Calorie restriction and stroke

Experimental and Translational Stroke Medicine

Volumn 3, Issue 1, 2011, Pages

  Manzanero, Silvia ^a   Gelderblom, Mathias ^b   Magnus, Tim ^b   Arumugam, Thiruma V ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Brain; Calorie restriction; Intermittent fasting; Strokeischemia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; CORTICOTROPIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SILENT INFORMATION REGULATOR PROTEIN; TUMOR NECROSIS FACTOR; UNCOUPLING PROTEIN; VASCULOTROPIN;

AGING; ANGIOGENESIS; APOPTOSIS; AUTOPHAGY; BLOOD PRESSURE; BODY FAT; BODY TEMPERATURE; BRAIN ISCHEMIA; BREATHING RATE; CALORIC RESTRICTION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CYTOKINE PRODUCTION; DNA REPAIR; DOWN REGULATION; EXCITOTOXICITY; HUMAN; LIPID BLOOD LEVEL; LIPID PEROXIDATION; METABOLIC RATE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; UPREGULATION;

EID: 80053106868     PISSN: None     EISSN: 20407378     Source Type: Journal    
DOI: 10.1186/2040-7378-3-8     Document Type: Review

References (160)

1. Masoro EJ. Subfield history: caloric restriction, slowing aging, and extending life. Sci Aging Knowledge Environ 2003, 2003(8):RE2.
2. Ye J, Keller JN. Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction. Aging 2010, 2(6):361-368. 2919256, 20606248.
3. Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273(5271):59-63. 10.1126/science.273.5271.59, 2987625, 8658196.
4. Mattson MP, Wan R. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem 2005, 16(3):129-137. 10.1016/j.jnutbio.2004.12.007, 15741046.
5. Bruce-Keller AJ, Umberger G, McFall R, Mattson MP. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol 1999, 45(1):8-15. 10.1002/1531-8249(199901)45:1<8::AID-ART4>3.0.CO;2-V, 9894871.
6. Greene AE, Todorova MT, McGowan R, Seyfried TN. Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia 2001, 42(11):1371-1378.
7. Jamrozik K, Broadhurst RJ, Anderson CS, Stewart-Wynne EG. The role of lifestyle factors in the etiology of stroke. A population-based case-control study in Perth, Western Australia. Stroke 1994, 25(1):51-59. 10.1161/01.STR.25.1.51, 8266383.
8. Zheng Z, Lee JE, Yenari MA. Stroke: molecular mechanisms and potential targets for treatment. Curr Mol Med 2003, 3(4):361-372. 10.2174/1566524033479717, 12776991.
9. McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. Nutrition 1935, 10(1):63-79.
10. McDonald RB, Ramsey JJ. Honoring Clive McCay and 75 years of calorie restriction research. J Nutr 2010, 140(7):1205-1210. 10.3945/jn.110.122804, 2884327, 20484554.
11. McCay CM, Maynard LA, Sperling G, Barnes LL. Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets restricted in calories. Nutrition 1939, 18(1):1-13.
12. Riesen WH, et al. The effect of restricted caloric intake on the longevity of rats. Am J Physiol 1947, 148(3):614-617.
13. Weindruch R, Walford RL. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982, 215(4538):1415-1418. 10.1126/science.7063854, 7063854.
14. Gerbase-DeLima M, Liu RK, Cheney KE, Mickey R, Walford RL. Immune function and survival in a long-lived mouse strain subjected to undernutrition. Gerontologia 1975, 21(4):184-202. 10.1159/000212044, 1102395.
15. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009, 325(5937):201-204. 10.1126/science.1173635, 2812811, 19590001.
16. Rezzi S, Martin FP, Shanmuganayagam D, Colman RJ, Nicholson JK, Weindruch R. Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates. Exp Gerontol 2009, 44(5):356-362. 10.1016/j.exger.2009.02.008, 2822382, 19264119.
17. Lane MA, Baer DJ, Rumpler WV, Weindruch R, Ingram DK, Tilmont EM, Cutler RG, Roth GS. Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci USA 1996, 93(9):4159-4164. 10.1073/pnas.93.9.4159, 39504, 8633033.
18. Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R. Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J 2000, 14(12):1825-1836. 10.1096/fj.99-0881com, 10973932.
