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Volumn 29, Issue 2-3, 1999, Pages 232-249

The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

(2)  Bredel, Markus a   Pollack, Ian F a  

a NONE

Author keywords

Apoptosis; Astrocytoma; Cell proliferation; Farnesyltransferase; Geranylgeranyltransferase; Glioblastoma multiforme; Glioma growth; Growth factor; Growth inhibition; High grade glioma; Mutation; p21 Ras overactivation; Signal transduction

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEIN P21;

EID: 0032927688     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(98)00057-5     Document Type: Review
Times cited : (50)

References (257)
  • 1
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • Aaronson S.A. Growth factors and cancer. Science. 254:1991;1146-1153.
    • (1991) Science , vol.254 , pp. 1146-1153
    • Aaronson, S.A.1
  • 3
    • 0026799441 scopus 로고
    • Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity
    • Adler V., Polotskaya A., Wagner F., Kraft A.S. Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity. J. Biol. Chem. 267:1992;17001-17005.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17001-17005
    • Adler, V.1    Polotskaya, A.2    Wagner, F.3    Kraft, A.S.4
  • 4
    • 0030018796 scopus 로고    scopus 로고
    • Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120-GAP and neurofibromin
    • Ahmadian M.R., Wiesmuller L., Lautwein A., Bischoff F.R., Wittinghofer A. Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120-GAP and neurofibromin. J. Biol. Chem. 271:1996;16409-16415.
    • (1996) J. Biol. Chem. , vol.271 , pp. 16409-16415
    • Ahmadian, M.R.1    Wiesmuller, L.2    Lautwein, A.3    Bischoff, F.R.4    Wittinghofer, A.5
  • 11
    • 0027233448 scopus 로고
    • Signal transduction via the MAP kinases: Proceed at your own RSK
    • Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad. Sci. USA. 90:1993;5889-5892.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5889-5892
    • Blenis, J.1
  • 13
    • 0029397307 scopus 로고
    • The p53 gene and its role in human brain tumors
    • Bogler O., Huang H.-J.S., Kleihues P., Cavenee W.K. The p53 gene and its role in human brain tumors. Glia. 15:1995;308-327.
    • (1995) Glia , vol.15 , pp. 308-327
    • Bogler, O.1    Huang, H.-J.S.2    Kleihues, P.3    Cavenee, W.K.4
  • 14
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski M.S., McCormick F. Proteins regulating Ras and its relatives. Nature. 366:1993;643-654.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 15
    • 0025729180 scopus 로고
    • Differential regulation of Ras-GAP and neurofibromatosis gene product activities
    • Bollag G., McCormick F. Differential regulation of Ras-GAP and neurofibromatosis gene product activities. Nature. 351:1991;576-579.
    • (1991) Nature , vol.351 , pp. 576-579
    • Bollag, G.1    McCormick, F.2
  • 16
    • 0025838675 scopus 로고
    • Regulators and effectors of Ras proteins
    • Bollag G., McCormick F. Regulators and effectors of Ras proteins. Annu. Rev. Cell Biol. 7:1991;601-632.
    • (1991) Annu. Rev. Cell Biol. , vol.7 , pp. 601-632
    • Bollag, G.1    McCormick, F.2
  • 17
    • 0030055981 scopus 로고    scopus 로고
    • Characterization of the C-terminal domain of Ras-GTPase-activating protein (Ras-GAP) as substrate for epidermal growth factor receptor and p60 (c-Src) kinase
    • Borowski P., Kornetzky L., Heiland M., Roloff S., Weber W., Laufs R. Characterization of the C-terminal domain of Ras-GTPase-activating protein (Ras-GAP) as substrate for epidermal growth factor receptor and p60 (c-Src) kinase. Biochem. Mol. Biol. Int. 39:1996;635-646.
    • (1996) Biochem. Mol. Biol. Int. , vol.39 , pp. 635-646
    • Borowski, P.1    Kornetzky, L.2    Heiland, M.3    Roloff, S.4    Weber, W.5    Laufs, R.6
  • 18
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancers: A review
    • Bos J.L. Ras oncogenes in human cancers: a review. Cancer Res. 49:1989;4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 19
    • 0344072260 scopus 로고
    • Mutational activation of human Ras genes
    • Bos J.L. Mutational activation of human Ras genes. Nato. ASI Ser. A. 170:1989;15-18.
    • (1989) Nato. ASI Ser. a , vol.170 , pp. 15-18
    • Bos, J.L.1
  • 20
    • 0026165752 scopus 로고
    • Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies
    • Boulton T.G., Cobb M.H. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul. 2:1991;357-371.
    • (1991) Cell Regul. , vol.2 , pp. 357-371
    • Boulton, T.G.1    Cobb, M.H.2
  • 21
    • 0025010979 scopus 로고
    • The GTPase superfamily: A conserved switch for all diverse functions
    • Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: a conserved switch for all diverse functions. Nature. 348:1990;125-132.
    • (1990) Nature , vol.348 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 22
    • 0030708665 scopus 로고    scopus 로고
    • The role of protein kinase C (PKC) in the evolution and proliferation of malignant glioma, and the application of PKC inhibition as a novel approach to anti-glioma-therapy
    • Bredel M., Pollack I.F. The role of protein kinase C (PKC) in the evolution and proliferation of malignant glioma, and the application of PKC inhibition as a novel approach to anti-glioma-therapy. Acta Neurochir. 139:1997;1000-1013.
    • (1997) Acta Neurochir. , vol.139 , pp. 1000-1013
    • Bredel, M.1    Pollack, I.F.2
  • 23
    • 0030721588 scopus 로고    scopus 로고
    • Basic fibroblast growth factor (bFGF) expression as a predictor of prognosis in pediatric high-grade gliomas
    • Bredel M., Pollack I.F., Campbell J.W., Hamilton R.L. Basic fibroblast growth factor (bFGF) expression as a predictor of prognosis in pediatric high-grade gliomas. Clin. Cancer Res. 3:1997;2157-2164.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 2157-2164
    • Bredel, M.1    Pollack, I.F.2    Campbell, J.W.3    Hamilton, R.L.4
  • 24
    • 0344934276 scopus 로고    scopus 로고
    • P21-Ras Inhibition as a novel therapeutic strategy to block malignant glioma growth
    • (in press)
    • M. Bredel, I.F. Pollack, J.M. Freund, A. Hamilton, S.M. Sebti, P21-Ras Inhibition as a novel therapeutic strategy to block malignant glioma growth, Neurosurgery (in press).
    • Neurosurgery
    • Bredel, M.1    Pollack, I.F.2    Freund, J.M.3    Hamilton, A.4    Sebti, S.M.5
  • 25
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21-Ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor
    • Buday L., Downhard J. Epidermal growth factor regulates p21-Ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor. Cell. 73:1993;611-620.
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downhard, J.2
  • 27
    • 0029125820 scopus 로고
    • K-Ras mutation and pancreatic adenocarcinoma
    • Caldas C., Kern S.E. K-Ras mutation and pancreatic adenocarcinoma. Int. J. Pancreatol. 18:1995;1-6.
    • (1995) Int. J. Pancreatol. , vol.18 , pp. 1-6
    • Caldas, C.1    Kern, S.E.2
  • 30
    • 0027050783 scopus 로고
    • Biochemistry of protein prenylation
    • Casay P.J. Biochemistry of protein prenylation. J. Lipid Res. 33:1992;1731-1740.
    • (1992) J. Lipid Res. , vol.33 , pp. 1731-1740
    • Casay, P.J.1
  • 32
    • 0027367141 scopus 로고
    • Regulated and constitutive activity by CDC25MM (GRF), a Ras-specific exchange factor
    • Cen H., Papageorge A.G., Vass W.C., Zhang K., Lowy D.R. Regulated and constitutive activity by CDC25MM (GRF), a Ras-specific exchange factor. Mol. Cell Biol. 13:1993;7718-7724.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 7718-7724
    • Cen, H.1    Papageorge, A.G.2    Vass, W.C.3    Zhang, K.4    Lowy, D.R.5
  • 33
    • 0028239183 scopus 로고
    • Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium
    • Chao T.-S.O., Foster D.A., Rapp U.R., Rosner M.R. Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J. Biol. Chem. 269:1994;7337-7341.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7337-7341
    • Chao, T.-S.O.1    Foster, D.A.2    Rapp, U.R.3    Rosner, M.R.4
  • 35
    • 0028971751 scopus 로고
    • Directions of p21-Ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2
    • Chen C.Y., Faller D.V. Directions of p21-Ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene. 11:1995;1487-1498.
    • (1995) Oncogene , vol.11 , pp. 1487-1498
    • Chen, C.Y.1    Faller, D.V.2
  • 36
    • 0029939164 scopus 로고    scopus 로고
    • Sos phosphorylation and dissociation of the Grb2-Sos complex by the ERK and JNK signaling pathways
    • Chen D., Waters S.B., Holt K.H., Pessin J.E. Sos phosphorylation and dissociation of the Grb2-Sos complex by the ERK and JNK signaling pathways. J. Biol. Chem. 271:1996;6328-6332.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6328-6332
    • Chen, D.1    Waters, S.B.2    Holt, K.H.3    Pessin, J.E.4
  • 37
    • 0026608787 scopus 로고
    • Nuclear localization and regulation of ERK- And RSK-encoded protein kinases
    • Chen R.H., Sarnecki C., Blenis J. Nuclear localization and regulation of ERK- and RSK-encoded protein kinases. Mol. Cell Biol. 12:1992;915-927.
