메뉴 건너뛰기




Volumn 16, Issue 1, 2009, Pages 14-29

The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: Role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival

Author keywords

Energy metabolism; Glycolysis; Mitochondrial uncoupling protein

Indexed keywords

3 NITROPROPIONIC ACID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE GROWTH FACTOR; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 4;

EID: 70349744001     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-009-9039-8     Document Type: Article
Times cited : (29)

References (73)
  • 1
    • 0027243086 scopus 로고
    • The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
    • Allsopp TE, Wyatt S, Paterson HF, Davies AM (1993) The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73:295-307
    • (1993) Cell , vol.73 , pp. 295-307
    • Allsopp, T.E.1    Wyatt, S.2    Paterson, H.F.3    Davies, A.M.4
  • 2
    • 27644448810 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in the CNS: In support of function and survival
    • Andrews ZB, Diano S, Horvath TL (2005a) Mitochondrial uncoupling proteins in the CNS: In support of function and survival. Nat Rev Neurosci 6:829-840
    • (2005) Nat Rev Neurosci , vol.6 , pp. 829-840
    • Andrews, Z.B.1    Diano, S.2    Horvath, T.L.3
  • 4
    • 0033667705 scopus 로고    scopus 로고
    • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    • Arsenijevic D, Onuma H, Pecqueur C et al (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26:435-439
    • (2000) Nat Genet , vol.26 , pp. 435-439
    • Arsenijevic, D.1    Onuma, H.2    Pecqueur, C.3
  • 5
    • 0036683694 scopus 로고    scopus 로고
    • Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury
    • Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, Horvath TL (2002) Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury. Biochem Pharmacol 64:363-367
    • (2002) Biochem Pharmacol , vol.64 , pp. 363-367
    • Bechmann, I.1    Diano, S.2    Warden, C.H.3    Bartfai, T.4    Nitsch, R.5    Horvath, T.L.6
  • 6
    • 0035923665 scopus 로고    scopus 로고
    • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    • Bennett BL, Sasaki DT, Murray BW et al (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98:13681-13686
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13681-13686
    • Bennett, B.L.1    Sasaki, D.T.2    Murray, B.W.3
  • 7
    • 0032582662 scopus 로고    scopus 로고
    • The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    • Bergmann A, Agapite J, McCall K, Steller H (1998) The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95:331-341
    • (1998) Cell , vol.95 , pp. 331-341
    • Bergmann, A.1    Agapite, J.2    McCall, K.3    Steller, H.4
  • 8
    • 29144468251 scopus 로고    scopus 로고
    • 3-Nitropropionic acid: A mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    • Brouillet E, Jacquard C, Bizat N, Blum D (2005) 3-Nitropropionic acid: A mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J Neurochem 95:1521-1540
    • (2005) J Neurochem , vol.95 , pp. 1521-1540
    • Brouillet, E.1    Jacquard, C.2    Bizat, N.3    Blum, D.4
  • 9
    • 1542348209 scopus 로고    scopus 로고
    • The energetics of Huntington's disease
    • Browne SE, Beal MF (2004) The energetics of Huntington's disease. Neurochem Res 29:531-546
    • (2004) Neurochem Res , vol.29 , pp. 531-546
    • Browne, S.E.1    Beal, M.F.2
  • 10
    • 0141632952 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons
    • Burkhalter J, Fiumelli H, Allaman I, Chatton JY, Martin JL (2003) Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons. J Neurosci 23:8212-8220
    • (2003) J Neurosci , vol.23 , pp. 8212-8220
    • Burkhalter, J.1    Fiumelli, H.2    Allaman, I.3    Chatton, J.Y.4    Martin, J.L.5
  • 11
    • 0035863129 scopus 로고    scopus 로고
    • Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons
    • Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z (2001) Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. J Neurosci 21:434-443
    • (2001) J Neurosci , vol.21 , pp. 434-443
    • Cavanaugh, J.E.1    Ham, J.2    Hetman, M.3    Poser, S.4    Yan, C.5    Xia, Z.6
