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Volumn 16, Issue 9, 2009, Pages 1119-1130

Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas

Author keywords

Angiogenesis; Clinical trials; Glioma

Indexed keywords

2 METHOXYESTRADIOL; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; BORTEZOMIB; CEDIRANIB; CILENGITIDE; DEFOROLIMUS; ENZASTAURIN; EVEROLIMUS; GROWTH FACTOR; IMMUNOMODULATING AGENT; IRINOTECAN; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; PRINOMASTAT; PROTEASOME INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; TYROSINE KINASE RECEPTOR; UNINDEXED DRUG; VASCULOTROPIN; VATALANIB;

EID: 67650713544     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2009.02.009     Document Type: Review
Times cited : (104)

References (277)
  • 2
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1 (1995) 27-31
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 3
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 4
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 5
    • 0034648793 scopus 로고    scopus 로고
    • Vascular-specific growth factors and blood vessel formation
    • Yancopoulos G.D., Davis S., Gale N.W., et al. Vascular-specific growth factors and blood vessel formation. Nature 407 (2000) 242-248
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1    Davis, S.2    Gale, N.W.3
  • 7
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P., Ferreira V., Breier G., et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380 (1996) 435-439
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3
  • 9
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 10
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire G.H., and Chalkley H.W. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst USA 6 (1945) 73-85
    • (1945) J Natl Cancer Inst USA , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2
  • 11
    • 0001148826 scopus 로고
    • The growth of malignant disease in man and the lower animals with special reference to the vascular system
    • Goldman E. The growth of malignant disease in man and the lower animals with special reference to the vascular system. Lancet 2 (1907) 1236-1240
    • (1907) Lancet , vol.2 , pp. 1236-1240
    • Goldman, E.1
  • 12
    • 0000912662 scopus 로고
    • Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • Ide A.G., Baker N.H., and Warren S.L. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am J Radiol 42 (1939) 891-899
    • (1939) Am J Radiol , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 13
    • 0013943005 scopus 로고
    • Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment
    • Folkman J., Cole P., and Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg 164 (1966) 491-502
    • (1966) Ann Surg , vol.164 , pp. 491-502
    • Folkman, J.1    Cole, P.2    Zimmerman, S.3
  • 14
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 82 (1990) 4-6
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 15
    • 0034265986 scopus 로고    scopus 로고
    • Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis
    • Rijken P.F., Bernsen H.J., Peters J.P., et al. Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis. Int J Radiat Oncol Biol Phys 48 (2000) 571-582
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 571-582
    • Rijken, P.F.1    Bernsen, H.J.2    Peters, J.P.3
  • 16
    • 0015982084 scopus 로고
    • Tumor growth and neovascularization: an experimental model using the rabbit cornea
    • Gimbrone Jr. M.A., Cotran R.S., Leapman S.B., et al. Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst 52 (1974) 413-427
    • (1974) J Natl Cancer Inst , vol.52 , pp. 413-427
    • Gimbrone Jr., M.A.1    Cotran, R.S.2    Leapman, S.B.3
  • 17
    • 0015380016 scopus 로고
    • Tumor dormancy in vivo by prevention of neovascularization
    • Gimbrone Jr. M.A., Leapman S.B., Cotran R.S., et al. Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136 (1972) 261-276
    • (1972) J Exp Med , vol.136 , pp. 261-276
    • Gimbrone Jr., M.A.1    Leapman, S.B.2    Cotran, R.S.3
  • 18
    • 0017341618 scopus 로고
    • Avascular and vascular phases of tumour growth in the chick embryo
    • Knighton D., Ausprunk D., Tapper D., et al. Avascular and vascular phases of tumour growth in the chick embryo. Br J Cancer 35 (1977) 347-356
    • (1977) Br J Cancer , vol.35 , pp. 347-356
    • Knighton, D.1    Ausprunk, D.2    Tapper, D.3
  • 19
    • 0014833051 scopus 로고
    • The blood supply of experimental liver metastases. II. A microcirculatory study of the normal and tumor vessels of the liver with the use of perfused silicone rubber
    • Lien W.M., and Ackerman N.B. The blood supply of experimental liver metastases. II. A microcirculatory study of the normal and tumor vessels of the liver with the use of perfused silicone rubber. Surgery 68 (1970) 334-340
    • (1970) Surgery , vol.68 , pp. 334-340
    • Lien, W.M.1    Ackerman, N.B.2
  • 20
    • 0023243816 scopus 로고
    • Tumours acquire their vasculature by vessel incorporation, not vessel ingrowth
    • Thompson W.D., Shiach K.J., Fraser R.A., et al. Tumours acquire their vasculature by vessel incorporation, not vessel ingrowth. J Pathol 151 (1987) 323-332
    • (1987) J Pathol , vol.151 , pp. 323-332
    • Thompson, W.D.1    Shiach, K.J.2    Fraser, R.A.3
  • 21
    • 0014365361 scopus 로고
    • Choriocarcinoma. Transfilter stimulation of vasoproliferation in the hamster cheek pouch. Studied by light and electron microscopy
    • Ehrmann R.L., and Knoth M. Choriocarcinoma. Transfilter stimulation of vasoproliferation in the hamster cheek pouch. Studied by light and electron microscopy. J Natl Cancer Inst 41 (1968) 1329-1341
    • (1968) J Natl Cancer Inst , vol.41 , pp. 1329-1341
    • Ehrmann, R.L.1    Knoth, M.2
  • 22
    • 0014304893 scopus 로고
    • Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique
    • Greenblatt M., and Shubi P. Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique. J Natl Cancer Inst 41 (1968) 111-124
    • (1968) J Natl Cancer Inst , vol.41 , pp. 111-124
    • Greenblatt, M.1    Shubi, P.2
  • 23
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 285 (1971) 1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 24
    • 0018094041 scopus 로고
    • Angiogenesis and oncogenesis
    • Gullino P.M. Angiogenesis and oncogenesis. J Natl Cancer Inst 61 (1978) 639-643
    • (1978) J Natl Cancer Inst , vol.61 , pp. 639-643
    • Gullino, P.M.1
  • 25
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Dameron K.M., Volpert O.V., Tainsky M.A., et al. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265 (1994) 1582-1584
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3
  • 26
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell P.H., Wiesener M.S., Chang G.W., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 28
    • 0030893967 scopus 로고    scopus 로고
    • Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity
    • Volpert O.V., Dameron K.M., and Bouck N. Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity. Oncogene 14 (1997) 1495-1502
    • (1997) Oncogene , vol.14 , pp. 1495-1502
    • Volpert, O.V.1    Dameron, K.M.2    Bouck, N.3
  • 29
  • 30
    • 0029782859 scopus 로고    scopus 로고
    • Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor
    • Cheng S.Y., Huang H.J., Nagane M., et al. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc Natl Acad Sci USA 93 (1996) 8502-8507
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8502-8507
    • Cheng, S.Y.1    Huang, H.J.2    Nagane, M.3
  • 31
    • 0028797077 scopus 로고
    • Angiogenic growth factors in neural embryogenesis and neoplasia
    • Zagzag D. Angiogenic growth factors in neural embryogenesis and neoplasia. Am J Pathol 146 (1995) 293-309
    • (1995) Am J Pathol , vol.146 , pp. 293-309
    • Zagzag, D.1
  • 32
    • 0015291143 scopus 로고
    • Tumor angiogenesis: a quantitative method for histologic grading
    • Brem S., Cotran R., and Folkman J. Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst 48 (1972) 347-356
    • (1972) J Natl Cancer Inst , vol.48 , pp. 347-356
    • Brem, S.1    Cotran, R.2    Folkman, J.3
  • 34
    • 0033674528 scopus 로고    scopus 로고
    • Expression of vascular permeability factor in glioblastoma specimens: correlation with tumor vascular endothelial surface and peritumoral edema
    • Vaquero J., Zurita M., Morales C., et al. Expression of vascular permeability factor in glioblastoma specimens: correlation with tumor vascular endothelial surface and peritumoral edema. J Neurooncol 49 (2000) 49-55
    • (2000) J Neurooncol , vol.49 , pp. 49-55
    • Vaquero, J.1    Zurita, M.2    Morales, C.3
  • 35
    • 0023891936 scopus 로고
    • Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier
    • Zagzag D., Brem S., and Robert F. Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier. Am J Pathol 131 (1988) 361-372
    • (1988) Am J Pathol , vol.131 , pp. 361-372
    • Zagzag, D.1    Brem, S.2    Robert, F.3
  • 36
    • 0024413619 scopus 로고
    • Angiogenesis and blood-brain barrier breakdown modulate CT contrast enhancement: an experimental study in a rabbit brain-tumor model
    • Zagzag D., Goldenberg M., and Brem S. Angiogenesis and blood-brain barrier breakdown modulate CT contrast enhancement: an experimental study in a rabbit brain-tumor model. AJR Am J Roentgenol 153 (1989) 141-146
    • (1989) AJR Am J Roentgenol , vol.153 , pp. 141-146
    • Zagzag, D.1    Goldenberg, M.2    Brem, S.3
  • 37
    • 0030665066 scopus 로고    scopus 로고
    • Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189
    • Cheng S.Y., Nagane M., Huang H.S., et al. Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc Natl Acad Sci USA 94 (1997) 12081-12087
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12081-12087
    • Cheng, S.Y.1    Nagane, M.2    Huang, H.S.3
  • 38
    • 0023233760 scopus 로고
    • The relationship between the capillary structure and hemorrhage in gliomas
    • Liwnicz B.H., Wu S.Z., and Tew Jr. J.M. The relationship between the capillary structure and hemorrhage in gliomas. J Neurosurg 66 (1987) 536-541
    • (1987) J Neurosurg , vol.66 , pp. 536-541
    • Liwnicz, B.H.1    Wu, S.Z.2    Tew Jr., J.M.3
  • 39
    • 0037407302 scopus 로고    scopus 로고
    • Dynamic, contrast-enhanced perfusion MRI in mouse gliomas: correlation with histopathology
    • Cha S., Johnson G., Wadghiri Y.Z., et al. Dynamic, contrast-enhanced perfusion MRI in mouse gliomas: correlation with histopathology. Magn Reson Med 49 (2003) 848-855
    • (2003) Magn Reson Med , vol.49 , pp. 848-855
    • Cha, S.1    Johnson, G.2    Wadghiri, Y.Z.3
  • 40
    • 0023831370 scopus 로고
    • Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy
    • Earnest F.t., Kelly P.J., Scheithauer B.W., et al. Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology 166 (1988) 823-827
    • (1988) Radiology , vol.166 , pp. 823-827
    • Earnest, F.t.1    Kelly, P.J.2    Scheithauer, B.W.3
  • 41
    • 0032916008 scopus 로고    scopus 로고
    • MRI enhancement and microvascular density in gliomas. Correlation with tumor cell proliferation
    • Tynninen O., Aronen H.J., Ruhala M., et al. MRI enhancement and microvascular density in gliomas. Correlation with tumor cell proliferation. Invest Radiol 34 (1999) 427-434
