Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity

Free Radical Biology and Medicine

Volumn 49, Issue 6, 2010, Pages 1023-1035

  Kwok, Ken Hon Hung ^a   Ho, Philip Wing Lok ^a   Chu, Andrew Chi Yuen ^a   Ho, Jessica Wing Man ^a   Liu, Hui Fang ^a   Yiu, David Chi Wai ^a   Chan, Koon Ho ^a   Kung, Michelle Hiu Wai ^a   Ramsden, David Boyer ^b   Ho, Shu Leong ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

Dopamine; Free radicals; Mitochondrial dysfunction; Neuroprotection; Oxidative stress; Parkinson disease; Uncoupling proteins

Indexed keywords

ADENOSINE TRIPHOSPHATE; DACTINOMYCIN; DOPAMINE; LACTIC ACID; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MPP; OXIDOREDUCTASE INHIBITOR; OXYGEN; POLYCLONAL ANTIBODY; PROTON; SUPEROXIDE; TOXIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 4; UNCOUPLING PROTEIN 5;

ARTICLE; ATTENUATION; BRAIN MITOCHONDRION; BRAIN OXYGEN CONSUMPTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; ENZYME SYNTHESIS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTON TRANSPORT;

EID: 77955514244     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.06.017     Document Type: Article

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