19. Yu BP, Chung HY. Stress resistance by caloric restriction for longevity. Ann N Y Acad Sci 2001, 928:39-47.
20. Nikolich-Zugich J, Messaoudi I. Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol 2005, 40(11):884-893. 10.1016/j.exger.2005.06.007, 16087306.
21. Swindell WR. Genes regulated by caloric restriction have unique roles within transcriptional networks. Mech Ageing Dev 2008, 129(10):580-592. 10.1016/j.mad.2008.06.001, 2688445, 18634819.
22. Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA 2003, 100(10):6216-6120. 10.1073/pnas.1035720100, 156352, 12724520.
23. Johnson JB, Laub DR, John S. The effect on health of alternate day calorie restriction: eating less and more than needed on alternate days prolongs life. Med Hypotheses 2006, 67(2):209-211. 10.1016/j.mehy.2006.01.030, 16529878.
24. Young JB, Mullen D, Landsberg L. Caloric restriction lowers blood pressure in the spontaneously hypertensive rat. Metabolism 1978, 27(12):1711-1714. 10.1016/0026-0495(78)90256-1, 723627.
25. Albanes D. Total calories, body weight, and tumor incidence in mice. Cancer Res 1987, 47(8):1987-1992.
26. Lee JH, Jung KJ, Kim JW, Kim HJ, Yu BP, Chung HY. Suppression of apoptosis by calorie restriction in aged kidney. Exp Gerontol 2004, 39(9):1361-1368. 10.1016/j.exger.2004.06.015, 15489059.
27. Shelton LM, Huysentruyt LC, Mukherjee P, Seyfried TN. Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse. ASN Neuro 2010, 2(3):e00038. 2908744, 20664705.
28. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956, 11(3):298-300.
29. Ku HH, Brunk UT, Sohal RS. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med 1993, 15(6):621-627. 10.1016/0891-5849(93)90165-Q, 8138188.
30. Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004, 3(3):205-214. 10.1038/nrd1330, 15031734.
31. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev 1994, 76(2-3):215-224. 10.1016/0047-6374(94)91595-4, 7885066.
32. Peters O, Back T, Lindauer U, Busch C, Megow D, Dreier J, Dirnagl U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1998, 18(2):196-205.
33. Domínguez C, Delgado P, Vilches A, Martín-Gallán P, Ribó M, Santamarina E, Molina C, Corbeto N, Rodríguez-Sureda V, Rosell A, Alvarez-Sabín J, Montaner J. Oxidative stress after thrombolysis-induced reperfusion in human stroke. Stroke 2010, 41(4):653-660. 10.1161/STROKEAHA.109.571935, 20185784.
34. Gredilla R, Barja G. Minireview: the role of oxidative stress in relation to caloric restriction and longevity. Endocrinology 2005, 146(9):3713-3717. 10.1210/en.2005-0378, 15919745.
35. Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am J Physiol Endocrinol Metab 2005, 289(3):E429-438. 10.1152/ajpendo.00435.2004, 15886224.
36. Sanz A, Caro P, Ibañez J, Gómez J, Gredilla R, Barja G. Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain. J Bioenerg Biomembr 2005, 37(2):83-90. 10.1007/s10863-005-4131-0, 15906153.
37. Caldeira da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ. Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 2008, 7(4):552-560. 10.1111/j.1474-9726.2008.00407.x, 18505478.
38. Keipert S, Klaus S, Heldmaier G, Jastroch M. UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. Biochim Biophys Acta 2010, 1797(2):324-330. 10.1016/j.bbabio.2009.11.008, 19958747.
39. Liu D, Chan SL, de Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med 2006, 8(3):389-414. 10.1385/NMM:8:3:389, 16775390.
40. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, Warden CH, Castilho RF, Melcher T, Gonzalez-Zulueta M, Nikolich K, Wieloch T. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med 2003, 9(8):1062-1068. 10.1038/nm903, 12858170.
41. Nakase T, Yoshida Y, Nagata K. Amplified expression of uncoupling proteins in human brain ischemic lesions. Neuropathology 2007, 27(5):442-447. 10.1111/j.1440-1789.2007.00815.x, 18018477.
42. Kwok KH, Ho PW, Chu AC, Ho JW, Liu HF, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL. Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. Free Radic Biol Med 2010, 49(6):1023-1035. 10.1016/j.freeradbiomed.2010.06.017, 20600837.