    • (1999) Invest Radiol , vol.34 , pp. 427-434
    • Tynninen, O.1    Aronen, H.J.2    Ruhala, M.3
  • 42
    • 0031941942 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma
    • Abdulrauf S.I., Edvardsen K., Ho K.L., et al. Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma. J Neurosurg 88 (1998) 513-520
    • (1998) J Neurosurg , vol.88 , pp. 513-520
    • Abdulrauf, S.I.1    Edvardsen, K.2    Ho, K.L.3
  • 43
    • 0021803702 scopus 로고
    • Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications
    • Burger P.C., Vogel F.S., Green S.B., et al. Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications. Cancer 56 (1985) 1106-1111
    • (1985) Cancer , vol.56 , pp. 1106-1111
    • Burger, P.C.1    Vogel, F.S.2    Green, S.B.3
  • 44
    • 0023700236 scopus 로고
    • Grading of astrocytomas. A simple and reproducible method
    • Daumas-Duport C., Scheithauer B., O'Fallon J., et al. Grading of astrocytomas. A simple and reproducible method. Cancer 62 (1988) 2152-2165
    • (1988) Cancer , vol.62 , pp. 2152-2165
    • Daumas-Duport, C.1    Scheithauer, B.2    O'Fallon, J.3
  • 46
    • 0036896003 scopus 로고    scopus 로고
    • Prognostic importance of glomeruloid microvascular proliferation indicates an aggressive angiogenic phenotype in human cancers
    • Straume O., Chappuis P.O., Salvesen H.B., et al. Prognostic importance of glomeruloid microvascular proliferation indicates an aggressive angiogenic phenotype in human cancers. Cancer Res 62 (2002) 6808-6811
    • (2002) Cancer Res , vol.62 , pp. 6808-6811
    • Straume, O.1    Chappuis, P.O.2    Salvesen, H.B.3
  • 47
    • 0016914733 scopus 로고
    • The role of vascular proliferation in the growth of brain tumors
    • Brem S. The role of vascular proliferation in the growth of brain tumors. Clin Neurosurg 23 (1976) 440-453
    • (1976) Clin Neurosurg , vol.23 , pp. 440-453
    • Brem, S.1
  • 48
    • 0027201773 scopus 로고
    • Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis
    • Abe T., Okamura K., Ono M., et al. Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis. J Clin Invest 92 (1993) 54-61
    • (1993) J Clin Invest , vol.92 , pp. 54-61
    • Abe, T.1    Okamura, K.2    Ono, M.3
  • 49
    • 0016708603 scopus 로고
    • In vitro demonstration of an endothelial proliferative factor produced by neural cell lines
    • Suddith R.L., Kelly P.J., Hutchison H.T., et al. In vitro demonstration of an endothelial proliferative factor produced by neural cell lines. Science 190 (1975) 682-684
    • (1975) Science , vol.190 , pp. 682-684
    • Suddith, R.L.1    Kelly, P.J.2    Hutchison, H.T.3
  • 50
    • 27944442568 scopus 로고    scopus 로고
    • Angiogenesis: update 2005
    • Dvorak H.F. Angiogenesis: update 2005. J Thromb Haemost 3 (2005) 1835-1842
    • (2005) J Thromb Haemost , vol.3 , pp. 1835-1842
    • Dvorak, H.F.1
  • 51
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25 (2004) 581-611
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 52
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate K.H., Breier G., Weich H.A., et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359 (1992) 845-848
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3
  • 53
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts W.G., and Palade G.E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res 57 (1997) 765-772
    • (1997) Cancer Res , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 54
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D., Itin A., Soffer D., et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359 (1992) 843-845
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3
  • 55
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3 (2003) 721-732
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 56
    • 0034213146 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression
    • Zagzag D., Zhong H., Scalzitti J.M., et al. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 88 (2000) 2606-2618
    • (2000) Cancer , vol.88 , pp. 2606-2618
    • Zagzag, D.1    Zhong, H.2    Scalzitti, J.M.3
  • 57
    • 0017370183 scopus 로고
    • Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
    • Ausprunk D.H., and Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Research 14 (1977) 53-65
    • (1977) Microvasc Research , vol.14 , pp. 53-65
    • Ausprunk, D.H.1    Folkman, J.2
  • 58
    • 0032850844 scopus 로고    scopus 로고
    • The extracellular matrix of gliomas: modulation of cell function
    • Gladson C.L. The extracellular matrix of gliomas: modulation of cell function. J Neuropathol Exp Neurol 58 (1999) 1029-1040
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 1029-1040
    • Gladson, C.L.1
  • 59
    • 27944465846 scopus 로고    scopus 로고
    • Changes in laminin isoforms associated with brain tumor invasion and angiogenesis
    • Ljubimova J.Y., Fujita M., Khazenzon N.M., et al. Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. Front Biosci 11 (2006) 81-88
    • (2006) Front Biosci , vol.11 , pp. 81-88
    • Ljubimova, J.Y.1    Fujita, M.2    Khazenzon, N.M.3
  • 60
    • 0029097797 scopus 로고
    • Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis
    • Mikkelsen T., Yan P.S., Ho K.L., et al. Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis. J Neurosurg 83 (1995) 285-290
    • (1995) J Neurosurg , vol.83 , pp. 285-290
    • Mikkelsen, T.1    Yan, P.S.2    Ho, K.L.3
  • 61
    • 0030070486 scopus 로고    scopus 로고
    • Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro
    • Zagzag D., Friedlander D.R., Dosik J., et al. Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro. Cancer Res 56 (1996) 182-189
    • (1996) Cancer Res , vol.56 , pp. 182-189
    • Zagzag, D.1    Friedlander, D.R.2    Dosik, J.3
  • 62
    • 0028888390 scopus 로고
    • Tenascin expression in astrocytomas correlates with angiogenesis
    • Zagzag D., Friedlander D.R., Miller D.C., et al. Tenascin expression in astrocytomas correlates with angiogenesis. Cancer Res 55 (1995) 907-914
    • (1995) Cancer Res , vol.55 , pp. 907-914
    • Zagzag, D.1    Friedlander, D.R.2    Miller, D.C.3
  • 63
    • 0037501115 scopus 로고    scopus 로고
    • Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells
    • Haskell H., Natarajan M., Hecker T.P., et al. Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells. Clin Cancer Res 9 (2003) 2157-2165
    • (2003) Clin Cancer Res , vol.9 , pp. 2157-2165
    • Haskell, H.1    Natarajan, M.2    Hecker, T.P.3
  • 64
    • 0033766009 scopus 로고    scopus 로고
    • Molecular events implicated in brain tumor angiogenesis and invasion
    • Zagzag D., Friedlander D.R., Margolis B., et al. Molecular events implicated in brain tumor angiogenesis and invasion. Pediatr Neurosurg 33 (2000) 49-55
    • (2000) Pediatr Neurosurg , vol.33 , pp. 49-55
    • Zagzag, D.1    Friedlander, D.R.2    Margolis, B.3
  • 65
    • 0036570318 scopus 로고    scopus 로고
    • Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase
    • Zagzag D., Shiff B., Jallo G.I., et al. Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase. Cancer Res 62 (2002) 2660-2668
    • (2002) Cancer Res , vol.62 , pp. 2660-2668
    • Zagzag, D.1    Shiff, B.2    Jallo, G.I.3
  • 66
    • 0020331685 scopus 로고
    • Angiogenesis: initiation and control
    • Folkman J. Angiogenesis: initiation and control. Ann N Y Acad Sci 401 (1982) 212-227
    • (1982) Ann N Y Acad Sci , vol.401 , pp. 212-227
    • Folkman, J.1
  • 67
    • 0021978223 scopus 로고
    • Tumor angiogenesis
    • Folkman J. Tumor angiogenesis. Adv Cancer Res 43 (1985) 175-203
    • (1985) Adv Cancer Res , vol.43 , pp. 175-203
    • Folkman, J.1
  • 68
    • 0022648938 scopus 로고
    • How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes Memorial Award Lecture
    • Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes Memorial Award Lecture. Cancer Res 46 (1986) 467-473
    • (1986) Cancer Res , vol.46 , pp. 467-473
    • Folkman, J.1
  • 69
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J., Maisonpierre P.C., Compton D., et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284 (1999) 1994-1998
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 70
    • 0033917495 scopus 로고    scopus 로고
    • Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis
    • Zagzag D., Amirnovin R., Greco M.A., et al. Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis. Lab Invest 80 (2000) 837-849
    • (2000) Lab Invest , vol.80 , pp. 837-849
    • Zagzag, D.1    Amirnovin, R.2    Greco, M.A.3
  • 71
    • 0032843659 scopus 로고    scopus 로고
    • In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis
    • Zagzag D., Hooper A., Friedlander D.R., et al. In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis. Exp Neurol 159 (1999) 391-400
    • (1999) Exp Neurol , vol.159 , pp. 391-400
    • Zagzag, D.1    Hooper, A.2    Friedlander, D.R.3
  • 72
    • 2342436921 scopus 로고    scopus 로고
    • Anti-angiogenic chemotherapy in central nervous system tumors
    • Kieran M.W. Anti-angiogenic chemotherapy in central nervous system tumors. Cancer Treat Res 117 (2004) 337-349
    • (2004) Cancer Treat Res , vol.117 , pp. 337-349
    • Kieran, M.W.1
  • 73
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G., Cohen T., Gengrinovitch S., et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 13 (1999) 9-22
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3
  • 74
    • 0141721621 scopus 로고    scopus 로고
    • Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
    • Autiero M., Luttun A., Tjwa M., et al. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost 1 (2003) 1356-1370
    • (2003) J Thromb Haemost , vol.1 , pp. 1356-1370
    • Autiero, M.1    Luttun, A.2    Tjwa, M.3
  • 75
    • 0037703184 scopus 로고    scopus 로고
    • Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    • Autiero M., Waltenberger J., Communi D., et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med 9 (2003) 936-943
    • (2003) Nat Med , vol.9 , pp. 936-943
    • Autiero, M.1    Waltenberger, J.2    Communi, D.3
  • 76
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23 (2005) 1011-1027
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 77
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2 (2002) 795-803
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 78
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 79
    • 0037182861 scopus 로고    scopus 로고
    • VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
    • Gerber H.P., Malik A.K., Solar G.P., et al. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417 (2002) 954-958
    • (2002) Nature , vol.417 , pp. 954-958
    • Gerber, H.P.1    Malik, A.K.2    Solar, G.P.3
  • 80
    • 0036344496 scopus 로고    scopus 로고
    • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    • Hattori K., Heissig B., Wu Y., et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med 8 (2002) 841-849
    • (2002) Nat Med , vol.8 , pp. 841-849
    • Hattori, K.1    Heissig, B.2    Wu, Y.3
  • 81
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • Luttun A., Tjwa M., Moons L., et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 8 (2002) 831-840
    • (2002) Nat Med , vol.8 , pp. 831-840
