-
1
-
-
34547574720
-
A new mutational AKTivation in the PI3K pathway
-
Brugge J, Hung MC, Mills GB (2007) A new mutational AKTivation in the PI3K pathway. Cancer cell 12: 104-107.
-
(2007)
Cancer cell
, vol.12
, pp. 104-107
-
-
Brugge, J.1
Hung, M.C.2
Mills, G.B.3
-
2
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
-
3
-
-
25144522599
-
Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas
-
Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005) Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. Neuropathol Appl Neurobiol 31: 486-90.
-
(2005)
Neuropathol Appl Neurobiol
, vol.31
, pp. 486-490
-
-
Knobbe, C.B.1
Trampe-Kieslich, A.2
Reifenberger, G.3
-
4
-
-
33947381317
-
PIK3CA alterations in primary (de novo) and secondary glioblastomas
-
Kita D, Yonekawa Y, Weller M, Ohgaki H (2007) PIK3CA alterations in primary (de novo) and secondary glioblastomas. Acta Neuropathol 113: 295-302.
-
(2007)
Acta Neuropathol
, vol.113
, pp. 295-302
-
-
Kita, D.1
Yonekawa, Y.2
Weller, M.3
Ohgaki, H.4
-
5
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, et al. (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
-
6
-
-
22144493794
-
PIK3CA mutations in glioblastoma multiforme
-
Hartmann C, Bartels G, Gehlhaar C, Holtkamp N, von Deimling A (2005) PIK3CA mutations in glioblastoma multiforme. Acta Neuropathol 109: 639-642.
-
(2005)
Acta Neuropathol
, vol.109
, pp. 639-642
-
-
Hartmann, C.1
Bartels, G.2
Gehlhaar, C.3
Holtkamp, N.4
von Deimling, A.5
-
7
-
-
38949133202
-
PIK3CA cancer mutations display gender and tissue specificity patterns
-
Benvenuti S, Frattini M, Arena S, Zanon C, Cappelletti V, et al. (2008) PIK3CA cancer mutations display gender and tissue specificity patterns. Hum Mutat 29: 284-288.
-
(2008)
Hum Mutat
, vol.29
, pp. 284-288
-
-
Benvenuti, S.1
Frattini, M.2
Arena, S.3
Zanon, C.4
Cappelletti, V.5
-
8
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
-
9
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
Saal LH, Holm K, Maurer M, Memeo L, Su T, et al. (2005) PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65: 2554-2559.
-
(2005)
Cancer Res
, vol.65
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
Memeo, L.4
Su, T.5
-
10
-
-
0025731596
-
Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
-
Stephens LR, Hughes KT, Irvine RF (1991) Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 351: 33-39.
-
(1991)
Nature
, vol.351
, pp. 33-39
-
-
Stephens, L.R.1
Hughes, K.T.2
Irvine, R.F.3
-
11
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
12
-
-
33845926387
-
Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
-
Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, et al. (2006) Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med 3: e485.
-
(2006)
PLoS Med
, vol.3
-
-
Lee, J.C.1
Vivanco, I.2
Beroukhim, R.3
Huang, J.H.4
Feng, W.L.5
-
13
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, et al. (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-44.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
-
14
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, et al. (2007) Activating E17K mutation in the gene encoding the protein kinase AKT in a subset of squamous cell carcinoma of the lung. Cell Cycle 7: 665-9.
-
(2007)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
Fabiani, F.4
De Rosa, N.5
-
15
-
-
52149086562
-
AKT1(E17K) in human solid tumours
-
Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, et al. (2008) AKT1(E17K) in human solid tumours. Oncogene 27: 5648-5650.
-
(2008)
Oncogene
, vol.27
, pp. 5648-5650
-
-
Bleeker, F.E.1
Felicioni, L.2
Buttitta, F.3
Lamba, S.4
Cardone, L.5
-
16
-
-
43249115083
-
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
-
Kim MS, Jeong EG, Yoo NJ, Lee SH (2008) Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Br J Cancer 98: 1533-1535.
-
(2008)
Br J Cancer
, vol.98
, pp. 1533-1535
-
-
Kim, M.S.1
Jeong, E.G.2
Yoo, N.J.3
Lee, S.H.4
-
17
-
-
39749125746
-
Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas
-
Schuller U, Ruiter M, Herms J, Kretzschmar HA, Grasbon-Frodl E (2008) Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas. Acta Neuropathol 115: 367-368.
-
(2008)
Acta Neuropathol
, vol.115
, pp. 367-368
-
-
Schuller, U.1
Ruiter, M.2
Herms, J.3
Kretzschmar, H.A.4
Grasbon-Frodl, E.5
-
18
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, et al. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
-
19
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, Edkins S, Davies H, et al. (2004) Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 431: 525-526.
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
Edkins, S.4
Davies, H.5
-
20
-
-
52949127312
-
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, et al. (2008) An Integrated Genomic Analysis of Human Glioblastoma Multiforme. Science 321: 1807-12.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
-
21
-
-
58349111311
-
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors
-
Bleeker FE, Lamba S, Leenstra S, Troost D, Hulsebos T, et al. (2009) IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat 30: 7-11.
-
(2009)
Hum Mutat
, vol.30
, pp. 7-11
-
-
Bleeker, F.E.1
Lamba, S.2
Leenstra, S.3
Troost, D.4
Hulsebos, T.5
-
22
-
-
34248547564
-
Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
-
Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, et al. (2007) Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 67: 3545-3550.
-
(2007)
Cancer Res
, vol.67
, pp. 3545-3550
-
-
Balakrishnan, A.1
Bleeker, F.E.2
Lamba, S.3
Rodolfo, M.4
Daniotti, M.5
|