  • 12
    • 3142545254 scopus 로고    scopus 로고
    • Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
    • Chan SL, Fu W, Zhang P, Cheng A, Lee J, Kokame K, Mattson MP (2004) Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress. J Biol Chem 279:28733-28743
    • (2004) J Biol Chem , vol.279 , pp. 28733-28743
    • Chan, S.L.1    Fu, W.2    Zhang, P.3    Cheng, A.4    Lee, J.5    Kokame, K.6    Mattson, M.P.7
  • 13
    • 33845985635 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells
    • Chan SL, Liu D, Kyriazis GA, Bagsiyao P, Ouyang X, Mattson MP (2006) Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells. J Biol Chem 281:37391-37403
    • (2006) J Biol Chem , vol.281 , pp. 37391-37403
    • Chan, S.L.1    Liu, D.2    Kyriazis, G.A.3    Bagsiyao, P.4    Ouyang, X.5    Mattson, M.P.6
  • 14
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A (2001) Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 276:9519-9525
    • (2001) J Biol Chem , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 15
    • 0028321583 scopus 로고
    • Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury
    • Cheng B, Goodman Y, Begley JG, Mattson MP (1994) Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury. Brain Res 650:331-335
    • (1994) Brain Res , vol.650 , pp. 331-335
    • Cheng, B.1    Goodman, Y.2    Begley, J.G.3    Mattson, M.P.4
  • 16
    • 60449092709 scopus 로고    scopus 로고
    • Mitochondrial UCP4 attenuates MPP(+)- and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression
    • Chu AC, Ho PW, Kwok KH, Ho JW, Chan KH, Liu HF, Kung MH, Ramsden DB, Ho SL (2008) Mitochondrial UCP4 attenuates MPP(+)- and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression. Free Radic Biol Med 46:810-820
    • (2008) Free Radic Biol Med , vol.46 , pp. 810-820
    • Chu, A.C.1    Ho, P.W.2    Kwok, K.H.3    Ho, J.W.4    Chan, K.H.5    Liu, H.F.6    Kung, M.H.7    Ramsden, D.B.8    Ho, S.L.9
  • 17
    • 33749344947 scopus 로고    scopus 로고
    • ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: A key role in glucose-mediated pancreatic beta-cell survival
    • Costes S, Broca C, Bertrand G, Lajoix AD, Bataille D, Bockaert J, Dalle S (2006) ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: A key role in glucose-mediated pancreatic beta-cell survival. Diabetes 55:2220-2230
    • (2006) Diabetes , vol.55 , pp. 2220-2230
    • Costes, S.1    Broca, C.2    Bertrand, G.3    Lajoix, A.D.4    Bataille, D.5    Bockaert, J.6    Dalle, S.7
  • 18
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • Crews CM, Alessandrini A, Erikson RL (1992) The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258:478-480
    • (1992) Science , vol.258 , pp. 478-480
    • Crews, C.M.1    Alessandrini, A.2    Erikson, R.L.3
  • 19
    • 33746238205 scopus 로고    scopus 로고
    • Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease
    • De la Monte SM, Wands JR (2006) Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis 9:167-181
    • (2006) J Alzheimers Dis , vol.9 , pp. 167-181
    • De la Monte, S.M.1    Wands, J.R.2
  • 21
    • 42349088894 scopus 로고    scopus 로고
    • The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells
    • Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G (2008) The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res 68:2813-2819
    • (2008) Cancer Res , vol.68 , pp. 2813-2819
    • Derdak, Z.1    Mark, N.M.2    Beldi, G.3    Robson, S.C.4    Wands, J.R.5    Baffy, G.6
  • 22
    • 0242468451 scopus 로고    scopus 로고
    • Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for preconditioning
    • Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL (2003) Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for preconditioning. Endocrinology 144:5014-5021
    • (2003) Endocrinology , vol.144 , pp. 5014-5021
    • Diano, S.1    Matthews, R.T.2    Patrylo, P.3    Yang, L.4    Beal, M.F.5    Barnstable, C.J.6    Horvath, T.L.7
  • 23
    • 34948890043 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins - What is their physiological role?