    • Luttun, A.1    Tjwa, M.2    Moons, L.3
  • 82
    • 0036782035 scopus 로고    scopus 로고
    • MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
    • Hiratsuka S., Nakamura K., Iwai S., et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2 (2002) 289-300
    • (2002) Cancer Cell , vol.2 , pp. 289-300
    • Hiratsuka, S.1    Nakamura, K.2    Iwai, S.3
  • 83
    • 0037423321 scopus 로고    scopus 로고
    • Angiogenesis-independent endothelial protection of liver: role of VEGFR-1
    • LeCouter J., Moritz D.R., Li B., et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299 (2003) 890-893
    • (2003) Science , vol.299 , pp. 890-893
    • LeCouter, J.1    Moritz, D.R.2    Li, B.3
  • 84
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • Safran M., and Kaelin Jr. W.G. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 111 (2003) 779-783
    • (2003) J Clin Invest , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin Jr., W.G.2
  • 85
    • 17844396959 scopus 로고    scopus 로고
    • Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1
    • Loeffler S., Fayard B., Weis J., et al. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer 115 (2005) 202-213
    • (2005) Int J Cancer , vol.115 , pp. 202-213
    • Loeffler, S.1    Fayard, B.2    Weis, J.3
  • 86
    • 0344578062 scopus 로고    scopus 로고
    • Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis
    • Valter M.M., Hugel A., Huang H.J., et al. Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. Cancer Res 59 (1999) 5608-5614
    • (1999) Cancer Res , vol.59 , pp. 5608-5614
    • Valter, M.M.1    Hugel, A.2    Huang, H.J.3
  • 87
    • 22844451172 scopus 로고    scopus 로고
    • Inactivation of Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression
    • Sahin A., Velten M., Pietsch T., et al. Inactivation of Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression. Int J Mol Med 15 (2005) 771-776
    • (2005) Int J Mol Med , vol.15 , pp. 771-776
    • Sahin, A.1    Velten, M.2    Pietsch, T.3
  • 88
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T., Nahari D., Cerem L.W., et al. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 271 (1996) 736-741
    • (1996) J Biol Chem , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3
  • 89
    • 0026673043 scopus 로고
    • Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C
    • Finkenzeller G., Marme D., Weich H.A., et al. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C. Cancer Res 52 (1992) 4821-4823
    • (1992) Cancer Res , vol.52 , pp. 4821-4823
    • Finkenzeller, G.1    Marme, D.2    Weich, H.A.3
  • 90
    • 0344837389 scopus 로고    scopus 로고
    • Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment
    • Guo P., Hu B., Gu W., et al. Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am J Pathol 162 (2003) 1083-1093
    • (2003) Am J Pathol , vol.162 , pp. 1083-1093
    • Guo, P.1    Hu, B.2    Gu, W.3
  • 91
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells
    • Pertovaara L., Kaipainen A., Mustonen T., et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 269 (1994) 6271-6274
    • (1994) J Biol Chem , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3
  • 92
    • 0028941001 scopus 로고
    • Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF
    • Tsai J.C., Goldman C.K., and Gillespie G.Y. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg 82 (1995) 864-873
    • (1995) J Neurosurg , vol.82 , pp. 864-873
    • Tsai, J.C.1    Goldman, C.K.2    Gillespie, G.Y.3
  • 93
    • 0033119572 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
    • Wang D., Huang H.J., Kazlauskas A., et al. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res 59 (1999) 1464-1472
    • (1999) Cancer Res , vol.59 , pp. 1464-1472
    • Wang, D.1    Huang, H.J.2    Kazlauskas, A.3
  • 94
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 20 (2002) 4368-4380
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 95
    • 0027534287 scopus 로고
    • Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms
    • Berkman R.A., Merrill M.J., Reinhold W.C., et al. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 91 (1993) 153-159
    • (1993) J Clin Invest , vol.91 , pp. 153-159
    • Berkman, R.A.1    Merrill, M.J.2    Reinhold, W.C.3
  • 96
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R., and Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2 (2002) 727-739
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 97
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis
    • Rak J., Mitsuhashi Y., Bayko L., et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 55 (1995) 4575-4580
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3
  • 98
    • 0034668187 scopus 로고    scopus 로고
    • Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
    • Berra E., Milanini J., Richard D.E., et al. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem Pharmacol 60 (2000) 1171-1178
    • (2000) Biochem Pharmacol , vol.60 , pp. 1171-1178
    • Berra, E.1    Milanini, J.2    Richard, D.E.3
  • 99
    • 0029785838 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
    • Gnarra J.R., Zhou S., Merrill M.J., et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci USA 93 (1996) 10589-10594
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10589-10594
    • Gnarra, J.R.1    Zhou, S.2    Merrill, M.J.3
  • 100
    • 0038507194 scopus 로고    scopus 로고
    • Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas
    • Na X., Wu G., Ryan C.K., et al. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. J Urol 170 (2003) 588-592
    • (2003) J Urol , vol.170 , pp. 588-592
    • Na, X.1    Wu, G.2    Ryan, C.K.3
  • 101
    • 0037228960 scopus 로고    scopus 로고
    • PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter
    • Pore N., Liu S., Haas-Kogan D.A., et al. PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Res 63 (2003) 236-241
    • (2003) Cancer Res , vol.63 , pp. 236-241
    • Pore, N.1    Liu, S.2    Haas-Kogan, D.A.3
  • 102
    • 0035836627 scopus 로고    scopus 로고
    • PTEN controls tumor-induced angiogenesis
    • Wen S., Stolarov J., Myers M.P., et al. PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci USA 98 (2001) 4622-4627
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4622-4627
    • Wen, S.1    Stolarov, J.2    Myers, M.P.3
  • 103
    • 0033573895 scopus 로고    scopus 로고
    • VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases
    • Doanes A.M., Hegland D.D., Sethi R., et al. VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases. Biochem Biophys Res Commun 255 (1999) 545-548
    • (1999) Biochem Biophys Res Commun , vol.255 , pp. 545-548
    • Doanes, A.M.1    Hegland, D.D.2    Sethi, R.3
  • 104
    • 0034979273 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in regulation of physiological angiogenesis
    • Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 280 (2001) C1358-C1366
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Ferrara, N.1
  • 105
    • 0031825437 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells
    • Esser S., Lampugnani M.G., Corada M., et al. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 111 (1998) 1853-1865
    • (1998) J Cell Sci , vol.111 , pp. 1853-1865
    • Esser, S.1    Lampugnani, M.G.2    Corada, M.3
  • 106
    • 2642607848 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins
    • Kevil C.G., Payne D.K., Mire E., et al. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. J Biol Chem 273 (1998) 15099-15103
    • (1998) J Biol Chem , vol.273 , pp. 15099-15103
    • Kevil, C.G.1    Payne, D.K.2    Mire, E.3
  • 107
    • 0034754014 scopus 로고    scopus 로고
    • VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways
    • Lal B.K., Varma S., Pappas P.J., et al. VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc Res 62 (2001) 252-262
    • (2001) Microvasc Res , vol.62 , pp. 252-262
    • Lal, B.K.1    Varma, S.2    Pappas, P.J.3
  • 108
    • 0028968307 scopus 로고
    • Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
    • Mandriota S.J., Seghezzi G., Vassalli J.D., et al. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 270 (1995) 9709-9716
    • (1995) J Biol Chem , vol.270 , pp. 9709-9716
    • Mandriota, S.J.1    Seghezzi, G.2    Vassalli, J.D.3
  • 109
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper M.S., Ferrara N., Orci L., et al. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181 (1991) 902-906
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3
  • 110
    • 0032540943 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
    • Tang H., Kerins D.M., Hao Q., et al. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem 273 (1998) 18268-18272
    • (1998) J Biol Chem , vol.273 , pp. 18268-18272
    • Tang, H.1    Kerins, D.M.2    Hao, Q.3
  • 111
    • 0031459892 scopus 로고    scopus 로고
    • Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins
    • Senger D.R., Claffey K.P., Benes J.E., et al. Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci USA 94 (1997) 13612-13617
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13612-13617
    • Senger, D.R.1    Claffey, K.P.2    Benes, J.E.3
  • 112
    • 0029999603 scopus 로고    scopus 로고
    • Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin
    • Senger D.R., Ledbetter S.R., Claffey K.P., et al. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol 149 (1996) 293-305
    • (1996) Am J Pathol , vol.149 , pp. 293-305
    • Senger, D.R.1    Ledbetter, S.R.2    Claffey, K.P.3
  • 113
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6 (2000) 389-395
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 114
    • 0032557564 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
    • Gerber H.P., Dixit V., and Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 273 (1998) 13313-13316
    • (1998) J Biol Chem , vol.273 , pp. 13313-13316
    • Gerber, H.P.1    Dixit, V.2    Ferrara, N.3
  • 115
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber H.P., McMurtrey A., Kowalski J., et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 273 (1998) 30336-30343
    • (1998) J Biol Chem , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3
  • 116
    • 0030999445 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells
    • Watanabe Y., Lee S.W., Detmar M., et al. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 14 (1997) 2025-2032
    • (1997) Oncogene , vol.14 , pp. 2025-2032
    • Watanabe, Y.1    Lee, S.W.2    Detmar, M.3
  • 117
    • 0031583917 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase
    • Wheeler-Jones C., Abu-Ghazaleh R., Cospedal R., et al. Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett 420 (1997) 28-32
    • (1997) FEBS Lett , vol.420 , pp. 28-32
    • Wheeler-Jones, C.1    Abu-Ghazaleh, R.2    Cospedal, R.3
  • 118
    • 0033558798 scopus 로고    scopus 로고
    • VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
    • Gupta K., Kshirsagar S., Li W., et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 247 (1999) 495-504
    • (1999) Exp Cell Res , vol.247 , pp. 495-504
    • Gupta, K.1    Kshirsagar, S.2    Li, W.3
  • 119
    • 0033965483 scopus 로고    scopus 로고
    • Akt takes center stage in angiogenesis signaling