43. Chu AC, Ho PW, Kwok KH, Ho JW, Chan KH, Liu HF, Kung MH, Ramsden DB, Ho SL. Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression. Free Radic Biol Med 2009, 46(6):810-820. 10.1016/j.freeradbiomed.2008.12.015, 19150400.
44. Lü JM, Lin PH, Yao Q, Chen C. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med 2010, 14(4):840-860. 10.1111/j.1582-4934.2009.00897.x, 2927345, 19754673.
45. Weindruch R, Kayo T, Lee CK, Prolla TA. Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. J Nutr 2001, 131(3):918S-923S.
46. Sohal RS, Ku HH, Agarwal S, Forster MJ, Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 1994, 74(1-2):121-133. 10.1016/0047-6374(94)90104-X, 7934203.
47. Arumugam TV, Phillips TM, Cheng A, Morrell CH, Mattson MP, Wan R. Age and energy intake interact to modify cell stress pathways and stroke outcome. Ann Neurol 2010, 67(1):41-52. 10.1002/ana.21798, 2844782, 20186857.
48. Canto C, Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 2009, 20(2):98-105. 10.1097/MOL.0b013e328328d0a4, 19276888.
49. Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310(5746):314-317. 10.1126/science.1117728, 16224023.
50. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999, 98(1):115-124. 10.1016/S0092-8674(00)80611-X, 10412986.
51. Masoro EJ, Yu BP, Bertrand HA. Action of food restriction in delaying the aging process. Proc Natl Acad Sci USA 1982, 79(13):4239-4241. 10.1073/pnas.79.13.4239, 346614, 6955798.
52. Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, Pasinetti GM. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol 2009, 66(3):352-361. 10.1001/archneurol.2008.588, 3052997, 19273754.
53. Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 2006, 127(1):59-69. 10.1016/j.cell.2006.09.015, 17018277.
54. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR, Global PD, . Gene Expression (GPEX) Consortium PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med 2010, 2(52):52ra73. 10.1126/scitranslmed.3001059, 3129986, 20926834, Gene Expression (GPEX) Consortium.
55. Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem 2009, 284(32):21379-21385. 10.1074/jbc.M109.018911, 2755862, 19542216.
56. Hancock CR, Han DH, Higashida K, Kim SH, Holloszy JO. Does calorie restriction induce mitochondrial biogenesis? A reevaluation. FASEB J 2011, 25(2):785-791. 10.1096/fj.10-170415, 21048043.
57. Duan W, Guo Z, Mattson MP. Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice. J Neurochem 2001, 76(2):619-626. 10.1046/j.1471-4159.2001.00071.x, 11208925.
58. Duan W, Lee J, Guo Z, Mattson MP. Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. J Mol Neurosci 2001, 16(1):1-12. 10.1385/JMN:16:1:1, 11345515.
59. Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci USA 2004, 101(52):18171-18176. 10.1073/pnas.0405831102, 539733, 15604149.
60. Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci USA 2009, 106(4):1255-1260. 10.1073/pnas.0808587106, 2633586, 19171901.
61. Gomez-Pinilla F. The influences of diet and exercise on mental health through hormesis. Ageing Res Rev 2008, 7(1):49-62. 10.1016/j.arr.2007.04.003, 17604236.
62. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000, 10(3):381-391. 10.1016/S0959-4388(00)00092-1, 10851172.
63. Zuccato C, Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 2009, 5(6):311-322. 10.1038/nrneurol.2009.54, 19498435.
64. Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002, 3(5):383-394. 10.1038/nrn812, 11988777.
65. Stahl K, Mylonakou MN, Skare T, Amiry-Moghaddam M, Torp R. Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease. Brain Res 2011, 1378:105-118.
66. Gardiner J, Barton D, Overall R, Marc J. Neurotrophic support and oxidative stress: converging effects in the normal and diseased nervous system. Neuroscientist 2009, 15(1):47-61.
67. Blake MJ, Fargnoli J, Gershon D, Holbrook NJ. Concomitant decline in heat-induced hyperthermia and HSP70 mRNA expression in aged rats. Am J Physiol 1991, 260(4 Pt 2):R663-R667.
68. Guo Z, Ersoz A, Butterfield DA, Mattson MP. Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid. J Neurochem 2000, 75(1):314-320.
69. Li CY, Lee JS, Ko YG, Kim JI, Seo JS. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 2000, 275(33):25665-25671. 10.1074/jbc.M906383199, 10806214.