    • Echtay KS (2007) Mitochondrial uncoupling proteins - what is their physiological role? Free Radic Biol Med 43:1351-1371
    • (2007) Free Radic Biol Med , vol.43 , pp. 1351-1371
    • Echtay, K.S.1
  • 24
    • 18244379331 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling proteins
    • Echtay KS, Roussel D, St-Pierre J et al (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 425:96-99
    • (2002) Nature , vol.425 , pp. 96-99
    • Echtay, K.S.1    Roussel, D.2    St-Pierre, J.3
  • 25
    • 33751251030 scopus 로고    scopus 로고
    • MEK inhibition exacerbates ischemic calcium imbalance and neuronal cell death in rat cortical cultures
    • Franceschini D, Giusti P, Skaper SD (2006) MEK inhibition exacerbates ischemic calcium imbalance and neuronal cell death in rat cortical cultures. Eur J Pharmacol 553:18-27
    • (2006) Eur J Pharmacol , vol.553 , pp. 18-27
    • Franceschini, D.1    Giusti, P.2    Skaper, S.D.3
  • 26
    • 23944494249 scopus 로고    scopus 로고
    • Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly
    • Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL (2005) Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metab 1:145-152
    • (2005) Cell Metab , vol.1 , pp. 145-152
    • Fridell, Y.W.1    Sánchez-Blanco, A.2    Silvia, B.A.3    Helfand, S.L.4
  • 27
    • 0035212435 scopus 로고    scopus 로고
    • Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checker-board stimulation in vivo
    • Gjedde A, Marret S (2001) Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checker-board stimulation in vivo. J Cereb Blood Flow Metab 21:1384-1392
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1384-1392
    • Gjedde, A.1    Marret, S.2
  • 28
    • 0002639306 scopus 로고    scopus 로고
    • Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function
    • Guo ZH, Mattson MP (2000) Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function. Cereb Cortex 10:50-57
    • (2000) Cereb Cortex , vol.10 , pp. 50-57
    • Guo, Z.H.1    Mattson, M.P.2
  • 29
    • 0043233065 scopus 로고    scopus 로고
    • CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region
    • Hara T, Hamada J, Yano S, Morioka M, Kai Y, Ushio Y (2003) CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region. J Neurochem 86:805-814
    • (2003) J Neurochem , vol.86 , pp. 805-814
    • Hara, T.1    Hamada, J.2    Yano, S.3    Morioka, M.4    Kai, Y.5    Ushio, Y.6
  • 30
    • 33847062554 scopus 로고    scopus 로고
    • MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia
    • Jover-Mengual T, Zukin RS, Etgen AM (2007) MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 148:1131-1143
    • (2007) Endocrinology , vol.148 , pp. 1131-1143
    • Jover-Mengual, T.1    Zukin, R.S.2    Etgen, A.M.3
  • 32
    • 24944450267 scopus 로고    scopus 로고
    • The mitochondrial uncoupler 2, 4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia
    • Korde AS, Pettigrew LC, Craddock SD, Maragos WF (2005) The mitochondrial uncoupler 2, 4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia. J Neurochem 94:1676-1684
    • (2005) J Neurochem , vol.94 , pp. 1676-1684
    • Korde, A.S.1    Pettigrew, L.C.2    Craddock, S.D.3    Maragos, W.F.4
  • 34
    • 12344276944 scopus 로고    scopus 로고
    • Superoxide dismutase evolution and life span regulation
    • Landis GN, Tower J (2005) Superoxide dismutase evolution and life span regulation. Mech Ageing Dev 126:365-379
    • (2005) Mech Ageing Dev , vol.126 , pp. 365-379
    • Landis, G.N.1    Tower, J.2
  • 35
    • 0038482050 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein Bim
    • Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ (2003) Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein Bim. J Biol Chem 278:18811-18816
    • (2003) J Biol Chem , vol.278 , pp. 18811-18816
    • Ley, R.1    Balmanno, K.2    Hadfield, K.3    Weston, C.4    Cook, S.J.5
  • 36
    • 14644430451 scopus 로고    scopus 로고
    • Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
    • Liévens JC, Rival T, Iché M, Chneiweiss H, Birman S (2005) Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila. Hum Mol Genet 14:713-724
    • (2005) Hum Mol Genet , vol.14 , pp. 713-724
    • Liévens, J.C.1    Rival, T.2    Iché, M.3    Chneiweiss, H.4    Birman, S.5
  • 37
    • 11244341098 scopus 로고    scopus 로고
    • Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: A novel mechanism of Ras-mediated tumor promotion
    • Lim JH, Lee ES, You HJ, Lee JW, Park JW, Chun YS (2004) Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: A novel mechanism of Ras-mediated tumor promotion. Oncogene 23:9427-9431