    • Dimmeler S., and Zeiher A.M. Akt takes center stage in angiogenesis signaling. Circ Res 86 (2000) 4-5
    • (2000) Circ Res , vol.86 , pp. 4-5
    • Dimmeler, S.1    Zeiher, A.M.2
  • 120
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang B.H., Zheng J.Z., Aoki M., et al. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 97 (2000) 1749-1753
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3
  • 121
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio Y., and Walsh K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem 274 (1999) 16349-16354
    • (1999) J Biol Chem , vol.274 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2
  • 122
    • 0033517244 scopus 로고    scopus 로고
    • Akt is more than just a Bad kinase
    • Khwaja A. Akt is more than just a Bad kinase. Nature 401 (1999) 33-34
    • (1999) Nature , vol.401 , pp. 33-34
    • Khwaja, A.1
  • 123
    • 0034724736 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt
    • Morales-Ruiz M., Fulton D., Sowa G., et al. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 86 (2000) 892-896
    • (2000) Circ Res , vol.86 , pp. 892-896
    • Morales-Ruiz, M.1    Fulton, D.2    Sowa, G.3
  • 124
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure N.M., Chen E.Y., Laderoute K.R., et al. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90 (1997) 3322-3331
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3
  • 125
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S., Fleming I., Fisslthaler B., et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 (1999) 601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3
  • 126
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • Fulton D., Gratton J.P., McCabe T.J., et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399 (1999) 597-601
    • (1999) Nature , vol.399 , pp. 597-601
    • Fulton, D.1    Gratton, J.P.2    McCabe, T.J.3
  • 127
    • 0343851651 scopus 로고    scopus 로고
    • Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
    • Dulak J., Jozkowicz A., Dembinska-Kiec A., et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20 (2000) 659-666
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 659-666
    • Dulak, J.1    Jozkowicz, A.2    Dembinska-Kiec, A.3
  • 128
    • 0030918007 scopus 로고    scopus 로고
    • Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF
    • Ziche M., Parenti A., Ledda F., et al. Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. Circ Res 80 (1997) 845-852
    • (1997) Circ Res , vol.80 , pp. 845-852
    • Ziche, M.1    Parenti, A.2    Ledda, F.3
  • 129
    • 0034698284 scopus 로고    scopus 로고
    • Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration
    • Dimmeler S., Dernbach E., and Zeiher A.M. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett 477 (2000) 258-262
    • (2000) FEBS Lett , vol.477 , pp. 258-262
    • Dimmeler, S.1    Dernbach, E.2    Zeiher, A.M.3
  • 131
    • 0028143547 scopus 로고
    • Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P
    • Ziche M., Morbidelli L., Masini E., et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 94 (1994) 2036-2044
    • (1994) J Clin Invest , vol.94 , pp. 2036-2044
    • Ziche, M.1    Morbidelli, L.2    Masini, E.3
  • 132
    • 0031737425 scopus 로고    scopus 로고
    • Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
    • Stratmann A., Risau W., and Plate K.H. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol 153 (1998) 1459-1466
    • (1998) Am J Pathol , vol.153 , pp. 1459-1466
    • Stratmann, A.1    Risau, W.2    Plate, K.H.3
  • 133
    • 1542319875 scopus 로고    scopus 로고
    • Targeting the Tie2/Tek receptor in astrocytomas
    • Zadeh G., Qian B., Okhowat A., et al. Targeting the Tie2/Tek receptor in astrocytomas. Am J Pathol 164 (2004) 467-476
    • (2004) Am J Pathol , vol.164 , pp. 467-476
    • Zadeh, G.1    Qian, B.2    Okhowat, A.3
  • 134
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre P.C., Suri C., Jones P.F., et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277 (1997) 55-60
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 135
    • 0006677050 scopus 로고    scopus 로고
    • Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway
    • Kim I., Kim H.G., So J.N., et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway. Circ Res 86 (2000) 24-29
    • (2000) Circ Res , vol.86 , pp. 24-29
    • Kim, I.1    Kim, H.G.2    So, J.N.3
  • 136
    • 0036018747 scopus 로고    scopus 로고
    • Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells
    • Harfouche R., Hassessian H.M., Guo Y., et al. Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells. Microvasc Res 64 (2002) 135-147
    • (2002) Microvasc Res , vol.64 , pp. 135-147
    • Harfouche, R.1    Hassessian, H.M.2    Guo, Y.3
  • 137
    • 0034737422 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
    • Papapetropoulos A., Fulton D., Mahboubi K., et al. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. J Biol Chem 275 (2000) 9102-9105
    • (2000) J Biol Chem , vol.275 , pp. 9102-9105
    • Papapetropoulos, A.1    Fulton, D.2    Mahboubi, K.3
  • 138
    • 0342657703 scopus 로고    scopus 로고
    • Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion
    • Kim I., Kim H.G., Moon S.O., et al. Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion. Circ Res 86 (2000) 952-959
    • (2000) Circ Res , vol.86 , pp. 952-959
    • Kim, I.1    Kim, H.G.2    Moon, S.O.3
  • 139
    • 0037143737 scopus 로고    scopus 로고
    • Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo
    • Lobov I.B., Brooks P.C., and Lang R.A. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci USA 99 (2002) 11205-11210
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11205-11210
    • Lobov, I.B.1    Brooks, P.C.2    Lang, R.A.3
  • 140
    • 0032941495 scopus 로고    scopus 로고
    • Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis
    • Schmidt N.O., Westphal M., Hagel C., et al. Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis. Int J Cancer 84 (1999) 10-18
    • (1999) Int J Cancer , vol.84 , pp. 10-18
    • Schmidt, N.O.1    Westphal, M.2    Hagel, C.3
  • 141
    • 0025201337 scopus 로고
    • Immunohistochemical localization of basic fibroblast growth factor in astrocytomas
    • Zagzag D., Miller D.C., Sato Y., et al. Immunohistochemical localization of basic fibroblast growth factor in astrocytomas. Cancer Res 50 (1990) 7393-7398
    • (1990) Cancer Res , vol.50 , pp. 7393-7398
    • Zagzag, D.1    Miller, D.C.2    Sato, Y.3
  • 142
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • Alavi A., Hood J.D., Frausto R., et al. Role of Raf in vascular protection from distinct apoptotic stimuli. Science 301 (2003) 94-96
    • (2003) Science , vol.301 , pp. 94-96
    • Alavi, A.1    Hood, J.D.2    Frausto, R.3
  • 143
    • 0037023780 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis
    • Pardo O.E., Arcaro A., Salerno G., et al. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. J Biol Chem 277 (2002) 12040-12046
    • (2002) J Biol Chem , vol.277 , pp. 12040-12046
    • Pardo, O.E.1    Arcaro, A.2    Salerno, G.3
  • 144
    • 18344363186 scopus 로고    scopus 로고
    • Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma
    • Yoshiji H., Kuriyama S., Yoshii J., et al. Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma. Hepatology 35 (2002) 834-842
    • (2002) Hepatology , vol.35 , pp. 834-842
    • Yoshiji, H.1    Kuriyama, S.2    Yoshii, J.3
  • 145
    • 0030848490 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor
    • Mandriota S.J., and Pepper M.S. Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor. J Cell Sci 110 (1997) 2293-2302
    • (1997) J Cell Sci , vol.110 , pp. 2293-2302
    • Mandriota, S.J.1    Pepper, M.S.2
  • 146
    • 0017370183 scopus 로고
    • Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
    • Ausprunk D.H., and Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 14 (1977) 53-65
    • (1977) Microvasc Res , vol.14 , pp. 53-65
    • Ausprunk, D.H.1    Folkman, J.2
  • 147
    • 0024077722 scopus 로고
    • Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis
    • Sato Y., and Rifkin D.B. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol 107 (1988) 1199-1205
    • (1988) J Cell Biol , vol.107 , pp. 1199-1205
    • Sato, Y.1    Rifkin, D.B.2
  • 148
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl P., Johansson B.R., Leveen P., et al. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277 (1997) 242-245
    • (1997) Science , vol.277 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3
  • 149
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111 (2003) 1287-1295
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3
  • 150
    • 22744445537 scopus 로고    scopus 로고
    • Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors
    • Sun J., Wang D.A., Jain R.K., et al. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene 24 (2005) 4701-4709
    • (2005) Oncogene , vol.24 , pp. 4701-4709
    • Sun, J.1    Wang, D.A.2    Jain, R.K.3
  • 151
    • 0035347301 scopus 로고    scopus 로고
    • Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival
    • Reinmuth N., Liu W., Jung Y.D., et al. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J 15 (2001) 1239-1241
    • (2001) FASEB J , vol.15 , pp. 1239-1241
    • Reinmuth, N.1    Liu, W.2    Jung, Y.D.3
  • 152
    • 0034467330 scopus 로고    scopus 로고
    • Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs
    • Dunn I.F., Heese O., and Black P.M. Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs. J Neurooncol 50 (2000) 121-137
    • (2000) J Neurooncol , vol.50 , pp. 121-137
    • Dunn, I.F.1    Heese, O.2    Black, P.M.3
  • 153
    • 0025803828 scopus 로고
    • Expression of angiogenic growth factor genes in primary human astrocytomas may contribute to their growth and progression
    • Maxwell M., Naber S.P., Wolfe H.J., et al. Expression of angiogenic growth factor genes in primary human astrocytomas may contribute to their growth and progression. Cancer Res 51 (1991) 1345-1351
    • (1991) Cancer Res , vol.51 , pp. 1345-1351
    • Maxwell, M.1    Naber, S.P.2    Wolfe, H.J.3
  • 154
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology
    • Goldman C.K., Kim J., Wong W.L., et al. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4 (1993) 121-133
    • (1993) Mol Biol Cell , vol.4 , pp. 121-133
    • Goldman, C.K.1    Kim, J.2    Wong, W.L.3
  • 155
    • 0033051030 scopus 로고    scopus 로고
    • Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras
    • Feldkamp M.M., Lau N., Rak J., et al. Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras. Int J Cancer 81 (1999) 118-124
    • (1999) Int J Cancer , vol.81 , pp. 118-124
    • Feldkamp, M.M.1    Lau, N.2    Rak, J.3
  • 156
    • 16644367311 scopus 로고    scopus 로고
    • IkappaBalphaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells
    • Wu J.L., Abe T., Inoue R., et al. IkappaBalphaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells. Neurol Res 26 (2004) 785-791
    • (2004) Neurol Res , vol.26 , pp. 785-791
    • Wu, J.L.1    Abe, T.2    Inoue, R.3
  • 157
    • 0029114319 scopus 로고