70. Tantucci M, Mariucci G, Taha E, Spaccatini C, Tozzi A, Luchetti E, Calabresi P, Ambrosini MV. Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. Neuroscience 2009, 163(3):735-740. 10.1016/j.neuroscience.2009.06.070, 19580850.
71. Vass K, Berger ML, Nowak TS, Welch WJ, Lassmann H. Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat. Neurosci Lett 1989, 100(1-3):259-264. 10.1016/0304-3940(89)90695-2, 2761775.
72. Lee AS. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 2001, 26(8):504-510. 10.1016/S0968-0004(01)01908-9, 11504627.
73. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ 2010, 17(3):488-498. 10.1038/cdd.2009.144, 2822118, 19816510.
74. Alirezaei M, Kemball CC, Lindsay Whitton J. Autophagy, inflammation and neurodegenerative disease. Eur J Neurosci 2011, 33(2):197-204. 10.1111/j.1460-9568.2010.07500.x, 21138487.
75. Shen W, Ganetzky B. Autophagy promotes synapse development in Drosophila. J Cell Biol 2009, 187(1):71-79. 10.1083/jcb.200907109, 2762098, 19786572.
76. Martinez-Vicente M, Cuervo AM. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 2007, 6(4):352-361. 10.1016/S1474-4422(07)70076-5, 17362839.
77. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci USA 2010, 107(32):14164-14169. 10.1073/pnas.1009485107, 2922576, 20660724.
78. Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009, 20(7):1992-2003. 10.1091/mbc.E08-12-1249, 2663920, 19225151.
79. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy 2010, 6(6):702-710. 10.4161/auto.6.6.12376, 3106288, 20534972.
80. Garelick MG, Kennedy BK. TOR on the brain. Exp Gerontol 2011, 46(2-3):155-163. 10.1016/j.exger.2010.08.030, 20849946.
81. Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, Palla S, Bleecker E, Pahor M. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr 2004, 79(4):544-551.
82. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004, 23(12):2369-2380. 10.1038/sj.emboj.7600244, 423286, 15152190.
83. Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 2005, 280(48):40364-40374. 10.1074/jbc.M509329200, 16183991.
84. Young DA, Nickerson-Nutter CL. mTOR--beyond transplantation. Curr Opin Pharmacol 2005, 5(4):418-423. 10.1016/j.coph.2005.03.004, 15955739.
85. Arundine M, Tymianski M. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 2004, 61(6):657-668. 10.1007/s00018-003-3319-x, 15052409.
86. Mattson MP. Neuroprotective signal transduction: relevance to stroke. Neurosci Biobehav Rev 1997, 21(2):193-206. 10.1016/S0149-7634(96)00010-3, 9062943.
87. Mattson MP, Culmsee C, Yu ZF. Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res 2000, 301(1):173-187. 10.1007/s004419900154, 10928290.
88. Lipton P. Ischemic cell death in brain neurons. Physiol Rev 1999, 79(4):1431-1568.
89. Phillis JW, Horrocks LA, Farooqui AA. Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. Brain Res Rev 2006, 52(2):201-243. 10.1016/j.brainresrev.2006.02.002, 16647138.
90. Green SP, Cairns B, Rae J, Errett-Baroncini C, Hongo JA, Erickson RW, Curnutte JT. Induction of gp91-phox, a component of the phagocyte NADPH oxidase, in microglial cells during central nervous system inflammation. J Cereb Blood Flow Metab 2001, 21(4):374-384.
91. Love S. Oxidative stress in brain ischemia. Brain Pathol 1999, 9(1):119-131.
92. Tang SC, Arumugam TV, Cutler RG, Jo DG, Magnus T, Chan SL, Mughal MR, Telljohann RS, Nassar M, Ouyang X, Calderan A, Ruzza P, Guiotto A, Mattson MP. Neuroprotective actions of a histidine analogue in models of ischemic stroke. J Neurochem 2007, 101(3):729-736. 10.1111/j.1471-4159.2006.04412.x, 17254011.
93. Ridder DA, Schwaninger M. NF-kappaB signaling in cerebral ischemia. Neuroscience 2009, 158(3):995-1006. 10.1016/j.neuroscience.2008.07.007, 18675321.
94. Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke. J Neuroimmunol 2007, 184(1-2):53-68. 10.1016/j.jneuroim.2006.11.014, 1868538, 17188755.
95. Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 2004, 101(17):6659-6663. 10.1073/pnas.0308291101, 404101, 15096581.
96. Kishi T, Hirooka Y, Ogawa K, Konno S, Sunagawa K. Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats. Clin Exp Hypertens 2011, 33(4):240-245. 10.3109/10641963.2011.583969, 21699450.
97. Kushiro T, Kobayashi F, Osada H, Tomiyama H, Satoh K, Otsuka Y, Kurumatani H, Kajiwara N. Role of sympathetic activity in blood pressure reduction with low calorie regimen. Hypertension 1991, 17(6 Pt 2):965-968.
98. Wan R, Camandola S, Mattson MP. Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats. J Nutr 2003, 133(6):1921-1929.
99. Lynch CD, Cooney PT, Bennett SA, Thornton PL, Khan AS, Ingram RL, Sonntag WE. Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats. Neurobiol Aging 1999, 20(2):191-200. 10.1016/S0197-4580(99)00032-9, 10537028.
100. Sonntag WE, Lynch C, Thornton P, Khan A, Bennett S, Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J Anat 2000, (197 Pt 4):575-585.
101. Shinmura K, Tamaki K, Bolli R. Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts. J Mol Cell Cardiol 2005, 39(2):285-296. 10.1016/j.yjmcc.2005.03.010, 15878170.
102. Ribeiro LC, Quincozes-Santos A, Leite MC, Abib RT, Kleinkauf-Rocha J, Biasibetti R, Rotta LN, Wofchuk ST, Perry ML, Gonçalves CA, Gottfried C. Caloric restriction increases hippocampal glutamate uptake and glutamine synthetase activity in Wistar rats. Neurosci Res 2009, 64(3):330-334. 10.1016/j.neures.2009.04.004, 19376166.
103. Yu ZF, Mattson MP. Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res 1999, 57(6):830-839. 10.1002/(SICI)1097-4547(19990915)57:6<830::AID-JNR8>3.0.CO;2-2, 10467254.
104. Lindvall O, Ernfors P, Bengzon J, Kokaia Z, Smith ML, Siesjö BK, Persson H. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci USA 1992, 89(2):648-652. 10.1073/pnas.89.2.648, 48296, 1731336.
105. Sommer C, Kollmar R, Schwab S, Kiessling M, Schäbitz WR. Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra. Brain Res Mol Brain Res 2003, 111(1-2):24-30.
106. Franklin TB, Krueger-Naug AM, Clarke DB, Arrigo AP, Currie RW. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. Int J Hyperthermia 2005, 21(5):379-392. 10.1080/02656730500069955, 16048836.
107. Mokrushin AA, Pavlinova LI, Plekhanov AY. Heat shock protein HSP70 increases the resistance of cortical cells to glutamate excitotoxicity. Bull Exp Biol Med 2005, 140(1):1-5. 10.1007/s10517-005-0396-x, 16254606.
108. Yu Z, Luo H, Fu W, Mattson MP. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol 1999, 155(2):302-314. 10.1006/exnr.1998.7002, 10072306.
109. Yu ZF, Mattson MP. Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res 1999, 57(6):830-839. 10.1002/(SICI)1097-4547(19990915)57:6<830::AID-JNR8>3.0.CO;2-2, 10467254.
110. Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem 1999, 72(3):1187-1203.
111. Millet L, Vidal H, Andreelli F, Larrouy D, Riou JP, Ricquier D, Laville M, Langin D. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest 1997, 100(11):2665-2670. 10.1172/JCI119811, 508469, 9389729.
112. Wei Z, Chigurupati S, Bagsiyao P, Henriquez A, Chan SL. The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival. Neurotox Res 2009, 16(1):14-29. 10.1007/s12640-009-9039-8, 19526295.
113. Kim DH, Zhao X. BDNF protects neurons following injury by modulation of caspase activity. Neurocrit Care 2005, 3(1):71-76. 10.1385/NCC:3:1:071, 16159102.
114. Kelly S, Bieneman A, Horsburgh K, Hughes D, Sofroniew MV, McCulloch J, Uney JB. Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro. J Cereb Blood Flow Metab 2001, 21(8):972-981.