    • (1992) Mol. Cell Biol. , vol.12 , pp. 915-927
    • Chen, R.H.1    Sarnecki, C.2    Blenis, J.3
  • 38
    • 0344934272 scopus 로고
    • Differential antagonism of Ras biological activity by the Ras GAP catalytic and SH2/SH3 domains
    • Clark G.J., Hisaka M.M., Abe K., Der C.J. Differential antagonism of Ras biological activity by the Ras GAP catalytic and SH2/SH3 domains. Proc. Am. Assoc. Cancer Res. 33:1992;A2369.
    • (1992) Proc. Am. Assoc. Cancer Res. , vol.33 , pp. 2369
    • Clark, G.J.1    Hisaka, M.M.2    Abe, K.3    Der, C.J.4
  • 39
    • 0027170176 scopus 로고
    • RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
    • Cook S.J., Rubinfeld B., Albert I., McCormick F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12:1993;3475-3485.
    • (1993) EMBO J. , vol.12 , pp. 3475-3485
    • Cook, S.J.1    Rubinfeld, B.2    Albert, I.3    McCormick, F.4
  • 40
    • 0027026591 scopus 로고
    • Protein prenyalation: More than just glue?
    • Cox A.D., Der C.J. Protein prenyalation: more than just glue? Curr. Opin. Cell Biol. 4:1992;1008-1016.
    • (1992) Curr. Opin. Cell Biol. , vol.4 , pp. 1008-1016
    • Cox, A.D.1    Der, C.J.2
  • 41
    • 0027304607 scopus 로고
    • Extracellular signals and reversible protein phosphorylation: What to MEK of it all
    • Crews C.M., Erikson R.L. Extracellular signals and reversible protein phosphorylation: what to MEK of it all. Cell. 74:1993;215-217.
    • (1993) Cell , vol.74 , pp. 215-217
    • Crews, C.M.1    Erikson, R.L.2
  • 42
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • Crews C.M., Alessandrini A., Erikson R.L. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 258:1992;478.
    • (1992) Science , vol.258 , pp. 478
    • Crews, C.M.1    Alessandrini, A.2    Erikson, R.L.3
  • 44
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathway
    • Davis R.L. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:1993;14553-14556.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14553-14556
    • Davis, R.L.1
  • 45
    • 0028721727 scopus 로고
    • Molecular changes involved in the carcinogenesis of brain tumors
    • Debiec-Rychter M., Liberski P.P. Molecular changes involved in the carcinogenesis of brain tumors. Folia Neuropathol. 32:1994;199-203.
    • (1994) Folia Neuropathol. , vol.32 , pp. 199-203
    • Debiec-Rychter, M.1    Liberski, P.P.2
  • 47
    • 0026031837 scopus 로고
    • Lovastatin selectively inhibits Ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells
    • Defeo-Jones D., McAvoy E.M., Jones R.E., Vuocolo G.A., Haskell K.M., Wegrzyn R.J., Oliff A. Lovastatin selectively inhibits Ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells. Mol. Cell Biol. 11:1991;2307-2310.
    • (1991) Mol. Cell Biol. , vol.11 , pp. 2307-2310
    • Defeo-Jones, D.1    McAvoy, E.M.2    Jones, R.E.3    Vuocolo, G.A.4    Haskell, K.M.5    Wegrzyn, R.J.6    Oliff, A.7
  • 49
    • 0029743912 scopus 로고    scopus 로고
    • Programmed cell death (apoptosis) and cancer chemotherapy
    • Denmeade S.R., Isaacs J.T. Programmed cell death (apoptosis) and cancer chemotherapy. Cancer Control. 3:1996;303-309.
    • (1996) Cancer Control , vol.3 , pp. 303-309
    • Denmeade, S.R.1    Isaacs, J.T.2
  • 50
    • 0026641090 scopus 로고
    • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH3T3 cells and in vitro
    • Dent P., Haser W., Haystead T.A., Vincent L.A., Roberts T.M., Sturgill T.W. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH3T3 cells and in vitro. Science. 257:1992;1404-1407.
    • (1992) Science , vol.257 , pp. 1404-1407
    • Dent, P.1    Haser, W.2    Haystead, T.A.3    Vincent, L.A.4    Roberts, T.M.5    Sturgill, T.W.6
  • 51
    • 0008903932 scopus 로고
    • Transforming genes of human bladder and lung carcinoma cell lines are homologues to the Ras genes of Harvey and Kirsten sarcoma viruses
    • Der C.J., Krontiris T.G., Cooper G.M. Transforming genes of human bladder and lung carcinoma cell lines are homologues to the Ras genes of Harvey and Kirsten sarcoma viruses. Proc. Natl. Acad. Sci. USA. 79:1982;3637-3640.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3637-3640
    • Der, C.J.1    Krontiris, T.G.2    Cooper, G.M.3
  • 52
  • 53
    • 0026679892 scopus 로고
    • Raf functions downstream of Ras1 in the sevenless signal transduction pathway
    • Dickson B., Sprenger F., Morrison D., Hafen E. Raf functions downstream of Ras1 in the sevenless signal transduction pathway. Nature. 360:1992;600-603.
    • (1992) Nature , vol.360 , pp. 600-603
    • Dickson, B.1    Sprenger, F.2    Morrison, D.3    Hafen, E.4
  • 54
    • 0028885029 scopus 로고
    • Distribution of epidermal growth factor receptor gene amplification in brain tumors and correlation to prognosis
    • Dietrich U., Lucius J., Baron E., Behnke J., Pabst B., Zoll B. Distribution of epidermal growth factor receptor gene amplification in brain tumors and correlation to prognosis. J. Neurol. 242:1995;683-688.
    • (1995) J. Neurol. , vol.242 , pp. 683-688
    • Dietrich, U.1    Lucius, J.2    Baron, E.3    Behnke, J.4    Pabst, B.5    Zoll, B.6
  • 58
    • 0026815475 scopus 로고
    • Regulation of p21Ras by GTPase activating proteins and guanine nucleotide exchange proteins
    • Downward J. Regulation of p21Ras by GTPase activating proteins and guanine nucleotide exchange proteins. Curr. Opin. Genet. Dev. 2:1992;13-18.
    • (1992) Curr. Opin. Genet. Dev. , vol.2 , pp. 13-18
    • Downward, J.1
  • 59
    • 0026830004 scopus 로고
    • Regulatory mechanisms for Ras proteins
    • Downward J. Regulatory mechanisms for Ras proteins. Bioessays. 14:1992;177-184.
    • (1992) Bioessays , vol.14 , pp. 177-184
    • Downward, J.1
  • 60
    • 0023198024 scopus 로고
    • Supratentorial malignant gliomas in childhood: A review of fifty cases
    • Dropcho E., Wisoff J., Walker R., Allen J.C. Supratentorial malignant gliomas in childhood: a review of fifty cases. Ann. Neurol. 22:1978;355-364.
    • (1978) Ann. Neurol. , vol.22 , pp. 355-364
    • Dropcho, E.1    Wisoff, J.2    Walker, R.3    Allen, J.C.4
  • 62
    • 0027910431 scopus 로고
    • Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
    • Egan S.E., Giddings B.W., Brooks M.W., Buday L., Sizeland A.M., Weinberg R.A. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature. 363:1993;45-51.
    • (1993) Nature , vol.363 , pp. 45-51
    • Egan, S.E.1    Giddings, B.W.2    Brooks, M.W.3    Buday, L.4    Sizeland, A.M.5    Weinberg, R.A.6
  • 63
    • 0025790916 scopus 로고
    • Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo
    • Ekstrand A.J., James C.D., Cavenee W.K., Seliger B., Pettersson R.F., Collins V.P. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 51:1991;2164-2172.
    • (1991) Cancer Res. , vol.51 , pp. 2164-2172
    • Ekstrand, A.J.1    James, C.D.2    Cavenee, W.K.3    Seliger, B.4    Pettersson, R.F.5    Collins, V.P.6
  • 64
    • 0027287255 scopus 로고
    • Multiple pathways to apoptosis
    • Evans V.G. Multiple pathways to apoptosis. Cell Biol. Int. 17:1993;461-476.
    • (1993) Cell Biol. Int. , vol.17 , pp. 461-476
    • Evans, V.G.1
  • 66
    • 0029807304 scopus 로고    scopus 로고
    • Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
    • Farrar M.A., Alberola-Ila J., Perlmutter R.M. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature. 383:1996;178-181.
    • (1996) Nature , vol.383 , pp. 178-181
    • Farrar, M.A.1    Alberola-Ila, J.2    Perlmutter, R.M.3
  • 67
    • 0027398668 scopus 로고
    • Prenyl group identification of rap2 proteins: A Ras superfamily member other than Ras that is farnesylated
    • Farrell F.X., Yamamoto K., Lapetina E.G. Prenyl group identification of rap2 proteins: a Ras superfamily member other than Ras that is farnesylated. Biochem. J. 289:1993;349-355.
    • (1993) Biochem. J. , vol.289 , pp. 349-355
    • Farrell, F.X.1    Yamamoto, K.2    Lapetina, E.G.3
  • 68
    • 0030771026 scopus 로고    scopus 로고
    • Signal transduction pathways and their relevance in human astrocytomas
    • Feldkamp M.M., Lau N., Guha A. Signal transduction pathways and their relevance in human astrocytomas. J. Neuro.-Oncol. 35:1997;223-248.
    • (1997) J. Neuro.-Oncol. , vol.35 , pp. 223-248
    • Feldkamp, M.M.1    Lau, N.2    Guha, A.3
  • 69
    • 0345365693 scopus 로고    scopus 로고
    • Astrocytomas are growth-inhibited by farnesyl transferase inhibitors despite the absence of oncogenic Ras mutations
    • Feldkamp M.M., Lau N., Guha A. Astrocytomas are growth-inhibited by farnesyl transferase inhibitors despite the absence of oncogenic Ras mutations. Proc. Am. Assoc. Cancer Res. 38:1997;A351.
