메뉴 건너뛰기




Volumn 45, Issue 6, 1999, Pages 1442-1453

Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens

Author keywords

Astrocytoma; EGFRvIII; Epidermal growth factor receptor; Glioblastoma multiforme; Glioma; Mitogen activated protein kinase; Ras; Survival

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

EID: 0032763824     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199912000-00034     Document Type: Article
Times cited : (209)

References (57)
  • 1
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/ neu-overexpressing human breast cancer xenografts
    • Baselga J, Norton L, Albanell J, Kim YM, Mendelsohn J: Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/ neu-overexpressing human breast cancer xenografts. Cancer Res 58:2825-2831, 1998.
    • (1998) Cancer Res , vol.58 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.M.4    Mendelsohn, J.5
  • 5
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancers: A review
    • Bos JL: Ras oncogenes in human cancers: A review. Cancer Res 49:4682-4689, 1989.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 6
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ: JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037, 1994.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 7
    • 0028237507 scopus 로고
    • Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification
    • Ekstrand AJ, Longo N, Hamid ML, Olson JJ, Liu L, Collins VP, James CD: Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification. Oncogene 9:2313-2320, 1994.
    • (1994) Oncogene , vol.9 , pp. 2313-2320
    • Ekstrand, A.J.1    Longo, N.2    Hamid, M.L.3    Olson, J.J.4    Liu, L.5    Collins, V.P.6    James, C.D.7
  • 8
    • 0032474835 scopus 로고    scopus 로고
    • Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells
    • Fenstermaker RA, Ciesielski MJ, Castiglia GJ: Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells. Oncogene 16:3435-3443, 1998.
    • (1998) Oncogene , vol.16 , pp. 3435-3443
    • Fenstermaker, R.A.1    Ciesielski, M.J.2    Castiglia, G.J.3
  • 10
    • 0028911678 scopus 로고
    • Expression of PDGF and PDGF receptors in human astrocytoma operative specimens supports the existence of an autocrine loop
    • Guha A, Dashner K, Black PM, Wagner JA, Stiles CD: Expression of PDGF and PDGF receptors in human astrocytoma operative specimens supports the existence of an autocrine loop. Int J Cancer 60:168-173, 1995.
    • (1995) Int J Cancer , vol.60 , pp. 168-173
    • Guha, A.1    Dashner, K.2    Black, P.M.3    Wagner, J.A.4    Stiles, C.D.5
  • 11
    • 0031465906 scopus 로고    scopus 로고
    • Proliferation of human malignant astrocytomas is dependent on Ras activation
    • Guha A, Feldkamp MM, Lau N, Boss G, Pawson A: Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 15:2755-2765, 1997.
    • (1997) Oncogene , vol.15 , pp. 2755-2765
    • Guha, A.1    Feldkamp, M.M.2    Lau, N.3    Boss, G.4    Pawson, A.5
  • 12
    • 0029040346 scopus 로고
    • Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome
    • Guha A, Gowacka D, Carrol R, Dashner K, Black PM, Stiles CD: Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome. J Neurol Neurosurg Psychiatry 58: 711-714, 1995.
    • (1995) J Neurol Neurosurg Psychiatry , vol.58 , pp. 711-714
    • Guha, A.1    Gowacka, D.2    Carrol, R.3    Dashner, K.4    Black, P.M.5    Stiles, C.D.6
  • 13
    • 0030062955 scopus 로고    scopus 로고
    • Ras-GTP levels are elevated in human NF1 peripheral nerve tumours
    • Guha A, Lau N, Gutmann D, Provias J, Pawson T, Boss G: Ras-GTP levels are elevated in human NF1 peripheral nerve tumours. Oncogene 12:507-513, 1996.
    • (1996) Oncogene , vol.12 , pp. 507-513
    • Guha, A.1    Lau, N.2    Gutmann, D.3    Provias, J.4    Pawson, T.5    Boss, G.6
  • 14
    • 0029837306 scopus 로고    scopus 로고
    • Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors
    • Han Y, Caday CG, Nanda A, Cavenee WK, Huang HJS: Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res 56:3859-3861, 1996.
    • (1996) Cancer Res , vol.56 , pp. 3859-3861
    • Han, Y.1    Caday, C.G.2    Nanda, A.3    Cavenee, W.K.4    Huang, H.J.S.5
  • 15
    • 0028804246 scopus 로고
    • Specific targeting of a mutant, activated EGF receptor found in glioblastoma using a monoclonal antibody
    • Hills D, Rowlinson-Busza G, Gullick WJ: Specific targeting of a mutant, activated EGF receptor found in glioblastoma using a monoclonal antibody. Int J Cancer 63:537-543, 1995.
    • (1995) Int J Cancer , vol.63 , pp. 537-543
    • Hills, D.1    Rowlinson-Busza, G.2    Gullick, W.J.3
  • 16
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Huang HJS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK: The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 272:2927-2935, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 2927-2935