    • Enhanced expression of transforming growth factor-beta and its type-I and type-II receptors in human glioblastoma
    • Yamada N., Kato M., Yamashita H., et al. Enhanced expression of transforming growth factor-beta and its type-I and type-II receptors in human glioblastoma. Int J Cancer 62 (1995) 386-392
    • (1995) Int J Cancer , vol.62 , pp. 386-392
    • Yamada, N.1    Kato, M.2    Yamashita, H.3
  • 158
    • 45849110280 scopus 로고    scopus 로고
    • Transforming growth factor-beta (TGF-beta) and brain tumours
    • Luwor R.B., Kaye A.H., and Zhu H.J. Transforming growth factor-beta (TGF-beta) and brain tumours. J Clin Neurosci 15 (2008) 845-855
    • (2008) J Clin Neurosci , vol.15 , pp. 845-855
    • Luwor, R.B.1    Kaye, A.H.2    Zhu, H.J.3
  • 159
    • 0022515570 scopus 로고
    • Transforming growth factor-beta inhibits endothelial cell proliferation
    • Frater-Schroder M., Muller G., Birchmeier W., et al. Transforming growth factor-beta inhibits endothelial cell proliferation. Biochem Biophys Res Commun 137 (1986) 295-302
    • (1986) Biochem Biophys Res Commun , vol.137 , pp. 295-302
    • Frater-Schroder, M.1    Muller, G.2    Birchmeier, W.3
  • 160
    • 0029883757 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces angiogenesis in vivo with a threshold pattern
    • Fajardo L.F., Prionas S.D., Kwan H.H., et al. Transforming growth factor beta1 induces angiogenesis in vivo with a threshold pattern. Lab Invest 74 (1996) 600-608
    • (1996) Lab Invest , vol.74 , pp. 600-608
    • Fajardo, L.F.1    Prionas, S.D.2    Kwan, H.H.3
  • 161
    • 0029871064 scopus 로고    scopus 로고
    • Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro
    • Koochekpour S., Merzak A., and Pilkington G.J. Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro. Cancer Lett 102 (1996) 209-215
    • (1996) Cancer Lett , vol.102 , pp. 209-215
    • Koochekpour, S.1    Merzak, A.2    Pilkington, G.J.3
  • 162
    • 4444341835 scopus 로고    scopus 로고
    • SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility
    • Hjelmeland M.D., Hjelmeland A.B., Sathornsumetee S., et al. SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther 3 (2004) 737-745
    • (2004) Mol Cancer Ther , vol.3 , pp. 737-745
    • Hjelmeland, M.D.1    Hjelmeland, A.B.2    Sathornsumetee, S.3
  • 163
    • 0035865158 scopus 로고    scopus 로고
    • Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape
    • Platten M., Wick W., and Weller M. Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape. Microsc Res Tech 52 (2001) 401-410
    • (2001) Microsc Res Tech , vol.52 , pp. 401-410
    • Platten, M.1    Wick, W.2    Weller, M.3
  • 164
    • 0034673243 scopus 로고    scopus 로고
    • Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression
    • Platten M., Wick W., Wild-Bode C., et al. Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression. Biochem Biophys Res Commun 268 (2000) 607-611
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 607-611
    • Platten, M.1    Wick, W.2    Wild-Bode, C.3
  • 165
    • 85047681729 scopus 로고    scopus 로고
    • Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas
    • Kunkel P., Muller S., Schirmacher P., et al. Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas. Neuro Oncol 3 (2001) 82-88
    • (2001) Neuro Oncol , vol.3 , pp. 82-88
    • Kunkel, P.1    Muller, S.2    Schirmacher, P.3
  • 166
    • 0036365052 scopus 로고    scopus 로고
    • In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
    • Abounader R., Lal B., Luddy C., et al. In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J 16 (2002) 108-110
    • (2002) FASEB J , vol.16 , pp. 108-110
    • Abounader, R.1    Lal, B.2    Luddy, C.3
  • 167
    • 0141925943 scopus 로고    scopus 로고
    • Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4
    • Brockmann M.A., Papadimitriou A., Brandt M., et al. Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4. Clin Cancer Res 9 (2003) 4578-4585
    • (2003) Clin Cancer Res , vol.9 , pp. 4578-4585
    • Brockmann, M.A.1    Papadimitriou, A.2    Brandt, M.3
  • 168
    • 0026806805 scopus 로고
    • Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system
    • Van Meir E., Ceska M., Effenberger F., et al. Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Res 52 (1992) 4297-4305
    • (1992) Cancer Res , vol.52 , pp. 4297-4305
    • Van Meir, E.1    Ceska, M.2    Effenberger, F.3
  • 169
    • 0025027767 scopus 로고
    • Human glioblastoma cells release interleukin 6 in vivo and in vitro
    • Van Meir E., Sawamura Y., Diserens A.C., et al. Human glioblastoma cells release interleukin 6 in vivo and in vitro. Cancer Res 50 (1990) 6683-6688
    • (1990) Cancer Res , vol.50 , pp. 6683-6688
    • Van Meir, E.1    Sawamura, Y.2    Diserens, A.C.3
  • 170
    • 17844397949 scopus 로고    scopus 로고
    • The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
    • Brat D.J., Bellail A.C., and Van Meir E.G. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 7 (2005) 122-133
    • (2005) Neuro Oncol , vol.7 , pp. 122-133
    • Brat, D.J.1    Bellail, A.C.2    Van Meir, E.G.3
  • 171
    • 0034872239 scopus 로고    scopus 로고
    • Interleukin-6 overexpression as a marker of malignancy in human gliomas
    • Rolhion C., Penault-Llorca F., Kemeny J.L., et al. Interleukin-6 overexpression as a marker of malignancy in human gliomas. J Neurosurg 94 (2001) 97-101
    • (2001) J Neurosurg , vol.94 , pp. 97-101
    • Rolhion, C.1    Penault-Llorca, F.2    Kemeny, J.L.3
  • 172
    • 0027404936 scopus 로고
    • Interleukin-8 stimulates angiogenesis in rats
    • Hu D.E., Hori Y., and Fan T.P. Interleukin-8 stimulates angiogenesis in rats. Inflammation 17 (1993) 135-143
    • (1993) Inflammation , vol.17 , pp. 135-143
    • Hu, D.E.1    Hori, Y.2    Fan, T.P.3
  • 173
    • 0027097806 scopus 로고
    • Interleukin-8 as a macrophage-derived mediator of angiogenesis
    • Koch A.E., Polverini P.J., Kunkel S.L., et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258 (1992) 1798-1801
    • (1992) Science , vol.258 , pp. 1798-1801
    • Koch, A.E.1    Polverini, P.J.2    Kunkel, S.L.3
  • 174
    • 0030856117 scopus 로고    scopus 로고
    • Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis
    • Desbaillets I., Diserens A.C., Tribolet N., et al. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med 186 (1997) 1201-1212
    • (1997) J Exp Med , vol.186 , pp. 1201-1212
    • Desbaillets, I.1    Diserens, A.C.2    Tribolet, N.3
  • 175
    • 0029417263 scopus 로고
    • Dual pathways of tubular morphogenesis of vascular endothelial cells by human glioma cells: vascular endothelial growth factor/basic fibroblast growth factor and interleukin-8
    • Wakabayashi Y., Shono T., Isono M., et al. Dual pathways of tubular morphogenesis of vascular endothelial cells by human glioma cells: vascular endothelial growth factor/basic fibroblast growth factor and interleukin-8. Jpn J Cancer Res 86 (1995) 1189-1197
    • (1995) Jpn J Cancer Res , vol.86 , pp. 1189-1197
    • Wakabayashi, Y.1    Shono, T.2    Isono, M.3
  • 176
    • 0033580218 scopus 로고    scopus 로고
    • Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma
    • Desbaillets I., Diserens A.C., de Tribolet N., et al. Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Oncogene 18 (1999) 1447-1456
    • (1999) Oncogene , vol.18 , pp. 1447-1456
    • Desbaillets, I.1    Diserens, A.C.2    de Tribolet, N.3
  • 177
    • 0030789842 scopus 로고    scopus 로고
    • Distribution of endogenous tumour necrosis factor alpha in gliomas
    • Maruno M., Kovach J.S., Kelly P.J., et al. Distribution of endogenous tumour necrosis factor alpha in gliomas. J Clin Pathol 50 (1997) 559-562
    • (1997) J Clin Pathol , vol.50 , pp. 559-562
    • Maruno, M.1    Kovach, J.S.2    Kelly, P.J.3
  • 178
    • 0029155901 scopus 로고
    • Detection of tumor necrosis factor-alpha protein and messenger RNA in human glial brain tumors: comparison of immunohistochemistry with in situ hybridization using molecular probes
    • Roessler K., Suchanek G., Breitschopf H., et al. Detection of tumor necrosis factor-alpha protein and messenger RNA in human glial brain tumors: comparison of immunohistochemistry with in situ hybridization using molecular probes. J Neurosurg 83 (1995) 291-297
    • (1995) J Neurosurg , vol.83 , pp. 291-297
    • Roessler, K.1    Suchanek, G.2    Breitschopf, H.3
  • 179
    • 0005636230 scopus 로고    scopus 로고
    • Effects of retinoic acid and tumor necrosis factor alpha on GL-15 glioblastoma cells
    • Chambaut-Guerin A.M., Costa S.L., Lefrancois T., et al. Effects of retinoic acid and tumor necrosis factor alpha on GL-15 glioblastoma cells. Neuroreport 11 (2000) 389-393
    • (2000) Neuroreport , vol.11 , pp. 389-393
    • Chambaut-Guerin, A.M.1    Costa, S.L.2    Lefrancois, T.3
  • 180
    • 0027732688 scopus 로고
    • Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration
    • Slowik M.R., De Luca L.G., Fiers W., et al. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. Am J Pathol 143 (1993) 1724-1730
    • (1993) Am J Pathol , vol.143 , pp. 1724-1730
    • Slowik, M.R.1    De Luca, L.G.2    Fiers, W.3
  • 181
    • 0029953517 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1
    • Ryuto M., Ono M., Izumi H., et al. Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1. J Biol Chem 271 (1996) 28220-28228
    • (1996) J Biol Chem , vol.271 , pp. 28220-28228
    • Ryuto, M.1    Ono, M.2    Izumi, H.3
  • 182
    • 0031009807 scopus 로고    scopus 로고
    • Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis
    • Yoshida S., Ono M., Shono T., et al. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 17 (1997) 4015-4023
    • (1997) Mol Cell Biol , vol.17 , pp. 4015-4023
    • Yoshida, S.1    Ono, M.2    Shono, T.3
  • 183
    • 0032568608 scopus 로고    scopus 로고
    • CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth
    • Babic A.M., Kireeva M.L., Kolesnikova T.V., et al. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci USA 95 (1998) 6355-6360
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6355-6360
    • Babic, A.M.1    Kireeva, M.L.2    Kolesnikova, T.V.3
  • 184
    • 0032817965 scopus 로고    scopus 로고
    • Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
    • Shimo T., Nakanishi T., Nishida T., et al. Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem 126 (1999) 137-145
    • (1999) J Biochem , vol.126 , pp. 137-145
    • Shimo, T.1    Nakanishi, T.2    Nishida, T.3
  • 185
    • 2242453283 scopus 로고    scopus 로고
    • Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells
    • Leu S.J., Lam S.C., and Lau L.F. Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem 277 (2002) 46248-46255
    • (2002) J Biol Chem , vol.277 , pp. 46248-46255
    • Leu, S.J.1    Lam, S.C.2    Lau, L.F.3
  • 186
    • 1642350329 scopus 로고    scopus 로고
    • Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas
    • Xie D., Yin D., Wang H.J., et al. Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas. Clin Cancer Res 10 (2004) 2072-2081
    • (2004) Clin Cancer Res , vol.10 , pp. 2072-2081
    • Xie, D.1    Yin, D.2    Wang, H.J.3
  • 187
    • 0033108116 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 content and pattern of expression correlates with histopathologic grade in diffusely infiltrating astrocytomas