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 351
    • Feldkamp, M.M.1    Lau, N.2    Guha, A.3
  • 70
    • 0345365694 scopus 로고    scopus 로고
    • A mutant epidermal growth factor receptor (p140EGF-R) confers a growth advantage to astrocytoma cell lines and results in increased Ras pathway activity
    • Feldkamp M.M., Lau N., Guha A. A mutant epidermal growth factor receptor (p140EGF-R) confers a growth advantage to astrocytoma cell lines and results in increased Ras pathway activity. Proc. Am. Assoc. Cancer Res. 38:1997;A620.
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 620
    • Feldkamp, M.M.1    Lau, N.2    Guha, A.3
  • 71
    • 0344934268 scopus 로고    scopus 로고
    • Astrocytomas express high levels of vascular endothelial growth factor (VEGF) which are reduced through Ras pathway inhibition
    • Feldkamp M.M., Rak J., Lau N., Kerbel R.S., Guha A. Astrocytomas express high levels of vascular endothelial growth factor (VEGF) which are reduced through Ras pathway inhibition. Clin. Neurol. Neurosurg. 99:1997;A5.
    • (1997) Clin. Neurol. Neurosurg. , vol.99 , pp. 5
    • Feldkamp, M.M.1    Rak, J.2    Lau, N.3    Kerbel, R.S.4    Guha, A.5
  • 72
    • 0029738762 scopus 로고    scopus 로고
    • Mutant H-Ras overexpression inhibits drug and U.V. induced apoptosis
    • Fernandez R.S., McGowan A.J., Cotter T.G. Mutant H-Ras overexpression inhibits drug and U.V. induced apoptosis. Anticancer Res. 16:1996;1691-1705.
    • (1996) Anticancer Res. , vol.16 , pp. 1691-1705
    • Fernandez, R.S.1    McGowan, A.J.2    Cotter, T.G.3
  • 74
    • 0026498785 scopus 로고
    • Chromosome 11p15 deletions in human malignant astrocytomas and primitive neuroectodermal tumors
    • Fults D., Petronio J., Noblett B.D., Pedone C.A. Chromosome 11p15 deletions in human malignant astrocytomas and primitive neuroectodermal tumors. Genomics. 14:1992;799-801.
    • (1992) Genomics , vol.14 , pp. 799-801
    • Fults, D.1    Petronio, J.2    Noblett, B.D.3    Pedone, C.A.4
  • 75
    • 0027229556 scopus 로고
    • Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
    • Gale N.W., Kaplan S., Lowenstein E.J., Schlessinger J., Bar-Sagi D. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature. 363:1993;88-92.
    • (1993) Nature , vol.363 , pp. 88-92
    • Gale, N.W.1    Kaplan, S.2    Lowenstein, E.J.3    Schlessinger, J.4    Bar-Sagi, D.5
  • 76
    • 0029097155 scopus 로고
    • The potential role of basic fibroblast growth factor in the transformation of cultured primary human fetal astrocytes and the proliferation of human glioma (U-87) cells
    • Gately S., Soff G.A., Brem S. The potential role of basic fibroblast growth factor in the transformation of cultured primary human fetal astrocytes and the proliferation of human glioma (U-87) cells. Neurosurgery. 37:1995;723-730.
    • (1995) Neurosurgery , vol.37 , pp. 723-730
    • Gately, S.1    Soff, G.A.2    Brem, S.3
  • 77
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal installation of a retroviral antisense K-Ras construct
    • Georges R.N., Mukhopadhyay T., Zhang Y., Yen N., Roth J.A. Prevention of orthotopic human lung cancer growth by intratracheal installation of a retroviral antisense K-Ras construct. Cancer Res. 53:1993;1743-1746.
    • (1993) Cancer Res. , vol.53 , pp. 1743-1746
    • Georges, R.N.1    Mukhopadhyay, T.2    Zhang, Y.3    Yen, N.4    Roth, J.A.5
  • 79
    • 0025877861 scopus 로고
    • Ras C-terminal processing enzymes - New drug targets?
    • Gibbs J.B. Ras C-terminal processing enzymes - new drug targets? Cell. 65:1991;1-4.
    • (1991) Cell , vol.65 , pp. 1-4
    • Gibbs, J.B.1
  • 80
    • 0027024351 scopus 로고
    • Pharmacological probes of Ras function
    • Gibbs J.B. Pharmacological probes of Ras function. Semin. Cancer Biol. 3:1992;383-390.
    • (1992) Semin. Cancer Biol. , vol.3 , pp. 383-390
    • Gibbs, J.B.1
  • 82
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs J.B., Oliff A., Kohl N.E. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell. 77:1994;175-178.
    • (1994) Cell , vol.77 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 84
    • 0026658128 scopus 로고
    • Transcriptional patterns of growth factors and proto-oncogenes in human glioblastomas and normal glial cells
    • Gillaspy G.E., Mapstone T.B., Samols D., Goldthwait D.A. Transcriptional patterns of growth factors and proto-oncogenes in human glioblastomas and normal glial cells. Cancer Lett. 65:1992;55-60.
    • (1992) Cancer Lett. , vol.65 , pp. 55-60
    • Gillaspy, G.E.1    Mapstone, T.B.2    Samols, D.3    Goldthwait, D.A.4
  • 85
    • 0028931406 scopus 로고
    • ERK phosphorylation potentiates Elk-1-mediated tenary complex formation and transactivation
    • Gille H., Kortenjahn M., Thomae O., Moomaw C., Slaughter C., Cobb M.H., Shaw P.E. ERK phosphorylation potentiates Elk-1-mediated tenary complex formation and transactivation. EMBO J. 14:1995;951-962.
    • (1995) EMBO J. , vol.14 , pp. 951-962
    • Gille, H.1    Kortenjahn, M.2    Thomae, O.3    Moomaw, C.4    Slaughter, C.5    Cobb, M.H.6    Shaw, P.E.7
  • 86
    • 0028338460 scopus 로고
    • Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-Fos transcription via phosphorylation of CREB
    • Ginty D.D., Bonni A., Greenberg M.E. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-Fos transcription via phosphorylation of CREB. Cell. 77:1994;713-725.
    • (1994) Cell , vol.77 , pp. 713-725
    • Ginty, D.D.1    Bonni, A.2    Greenberg, M.E.3
  • 87
    • 0025911654 scopus 로고
    • Radioimmunoassay of insulin-like growth factor in cyst fluid of central nervous system tumors
    • Glick R.P., Unterman T.G., Hollis R. Radioimmunoassay of insulin-like growth factor in cyst fluid of central nervous system tumors. J. Neurosurg. 74:1991;972-978.
    • (1991) J. Neurosurg. , vol.74 , pp. 972-978
    • Glick, R.P.1    Unterman, T.G.2    Hollis, R.3
  • 88
    • 0025277259 scopus 로고
    • Prenyl proteins in eukaryotic cells: A new type of membrane anchor
    • Glomset J.A., Gelb M.H., Farnsworth C.C. Prenyl proteins in eukaryotic cells: a new type of membrane anchor. Trends Biochem. Sci. 15:1990;139-142.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 139-142
    • Glomset, J.A.1    Gelb, M.H.2    Farnsworth, C.C.3
  • 89
    • 0030587081 scopus 로고    scopus 로고
    • Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2
    • Gomez J., Martinez C., Fernandez B., Garcia A., Rebollo A. Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2. J. Immunol. 157:1996;2272-2281.
    • (1996) J. Immunol. , vol.157 , pp. 2272-2281
    • Gomez, J.1    Martinez, C.2    Fernandez, B.3    Garcia, A.4    Rebollo, A.5
  • 90
    • 0025888298 scopus 로고
    • Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases
    • Gonzalez F.A., Raden D.L., Davis R.J. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 266:1991;22159-22163.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22159-22163
    • Gonzalez, F.A.1    Raden, D.L.2    Davis, R.J.3
  • 92
    • 0030062955 scopus 로고    scopus 로고
    • Ras-GTP levels are elevated in human NF1 peripheral nerve tumors
    • Guha A., Lau N., Gutmann D., Provias J., Pawson T., Boss G. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene. 12:1996;507-513.
    • (1996) Oncogene , vol.12 , pp. 507-513
    • Guha, A.1    Lau, N.2    Gutmann, D.3    Provias, J.4    Pawson, T.5    Boss, G.6
  • 93
    • 0345365687 scopus 로고
    • Ras-mediated proliferation of human astrocytoma cells
    • Guha A., Lau N., Pawson A. Ras-mediated proliferation of human astrocytoma cells. Proc. Am. Assoc. Cancer Res. 36:1995;A1029.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 1029
    • Guha, A.1    Lau, N.2    Pawson, A.3
  • 94
    • 0029892569 scopus 로고    scopus 로고
    • Increased neurofibromatosis 1 gene expression in astrocytic tumors: Positive regulation by p21-Ras
    • Gutmann D.H., Giordano M.J., Mahadeo D.K., Lau N., Silbergeld D., Guha A. Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-Ras. Oncogene. 12:1996;2121-2127.
    • (1996) Oncogene , vol.12 , pp. 2121-2127
    • Gutmann, D.H.1    Giordano, M.J.2    Mahadeo, D.K.3    Lau, N.4    Silbergeld, D.5    Guha, A.6
  • 95
    • 0025373180 scopus 로고
    • Ras and GAP - Who's controlling whom
    • Hall A. Ras and GAP - who's controlling whom. Cell. 61:1990;921-923.