115. Imuta N, Hori O, Kitao Y, Tabata Y, Yoshimoto T, Matsuyama T, Ogawa S. Hypoxia-mediated induction of heme oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis. Antioxid Redox Signal 2007, 9(5):543-552. 10.1089/ars.2006.1519, 17330989.
116. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303(5666):2011-2015. 10.1126/science.1094637, 14976264.
117. Hasegawa K, Yoshikawa K. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci 2008, 28(35):8772-8784. 10.1523/JNEUROSCI.3052-08.2008, 18753379.
118. Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007, 6(4):505-514. 10.1111/j.1474-9726.2007.00304.x, 17521387.
119. Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol 1999, 159(1):65-72. 10.1006/exnr.1999.7160, 10486175.
120. Dick O, Bading H. Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem 2010, 285(25):19354-19361. 10.1074/jbc.M110.127654, 2885215, 20404335.
121. Leker RR, Aharonowiz M, Greig NH, Ovadia H. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Exp Neurol 2004, 187(2):478-486. 10.1016/j.expneurol.2004.01.030, 15144874.
122. Won CK, Ji HH, Koh PO. Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 2006, 398(1-2):39-43. 10.1016/j.neulet.2005.12.060, 16423457.
123. Kuningas M, Mägi R, Westendorp RG, Slagboom PE, Remm M, van Heemst D. Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet 2007, 15(3):294-301. 10.1038/sj.ejhg.5201766, 17245409.
124. Lanzillotta A, Sarnico I, Ingrassia R, Boroni F, Branca C, Benarese M, Faraco G, Blasi F, Chiarugi A, Spano P, Pizzi M. The acetylation of RelA in Lys310 dictates the NF-kappaB-dependent response in post-ischemic injury. Cell Death Dis 2010, 1(11):e96. 10.1038/cddis.2010.76, 3032326, 21368872.
125. Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH. SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med 2007, 39(1):8-13.
126. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305(5682):390-392. 10.1126/science.1099196, 15205477.
127. Meng S, Lin L, Lama S, Qiao M, Tuor UI. Cerebral expression of DNA repair protein, Ku70, and its association with cell proliferation following cerebral hypoxia-ischemia in neonatal rats. Int J Dev Neurosci 2009, 27(2):129-134. 10.1016/j.ijdevneu.2008.12.002, 19121380.
128. Han B, Wang Q, Cui G, Shen X, Zhu Z. Post-treatment of Bax-inhibiting peptide reduces neuronal death and behavioral deficits following global cerebral ischemia. Neurochem Int 2011, 58(2):224-233. 10.1016/j.neuint.2010.12.008, 21167243.
129. Nemoto S, Fergusson MM, Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 2005, 280(16):16456-16460. 10.1074/jbc.M501485200, 15716268.
130. Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC. Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. J Neurosci Res 2010, 88(3):605-613.
131. Luo Y, Zhu W, Jia J, Zhang C, Xu Y. NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury. J Mol Neurosci 2009, 39(1-2):262-268. 10.1007/s12031-009-9196-5, 19343277.
132. Wang P, Xu TY, Guan YF, Tian WW, Viollet B, Rui YC, Zhai QW, Su DF, Miao CY. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 2011, 69(2):360-374. 10.1002/ana.22236, 21246601.
133. Zhu HR, Wang ZY, Zhu XL, Wu XX, Li EG, Xu Y. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 2010, 59(1-2):70-76. 10.1016/j.neuropharm.2010.03.017, 20381504.
134. Raval AP, Dave KR, Perez-Pinzon MA. Resveratrol mimics ischemic preconditioning in the brain. J Cereb Blood Flow Metab 2006, 26(9):1141-1147.
135. Liu D, Gharavi R, Pitta M, Gleichmann M, Mattson MP. Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med 2009, 11(1):28-42. 10.1007/s12017-009-8058-1, 2677622, 19288225.
136. Pfister JA, Ma C, Morrison BE, D'Mello SR. Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One 2008, 3(12):e4090. 10.1371/journal.pone.0004090, 2605257, 19116652.
137. Chiba T, Ezaki O. Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun 2010, 399(1):98-103. 10.1016/j.bbrc.2010.07.048, 20643106.
138. Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 2009, 7:97. 10.1186/1479-5876-7-97, 2780998, 19919699.
139. Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, Zhang X, Liu N, Ikeda Y, Matsuura T, Abe K. In vivo imaging of autophagy in a mouse stroke model. Autophagy 2010, 6(8):1107-1114. 10.4161/auto.6.8.13427, 20930570.
140. Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 2008, 172(2):454-469. 10.2353/ajpath.2008.070876, 2312361, 18187572.
141. Rami A, Kogel D. Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?. Autophagy 2008, 4(4):422-426.
142. Ghiglieri V, Pendolino V, Bagetta V, Sgobio C, Calabresi P, Picconi B. mTOR inhibitor rapamycin suppresses striatal post-ischemic LTP. Exp Neurol 2010, 226(2):328-331. 10.1016/j.expneurol.2010.09.012, 20854816.
143. Delgoffe GM, Powell JD. mTOR: taking cues from the immune microenvironment. Immunology 2009, 127(4):459-465. 10.1111/j.1365-2567.2009.03125.x, 2729523, 19604300.
144. Lu DY, Liou HC, Tang CH, Fu WM. Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem Pharmacol 2006, 72(8):992-1000. 10.1016/j.bcp.2006.06.038, 16919605.
145. Kernie SG, Parent JM. Forebrain neurogenesis after focal Ischemic and traumatic brain injury. Neurobiol Dis 2010, 37(2):267-274. 10.1016/j.nbd.2009.11.002, 2864918, 19909815.
146. Lee J, Duan W, Mattson MP. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 2002, 82(6):1367-1375. 10.1046/j.1471-4159.2002.01085.x, 12354284.
147. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 2003, 111(12):1843-1851. 161428, 12813020.
148. Dong W, Li N, Gao D, Zhen H, Zhang X, Li F. Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors. J Vasc Surg 2008, 48(3):709-714. 10.1016/j.jvs.2008.04.007, 18572362.
149. Kondo M, Shibata R, Miura R, Shimano M, Kondo K, Li P, Ohashi T, Kihara S, Maeda N, Walsh K, et al. Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem 2009, 284(3):1718-1724. 2615500, 18990685.
150. Zhu M, Miura J, Lu LX, Bernier M, DeCabo R, Lane MA, Roth GS, Ingram DK. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol 2004, 39(7):1049-1059. 10.1016/j.exger.2004.03.024, 15236764.
151. Wan R, Ahmet I, Brown M, Cheng A, Kamimura N, Talan M, Mattson MP. Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats. J Nutr Biochem 2010, 21(5):413-417. 10.1016/j.jnutbio.2009.01.020, 2854256, 19423320.
152. Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, Kudo C, Shin HK, Moskowitz MA, Ouchi N. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation 2008, 117(2):216-223. 10.1161/CIRCULATIONAHA.107.725044, 18158361.
153. Fassbender K, Schmidt R, Mossner R, Daffertshofer M, Hennerici M. Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke 1994, 25(6):1105-1108. 10.1161/01.STR.25.6.1105, 8202965.
154. Neidert S, Katan M, Schuetz P, Fluri F, Ernst A, Bingisser R, Kappos L, Engelter ST, Steck A, Muller B, et al. Anterior pituitary axis hormones and outcome in acute ischaemic stroke. J Intern Med 2011, 269(4):420-432. 10.1111/j.1365-2796.2010.02327.x, 21205022.
155. Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology 2005, 146(2):851-860.
156. Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci USA 2006, 103(20):7901-7905. 10.1073/pnas.0600161103, 1458512, 16682650.
157. Davis LM, Pauly JR, Readnower RD, Rho JM, Sullivan PG. Fasting is neuroprotective following traumatic brain injury. J Neurosci Res 2008, 86(8):1812-1822. 10.1002/jnr.21628, 18241053.
158. Katare RG, Kakinuma Y, Arikawa M, Yamasaki F, Sato T. Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway. J Mol Cell Cardiol 2009, 46(3):405-412. 10.1016/j.yjmcc.2008.10.027, 19059263.
159. Plunet WT, Streijger F, Lam CK, Lee JH, Liu J, Tetzlaff W. Dietary restriction started after spinal cord injury improves functional recovery. Exp Neurol 2008, 213(1):28-35. 10.1016/j.expneurol.2008.04.011, 18585708.
160. McEwen BR, Paterson PG. Caloric restriction provided after global ischemia does not reduce hippocampal cornu ammonis injury or improve functional recovery. Neuroscience 2010, 166(1):263-270. 10.1016/j.neuroscience.2009.11.076, 20005922.