    • (2004) Oncogene , vol.23 , pp. 9427-9431
    • Lim, J.H.1    Lee, E.S.2    You, H.J.3    Lee, J.W.4    Park, J.W.5    Chun, Y.S.6
  • 39
    • 84958039680 scopus 로고
    • Reversible inhibition of the coupling between phosphorylation and oxidation
    • Loomis WF, Lipmann F (1948) Reversible inhibition of the coupling between phosphorylation and oxidation. J Biol Chem 173:807-808
    • (1948) J Biol Chem , vol.173 , pp. 807-808
    • Loomis, W.F.1    Lipmann, F.2
  • 40
    • 34247631690 scopus 로고    scopus 로고
    • The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
    • Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21:1037-1049
    • (2007) Genes Dev , vol.21 , pp. 1037-1049
    • Lum, J.J.1    Bui, T.2    Gruber, M.3    Gordan, J.D.4    DeBerardinis, R.J.5    Covello, K.L.6    Simon, M.C.7    Thompson, C.B.8
  • 41
    • 13844262750 scopus 로고    scopus 로고
    • 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells
    • Mandavilli BS, Boldogh I, Van Houten B (2005) 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells. Brain Res Mol Brain Res 133:215-223
    • (2005) Brain Res Mol Brain Res , vol.133 , pp. 215-223
    • Mandavilli, B.S.1    Boldogh, I.2    Van Houten, B.3
  • 42
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett 443:326-330
    • (1999) FEBS Lett , vol.443 , pp. 326-330
    • Mao, W.1    Yu, X.X.2    Zhong, A.3    Li, W.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 43
    • 0035955751 scopus 로고    scopus 로고
    • Antiischemic effects of SB203580 are mediated through the inhibition of p38α mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase
    • Martin JL, Avkiran M, Quinlan RA, Cohen P, Marber MS (2001) Antiischemic effects of SB203580 are mediated through the inhibition of p38α mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase. Circ Res 89:750-752
    • (2001) Circ Res , vol.89 , pp. 750-752
    • Martin, J.L.1    Avkiran, M.2    Quinlan, R.A.3    Cohen, P.4    Marber, M.S.5
  • 45
    • 0036043866 scopus 로고    scopus 로고
    • Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders
    • Mattson MP, Liu D (2002) Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders. Neuromolecular Med 2:215-231
    • (2002) Neuromolecular Med , vol.2 , pp. 215-231
    • Mattson, M.P.1    Liu, D.2
  • 46
    • 0037423004 scopus 로고    scopus 로고
    • D-(+)-glucose rescue against 1-methyl-4-phenylpyridinium toxicity through anaerobic glycolysis in neuroblastoma cells
    • Mazzio E, Soliman KF (2003) D-(+)-glucose rescue against 1-methyl-4-phenylpyridinium toxicity through anaerobic glycolysis in neuroblastoma cells. Brain Res 962:48-60
    • (2003) Brain Res , vol.962 , pp. 48-60
    • Mazzio, E.1    Soliman, K.F.2
  • 48
    • 0346788896 scopus 로고    scopus 로고
    • Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling
    • Miwa S, Brand MD (2003) Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling. Biochem Soc Trans 31:1300-1301
    • (2003) Biochem Soc Trans , vol.31 , pp. 1300-1301
    • Miwa, S.1    Brand, M.D.2
  • 49
    • 0022444637 scopus 로고
    • Effect of nerve growth factor on glucose utilization and nucleotide content of pheochromocytoma cells (clone PC12)
    • Morelli A, Grasso M, Calissano P (1986) Effect of nerve growth factor on glucose utilization and nucleotide content of pheochromocytoma cells (clone PC12). J Neurochem 47:375-381
    • (1986) J Neurochem , vol.47 , pp. 375-381
    • Morelli, A.1    Grasso, M.2    Calissano, P.3
  • 53
    • 0038364056 scopus 로고    scopus 로고
    • Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy
    • Ravikumar B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC (2003) Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 12:985-994
    • (2003) Hum Mol Genet , vol.12 , pp. 985-994
    • Ravikumar, B.1    Stewart, A.2    Kita, H.3    Kato, K.4    Duden, R.5    Rubinsztein, D.C.6
  • 54
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard DE, Berra E, Gothié E, Roux D, Pouysségur J (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 274:32631-32637
    • (1999) J Biol Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothié, E.3    Roux, D.4    Pouysségur, J.5
  • 56
    • 0028277844 scopus 로고
    • Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras
    • Rosen LB, Ginty DD, Weber MJ, Greenberg ME (1994) Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12:1207-1221
    • (1994) Neuron , vol.12 , pp. 1207-1221
    • Rosen, L.B.1    Ginty, D.D.2    Weber, M.J.3    Greenberg, M.E.4