    • (1990) Cell , vol.61 , pp. 921-923
    • Hall, A.1
  • 96
    • 0027935756 scopus 로고
    • Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation
    • Hallberg B., Rayter S.I., Downward J. Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J. Biol. Chem. 269:1994;3913-3916.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3913-3916
    • Hallberg, B.1    Rayter, S.I.2    Downward, J.3
  • 97
    • 0024406286 scopus 로고
    • All Ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock J.F., Magee A.I., Childs J.E., Marshall C.J. All Ras proteins are polyisoprenylated but only some are palmitoylated. Cell. 57:1989;1167-1177.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 98
    • 0025013547 scopus 로고
    • A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21-Ras to the plasma membrane
    • Hancock J.F., Paterson H., Marshall J.C. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21-Ras to the plasma membrane. Cell. 63:1990;133-139.
    • (1990) Cell , vol.63 , pp. 133-139
    • Hancock, J.F.1    Paterson, H.2    Marshall, J.C.3
  • 99
    • 0000953693 scopus 로고
    • An unidentified virus which causes the rapid production of tumors in mice
    • Harvey J.J. An unidentified virus which causes the rapid production of tumors in mice. Nature. 204:1964;1104-1105.
    • (1964) Nature , vol.204 , pp. 1104-1105
    • Harvey, J.J.1
  • 100
    • 0027191808 scopus 로고
    • Functional analysis of a growth factor-responsive transcription factor complex
    • Hill C.S., Marais R., John S., Wynne J., Dalton S., Treisman R. Functional analysis of a growth factor-responsive transcription factor complex. Cell. 73:1993;395-406.
    • (1993) Cell , vol.73 , pp. 395-406
    • Hill, C.S.1    Marais, R.2    John, S.3    Wynne, J.4    Dalton, S.5    Treisman, R.6
  • 106
    • 0028063058 scopus 로고
    • Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells
    • James G.L., Brown M.S., Cobb M.H., Goldstein J.L. Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells. J. Biol. Chem. 269:1994;27705-27714.
    • (1994) J. Biol. Chem. , vol.269 , pp. 27705-27714
    • James, G.L.1    Brown, M.S.2    Cobb, M.H.3    Goldstein, J.L.4
  • 108
    • 0027053631 scopus 로고
    • Overview of genetic and molecular events in the pathogenesis of lung cancer
    • Johnson B.E., Kelley M.J. Overview of genetic and molecular events in the pathogenesis of lung cancer. Chest. 103:1993;1-3.
    • (1993) Chest , vol.103 , pp. 1-3
    • Johnson, B.E.1    Kelley, M.J.2
  • 109
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • Kato K., Cox A.D., Hisaka M.M., Graham S.M., Buss J.E., Der C.J. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl. Acad. Sci. USA. 89:1992;6403-6407.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6403-6407
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4    Buss, J.E.5    Der, C.J.6
  • 110
    • 0029067403 scopus 로고
    • PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine
    • Kavanaugh W.M., Turck C.W., Williams L.T. PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science. 268:1995;1177-1179.
    • (1995) Science , vol.268 , pp. 1177-1179
    • Kavanaugh, W.M.1    Turck, C.W.2    Williams, L.T.3
  • 111
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.1    Wyllie, A.H.2    Currie, A.R.3
  • 112
    • 0001446334 scopus 로고
    • Morphologic responses to a murine erythroblastosis virus
    • Kirsten W.H., Mayer L.A. Morphologic responses to a murine erythroblastosis virus. J. Natl. Cancer Inst. 39:1967;311-335.
    • (1967) J. Natl. Cancer Inst. , vol.39 , pp. 311-335
    • Kirsten, W.H.1    Mayer, L.A.2
  • 113
    • 0027586253 scopus 로고
    • Prognostic factors of lung cancer
    • Kleisbauer J.P., Thomas P. Prognostic factors of lung cancer. Rev. Prat. 43:1993;852-855.
    • (1993) Rev. Prat. , vol.43 , pp. 852-855
    • Kleisbauer, J.P.1    Thomas, P.2
  • 114
    • 0029831486 scopus 로고    scopus 로고
    • Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
    • Klingshoffer R.A., Duckworth B., Valius M., Cantley L., Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol. Cell Biol. 16:1996;5905-5914.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 5905-5914
    • Klingshoffer, R.A.1    Duckworth, B.2    Valius, M.3    Cantley, L.4    Kazlauskas, A.5
  • 115
    • 0025765803 scopus 로고
    • SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins
    • Koch C.A., Anderson D., Moran M.F., Ellis C., Pawson T. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science. 252:1991;668-674.
    • (1991) Science , vol.252 , pp. 668-674
    • Koch, C.A.1    Anderson, D.2    Moran, M.F.3    Ellis, C.4    Pawson, T.5
  • 116
    • 0029074787 scopus 로고
    • Development of inhibitors of protein farnesylation as potential chemotherapeutic agents
    • (Suppl.)
    • Kohl N.E., Conner M.W., Gibbs J.B., Graham S.L., Hartman G.D., Oliff A. Development of inhibitors of protein farnesylation as potential chemotherapeutic agents. J. Biol. Chem. 22:1995;145-150. (Suppl.).
    • (1995) J. Biol. Chem. , vol.22 , pp. 145-150
    • Kohl, N.E.1    Conner, M.W.2    Gibbs, J.B.3    Graham, S.L.4    Hartman, G.D.5    Oliff, A.6
  • 119
    • 0028905991 scopus 로고
    • Apoptosis and cell proliferation in HHV-6 infections. Regulatory mechanisms of p53/bcl-2/Ras interactions
    • Krueger G.R., Buja L.M., Rojo J., Lasch J., Koch B., Leyssens N. Apoptosis and cell proliferation in HHV-6 infections. Regulatory mechanisms of p53/bcl-2/Ras interactions. Pathology. 16:1995;120-127.
    • (1995) Pathology , vol.16 , pp. 120-127
    • Krueger, G.R.1    Buja, L.M.2    Rojo, J.3    Lasch, J.4    Koch, B.5    Leyssens, N.6
  • 121
    • 0027502176 scopus 로고
    • Influence of guanine nucleotides on complex formation between Ras and CDC25 protein
    • Lai C.-C., Boguski M., Broek D., Powers S. Influence of guanine nucleotides on complex formation between Ras and CDC25 protein. Mol. Cell Biol. 13:1993;1345-1352.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 1345-1352
    • Lai, C.-C.1    Boguski, M.2    Broek, D.3    Powers, S.4
  • 122
    • 0028087884 scopus 로고
    • Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors
    • Lang F.F., Miller C.C., Koslow M., Newcomb E.W. Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J. Neurosurg. 81:1994;427-436.
    • (1994) J. Neurosurg. , vol.81 , pp. 427-436
    • Lang, F.F.1    Miller, C.C.2    Koslow, M.3    Newcomb, E.W.4
  • 123
    • 0028074621 scopus 로고
    • Ras-dependent growth factor regulation of MEK kinase in PC12 cells
    • Lange-Carter C.A., Johnson G.L. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science. 265:1994;1458-1461.
    • (1994) Science , vol.265 , pp. 1458-1461
    • Lange-Carter, C.A.1    Johnson, G.L.2
  • 124
    • 0026541143 scopus 로고
    • Activation of extracelluar signal-regulated kinase, ERK2, by p21-Ras oncoproteins
    • Leevers S.L., Marshall C.J. Activation of extracelluar signal-regulated kinase, ERK2, by p21-Ras oncoproteins. EMBO J. 11:1992;569-574.
    • (1992) EMBO J. , vol.11 , pp. 569-574
    • Leevers, S.L.1    Marshall, C.J.2
  • 125
    • 0027283659 scopus 로고
    • Growth factors induce nuclear translocation of MAP kinases (p42-Mapk and p44-Mapk) but not of their activator MAPK kinase kinase (p45-Mapkk) in fibroblasts
    • Lenormand P., Sardet C., Pages G., L'Allemain G., Brunet A., Pouyssegur J. Growth factors induce nuclear translocation of MAP kinases (p42-Mapk and p44-Mapk) but not of their activator MAPK kinase kinase (p45-Mapkk) in fibroblasts. J. Cell Biol. 122:1993;1079-1088.
    • (1993) J. Cell Biol. , vol.122 , pp. 1079-1088
    • Lenormand, P.1    Sardet, C.2    Pages, G.3    L'Allemain, G.4    Brunet, A.5    Pouyssegur, J.6
  • 127
    • 0028810275 scopus 로고
    • Disruption of oncongenic K-Ras-4B processing and signaling by a potent geranylgeranyltransferase I inhibitor
    • Lerner E.C., Qian Y., Hamilton A.D., Sebti S.M. Disruption of oncongenic K-Ras-4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J. Biol. Chem. 270:1995;26770-26773.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26770-26773
    • Lerner, E.C.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 128
    • 0344503464 scopus 로고    scopus 로고
    • Inhibition of K-Ras but not H- Or N-Ras prenylation requires both farnesyltransferase and geranylgeranyltransferase I inhibitors in human tumor cell lines
    • Lerner E.C., Zhang T.T., Qian Y., Hamilton A.D., Sebti S.M. Inhibition of K-Ras but not H- or N-Ras prenylation requires both farnesyltransferase and geranylgeranyltransferase I inhibitors in human tumor cell lines. Proc. Am. Assoc. Cancer Res. 38:1997;A352.
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 352
    • Lerner, E.C.1    Zhang, T.T.2    Qian, Y.3    Hamilton, A.D.4    Sebti, S.M.5
  • 130
    • 0026071171 scopus 로고
    • Raf-1: A kinase currently without a cause but not lacking effects
    • Li P., Wood K., Mamon H., Haser W., Roberts T. Raf-1: A kinase currently without a cause but not lacking effects. Cell. 64:1991;479-482.