    • Hirano H., Lopes M.B., Laws Jr. E.R., et al. Insulin-like growth factor-1 content and pattern of expression correlates with histopathologic grade in diffusely infiltrating astrocytomas. Neuro Oncol 1 (1999) 109-119
    • (1999) Neuro Oncol , vol.1 , pp. 109-119
    • Hirano, H.1    Lopes, M.B.2    Laws Jr., E.R.3
  • 188
  • 189
    • 17844367105 scopus 로고    scopus 로고
    • Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery
    • discussion 390
    • Bello L., Francolini M., Marthyn P., et al. Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery. Neurosurgery 49 (2001) 380-389 discussion 390
    • (2001) Neurosurgery , vol.49 , pp. 380-389
    • Bello, L.1    Francolini, M.2    Marthyn, P.3
  • 190
    • 35348866157 scopus 로고    scopus 로고
    • Integrins: molecular determinants of glioma invasion
    • D'Abaco G.M., and Kaye A.H. Integrins: molecular determinants of glioma invasion. J Clin Neurosci 14 (2007) 1041-1048
    • (2007) J Clin Neurosci , vol.14 , pp. 1041-1048
    • D'Abaco, G.M.1    Kaye, A.H.2
  • 191
    • 0033038483 scopus 로고    scopus 로고
    • Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas
    • Forsyth P.A., Wong H., Laing T.D., et al. Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. Br J Cancer 79 (1999) 1828-1835
    • (1999) Br J Cancer , vol.79 , pp. 1828-1835
    • Forsyth, P.A.1    Wong, H.2    Laing, T.D.3
  • 192
    • 0030030963 scopus 로고    scopus 로고
    • Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas
    • Rao J.S., Yamamoto M., Mohaman S., et al. Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas. Clin Exp Metastasis 14 (1996) 12-18
    • (1996) Clin Exp Metastasis , vol.14 , pp. 12-18
    • Rao, J.S.1    Yamamoto, M.2    Mohaman, S.3
  • 193
    • 0036207326 scopus 로고    scopus 로고
    • Proteases and the biology of glioma invasion
    • Binder D.K., and Berger M.S. Proteases and the biology of glioma invasion. J Neurooncol 56 (2002) 149-158
    • (2002) J Neurooncol , vol.56 , pp. 149-158
    • Binder, D.K.1    Berger, M.S.2
  • 194
    • 0031870786 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
    • Lamoreaux W.J., Fitzgerald M.E., Reiner A., et al. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc Res 55 (1998) 29-42
    • (1998) Microvasc Res , vol.55 , pp. 29-42
    • Lamoreaux, W.J.1    Fitzgerald, M.E.2    Reiner, A.3
  • 195
    • 0034765067 scopus 로고    scopus 로고
    • Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta
    • Wick W., Platten M., and Weller M. Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. J Neurooncol 53 (2001) 177-185
    • (2001) J Neurooncol , vol.53 , pp. 177-185
    • Wick, W.1    Platten, M.2    Weller, M.3
  • 196
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q., and Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14 (2000) 163-176
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 197
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275 (1997) 964-967
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 198
    • 0032945433 scopus 로고    scopus 로고
    • Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
    • Takahashi T., Kalka C., Masuda H., et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5 (1999) 434-438
    • (1999) Nat Med , vol.5 , pp. 434-438
    • Takahashi, T.1    Kalka, C.2    Masuda, H.3
  • 199
    • 18444389451 scopus 로고    scopus 로고
    • Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    • Heissig B., Hattori K., Dias S., et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109 (2002) 625-637
    • (2002) Cell , vol.109 , pp. 625-637
    • Heissig, B.1    Hattori, K.2    Dias, S.3
  • 200
    • 0142195911 scopus 로고    scopus 로고
    • Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
    • Ruzinova M.B., Schoer R.A., Gerald W., et al. Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell 4 (2003) 277-289
    • (2003) Cancer Cell , vol.4 , pp. 277-289
    • Ruzinova, M.B.1    Schoer, R.A.2    Gerald, W.3
  • 201
    • 0038644403 scopus 로고    scopus 로고
    • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
    • De Palma M., Venneri M.A., Roca C., et al. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med 9 (2003) 789-795
    • (2003) Nat Med , vol.9 , pp. 789-795
    • De Palma, M.1    Venneri, M.A.2    Roca, C.3
  • 202
    • 20144386931 scopus 로고    scopus 로고
    • Contribution of bone marrow-derived endothelial cells to human tumor vasculature
    • Peters B.A., Diaz L.A., Polyak K., et al. Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11 (2005) 261-262
    • (2005) Nat Med , vol.11 , pp. 261-262
    • Peters, B.A.1    Diaz, L.A.2    Polyak, K.3
  • 203
    • 0034666258 scopus 로고    scopus 로고
    • Progress in antiangiogenic gene therapy of cancer
    • Feldman A.L., and Libutti S.K. Progress in antiangiogenic gene therapy of cancer. Cancer 89 (2000) 1181-1194
    • (2000) Cancer , vol.89 , pp. 1181-1194
    • Feldman, A.L.1    Libutti, S.K.2
  • 204
    • 0036105592 scopus 로고    scopus 로고
    • Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons
    • Bauvois B., Dumont J., Mathiot C., et al. Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons. Leukemia 16 (2002) 791-798
    • (2002) Leukemia , vol.16 , pp. 791-798
    • Bauvois, B.1    Dumont, J.2    Mathiot, C.3
  • 205
    • 0036554710 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis
    • Izawa J.I., Sweeney P., Perrotte P., et al. Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis. Clin Cancer Res 8 (2002) 1258-1270
    • (2002) Clin Cancer Res , vol.8 , pp. 1258-1270
    • Izawa, J.I.1    Sweeney, P.2    Perrotte, P.3
  • 206
    • 0035043493 scopus 로고    scopus 로고
    • Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha
    • Ozawa S., Shinohara H., Kanayama H.O., et al. Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha. Neoplasia 3 (2001) 154-164
    • (2001) Neoplasia , vol.3 , pp. 154-164
    • Ozawa, S.1    Shinohara, H.2    Kanayama, H.O.3
  • 207
    • 0032719528 scopus 로고    scopus 로고
    • Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule
    • Slaton J.W., Perrotte P., Inoue K., et al. Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res 5 (1999) 2726-2734
    • (1999) Clin Cancer Res , vol.5 , pp. 2726-2734
    • Slaton, J.W.1    Perrotte, P.2    Inoue, K.3
  • 208
    • 0036482917 scopus 로고    scopus 로고
    • Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b: Report of 2 cases
    • Marler JJ, Rubin JB, Trede NS, et al. Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b: report of 2 cases. Pediatrics 2002;109:E37.
    • (2002) Pediatrics , vol.109
    • Marler, J.J.1    Rubin, J.B.2    Trede, N.S.3
  • 209
    • 0035134688 scopus 로고    scopus 로고
    • Interferon in oncological practice. review of interferon biology, clinical applications, and toxicities
    • Jonasch E., and Haluska F.G. Interferon in oncological practice. review of interferon biology, clinical applications, and toxicities. Oncologist 6 (2001) 34-55
    • (2001) Oncologist , vol.6 , pp. 34-55
    • Jonasch, E.1    Haluska, F.G.2
  • 210
    • 0032555937 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by interleukin 4
    • Volpert O.V., Fong T., Koch A.E., et al. Inhibition of angiogenesis by interleukin 4. J Exp Med 188 (1998) 1039-1046
    • (1998) J Exp Med , vol.188 , pp. 1039-1046
    • Volpert, O.V.1    Fong, T.2    Koch, A.E.3
  • 211
    • 0034652459 scopus 로고    scopus 로고
    • Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12
    • Duda D.G., Sunamura M., Lozonschi L., et al. Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12. Cancer Res 60 (2000) 1111-1116
    • (2000) Cancer Res , vol.60 , pp. 1111-1116
    • Duda, D.G.1    Sunamura, M.2    Lozonschi, L.3
  • 212
    • 0035915810 scopus 로고    scopus 로고
    • Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer
    • Oshikawa K., Rakhmilevich A.L., Shi F., et al. Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer. Hum Gene Ther 12 (2001) 149-160
    • (2001) Hum Gene Ther , vol.12 , pp. 149-160
    • Oshikawa, K.1    Rakhmilevich, A.L.2    Shi, F.3
  • 213
    • 0032787604 scopus 로고    scopus 로고
    • Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience
    • Huang S., Ullrich S.E., and Bar-Eli M. Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience. J Interferon Cytokine Res 19 (1999) 697-703
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 697-703
    • Huang, S.1    Ullrich, S.E.2    Bar-Eli, M.3
  • 214
    • 0030717692 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases: structure, regulation and biological functions
    • Gomez D.E., Alonso D.F., Yoshiji H., et al. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur J Cell Biol 74 (1997) 111-122
    • (1997) Eur J Cell Biol , vol.74 , pp. 111-122
    • Gomez, D.E.1    Alonso, D.F.2    Yoshiji, H.3
  • 215
    • 0032816628 scopus 로고    scopus 로고
    • Inhibition of endothelial cell migration by gene transfer of tissue inhibitor of metalloproteinases-1
    • Fernandez H.A., Kallenbach K., Seghezzi G., et al. Inhibition of endothelial cell migration by gene transfer of tissue inhibitor of metalloproteinases-1. J Surg Res 82 (1999) 156-162
    • (1999) J Surg Res , vol.82 , pp. 156-162
    • Fernandez, H.A.1    Kallenbach, K.2    Seghezzi, G.3
  • 216
    • 0027383944 scopus 로고
    • Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
    • Murphy A.N., Unsworth E.J., and Stetler-Stevenson W.G. Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol 157 (1993) 351-358
    • (1993) J Cell Physiol , vol.157 , pp. 351-358
    • Murphy, A.N.1    Unsworth, E.J.2    Stetler-Stevenson, W.G.3
  • 217
    • 0036839094 scopus 로고    scopus 로고
    • Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model
    • Spurbeck W.W., Ng C.Y., Strom T.S., et al. Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model. Blood 100 (2002) 3361-3368
    • (2002) Blood , vol.100 , pp. 3361-3368
    • Spurbeck, W.W.1    Ng, C.Y.2    Strom, T.S.3
  • 218
    • 0036831302 scopus 로고    scopus 로고
    • The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
    • Hajitou A., Grignet C., Devy L., et al. The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells. FASEB J 16 (2002) 1802-1804
    • (2002) FASEB J , vol.16 , pp. 1802-1804
    • Hajitou, A.1    Grignet, C.2    Devy, L.3
  • 219
    • 0037372436 scopus 로고    scopus 로고
    • Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells
    • Wajih N., and Sane D.C. Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells. Blood 101 (2003) 1857-1863
    • (2003) Blood , vol.101 , pp. 1857-1863
    • Wajih, N.1    Sane, D.C.2
  • 220
    • 17444390815 scopus 로고    scopus 로고
    • Multiple forms of angiostatin induce apoptosis in endothelial cells
    • Lucas R., Holmgren L., Garcia I., et al. Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood 92 (1998) 4730-4741
    • (1998) Blood , vol.92 , pp. 4730-4741
    • Lucas, R.1    Holmgren, L.2    Garcia, I.3
  • 221
    • 0035810936 scopus 로고    scopus 로고
    • Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin
    • Moser T.L., Kenan D.J., Ashley T.A., et al. Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci USA 98 (2001) 6656-6661
