Frequent alterations in the expression of serine/threonine kinases in human cancers

Cancer Research

Volumn 66, Issue 16, 2006, Pages 8147-8154

  Capra, Maria ^a,b   Nuciforo, Paolo Giovanni ^a   Confalonieri, Stefano ^a   Quarto, Micaela ^a   Bianchi, Marco ^a   Nebuloni, Manuela ^c   Boldorini, Renzo ^f   Pallotti, Francesco ^d   Viale, Giuseppe ^b,e   Gishizky, Mikhail L ^g,h   Draetta, Giulio F ^b,i   Di Fiore, Pier Paolo ^a,b,e  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Fondazione Policlinico   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

^g SUGEN   (United States)

^h Entelos Inc   (United States)

ⁱ MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURORA B KINASE; CRK LIKE PROTEIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 4; POLO LIKE KINASE 1; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; S6 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ARTICLE; CANCER; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ANALYSIS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALIGNANT TRANSFORMATION; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY;

DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TEMPLATES, GENETIC;

EID: 33748058131     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3489     Document Type: Article

References (43)

1. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 2002;298:1912-34.
2. Schlessinger J, Ullrich A. Growth factor signaling by receptor tyrosine kinases. Neuron 1992;9:383-91.
3. Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001;411:355-65.
4. Edelman AM, Blumenthal DK, Krebs EG. Protein serine/threonine kinases. Annu Rev Biochem 1987;56: 567-613.
5. Freeman SM, Whartenby KA. The role of the mitogen-activated protein kinase cellular signaling pathway in tumor cell survival and apoptosis. Drug News Perspect 2004;17:237-42.
6. Warner SL, Bearss DJ, Han H, Von Hoff DD. Targeting Aurora-2 kinase in cancer. Mol Cancer Ther 2003;2:589-95.
7. Eckerdt F, Yuan J, Strebhardt K. Polo-like kinases and oncogenesis. Oncogene 2005;24:267-76.
8. Scapin G. Structural biology in drug design: selective protein kinase inhibitors. Drug Discov Today 2002;7: 601-11.
9. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
10. Bardelli A, Parsons DW, Silliman N, et al. Mutational analysis of the tyrosine kinome in colorectal cancers. Science 2003;300:949.
11. Stephens P, Edkins S, Davies H, et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 2005;37:590-2.
12. Yamada S, Ohira M, Horie H, et al. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. Oncogene 2004;23:5901-11.
13. Schaefer KL, Brachwitz K, Wai DH, et al. Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. Cancer Res 2004;64:3395-405.
14. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4:844-7.
15. Rugarli EI, Lutz B, Kuratani SC, et al. Expression pattern of the Kallmann syndrome gene in the olfactory system suggests a role in neuronal targeting. Nat Genet 1993;4:19-26.
16. Ko TK, Kelly E, Pines J. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J Cell Sci 2001;114:2591-603.
17. Kalnina Z, Zayakin P, Silina K, Line A. Alterations of pre-mRNA splicing in cancer. Genes Chromosomes Cancer 2005;42:342-57.
18. Venables JP. Aberrant and alternative splicing in cancer. Cancer Res 2004;64:7647-54.
19. Abe Y, Matsumoto S, Wei S, et al. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. J Biol Chem 2001;276:44003-11.
20. Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273: 29066-71.
21. Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001;2:21-32.
22. Keen N, Taylor S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 2004;4:927-36.
23. Chen JJ, London M. Regulation of protein synthesis by heme-regulated eIF-2α kinase. Trends Biochem Sci 1995;20:105-8.
24. Davila M, Frost AR, Grizzle WE, Chakrabarti R. LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer. J Biol Chem 2003;278:36868-75.
25. Yoshioka K, Foletta V, Bernard O, Itoh K. A role for LIM kinase in cancer invasion. Proc Natl Acad Sci U S A 2003;100:7247-52.
26. Yang N, Higuchi O, Ohashi K, et al. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998;393:809-12.
27. Yin MJ, Shao L, Voehringer D, Smeal T, Jallal B. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem 2003;278: 52454-60.
28. Belham C, Roig J, Caldwell JA, et al. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem 2003;278:34897-909.
29. Hayashi S, Okada T, Igarashi N, Fujita T, Jahangeer S, Nakamura S. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J Biol Chem 2002;277:33319-24.
30. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
31. Lang F, Cohen P. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001;2001:RE17.
32. Vallenius T, Makela TP. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. J Cell Sci 2002;115:2067-73.
33. Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J Biol Chem 2003;278: 21678-84.
34. Schultz J, Jones T, Bork P, et al. Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35 [correction of 4q35]. Genomics 2001;71:368-70.
35. D'Orazi G, Cecchinelli B, Bruno T, et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 2002;4:11-9.
36. Hofmann TG, Moller A, Sirma H, et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 2002;4:1-10.
37. English JM, Cobb MH. Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci 2002;23:40-5.
38. Platanias LC. Map kinase signaling pathways and hematologic malignancies. Blood 2003;101:4667-79.
39. Wright JH, Wang X Manning G, et al. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Mol Cell Biol 2003;23:2068-82.
40. Hu Y, Leo C, Yu S, et al. Identification and functional characterization of a novel human misshapen/Nek interacting kinase-related kinase, hMINKβ. J Biol Chem 2004;279:54387-97.
41. Takai N, Hamanaka R, Yoshimatsu J, Miyakawa I. Polo-like kinases (Plks) and cancer. Oncogene 2005;24: 287-91.
42. Hutchison M, Berman KS, Cobb MH. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J Biol Chem 1998;273: 28625-32.
43. Timm T, Li XY, Biernat J, et al. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 2003;22:5090-101.