    • (1991) Cell , vol.64 , pp. 479-482
    • Li, P.1    Wood, K.2    Mamon, H.3    Haser, W.4    Roberts, T.5
  • 133
    • 0029063175 scopus 로고
    • Activated H-Ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest
    • Lin H.J., Eviner V., Prendergast G.C., White E. Activated H-Ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol. Cell Biol. 15:1995;4536-4544.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 4536-4544
    • Lin, H.J.1    Eviner, V.2    Prendergast, G.C.3    White, E.4
  • 134
    • 0029740245 scopus 로고    scopus 로고
    • A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes
    • Lipeski L.E., Boylan J.M., Gruppuso P.A. A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes. Biochem. Mol. Biol. Int. 39:1996;975-983.
    • (1996) Biochem. Mol. Biol. Int. , vol.39 , pp. 975-983
    • Lipeski, L.E.1    Boylan, J.M.2    Gruppuso, P.A.3
  • 135
    • 0026976992 scopus 로고
    • Recent results in animal models of pancreatic carcinoma: Histogenesis of tumors
    • Longnecker D.S., Memoli V., Pettengill O.S. Recent results in animal models of pancreatic carcinoma: histogenesis of tumors. Yale J. Biol. Med. 65:1992;457-464.
    • (1992) Yale J. Biol. Med. , vol.65 , pp. 457-464
    • Longnecker, D.S.1    Memoli, V.2    Pettengill, O.S.3
  • 139
    • 0029811985 scopus 로고    scopus 로고
    • Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
    • Luo Z., Tzivion G., Belshaw P.J., Vavvas D., Marshall M., Avruch J. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature. 383:1996;181-185.
    • (1996) Nature , vol.383 , pp. 181-185
    • Luo, Z.1    Tzivion, G.2    Belshaw, P.J.3    Vavvas, D.4    Marshall, M.5    Avruch, J.6
  • 147
    • 0027297647 scopus 로고
    • The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
    • Marais R., Wynne J., Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 73:1993;381-393.
    • (1993) Cell , vol.73 , pp. 381-393
    • Marais, R.1    Wynne, J.2    Treisman, R.3
  • 148
    • 0029098336 scopus 로고
    • Muations in the Ras proto-oncogene: Clues to etiology and molecular pathogenesis of mouse liver tumors
    • Maronpot R.R., Fox T., Malarkey D.E., Goldsworthy T.L. Muations in the Ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors. Toxicology. 101:1995;125-156.
    • (1995) Toxicology , vol.101 , pp. 125-156
    • Maronpot, R.R.1    Fox, T.2    Malarkey, D.E.3    Goldsworthy, T.L.4
  • 149
    • 0030581475 scopus 로고    scopus 로고
    • Raf gets it together
    • Marshall C.J. Raf gets it together. Nature. 383:1996;127-128.
    • (1996) Nature , vol.383 , pp. 127-128
    • Marshall, C.J.1
  • 150
    • 0028152333 scopus 로고
    • MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
    • Marshall C.J. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4:1994;82-89.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 82-89
    • Marshall, C.J.1
  • 151
    • 0027284950 scopus 로고
    • Protein prenylation: A mediator of protein-protein interactions
    • Marshall C.J. Protein prenylation: a mediator of protein-protein interactions. Science. 259:1993;1865-1866.
    • (1993) Science , vol.259 , pp. 1865-1866
    • Marshall, C.J.1
  • 152
    • 0028863505 scopus 로고
    • Interactions between Ras and Raf: Key regulatory proteins in cellular transformation
    • Marshall M. Interactions between Ras and Raf: key regulatory proteins in cellular transformation. Mol. Reprod. Dev. 42:1995;493-499.
    • (1995) Mol. Reprod. Dev. , vol.42 , pp. 493-499
    • Marshall, M.1
  • 153
    • 0025282206 scopus 로고
    • Co-expression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintainance
    • Maxwell M., Naber S.P., Wolfe H.J., Galanopoulos T., Hedley-Whyte E.T., Black P.M., Antoniades N.H. Co-expression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintainance. J. Clin. Invest. 86:1990;131-140.
    • (1990) J. Clin. Invest. , vol.86 , pp. 131-140
    • Maxwell, M.1    Naber, S.P.2    Wolfe, H.J.3    Galanopoulos, T.4    Hedley-Whyte, E.T.5    Black, P.M.6    Antoniades, N.H.7
  • 155
    • 0028137615 scopus 로고
    • Activators and effectors of Ras p21 proteins
    • McCormick F. Activators and effectors of Ras p21 proteins. Curr. Opin. Genet. Dev. 4:1994;71-76.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 71-76
    • McCormick, F.1
  • 156
    • 0027212082 scopus 로고
    • How receptors turn Ras on
    • McCormick F. How receptors turn Ras on. Nature. 363:1993;15-16.
    • (1993) Nature , vol.363 , pp. 15-16
    • McCormick, F.1
  • 157
    • 0027765880 scopus 로고
    • The GTPase superfamily. Introduction
    • McCormick F. The GTPase superfamily. Introduction. Ciba Found. Symp. 176:1993;1-5.
    • (1993) Ciba Found. Symp. , vol.176 , pp. 1-5
    • McCormick, F.1
  • 158
    • 80052373735 scopus 로고    scopus 로고
    • In-vitro effects of the farnesyltransferase inhibitor '749 on leukemic cell lines with Ras mutations and myelodysplastic syndrome (MDS) patients' samples with and without Ras mutations
    • Melnyk A., Albitar M., Bartram C., Oliff A., Andreeff M. In-vitro effects of the farnesyltransferase inhibitor '749 on leukemic cell lines with Ras mutations and myelodysplastic syndrome (MDS) patients' samples with and without Ras mutations. Proc. Am. Assoc. Cancer Res. 37:1996;A2875.
    • (1996) Proc. Am. Assoc. Cancer Res. , vol.37 , pp. 2875
    • Melnyk, A.1    Albitar, M.2    Bartram, C.3    Oliff, A.4    Andreeff, M.5
  • 159
    • 0027337519 scopus 로고
    • Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase
    • Moodie S.A., Willumsen B.M., Weber M.J., Wolfman A. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science. 260:1993;1658-1660.
    • (1993) Science , vol.260 , pp. 1658-1660
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3    Wolfman, A.4
  • 160
    • 0028096233 scopus 로고
    • The 3Rs of life: Ras, Raf and growth regulation
    • Moodie S.A., Wolfman A. The 3Rs of life: Ras, Raf and growth regulation. Trends Genet. 10:1994;44-48.
    • (1994) Trends Genet. , vol.10 , pp. 44-48
    • Moodie, S.A.1    Wolfman, A.2
  • 161
    • 0027236646 scopus 로고
    • Muant H-Ras overexpression inhibits a random apoptotic nuclease in myeloid leukemia cells
    • Moore J., Boswell S., Hoffman R., Burgess G., Hromas R. Muant H-Ras overexpression inhibits a random apoptotic nuclease in myeloid leukemia cells. Leuk. Res. 17:1993;703-709.
    • (1993) Leuk. Res. , vol.17 , pp. 703-709
    • Moore, J.1    Boswell, S.2    Hoffman, R.3    Burgess, G.4    Hromas, R.5
  • 164
    • 0029107760 scopus 로고
    • The 2.2A crystal structure of Rhe Ras-binding domain of the serine/threonine kinase c-Rafl in complex with RaplA and a GTP analogue
    • Nassar N., Horn G., Scherer A., McCormick F., Wittinghofer A. The 2.2A crystal structure of Rhe Ras-binding domain of the serine/threonine kinase c-Rafl in complex with RaplA and a GTP analogue. Nature. 375:1995;554-560.
    • (1995) Nature , vol.375 , pp. 554-560
    • Nassar, N.1    Horn, G.2    Scherer, A.3    McCormick, F.4    Wittinghofer, A.5
  • 165
    • 0027210447 scopus 로고
    • Posttranslational processing of the Ras superfamily of small GTP-binding proteins
    • Newman C.M., Magee A.I. Posttranslational processing of the Ras superfamily of small GTP-binding proteins. Biochem. Biophys. Acta. 1155:1993;79-96.
    • (1993) Biochem. Biophys. Acta , vol.1155 , pp. 79-96
    • Newman, C.M.1    Magee, A.I.2
  • 166
    • 0027522046 scopus 로고
    • Potent inhibition of human tumor p21-Ras farnesyltransferase by A1A2-lacking p21-Ras CA1A2X peptidomimetics
    • Nigam M., Seong C.M., Qian Y., Hamilton D.A., Sebti S.M. Potent inhibition of human tumor p21-Ras farnesyltransferase by A1A2-lacking p21-Ras CA1A2X peptidomimetics. J. Biol. Chem. 268:1993;20695-20698.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20695-20698
    • Nigam, M.1    Seong, C.M.2    Qian, Y.3    Hamilton, D.A.4    Sebti, S.M.5
  • 167
    • 0027410497 scopus 로고
    • The MAP kinase cascade is essential for diverse signal transduction pathways
    • Nishida E., Gotoh Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18:1993;128-131.
    • (1993) Trends Biochem. Sci. , vol.18 , pp. 128-131
    • Nishida, E.1    Gotoh, Y.2
  • 168
    • 0026045167 scopus 로고
    • Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines
    • Nister M., Claesson-Welch L., Eriksson A., Heldin C.-H., Westermark B. Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. J. Biol. Chem. 266:1991;16755-16763.