    • Huang, H.J.S.1    Nagane, M.2    Klingbeil, C.K.3    Lin, H.4    Nishikawa, R.5    Ji, X.D.6    Huang, C.M.7    Gill, G.N.8    Wiley, H.S.9    Cavenee, W.K.10
  • 21
    • 0028123442 scopus 로고
    • The p53 gene and protein in human brain tumors
    • Louis DN: The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53:11-21, 1994.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 11-21
    • Louis, D.N.1
  • 22
    • 0029094065 scopus 로고
    • A tiger behind many doors: Multiple genetic pathways to malignant glioma
    • Louis DN, Gusella JF: A tiger behind many doors: Multiple genetic pathways to malignant glioma. Trends Genet 11:412-415, 1995.
    • (1995) Trends Genet , vol.11 , pp. 412-415
    • Louis, D.N.1    Gusella, J.F.2
  • 23
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ: Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185, 1995.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 25
    • 0029591402 scopus 로고
    • Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
    • Montgomery RB, Moscatello DK, Wong AJ, Cooper JA, Stahl WL: Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor. J Biol Chem 270:30562-30566, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 30562-30566
    • Montgomery, R.B.1    Moscatello, D.K.2    Wong, A.J.3    Cooper, J.A.4    Stahl, W.L.5
  • 28
    • 0030946460 scopus 로고    scopus 로고
    • A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors
    • Moscatello DK, Ramirez G, Wong AJ: A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors. Cancer Res 57:1419-1424, 1997.
    • (1997) Cancer Res , vol.57 , pp. 1419-1424
    • Moscatello, D.K.1    Ramirez, G.2    Wong, A.J.3
  • 29
    • 0029961912 scopus 로고    scopus 로고
    • A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis
    • Nagane M, Coufal F, Lin H, Bögler O, Cavenee WK, Huang HJ: A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. Cancer Res 56:5079-5086, 1996.
    • (1996) Cancer Res , vol.56 , pp. 5079-5086
    • Nagane, M.1    Coufal, F.2    Lin, H.3    Bögler, O.4    Cavenee, W.K.5    Huang, H.J.6
  • 32
    • 0029949509 scopus 로고    scopus 로고
    • Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor
    • Okamoto S, Yoshikawa K, Obata Y, Shibuya M, Aoki S, Yoshida J, Takahashi T: Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor. Br J Cancer 73:1366-1372, 1996.
    • (1996) Br J Cancer , vol.73 , pp. 1366-1372
    • Okamoto, S.1    Yoshikawa, K.2    Obata, Y.3    Shibuya, M.4    Aoki, S.5    Yoshida, J.6    Takahashi, T.7
  • 34
    • 15144341822 scopus 로고    scopus 로고
    • Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: Implications for subdomain contributions to receptor assembly
    • O'Rourke DM, Nute EJ, Davis JG, Wu C, Lee A, Murali R, Zhang HT, Qian X, Kao CC, Greene MI: Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: Implications for subdomain contributions to receptor assembly. Oncogene 16:1197-1207, 1998.
    • (1998) Oncogene , vol.16 , pp. 1197-1207
    • O'Rourke, D.M.1    Nute, E.J.2    Davis, J.G.3    Wu, C.4    Lee, A.5    Murali, R.6    Zhang, H.T.7    Qian, X.8    Kao, C.C.9    Greene, M.I.10
  • 35
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes DF, Weber BL, Baselga JM, Tripathy D, Baly D, Baughman SA, Twaddell T, Glaspy JA, Slamon DJ: Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 16:2659-2671, 1998.
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3    Weber, B.L.4    Baselga, J.M.5    Tripathy, D.6    Baly, D.7    Baughman, S.A.8    Twaddell, T.9    Glaspy, J.A.10    Slamon, D.J.11
  • 36
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Welch HA, Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359:845-848, 1992.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Welch, H.A.3    Risau, W.4
  • 38
    • 0029815093 scopus 로고    scopus 로고
    • Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway
    • Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, Cavenee WK, Huang HS: Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem 271:25639-25645, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 25639-25645
    • Prigent, S.A.1    Nagane, M.2    Lin, H.3    Huvar, I.4    Boss, G.R.5    Feramisco, J.R.6    Cavenee, W.K.7    Huang, H.S.8
  • 39
    • 0344447168 scopus 로고    scopus 로고
    • Expression of a variant epidermal growth factor receptor in Barrett's esophagus and gastric adenocarcinoma
    • abstr
    • Ramirez G, Moscatello DK, Palazzo J, Peraza S, Wong AJ: Expression of a variant epidermal growth factor receptor in Barrett's esophagus and gastric adenocarcinoma. Proc Am Assoc Cancer Res 38:277, 1997 (abstr).
    • (1997) Proc am Assoc Cancer Res , vol.38 , pp. 277
    • Ramirez, G.1    Moscatello, D.K.2    Palazzo, J.3    Peraza, S.4    Wong, A.J.5
  • 40
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP: Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 53:2736-2739, 1993.
