Mechanism and biological significance of CD44 cleavage

Cancer Science

Volumn 95, Issue 12, 2004, Pages 930-935

  Nagano, Osamu ^a   Saya, Hideyuki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; GAMMA SECRETASE; HERMES ANTIGEN; HYALURONIC ACID; PRESENILIN 1;

CANCER CELL; CELL ADHESION; CELL DIVISION; CELL INVASION; CELL MEMBRANE; CELL MIGRATION; CELL NUCLEUS; CELL SURFACE; DRUG TARGETING; EXTRACELLULAR MATRIX; HUMAN; METASTASIS; MICROENVIRONMENT; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL;

ANIMALS; ANTIGENS, CD44; CELL MOVEMENT; EXTRACELLULAR MATRIX; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 11844256383     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2004.tb03179.x     Document Type: Review

References (33)

1. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990; 61: 1303-13.
2. Cichy J, Pure E. The liberation of CD44. J Cell Biol 2003; 161: 839-43.
3. Gunthert U, Hofmann M, Rudy W, Reber S, Zoller M, Haussmann I, Matzku S, Wenzel A, Ponta H, Herrlich P. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991; 65: 13-24.
4. Lesley J, Hyman R. CD44 structure and function. Front Biosci 1998; 3: D616-30.
5. Guo YJ, Liu G, Wang X, Jin D, Wu M, Ma J, Sy MS. Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer. Cancer Res 1994; 54 422-6.
6. Ristamaki R, Joensuu H, Lappalainen K, Teerenhovi L, Jalkanen S. Elevated serum CD44 level is associated with unfavorable outcome in non-Hodgkin's lymphoma. Blood 1997; 90: 4039-45.
7. Okamoto I, Kawano Y, Tsuiki H, Sasaki J, Nakao M, Matsumoto M, Suga M, Ando M, Nakajima M, Saya H. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene 1999; 18: 1435-46.
8. 2+ influx and PKC activation. J Cell Biol 2004; 165: 893-902.
9. Goebeler M, Kaufmann D, Brocker EB, Klein CE. Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors. J Cell Sci 1996; 109 Pt 7: 1957-64.
10. Okamoto I, Tsuiki H, Kenyon LC, Godwin AK, Emlet DR, Holgado-Madruga M, Lanham IS, Joynes CJ, Vo KT, Guha A, Matsumoto M, Ushio Y, Saya H, Wong AJ. Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors. Am J Pathol 2002; 160: 441-7.
11. Thomas L, Etoh T, Stamenkovic I, Mihm MC Jr, Byers HR. Migration of human melanoma cells on hyaluronate is related to CD44 expression. J Invest Dermatol 1993; 100: 115-20.
12. Yu Q, Toole BP, Stamenkovic I. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J Exp Med 1997; 186: 1985-96.
13. Okamoto I, Kawano Y, Matsumoto M, Suga M, Kaibuchi K, Ando M, Saya H. Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins. J Biol Chem 1999; 274: 25525-34.
14. Kawano Y, Okamoto I, Murakami D, Itoh H, Yoshida M, Ueda S, Saya H. Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins. J Biol Chem 2000; 275: 29628-35.
15. Nakamura H, Suenaga N, Taniwaki K, Matsuki H, Yonezawa K, Fujii M, Okada Y, Seiki M. Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase. Cancer Res 2004; 64: 876-82.
16. Kajita M, Itoh Y, Chiba T, Mori H, Okada A, Kinoh H, Seiki M. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol 2001; 153: 893-904.
17. Mori H, Tomari T, Koshikawa N, Kajita M, Itoh Y, Sato H, Tojo H, Yana I, Seiki M. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J 2002; 21: 3949-59.
18. Sugahara KN, Murai T, Nishinakamura H, Kawashima H, Saya H, Miyasaka M. Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells. J Biol Chem 2003; 278: 32259-65.
19. Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 2003; 22: 1511-6.
20. Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmmer AK, Edbauer D, Walter J, Steiner H, Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem 2002; 277: 44754-9.
21. Okamoto I, Kawano Y, Murakami D, Sasayama T, Araki N, Miki T, Wong AJ, Saya H. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol 2001; 155: 755-62.
22. Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 2002; 21: 1948-56.
23. Ebinu JO, Yankner BA. A RIP tide in neuronal signal transduction. Neuron 2002; 34: 499-502.
24. Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 2000; 100: 391-8.
25. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998; 393: 382-6.
26. Tammi R, Rilla K, Pienimaki JP, MacCallum DK, Hogg M, Luukkonen M, Hascall VC, Tammi M. Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. J Biol Chem 2001; 276: 35111-22.
27. Knudson CB. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix. J Cell Biol 1993; 120: 825-34.
28. Hall CL, Collis LA, Bo AJ, Lange L, McNicol A, Gerrard JM, Turley EA. Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion. Matrix Biol 2001; 20: 183-92.
29. Zoltan-Jones A, Huang L, Ghatak S, Toole BP. Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. J Biol Chem 2003; 278: 45801-10.
30. 2+]i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils. J Cell Biol 1994; 127: 489-503.
31. Lee J, Ishihara A, Oxford G, Johnson B, Jacobson K. Regulation of cell movement is mediated by stretch-activated calcium channels. Nature 1999; 400: 382-6.
32. Burridge K, Wennerberg K. Rho and Rac take center stage. Cell 2004; 116: 167-79.
33. Yu M, Sato H, Seiki M, Spiegel S, Thompson EW. Calcium influx inhibits MT1-MMP processing and blocks MMP-2 activation. FEBS Lett 1997; 412: 568-72.