    • (1991) J. Biol. Chem. , vol.266 , pp. 16755-16763
    • Nister, M.1    Claesson-Welch, L.2    Eriksson, A.3    Heldin, C.-H.4    Westermark, B.5
  • 169
    • 0028927887 scopus 로고
    • Constitutive expression of the c-H-Ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line
    • Nooter K., Boersma A.W., Oostrum R.G., Burger H., Jochemsen A.G., Stoter G. Constitutive expression of the c-H-Ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line. Br. J. Cancer. 71:1995;555-561.
    • (1995) Br. J. Cancer , vol.71 , pp. 555-561
    • Nooter, K.1    Boersma, A.W.2    Oostrum, R.G.3    Burger, H.4    Jochemsen, A.G.5    Stoter, G.6
  • 170
    • 0028882666 scopus 로고
    • The role of transformation-associated genes in the evolution of astrocytic brain tumors
    • Ohgaki H., Schauble B., zur Hausen A., von Ammon K., Kleihues P. The role of transformation-associated genes in the evolution of astrocytic brain tumors. Virchows Arch. 427:1995;113-118.
    • (1995) Virchows Arch. , vol.427 , pp. 113-118
    • Ohgaki, H.1    Schauble, B.2    Zur Hausen, A.3    Von Ammon, K.4    Kleihues, P.5
  • 171
    • 0027468233 scopus 로고
    • A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
    • Olivier J.P., Raabe T., Henkemeyer M., Dickson B., Mbamulu G., Margolis B., Schlessinger J., Hafen E., Pawson T. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell. 73:1993;179-191.
    • (1993) Cell , vol.73 , pp. 179-191
    • Olivier, J.P.1    Raabe, T.2    Henkemeyer, M.3    Dickson, B.4    Mbamulu, G.5    Margolis, B.6    Schlessinger, J.7    Hafen, E.8    Pawson, T.9
  • 172
    • 0026464014 scopus 로고
    • Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
    • Olopade O., Bohlander S., Pomykala H., Maltepe E., Van Melle E., Le Beau M., Diaz M. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. Genomics. 14:1992;437-443.
    • (1992) Genomics , vol.14 , pp. 437-443
    • Olopade, O.1    Bohlander, S.2    Pomykala, H.3    Maltepe, E.4    Van Melle, E.5    Le Beau, M.6    Diaz, M.7
  • 174
    • 0026742392 scopus 로고
    • Overexpression of multiple oncogenes related to histopathological grade of astrocystic glioma
    • Orian J.M., Vasilopoulos K., Yoshida S., Kaye A.H., Chow C.W., Gonzales M.F. Overexpression of multiple oncogenes related to histopathological grade of astrocystic glioma. Br. J. Cancer. 66:1992;106-112.
    • (1992) Br. J. Cancer , vol.66 , pp. 106-112
    • Orian, J.M.1    Vasilopoulos, K.2    Yoshida, S.3    Kaye, A.H.4    Chow, C.W.5    Gonzales, M.F.6
  • 175
    • 0342433200 scopus 로고    scopus 로고
    • Characterization of prenyl groups attached to K-Ras in DLD-1 human colon carcinoma cells treated with the FPT inhibitor SCH 44342
    • Pai J.J., Bishop W.R., Catino J., Kirschmeier P., Whyte D. Characterization of prenyl groups attached to K-Ras in DLD-1 human colon carcinoma cells treated with the FPT inhibitor SCH 44342. Proc. Am. Assoc. Cancer Res. 37:1996;503.
    • (1996) Proc. Am. Assoc. Cancer Res. , vol.37 , pp. 503
    • Pai, J.J.1    Bishop, W.R.2    Catino, J.3    Kirschmeier, P.4    Whyte, D.5
  • 176
    • 0020328955 scopus 로고
    • Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus Ras gene
    • Parada L.F., Tabin C.J., Shih C., Weinberg R.A. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus Ras gene. Nature. 297:1982;474-478.
    • (1982) Nature , vol.297 , pp. 474-478
    • Parada, L.F.1    Tabin, C.J.2    Shih, C.3    Weinberg, R.A.4
  • 180
    • 0009869779 scopus 로고
    • Mechanisms underlying local invasive behavior of brain tumors
    • Pilkington G.J. Mechanisms underlying local invasive behavior of brain tumors. Anticancer Res. 15:1995;1675-1676.
    • (1995) Anticancer Res. , vol.15 , pp. 1675-1676
    • Pilkington, G.J.1
  • 181
    • 0030952893 scopus 로고    scopus 로고
    • K-Ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas
    • Pinto M.M., Emanuel J.R., Chaturvedi V., Costa J. K-Ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas. Acta Cytol. 41:1997;427-434.
    • (1997) Acta Cytol. , vol.41 , pp. 427-434
    • Pinto, M.M.1    Emanuel, J.R.2    Chaturvedi, V.3    Costa, J.4
  • 182
    • 0027944927 scopus 로고
    • Current concepts in the diagnosis and treatment of pediatric brain tumors
    • Pollack I.F. Current concepts in the diagnosis and treatment of pediatric brain tumors. New Engl. J. Med. 331:1994;1500-1507.
    • (1994) New Engl. J. Med. , vol.331 , pp. 1500-1507
    • Pollack, I.F.1
  • 183
    • 0025312789 scopus 로고
    • Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium
    • Pollack I.F., Randall M.S., Kristofik M.P., Kelly R.H., Selker R.G., Vertosick F.T. Jr. Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. J. Neurosurg. 73:1990;106-112.
    • (1990) J. Neurosurg. , vol.73 , pp. 106-112
    • Pollack, I.F.1    Randall, M.S.2    Kristofik, M.P.3    Kelly, R.H.4    Selker, R.G.5    Vertosick F.T., Jr.6
  • 184
    • 0025780988 scopus 로고
    • Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways
    • Pollack I.F., Randall M.S., Kristofik M.P., Kelly R.H., Selker R.G., Vertosick F.T. Jr. Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways. J. Neurosurg. 75:1991;284-293.
    • (1991) J. Neurosurg. , vol.75 , pp. 284-293
    • Pollack, I.F.1    Randall, M.S.2    Kristofik, M.P.3    Kelly, R.H.4    Selker, R.G.5    Vertosick F.T., Jr.6
  • 187
    • 0027494804 scopus 로고
    • Tumor induction by Ras and Myc oncogenes in fetal and neonatal brain: Modulating effects of developmental stage and retroviral dose
    • Radner H., El Shabrawi Y., Eibl R.H., Brustle O., Kenner L., Kleihues P., Wiestler O.D. Tumor induction by Ras and Myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral dose. Acta Neuropathol. 86:1993;456-465.
    • (1993) Acta Neuropathol. , vol.86 , pp. 456-465
    • Radner, H.1    El Shabrawi, Y.2    Eibl, R.H.3    Brustle, O.4    Kenner, L.5    Kleihues, P.6    Wiestler, O.D.7
  • 188
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G., Liu L., Ichimura K., Schmidt E.E., Collins V.P. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53:1993;2736-2739.
    • (1993) Cancer Res. , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 189
    • 0025194466 scopus 로고
    • Inhibition of purified p21-Ras farnesylproteintransferase by Cys-AAX tetrapeptides
    • Reiss Y., Goldstein J.L., Seabra M.C., Casey P.J., Brown M.S. Inhibition of purified p21-Ras farnesylproteintransferase by Cys-AAX tetrapeptides. Cell. 62:1990;81-88.
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casey, P.J.4    Brown, M.S.5
  • 190
    • 0025923649 scopus 로고
    • Nonidentical subunits of p21-H-Ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions
    • Reiss Y., Seabra M.C., Armstrong S.A., Slaughter C.A., Goldstein J.L., Brown M.S. Nonidentical subunits of p21-H-Ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. J. Biol. Chem. 266:1991;10672-10677.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10672-10677
    • Reiss, Y.1    Seabra, M.C.2    Armstrong, S.A.3    Slaughter, C.A.4    Goldstein, J.L.5    Brown, M.S.6
  • 192
    • 0027408247 scopus 로고
    • Identification of a ten-amino acid proline-rich SH3 binding site
    • Ren R., Mayer B.J., Cicchetti P., Baltimore D. Identification of a ten-amino acid proline-rich SH3 binding site. Science. 259:1993;1157-1161.
    • (1993) Science , vol.259 , pp. 1157-1161
    • Ren, R.1    Mayer, B.J.2    Cicchetti, P.3    Baltimore, D.4
  • 194
    • 0028954148 scopus 로고
    • Region-specific loss of heterozygosity on chromosome 19 is related to the morphologic type of human glioma
    • Ritland S.R., Vinod G., Jenkins R.B. Region-specific loss of heterozygosity on chromosome 19 is related to the morphologic type of human glioma. Genes Chrom. Cancer. 12:1995;277-287.
    • (1995) Genes Chrom. Cancer , vol.12 , pp. 277-287
    • Ritland, S.R.1    Vinod, G.2    Jenkins, R.B.3
  • 195
    • 0029814709 scopus 로고    scopus 로고
    • Requirement of phospholipase C-gamma, the tyrosine phosphatase SYP and the adaptor proteins SHC and NCK for PDGF-induced DNA synthesis - Evidence for the existence of Ras-dependent and Ras-independent pathways
    • Roche S., McGlade J., Jones M., Gish G.D., Pawson T., Courtneidge S.A. Requirement of phospholipase C-gamma, the tyrosine phosphatase SYP and the adaptor proteins SHC and NCK for PDGF-induced DNA synthesis - evidence for the existence of Ras-dependent and Ras-independent pathways. EMBO J. 15:1996;4940-4948.
    • (1996) EMBO J. , vol.15 , pp. 4940-4948
    • Roche, S.1    McGlade, J.2    Jones, M.3    Gish, G.D.4    Pawson, T.5    Courtneidge, S.A.6
  • 196
    • 0026680448 scopus 로고
    • Clinical significance of Ras oncogene activation in human lung cancer
    • Rodenhuis S., Slebos R.J. Clinical significance of Ras oncogene activation in human lung cancer. Cancer Res. 52:1992;2665-2669.
