, M.H.; Shen, Y.L.; Keegan, P.; Pazdur, R. FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist 2009, 14, 1131-1138.
-
(2009)
Oncologist
, vol.14
, pp. 1131-1138
-
-
Cohen, M.H.1
Shen, Y.L.2
Keegan, P.3
Pazdur, R.4
-
185
-
-
77950804823
-
A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry
-
El Hallani, S.; Boisselier, B.; Peglion, F.; Rousseau, A.; Colin, C.; Idbaih, A.; Marie, Y.; Mokhtari, K.; Thomas, J.L.; Eichmann, A. et al. A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry. Brain 2010, 133, 973-982.
-
(2010)
Brain
, vol.133
, pp. 973-982
-
-
Hallani, S.E.1
Boisselier, B.2
Peglion, F.3
Rousseau, A.4
Colin, C.5
Idbaih, A.6
Marie, Y.7
Mokhtari, K.8
Thomas, J.L.9
Eichmann, A.10
-
186
-
-
77950841050
-
Angiogenesis in glioblastoma: Just another moving target?
-
Weller, M. Angiogenesis in glioblastoma: Just another moving target? Brain 2010, 133, 955-956.
-
(2010)
Brain
, vol.133
, pp. 955-956
-
-
Weller, M.1
-
187
-
-
77954924659
-
Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
-
Stupp, R.; Hegi, M.E.; Neyns, B.; Goldbrunner, R.; Schlegel, U.; Clement, P.M.; Grabenbauer, G.G.; Ochsenbein, A.F.; Simon, M.; Dietrich, P.Y. et al. Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J. Clin. Oncol. 2010, 28, 2712-2718.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 2712-2718
-
-
Stupp, R.1
Hegi, M.E.2
Neyns, B.3
Goldbrunner, R.4
Schlegel, U.5
Clement, P.M.6
Grabenbauer, G.G.7
Ochsenbein, A.F.8
Simon, M.9
Dietrich, P.Y.10
-
188
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
-
Stommel, J.M.; Kimmelman, A.C.; Ying, H.; Nabioullin, R.; Ponugoti, A.H.; Wiedemeyer, R.; Stegh, A.H.; Bradner, J.E.; Ligon, K.L.; Brennan, C. et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007, 318, 287-290.
-
(2007)
Science
, vol.318
, pp. 287-290
-
-
Stommel, J.M.1
Kimmelman, A.C.2
Ying, H.3
Nabioullin, R.4
Ponugoti, A.H.5
Wiedemeyer, R.6
Stegh, A.H.7
Bradner, J.E.8
Ligon, K.L.9
Brennan, C.10
|