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6656-6661
    • Moser, T.L.1    Kenan, D.J.2    Ashley, T.A.3
  • 222
    • 0033014037 scopus 로고    scopus 로고
    • Angiostatin binds ATP synthase on the surface of human endothelial cells
    • Moser T.L., Stack M.S., Asplin I., et al. Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci USA 96 (1999) 2811-2816
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2811-2816
    • Moser, T.L.1    Stack, M.S.2    Asplin, I.3
  • 223
    • 0037008721 scopus 로고    scopus 로고
    • Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1
    • Kim Y.M., Hwang S., Kim Y.M., et al. Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem 277 (2002) 27872-27879
    • (2002) J Biol Chem , vol.277 , pp. 27872-27879
    • Kim, Y.M.1    Hwang, S.2    Kim, Y.M.3
  • 224
    • 0036584733 scopus 로고    scopus 로고
    • Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin
    • Urbich C., Reissner A., Chavakis E., et al. Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB J 16 (2002) 706-708
    • (2002) FASEB J , vol.16 , pp. 706-708
    • Urbich, C.1    Reissner, A.2    Chavakis, E.3
  • 225
    • 0035970051 scopus 로고    scopus 로고
    • Interaction of endostatin with integrins implicated in angiogenesis
    • Rehn M., Veikkola T., Kukk-Valdre E., et al. Interaction of endostatin with integrins implicated in angiogenesis. Proc Natl Acad Sci USA 98 (2001) 1024-1029
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1024-1029
    • Rehn, M.1    Veikkola, T.2    Kukk-Valdre, E.3
  • 226
    • 0032536859 scopus 로고    scopus 로고
    • Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution
    • Hohenester E., Sasaki T., Olsen B.R., et al. Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution. EMBO J 17 (1998) 1656-1664
    • (1998) EMBO J , vol.17 , pp. 1656-1664
    • Hohenester, E.1    Sasaki, T.2    Olsen, B.R.3
  • 227
    • 0034307327 scopus 로고    scopus 로고
    • Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase
    • Kim Y.M., Jang J.W., Lee O.H., et al. Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase. Cancer Res 60 (2000) 5410-5413
    • (2000) Cancer Res , vol.60 , pp. 5410-5413
    • Kim, Y.M.1    Jang, J.W.2    Lee, O.H.3
  • 228
    • 0033597130 scopus 로고    scopus 로고
    • Endostatin induces endothelial cell apoptosis
    • Dhanabal M., Ramchandran R., Waterman M.J., et al. Endostatin induces endothelial cell apoptosis. J Biol Chem 274 (1999) 11721-11726
    • (1999) J Biol Chem , vol.274 , pp. 11721-11726
    • Dhanabal, M.1    Ramchandran, R.2    Waterman, M.J.3
  • 229
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov 6 (2007) 273-286
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 230
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • Vredenburgh J.J., Desjardins A., Herndon II J.E., et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25 (2007) 4722-4729
    • (2007) J Clin Oncol , vol.25 , pp. 4722-4729
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 231
    • 33646675851 scopus 로고    scopus 로고
    • MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
    • Pope W.B., Lai A., Nghiemphu P., et al. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 66 (2006) 1258-1260
    • (2006) Neurology , vol.66 , pp. 1258-1260
    • Pope, W.B.1    Lai, A.2    Nghiemphu, P.3
  • 232
    • 67650769211 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan therapy in relapsed, heavily pre-treated malignant glioma: A case series
    • Friedland D.M., Ali S.A., Ahmad A., et al. Bevacizumab plus irinotecan therapy in relapsed, heavily pre-treated malignant glioma: A case series. J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 12500
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 12500
    • Friedland, D.M.1    Ali, S.A.2    Ahmad, A.3
  • 233
    • 0033897173 scopus 로고    scopus 로고
    • A phase II study of temozolomide vs. Procarbazine in patients with glioblastoma multiforme at first relapse
    • Yung W.K., Albright R.E., Olson J., et al. A phase II study of temozolomide vs. Procarbazine in patients with glioblastoma multiforme at first relapse. Br J Cancer 83 (2000) 588-593
    • (2000) Br J Cancer , vol.83 , pp. 588-593
    • Yung, W.K.1    Albright, R.E.2    Olson, J.3
  • 234
    • 33744513575 scopus 로고    scopus 로고
    • ®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
    • ®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 407 (2005) 597-612
    • (2005) Methods Enzymol , vol.407 , pp. 597-612
    • Adnane, L.1    Trail, P.A.2    Taylor, I.3
  • 235
    • 36849058341 scopus 로고    scopus 로고
    • A phase I trial of sorafenib (BAY 43-9006) for patients with recurrent or progressive malignant glioma (NABTT 0401)
    • Nabors L.B., Rosenfeld M., Chamberlain M., et al. A phase I trial of sorafenib (BAY 43-9006) for patients with recurrent or progressive malignant glioma (NABTT 0401). J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2058
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2058
    • Nabors, L.B.1    Rosenfeld, M.2    Chamberlain, M.3
  • 236
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di Tomaso E., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11 (2007) 83-95
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 237
    • 36549065256 scopus 로고    scopus 로고
    • A phase II trial of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
    • Batchelor T., Sorensen A.G., Ancukiewicz M., et al. A phase II trial of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2001
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2001
    • Batchelor, T.1    Sorensen, A.G.2    Ancukiewicz, M.3
  • 238
    • 0033947625 scopus 로고    scopus 로고
    • New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis
    • Bold G., Altmann K.H., Frei J., et al. New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J Med Chem 43 (2000) 2310-2323
    • (2000) J Med Chem , vol.43 , pp. 2310-2323
    • Bold, G.1    Altmann, K.H.2    Frei, J.3
  • 239
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood J.M., Bold G., Buchdunger E., et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 60 (2000) 2178-2189
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 240
    • 36849013254 scopus 로고    scopus 로고
    • Phase I trial of imatinib mesylate, hydroxyurea and vatalanib for patients with recurrent glioblastoma multiforme (GBM)
    • Sathornsumetee S., Rich J.N., Vredenburgh J.J., et al. Phase I trial of imatinib mesylate, hydroxyurea and vatalanib for patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2027
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2027
    • Sathornsumetee, S.1    Rich, J.N.2    Vredenburgh, J.J.3
  • 241
    • 3142774878 scopus 로고    scopus 로고
    • AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
    • Traxler P., Allegrini P.R., Brandt R., et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64 (2004) 4931-4941
    • (2004) Cancer Res , vol.64 , pp. 4931-4941
    • Traxler, P.1    Allegrini, P.R.2    Brandt, R.3
  • 242
    • 28044436878 scopus 로고    scopus 로고
    • A phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases, in recurrent GBM patients
    • Reardon D., Cloughesy T., Conrad C., et al. A phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases, in recurrent GBM patients. J Clin Oncol (Meeting Abstracts) 23 16 Suppl. (2005) 3063
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , Issue.16 SUPPL , pp. 3063
    • Reardon, D.1    Cloughesy, T.2    Conrad, C.3
  • 243
    • 33847359256 scopus 로고    scopus 로고
    • Targeting malignant glioma survival signalling to improve clinical outcomes
    • Wong M.L., Kaye A.H., and Hovens C.M. Targeting malignant glioma survival signalling to improve clinical outcomes. J Clin Neurosci 14 (2007) 301-308
    • (2007) J Clin Neurosci , vol.14 , pp. 301-308
    • Wong, M.L.1    Kaye, A.H.2    Hovens, C.M.3
  • 244
    • 21044431575 scopus 로고    scopus 로고
    • Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
    • Chang S.M., Wen P., Cloughesy T., et al. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest New Drugs 23 (2005) 357-361
    • (2005) Invest New Drugs , vol.23 , pp. 357-361
    • Chang, S.M.1    Wen, P.2    Cloughesy, T.3
  • 245
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study
    • Galanis E., Buckner J.C., Maurer M.J., et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 23 (2005) 5294-5304
    • (2005) J Clin Oncol , vol.23 , pp. 5294-5304
    • Galanis, E.1    Buckner, J.C.2    Maurer, M.J.3
  • 246
    • 33847402740 scopus 로고    scopus 로고
    • A pilot study to assess the tolerability and efficacy of RAD-001 (everolimus) with gefitinib in patients with recurrent glioblastoma multiforme (GBM)
    • Nguyen TD, Lassman AB, Lis E, et al. A pilot study to assess the tolerability and efficacy of RAD-001 (everolimus) with gefitinib in patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol (Meeting Abstracts), 2006;24:1507.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 1507
    • Nguyen, T.D.1    Lassman, A.B.2    Lis, E.3
  • 247
    • 33847381616 scopus 로고    scopus 로고
    • Phase I trial of bortezomib in adults with recurrent malignant glioma
    • Phuphanich S, Supko J, Carson KA, et al. Phase I trial of bortezomib in adults with recurrent malignant glioma. J Clin Oncol (Meeting Abstracts), 2006;24:1567.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 1567
    • Phuphanich, S.1    Supko, J.2    Carson, K.A.3
  • 248
    • 67650781740 scopus 로고    scopus 로고
    • A phase I trial using the proteasome inhibitor bortezomib and concurrent temazolomide and radiotherapy for high grade gliomas
    • Dicker A., Werner-Wasik M., Machtay M., et al. A phase I trial using the proteasome inhibitor bortezomib and concurrent temazolomide and radiotherapy for high grade gliomas. J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2061
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2061
    • Dicker, A.1    Werner-Wasik, M.2    Machtay, M.3
  • 249
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
    • Graff J.R., McNulty A.M., Hanna K.R., et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65 (2005) 7462-7469
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3
  • 250
    • 0036137647 scopus 로고    scopus 로고
    • Antiangiogenic effects of a protein kinase Cbeta-selective small molecule
    • Teicher B.A., Alvarez E., Menon K., et al. Antiangiogenic effects of a protein kinase Cbeta-selective small molecule. Cancer Chemother Pharmacol 49 (2002) 69-77
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 69-77
    • Teicher, B.A.1    Alvarez, E.2    Menon, K.3
  • 251
    • 33646555670 scopus 로고    scopus 로고
    • Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas
    • Fine H.A., Kim L., Royce C., et al. Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas. J Clin Oncol (Meeting Abstracts) 23 16 Suppl. (2005) 1504
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , Issue.16 SUPPL , pp. 1504
    • Fine, H.A.1    Kim, L.2    Royce, C.3
  • 252
    • 34848883049 scopus 로고    scopus 로고
    • Phase I/II study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM) or gliosarcoma