    • (1992) Cancer Res. , vol.52 , pp. 2665-2669
    • Rodenhuis, S.1    Slebos, R.J.2
  • 198
    • 0027294981 scopus 로고
    • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
    • Rozakis-Adcock M., Fernley R., Wade J., Pawson T., Bowtell D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature. 363:1993;83-85.
    • (1993) Nature , vol.363 , pp. 83-85
    • Rozakis-Adcock, M.1    Fernley, R.2    Wade, J.3    Pawson, T.4    Bowtell, D.5
  • 200
    • 0028789820 scopus 로고
    • MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes
    • Rozakis-Adcock M., Van der Geer P., Mbamalu G., Pawson T. MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes. Oncogene. 11:1995;1417-1426.
    • (1995) Oncogene , vol.11 , pp. 1417-1426
    • Rozakis-Adcock, M.1    Van Der Geer, P.2    Mbamalu, G.3    Pawson, T.4
  • 201
    • 0022977712 scopus 로고
    • A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinase modifies the kinase function and transforming activity of Fujinami sarcoma virus
    • Sadowski I., Stone J.C., Pawson T. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinase modifies the kinase function and transforming activity of Fujinami sarcoma virus. Mol. Cell Biol. 6:1986;4396-4408.
    • (1986) Mol. Cell Biol. , vol.6 , pp. 4396-4408
    • Sadowski, I.1    Stone, J.C.2    Pawson, T.3
  • 202
    • 0027948205 scopus 로고
    • Induction of apoptosis by a dominant negative H-Ras mutant (116Y) in K562 cells
    • Sakai N., Ogiso Y., Fujita H., Watari H., Koike T., Kuzumaki N. Induction of apoptosis by a dominant negative H-Ras mutant (116Y) in K562 cells. Exp. Cell Res. 215:1994;131-136.
    • (1994) Exp. Cell Res. , vol.215 , pp. 131-136
    • Sakai, N.1    Ogiso, Y.2    Fujita, H.3    Watari, H.4    Koike, T.5    Kuzumaki, N.6
  • 203
    • 0030029271 scopus 로고    scopus 로고
    • Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence
    • Saleh M., Stacker S.A., Wilks A.F. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res. 56:1996;393-401.
    • (1996) Cancer Res. , vol.56 , pp. 393-401
    • Saleh, M.1    Stacker, S.A.2    Wilks, A.F.3
  • 204
    • 0025323865 scopus 로고
    • Application of automated image analysis to demonstrate the correlation between Ras p21 expression and severity of glioma
    • Salgaller M., Agius L., Yates A., Pearl D., Roberts W., Stephens R. Application of automated image analysis to demonstrate the correlation between Ras p21 expression and severity of glioma, Biochem. Biophys. Res. Commun. 169:1990;482-491.
    • (1990) Biochem. Biophys. Res. Commun. , vol.169 , pp. 482-491
    • Salgaller, M.1    Agius, L.2    Yates, A.3    Pearl, D.4    Roberts, W.5    Stephens, R.6
  • 205
    • 0019973408 scopus 로고
    • T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- And Harvey-MSV transforming genes
    • Santos E., Tronick S.R., Aaronson S.A., Pulciani S., Barbacid M. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature. 298:1982;343-347.
    • (1982) Nature , vol.298 , pp. 343-347
    • Santos, E.1    Tronick, S.R.2    Aaronson, S.A.3    Pulciani, S.4    Barbacid, M.5
  • 206
    • 0026483357 scopus 로고
    • Function of Ras as a molecular switch in signal transduction
    • Satoh T., Nakafuku M., Kaziro Y. Function of Ras as a molecular switch in signal transduction. J. Biol. Chem. 267:1992;24149-24152.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24149-24152
    • Satoh, T.1    Nakafuku, M.2    Kaziro, Y.3
  • 209
    • 0025819073 scopus 로고
    • Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit
    • Seabra M.C., Reiss Y., Casey P.J., Brown M.S., Goldstein J.L. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 65:1991;429-434.
    • (1991) Cell , vol.65 , pp. 429-434
    • Seabra, M.C.1    Reiss, Y.2    Casey, P.J.3    Brown, M.S.4    Goldstein, J.L.5
  • 210
    • 0026690922 scopus 로고
    • Purification and characterization of mitogen-activated protein kinase activators from epidermal growth factor-stimulated A431 cells
    • Seger R., Ahu N.G., Posada J., Munar E.S., Jensen A.M., Cooper J.A., Cobb M.H., Krebs E.G. Purification and characterization of mitogen-activated protein kinase activators from epidermal growth factor-stimulated A431 cells. J. Biol. Chem. 267:1992;14373-14381.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14373-14381
    • Seger, R.1    Ahu, N.G.2    Posada, J.3    Munar, E.S.4    Jensen, A.M.5    Cooper, J.A.6    Cobb, M.H.7    Krebs, E.G.8
  • 211
    • 0345650798 scopus 로고    scopus 로고
    • Farnesyl: Protein transferase inhibitors (FTIs) block tyrosine kinase signal transduction and act in concert with an anti-EGF receptor antibody to inhibit cancer cell growth
    • Sepp-Lorenzino L., Bos M., Ma Z., Baselga J., Rands E., Kohl N.E., Oliff A., Mendelsohn J., Rosen N. Farnesyl: protein transferase inhibitors (FTIs) block tyrosine kinase signal transduction and act in concert with an anti-EGF receptor antibody to inhibit cancer cell growth. Proc. Am. Assoc. Cancer Res. 37:1996;A2877.
    • (1996) Proc. Am. Assoc. Cancer Res. , vol.37 , pp. 2877
    • Sepp-Lorenzino, L.1    Bos, M.2    Ma, Z.3    Baselga, J.4    Rands, E.5    Kohl, N.E.6    Oliff, A.7    Mendelsohn, J.8    Rosen, N.9
  • 212
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesylprotein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino L., Ma Z., Rands E., Kohl N.E., Gibbs J.B., Oliff A., Rosen N. A peptidomimetic inhibitor of farnesylprotein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 55:1995;5302-5309.
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 213
    • 0026659515 scopus 로고
    • Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
    • Shou C., Farnsworth C.L., Neel B.G., Feig L.A. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature. 358:1992;351-354.
    • (1992) Nature , vol.358 , pp. 351-354
    • Shou, C.1    Farnsworth, C.L.2    Neel, B.G.3    Feig, L.A.4
  • 214
    • 0027404990 scopus 로고
    • An SH3-SH2-SH3 protein is required for p21-Ras activation and binds to sevenless and Sos proteins in vitro
    • Simon M.A., Dodson G.S., Rubin G.M. An SH3-SH2-SH3 protein is required for p21-Ras activation and binds to sevenless and Sos proteins in vitro. Cell. 73:1993;169-177.
    • (1993) Cell , vol.73 , pp. 169-177
    • Simon, M.A.1    Dodson, G.S.2    Rubin, G.M.3
  • 215
    • 0029796635 scopus 로고    scopus 로고
    • Genetic aspects of colorectal cancer: The surgeon's view
    • (Suppl.)
    • Sjodahl R., Nystrom P.O. Genetic aspects of colorectal cancer: The surgeon's view. Scand. J. Gastroenterol. 220:1996;132-136. (Suppl.).
    • (1996) Scand. J. Gastroenterol. , vol.220 , pp. 132-136
    • Sjodahl, R.1    Nystrom, P.O.2
  • 216
    • 0022472990 scopus 로고
    • Requirement for c-Ras proteins during viral oncogene transformation
    • Smith M.R., DeGudicibus S.J., Stacey D.W. Requirement for c-Ras proteins during viral oncogene transformation. Nature. 320:1986;540-543.
    • (1986) Nature , vol.320 , pp. 540-543
    • Smith, M.R.1    Degudicibus, S.J.2    Stacey, D.W.3
  • 218
    • 0027193964 scopus 로고
    • Myelodysplastic syndromes: From morphology to molecular biology: Part II. The molecular genetics of myelodysplasia
    • Stephenson J., Mufti G.J., Yoshida Y. Myelodysplastic syndromes: from morphology to molecular biology: Part II. The molecular genetics of myelodysplasia. Int. J. Hematol. 57:1993;99-112.
    • (1993) Int. J. Hematol. , vol.57 , pp. 99-112
    • Stephenson, J.1    Mufti, G.J.2    Yoshida, Y.3
  • 219
  • 220
    • 0028149381 scopus 로고
    • The coordinated action of protein tyrosine phosphatases and kinases in cell signaling
    • Sun H., Tonks N.K. The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. Trends Biochem. Sci. 19:1994;480-485.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 480-485
    • Sun, H.1    Tonks, N.K.2
  • 221
    • 0344934217 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for disruption of K-Ras prenylation but each alone is sufficient for inhibition of human tumor growth
    • Sun J., Qian Y., Hamilton A.D., Sebti S.M. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for disruption of K-Ras prenylation but each alone is sufficient for inhibition of human tumor growth. Proc. Am. Assoc. Cancer Res. 38:1997;A352.
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 352
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 222
    • 0029023145 scopus 로고
    • Ras CAAX peptidomimetic FTI-276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletio
    • Sun J., Qian Y., Hamilton A.D., Sebti S.M. Ras CAAX peptidomimetic FTI-276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletio. Cancer Res. 55:1995;4243-4247.
    • (1995) Cancer Res. , vol.55 , pp. 4243-4247
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 223
    • 0027213688 scopus 로고
    • Inhibitors of Ras farnesyltransferases
    • Tamanoi F. Inhibitors of Ras farnesyltransferases. Trends Biochem. Sci. 18:1993;349-353.
