Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors

Cancer Research

Volumn 62, Issue 13, 2002, Pages 3729-3735

  Lokker, Nathalie A ^a   Sullivan, Carol M ^a   Hollenbach, Stanley J ^a   Israel, Mark A ^b   Giese, Neill A ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[(2H BENZO[D]1,3 DIOXALAN 5 YLMETHYL)AMINO][4 (6,7 DIMETHOXYQUINAZOLIN 4YL]METHANE 1 THIONE; CT 52923; LIGAND; PIPERAZINYLQUINAZOLINE KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR C; PLATELET DERIVED GROWTH FACTOR D; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; AUTOPHOSPHORYLATION; BRAIN TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC VALUE; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; MITOGENESIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ASSAY; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; XENOGRAFT;

3T3 CELLS; ANIMALS; BRAIN NEOPLASMS; CELL DIVISION; CELL SURVIVAL; GLIOBLASTOMA; HUMANS; LIGANDS; LYMPHOKINES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PIPERAZINES; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RATS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 0036645057     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Brain and other central nervous system tumors: Rates, trends, and epidemiology
2. Biology and treatment of malignant glioma
3. Malignant glioma: Genetics and biology of a grave matter
4. Platelet-derived growth factor: Mechanism of action and possible in vivo function
5. Platelet-derived growth factor receptor signals
6. Cytogenetic and molecular abnormalities in astrocytic gliomas
7. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
8. Developmental roles of platelet-derived growth factors
9. PDGF-D is a specific, protease-activated ligand for the PDGF-betareceptor
10. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF-α and β receptor
11. Lichenstein a new protease-activated growth factor
12. PDGF-C is a new protease-activated ligand for the PDGF-α-receptor
13. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
14. Control of meningioma cell growth by platelet-derived growth factor (PDGF)
15. Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
16. Inhibition of glioma cell growth by a truncated platelet-derived growth factor-β receptor
17. Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant
18. Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury
19. Molecular localization of the transforming and secretory properties of PDGF-A and PDGF-B
20. Expression of PDGF and PDGF-receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
21. Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
22. Platelet-derived growth factor (PDGF) and receptor (PDGFR) expression in human meningiomas: Correlations with clinicopathological features and cytogenetic analysis
23. Autocrine growth stimulation of human meningioma cells by platelet-derived growth factor
24. Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
25. Platelet-derived growth factor in human glioma
26. Molecular genetics of human glioma
27. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-α and their receptors in human malignant glioma cell lines
28. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
29. Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy
30. Invasiveness and chemotactic activity of oncogene transformed NIH/3T3 cells
31. Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media
32. Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation
33. Transformation of NIH 3T3 cells by a human c-sis cDNA clone
34. Colony-stimulating factor-1 receptor (c-fms)
35. Cell signaling by receptor tyrosine kinases
36. Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF-cell-surface receptors
37. Inhibition of v-fms-induced tumor growth in nude mice by castanospermine
38. The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences
39. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
40. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
41. Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB
42. Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects
43. Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells
44. Molecular genetics of brain tumors
45. Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs
46. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
47. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
48. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
49. Mechanism of action and in vivo role of platelet-derived growth factor