  • 57
    • 0037303935 scopus 로고    scopus 로고
    • Traffic at the intersection of neurotrophic factor signaling and neurodegeneration
    • Salehi A, Delcroix JD, Mobley WC (2003) Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci 26:73-80
    • (2003) Trends Neurosci , vol.26 , pp. 73-80
    • Salehi, A.1    Delcroix, J.D.2    Mobley, W.C.3
  • 59
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271:32529-32537
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 60
    • 0032852479 scopus 로고    scopus 로고
    • CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
    • Shaywitz AJ, Greenberg ME (1999) CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861
    • (1999) Annu Rev Biochem , vol.68 , pp. 821-861
    • Shaywitz, A.J.1    Greenberg, M.E.2
  • 61
    • 0027963452 scopus 로고
    • Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
    • Shimazaki K, Ishida A, Kawai N (1994) Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neurosci Res 20:95-99
    • (1994) Neurosci Res , vol.20 , pp. 95-99
    • Shimazaki, K.1    Ishida, A.2    Kawai, N.3
  • 62
    • 0037155198 scopus 로고    scopus 로고
    • Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells
    • Song C, Perides G, Liu YF (2002) Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells. J Biol Chem 277:6703-6707
    • (2002) J Biol Chem , vol.277 , pp. 6703-6707
    • Song, C.1    Perides, G.2    Liu, Y.F.3
  • 63
    • 7044239977 scopus 로고    scopus 로고
    • Uncoupled and surviving: Individual mice with high metabolism have greater mitochondrial uncoupling and live longer
    • Speakman JR, Talbot DA, Selman C, Snart S, McLaren JS, Redman P et al (2004) Uncoupled and surviving: Individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell 3:87-95
    • (2004) Aging Cell , vol.3 , pp. 87-95
    • Speakman, J.R.1    Talbot, D.A.2    Selman, C.3    Snart, S.4    McLaren, J.S.5    Redman, P.6
  • 64
    • 0030726009 scopus 로고    scopus 로고
    • Mild uncoupling of mitochondria
    • Starkov AA (1997) Mild uncoupling of mitochondria. Biosci Rep 17:273-279
    • (1997) Biosci Rep , vol.17 , pp. 273-279
    • Starkov, A.A.1
  • 67
    • 0034659866 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus
    • Sugino T, Nozaki K, Takagi Y, Hattori I, Hashimoto N, Moriguchi T, Nishida E (2000) Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus. J Neurosci 20:4506-4514
    • (2000) J Neurosci , vol.20 , pp. 4506-4514
    • Sugino, T.1    Nozaki, K.2    Takagi, Y.3    Hattori, I.4    Hashimoto, N.5    Moriguchi, T.6    Nishida, E.7
  • 68
    • 0029122720 scopus 로고
    • Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
    • Tsakiridis T, McDowell HE, Walker T, Downes CP, Hundal HS, Vranic M, Klip A (1995) Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells. Endocrinology 136:4315-4322
    • (1995) Endocrinology , vol.136 , pp. 4315-4322
    • Tsakiridis, T.1    McDowell, H.E.2    Walker, T.3    Downes, C.P.4    Hundal, H.S.5    Vranic, M.6    Klip, A.7
  • 70
    • 34248181508 scopus 로고    scopus 로고
    • Anaerobic glycolysis protection against 1-methy-4-phenylpyridinium (MPP+) toxicity in C6 glioma cells
    • Williams ZR, Goodman CB, Soliman KF (2007) Anaerobic glycolysis protection against 1-methy-4-phenylpyridinium (MPP+) toxicity in C6 glioma cells. Neurochem Res 32:1071-1080
    • (2007) Neurochem Res , vol.32 , pp. 1071-1080
    • Williams, Z.R.1    Goodman, C.B.2    Soliman, K.F.3
  • 71
    • 0031594573 scopus 로고    scopus 로고
    • Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
    • Xing J, Kornhauser JM, Xia Z, Thiele EA, Greenberg ME (1998) Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol 18:1946-1955
    • (1998) Mol Cell Biol , vol.18 , pp. 1946-1955
    • Xing, J.1    Kornhauser, J.M.2    Xia, Z.3    Thiele, E.A.4    Greenberg, M.E.5
  • 72
    • 2942577753 scopus 로고    scopus 로고
    • Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP
    • Yung HW, Wyttenbach A, Tolkovsky AM (2004) Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP. Biochem Pharmacol 68:351-360
    • (2004) Biochem Pharmacol , vol.68 , pp. 351-360
    • Yung, H.W.1    Wyttenbach, A.2    Tolkovsky, A.M.3
  • 73
    • 34047130812 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in Huntington's disease
    • Zuccato C, Cattaneo E (2007) Role of brain-derived neurotrophic factor in Huntington's disease. Prog Neurobiol 81:294-330
    • (2007) Prog Neurobiol , vol.81 , pp. 294-330
    • Zuccato, C.1    Cattaneo, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.