    • (1993) Trends Biochem. Sci. , vol.18 , pp. 349-353
    • Tamanoi, F.1
  • 225
    • 0026534571 scopus 로고
    • Ras is essential for nerve growth factor- And phorbol ester-induced tyrosine phosphorylation of MAP kinases
    • Thomas S.M., DeMarco M., D'Arcangelo G., Halegona S., Brugge J.S. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell. 68:1992;1031-1040.
    • (1992) Cell , vol.68 , pp. 1031-1040
    • Thomas, S.M.1    Demarco, M.2    D'Arcangelo, G.3    Halegona, S.4    Brugge, J.S.5
  • 226
    • 0029092309 scopus 로고
    • The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlated with a decrease in growth rate and tumorigenic potential
    • Tsuda T., Marinetti M.R., Masuelli L., Cutler M.L. The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlated with a decrease in growth rate and tumorigenic potential. Oncogene. 11:1995;397-403.
    • (1995) Oncogene , vol.11 , pp. 397-403
    • Tsuda, T.1    Marinetti, M.R.2    Masuelli, L.3    Cutler, M.L.4
  • 230
    • 0030802366 scopus 로고    scopus 로고
    • Molecular pathogenesis of astrocytoma and glioblastoma multiforme
    • Van de Kleft E. Molecular pathogenesis of astrocytoma and glioblastoma multiforme. Acta Neurochir. 139:1997;589-599.
    • (1997) Acta Neurochir. , vol.139 , pp. 589-599
    • Van De Kleft, E.1
  • 232
    • 0027952893 scopus 로고
    • Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
    • Vassbotn F.S., Ostman A., Langeland N., Holmsen H., Westermark B., Heldin C.H., Nister M. Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. J. Cell. Physiol. 158:1994;381-389.
    • (1994) J. Cell. Physiol. , vol.158 , pp. 381-389
    • Vassbotn, F.S.1    Ostman, A.2    Langeland, N.3    Holmsen, H.4    Westermark, B.5    Heldin, C.H.6    Nister, M.7
  • 233
    • 0028912593 scopus 로고
    • A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and Ras processing
    • Vogt A., Qian Y., Blaskovich M.A., Fossum R.D., Hamilton A.D., Sebti S.M. A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing. J. Biol. Chem. 270:1995;660-664.
    • (1995) J. Biol. Chem. , vol.270 , pp. 660-664
    • Vogt, A.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Hamilton, A.D.5    Sebti, S.M.6
  • 234
    • 0027250250 scopus 로고
    • Mammalian Ras interacts with the serine/threonine kinase Raf
    • Voijek A.B., Hollenberg S.M., Cooper J.A. Mammalian Ras interacts with the serine/threonine kinase Raf. Cell. 74:1993;205-214.
    • (1993) Cell , vol.74 , pp. 205-214
    • Voijek, A.B.1    Hollenberg, S.M.2    Cooper, J.A.3
  • 235
    • 0029954462 scopus 로고    scopus 로고
    • Pancreatic carcinoma in perspective, a continuing challenge
    • Wanebo H.J., Vezeridis M.P. Pancreatic carcinoma in perspective, a continuing challenge. Cancer. 78:1996;580-591.
    • (1996) Cancer , vol.78 , pp. 580-591
    • Wanebo, H.J.1    Vezeridis, M.P.2
  • 236
    • 0029787957 scopus 로고    scopus 로고
    • An effect of K-Ras gene mutation on epidermal growth factor receptor signal transduction in panc-1 pancreatic carcinoma cells
    • Watanabe M., Nobuta A., Tanaka J., Asaka M. An effect of K-Ras gene mutation on epidermal growth factor receptor signal transduction in panc-1 pancreatic carcinoma cells. Int. J. Cancer. 67:1996;264-268.
    • (1996) Int. J. Cancer , vol.67 , pp. 264-268
    • Watanabe, M.1    Nobuta, A.2    Tanaka, J.3    Asaka, M.4
  • 237
    • 0024203849 scopus 로고
    • Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines
    • Werner M.H., Humphrey P.A., Bigner D.D., Bigner S.H. Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines. Acta Neuropathol. 77:1988;196-201.
    • (1988) Acta Neuropathol. , vol.77 , pp. 196-201
    • Werner, M.H.1    Humphrey, P.A.2    Bigner, D.D.3    Bigner, S.H.4
  • 238
    • 0029401049 scopus 로고
    • Platelet-derived growth factor in human glioma
    • Westermark B., Carlhendrik H., Nister M. Platelet-derived growth factor in human glioma. Glia. 15:1995;257-263.
    • (1995) Glia , vol.15 , pp. 257-263
    • Westermark, B.1    Carlhendrik, H.2    Nister, M.3
  • 239
    • 0022234123 scopus 로고
    • Growth factors and oncogenes in human malignant glioma
    • Westermark B., Nister M., Heldin C.H. Growth factors and oncogenes in human malignant glioma. Neurol. Clin. 3:1985;785-799.
    • (1985) Neurol. Clin. , vol.3 , pp. 785-799
    • Westermark, B.1    Nister, M.2    Heldin, C.H.3
  • 240
    • 0023874371 scopus 로고
    • Growth factors in cultured human glioma cells: Different effects of FGF, EGF, and PDGF
    • Westphal M., Brunken M., Rhode E., Herrmann H.-D. Growth factors in cultured human glioma cells: different effects of FGF, EGF, and PDGF. Cancer Lett. 38:1988;283-296.
    • (1988) Cancer Lett. , vol.38 , pp. 283-296
    • Westphal, M.1    Brunken, M.2    Rhode, E.3    Herrmann, H.-D.4
  • 245
    • 0021170342 scopus 로고
    • The p21-Ras C-terminus in required for transformation and membrane association
    • Willumsen B.M., Christensen A., Hubbert N.C., Papageorge A.G., Lowy D.R. The p21-Ras C-terminus in required for transformation and membrane association. Nature. 310:1984;583-586.
    • (1984) Nature , vol.310 , pp. 583-586
    • Willumsen, B.M.1    Christensen, A.2    Hubbert, N.C.3    Papageorge, A.G.4    Lowy, D.R.5
  • 246
    • 0021528719 scopus 로고
    • Harvey murine sarcoma virus p21-Ras protein: Biological and biochemical significance of the cysteine nearest the carboxyl terminus
    • Willumsen B.M., Norris K., Papageorge A.G., Hubbert N.C., Lowy D.R. Harvey murine sarcoma virus p21-Ras protein: biological and biochemical significance of the cysteine nearest the carboxyl terminus. EMBO J. 3:1984;2581-2585.
    • (1984) EMBO J. , vol.3 , pp. 2581-2585
    • Willumsen, B.M.1    Norris, K.2    Papageorge, A.G.3    Hubbert, N.C.4    Lowy, D.R.5
  • 247
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • Wong A.J., Bigner S.H., Bigner D.D., Kinzler K.W., Hamilton S.R., Vogelstein B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. USA. 84:1987;6899-6903.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3    Kinzler, K.W.4    Hamilton, S.R.5    Vogelstein, B.6
  • 248
    • 0027203515 scopus 로고
    • In vitro models of thyroid cancer
    • Wynford-Thomas D. In vitro models of thyroid cancer. Cancer Surv. 16:1993;115-134.
    • (1993) Cancer Surv. , vol.16 , pp. 115-134
    • Wynford-Thomas, D.1
  • 249
    • 0029789643 scopus 로고    scopus 로고
    • Coupling of the Ras-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
    • Xing J., Ginty D.D., Greenberg M.E. Coupling of the Ras-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 273:1996;959-963.
    • (1996) Science , vol.273 , pp. 959-963
    • Xing, J.1    Ginty, D.D.2    Greenberg, M.E.3
  • 251
    • 0345365654 scopus 로고    scopus 로고
    • Enhanced expression of transforming growth factor (TGF)-beta and its type I and type II receptors in human gliobloastoma tissues
    • Yamada N., Iwasa H., Kato M., Miyazono K. Enhanced expression of transforming growth factor (TGF)-beta and its type I and type II receptors in human gliobloastoma tissues. Proc. Am. Assoc. Cancer Res. 38:1997;A229.
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 229
    • Yamada, N.1    Iwasa, H.2    Kato, M.3    Miyazono, K.4
  • 252
    • 0029154458 scopus 로고
    • Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype
    • Yan N., Ricca C., Fletcher J., Glover T., Seizinger B.R., Manne V. Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype. Cancer Res. 55:1995;3569-3575.
    • (1995) Cancer Res. , vol.55 , pp. 3569-3575
    • Yan, N.1    Ricca, C.2    Fletcher, J.3    Glover, T.4    Seizinger, B.R.5    Manne, V.6
  • 253
    • 0026001936 scopus 로고
    • A protein geranylgeranyltransferase from bovine brain: Implications for protein prenylation specificity
    • Yokoyama K., Goodwin G.W., Ghomashchi F., Glomset J.A., Gelb M.H. A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity. Proc. Natl. Acad. Sci. USA. 88:1991;5302-5306.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5302-5306
    • Yokoyama, K.1    Goodwin, G.W.2    Ghomashchi, F.3    Glomset, J.A.4    Gelb, M.H.5
  • 255
    • 0016440775 scopus 로고
    • Incidence of malignant tumors in United States children
    • Young J.L., Miller R.W. Incidence of malignant tumors in United States children. J. Pediatr. 86:1975;254-258.
    • (1975) J. Pediatr. , vol.86 , pp. 254-258
    • Young, J.L.1    Miller, R.W.2


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