    • Butowski N.A., Lamborn K., Chang S., et al. Phase I/II study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM) or gliosarcoma. J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 12511
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 12511
    • Butowski, N.A.1    Lamborn, K.2    Chang, S.3
  • 253
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
    • Gupta D., Treon S.P., Shima Y., et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 15 (2001) 1950-1961
    • (2001) Leukemia , vol.15 , pp. 1950-1961
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3
  • 254
    • 33646260913 scopus 로고    scopus 로고
    • Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells
    • Tamilarasan K.P., Kolluru G.K., Rajaram M., et al. Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells. BMC Cell Biol 7 (2006) 17
    • (2006) BMC Cell Biol , vol.7 , pp. 17
    • Tamilarasan, K.P.1    Kolluru, G.K.2    Rajaram, M.3
  • 255
    • 0033954292 scopus 로고    scopus 로고
    • Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas
    • Fine H.A., Figg W.D., Jaeckle K., et al. Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J Clin Oncol 18 (2000) 708-715
    • (2000) J Clin Oncol , vol.18 , pp. 708-715
    • Fine, H.A.1    Figg, W.D.2    Jaeckle, K.3
  • 256
    • 0037811745 scopus 로고    scopus 로고
    • Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas
    • Fine H.A., Wen P.Y., Maher E.A., et al. Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas. J Clin Oncol 21 (2003) 2299-2304
    • (2003) J Clin Oncol , vol.21 , pp. 2299-2304
    • Fine, H.A.1    Wen, P.Y.2    Maher, E.A.3
  • 257
    • 67650771897 scopus 로고    scopus 로고
    • Phase II trial of thalidomide in combination with irinotecan in adults with recurrent glioblastoma multiforme
    • Puduvalli V.K., Giglio P., Groves M.D., et al. Phase II trial of thalidomide in combination with irinotecan in adults with recurrent glioblastoma multiforme. J Clin Oncol (Meeting Abstracts) 23 16 Suppl. (2005) 1524
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , Issue.16 SUPPL , pp. 1524
    • Puduvalli, V.K.1    Giglio, P.2    Groves, M.D.3
  • 258
    • 13444256401 scopus 로고    scopus 로고
    • Efficacy of lenalidomide in myelodysplastic syndromes
    • List A., Kurtin S., Roe D.J., et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med 352 (2005) 549-557
    • (2005) N Engl J Med , vol.352 , pp. 549-557
    • List, A.1    Kurtin, S.2    Roe, D.J.3
  • 259
    • 37249075870 scopus 로고    scopus 로고
    • A Phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors
    • Fine H.A., Kim L., Albert P.S., et al. A Phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors. Clin Cancer Res 13 (2007) 7101-7106
    • (2007) Clin Cancer Res , vol.13 , pp. 7101-7106
    • Fine, H.A.1    Kim, L.2    Albert, P.S.3
  • 260
    • 0036792055 scopus 로고    scopus 로고
    • Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance
    • Ma L., del Soldato P., and Wallace J.L. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Proc Natl Acad Sci USA 99 (2002) 13243-13247
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13243-13247
    • Ma, L.1    del Soldato, P.2    Wallace, J.L.3
  • 261
    • 34249308965 scopus 로고    scopus 로고
    • Phase I/II trial of twice-daily temozolomide and celecoxib for treatment of relapsed malignant glioma: Final data
    • Pannullo S.C., Burton J., Serventi J., et al. Phase I/II trial of twice-daily temozolomide and celecoxib for treatment of relapsed malignant glioma: Final data. J Clin Oncol (Meeting Abstracts) 24 18 Suppl. (2006) 1519
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , Issue.18 SUPPL , pp. 1519
    • Pannullo, S.C.1    Burton, J.2    Serventi, J.3
  • 262
    • 0025343857 scopus 로고
    • Growth inhibitory effects of interferon-beta but not interferon-alpha on human glioma cells: correlation of receptor binding, 2′, 5′-oligoadenylate synthetase and protein kinase activity
    • Rosenblum M.G., Yung W.K., Kelleher P.J., et al. Growth inhibitory effects of interferon-beta but not interferon-alpha on human glioma cells: correlation of receptor binding, 2′, 5′-oligoadenylate synthetase and protein kinase activity. J Interferon Res 10 (1990) 141-151
    • (1990) J Interferon Res , vol.10 , pp. 141-151
    • Rosenblum, M.G.1    Yung, W.K.2    Kelleher, P.J.3
  • 263
    • 0023200679 scopus 로고
    • Antitumor effect of recombinant murine interferon-beta against mouse malignant glioma
    • Kuroki M., Tanaka R., Suzuki Y., et al. Antitumor effect of recombinant murine interferon-beta against mouse malignant glioma. J Interferon Res 7 (1987) 301-311
    • (1987) J Interferon Res , vol.7 , pp. 301-311
    • Kuroki, M.1    Tanaka, R.2    Suzuki, Y.3
  • 264
    • 0033902039 scopus 로고    scopus 로고
    • Efficient inhibition of in vivo human malignant glioma growth and angiogenesis by interferon-beta treatment at early stage of tumor development
    • Hong Y.K., Chung D.S., Joe Y.A., et al. Efficient inhibition of in vivo human malignant glioma growth and angiogenesis by interferon-beta treatment at early stage of tumor development. Clin Cancer Res 6 (2000) 3354-3360
    • (2000) Clin Cancer Res , vol.6 , pp. 3354-3360
    • Hong, Y.K.1    Chung, D.S.2    Joe, Y.A.3
  • 265
    • 0029075603 scopus 로고
    • Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas
    • Singh R.K., Gutman M., Bucana C.D., et al. Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 92 (1995) 4562-4566
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4562-4566
    • Singh, R.K.1    Gutman, M.2    Bucana, C.D.3
  • 266
    • 40849090265 scopus 로고    scopus 로고
    • A phase II study of temozolomide plus pegylated interferon alfa-2b for recurrent anaplastic glioma and glioblastoma multiforme
    • Groves M.D., Puduvalli V., Gilbert M.R., et al. A phase II study of temozolomide plus pegylated interferon alfa-2b for recurrent anaplastic glioma and glioblastoma multiforme. J Clin Oncol (Meeting Abstracts) 23 16 Suppl. (2005) 1519
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , Issue.16 SUPPL , pp. 1519
    • Groves, M.D.1    Puduvalli, V.2    Gilbert, M.R.3
  • 267
    • 67649359584 scopus 로고    scopus 로고
    • Phase I analysis of systemic interferon alpha utilized with gliadel in adults with recurrent glioblastoma multiforme (GBM)
    • Lawson D.H., Phuphanich S., McKenzie E., et al. Phase I analysis of systemic interferon alpha utilized with gliadel in adults with recurrent glioblastoma multiforme (GBM). J Clin Oncol (Meeting Abstracts) 24 18 Suppl. (2006) 11508
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , Issue.18 SUPPL , pp. 11508
    • Lawson, D.H.1    Phuphanich, S.2    McKenzie, E.3
  • 268
    • 34247895532 scopus 로고    scopus 로고
    • Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro
    • Loges S., Butzal M., Otten J., et al. Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro. Biochem Biophys Res Commun 357 (2007) 1016-1020
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 1016-1020
    • Loges, S.1    Butzal, M.2    Otten, J.3
  • 269
    • 33845628019 scopus 로고    scopus 로고
    • Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice
    • discussion 1312
    • Yamada S., Bu X.Y., Khankaldyyan V., et al. Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery 59 (2006) 1304-1312 discussion 1312
    • (2006) Neurosurgery , vol.59 , pp. 1304-1312
    • Yamada, S.1    Bu, X.Y.2    Khankaldyyan, V.3
  • 270
    • 52949091008 scopus 로고    scopus 로고
    • Phase IIa trial of cilengitide (EMD121974) single-agent therapy in patients (pts) with recurrent glioblastoma (GBM): EMD 121974-009
    • Reardon D., Fink K., Nabors B., et al. Phase IIa trial of cilengitide (EMD121974) single-agent therapy in patients (pts) with recurrent glioblastoma (GBM): EMD 121974-009. J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2002
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2002
    • Reardon, D.1    Fink, K.2    Nabors, B.3
  • 271
    • 56749119313 scopus 로고    scopus 로고
    • Phase I/IIa trial of cilengitide (EMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients (pts) with newly diagnosed glioblastoma (GBM)
    • Stupp R., Goldbrunner R., Neyns B., et al. Phase I/IIa trial of cilengitide (EMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients (pts) with newly diagnosed glioblastoma (GBM). J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2000
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2000
    • Stupp, R.1    Goldbrunner, R.2    Neyns, B.3
  • 272
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R., Mason W.P., van den Bent M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352 (2005) 987-996
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 273
    • 0033864065 scopus 로고    scopus 로고
    • Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. A novel pharmacological approach for tissue remodelling-related diseases
    • Scatena R. Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. A novel pharmacological approach for tissue remodelling-related diseases. Expert Opin Investig Drugs 9 (2000) 2159-2165
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2159-2165
    • Scatena, R.1
  • 274
    • 4243269889 scopus 로고    scopus 로고
    • Randomized phase II study of temozolomide (TMZ) with and without the matrix metalloprotease (MMP) inhibitor prinomastat in patients (pts) with glioblastoma multiforme (GBM) following best surgery and radiation therapy
    • abstr 100
    • Levin V., Phuphanich S., Glantz M., et al. Randomized phase II study of temozolomide (TMZ) with and without the matrix metalloprotease (MMP) inhibitor prinomastat in patients (pts) with glioblastoma multiforme (GBM) following best surgery and radiation therapy. Proc Am Soc Clin Oncol 21 (2002) abstr 100
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Levin, V.1    Phuphanich, S.2    Glantz, M.3
  • 275
    • 0037320432 scopus 로고    scopus 로고
    • 2-Methoxyestradiol, a promising anticancer agent
    • Lakhani N.J., Sarkar M.A., Venitz J., et al. 2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy 23 (2003) 165-172
    • (2003) Pharmacotherapy , vol.23 , pp. 165-172
    • Lakhani, N.J.1    Sarkar, M.A.2    Venitz, J.3
  • 276
    • 39149097386 scopus 로고    scopus 로고
    • Phase II open-label, safety, pharmacokinetic and efficacy study of 2-methoxyestradiol nanocrystal colloidal dispersion administered orally to patients with recurrent glioblastoma multiforme
    • Kirkpatrick J., Desjardins A., Quinn J., et al. Phase II open-label, safety, pharmacokinetic and efficacy study of 2-methoxyestradiol nanocrystal colloidal dispersion administered orally to patients with recurrent glioblastoma multiforme. J Clin Oncol (Meeting Abstracts) 25 18 Suppl. (2007) 2065
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL , pp. 2065
    • Kirkpatrick, J.1    Desjardins, A.2    Quinn, J.3
  • 277
    • 14544305077 scopus 로고    scopus 로고
    • Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions
    • Gasparini G., Longo R., Fanelli M., et al. Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions. J Clin Oncol 23 (2005) 1295-1311
    • (2005) J Clin Oncol , vol.23 , pp. 1295-1311
    • Gasparini, G.1    Longo, R.2    Fanelli, M.3


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