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 41
    • 0030983005 scopus 로고    scopus 로고
    • Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate
    • Reist CJ, Archer GE, Wikstrand CJ, Bigner DD, Zalutsky MR: Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate. Cancer Res 57:1510-1515, 1997.
    • (1997) Cancer Res , vol.57 , pp. 1510-1515
    • Reist, C.J.1    Archer, G.E.2    Wikstrand, C.J.3    Bigner, D.D.4    Zalutsky, M.R.5
  • 42
    • 0030818101 scopus 로고    scopus 로고
    • In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: Comparison with its murine parent
    • Reist CJ, Batra SK, Pegram CN, Bigner DD, Zalutsky MR: In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: Comparison with its murine parent. Nucl Med Biol 24:639-647, 1997.
    • (1997) Nucl Med Biol , vol.24 , pp. 639-647
    • Reist, C.J.1    Batra, S.K.2    Pegram, C.N.3    Bigner, D.D.4    Zalutsky, M.R.5
  • 44
    • 0028872684 scopus 로고
    • Determination of absolute amounts of Ras-GDP and GTP bound to Ras in mammalian cells: Comparison of parental and Ras-overproducing NIH 3T3 fibroblasts
    • Scheele JS, Rhee JM, Boss GR: Determination of absolute amounts of Ras-GDP and GTP bound to Ras in mammalian cells: Comparison of parental and Ras-overproducing NIH 3T3 fibroblasts. Proc Natl Acad Sci U S A 92:1097-1100, 1994.
    • (1994) Proc Natl Acad Sci U S A , vol.92 , pp. 1097-1100
    • Scheele, J.S.1    Rhee, J.M.2    Boss, G.R.3
  • 45
    • 0031893630 scopus 로고    scopus 로고
    • Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF receptor-specific antibody-toxin
    • Schmidt M, Reiser P, Hills D, Gullick WJ, Wels W: Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF receptor-specific antibody-toxin. Int J Cancer 75:878-884, 1998.
    • (1998) Int J Cancer , vol.75 , pp. 878-884
    • Schmidt, M.1    Reiser, P.2    Hills, D.3    Gullick, W.J.4    Wels, W.5
  • 46
    • 0027361809 scopus 로고
    • Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
    • Shamah SM, Stiles CD, Guha A: Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol 13:7203-7212, 1993.
    • (1993) Mol Cell Biol , vol.13 , pp. 7203-7212
    • Shamah, S.M.1    Stiles, C.D.2    Guha, A.3
  • 47
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182, 1987.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 48
    • 0023791645 scopus 로고
    • Expression of an altered epidermal growth factor receptor by human glioblastoma cells
    • Steck PA, Lee P, Hung MC, Yung WK: Expression of an altered epidermal growth factor receptor by human glioblastoma cells. Cancer Res 48:5433-5439, 1988.
    • (1988) Cancer Res , vol.48 , pp. 5433-5439
    • Steck, P.A.1    Lee, P.2    Hung, M.C.3    Yung, W.K.4
  • 50
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • Sugawa N, Ekstrand AJ, James CD, Collins VP: Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci U S A 87:8602-8606, 1990.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 51
    • 0026735230 scopus 로고
    • Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I
    • Trojan J, Blossey BK, Johnson TR, Rudin SD, Tykocinski M, Ilan J, Ilan J: Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I. Proc Natl Acad Sci U S A 89:4874-4878, 1992.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4874-4878
    • Trojan, J.1    Blossey, B.K.2    Johnson, T.R.3    Rudin, S.D.4    Tykocinski, M.5    Ilan, J.6    Ilan, J.7
  • 53
    • 0026033511 scopus 로고
    • Retinoblastoma gene deletions in human glioblastomas
    • Venter D, Bevan K, Ludwig R: Retinoblastoma gene deletions in human glioblastomas. Oncogene 6:445-448, 1991.
    • (1991) Oncogene , vol.6 , pp. 445-448
    • Venter, D.1    Bevan, K.2    Ludwig, R.3
  • 54
    • 0031782321 scopus 로고    scopus 로고
    • Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation
    • Walker F, Kato A, Gonez LJ, Hibbs ML, Pouliot N, Levitzki A, Burgess AW: Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation. Mol Cell Biol 18:7192-7204, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 7192-7204
    • Walker, F.1    Kato, A.2    Gonez, L.J.3    Hibbs, M.L.4    Pouliot, N.5    Levitzki, A.6    Burgess, A.W.7
  • 57
    • 0023912033 scopus 로고
    • Amplification of the structurally and functionally altered epidermal growth factor receptor gene (cerbB) in human brain tumors
    • Yamazaki H, Fukui Y, Ueyama Y, Tamaoki N, Kawamoto T, Taniguchi S, Shibuya M: Amplification of the structurally and functionally altered epidermal growth factor receptor gene (cerbB) in human brain tumors. Mol Cell Biol 8:1816-1820, 1988.
    • (1988) Mol Cell Biol , vol.8 , pp. 1816-1820
    • Yamazaki, H.1    Fukui, Y.2    Ueyama, Y.3    Tamaoki, N.4    Kawamoto, T.5    Taniguchi, S.6    Shibuya, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.