-
1
-
-
57349093783
-
Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction
-
Fontana L. Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction. Exp Gerontol. 2009; 44:41-45.
-
(2009)
Exp Gerontol.
, vol.44
, pp. 41-45
-
-
Fontana, L.1
-
2
-
-
33847772417
-
Anti-inflammatory mechanisms of dietary restriction in slowing aging processes
-
Morgan TE, Wong AM, and Finch CE. Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdiscip Top Gerontol. 2007; 35:83-97.
-
(2007)
Interdiscip Top Gerontol.
, vol.35
, pp. 83-97
-
-
Morgan, T.E.1
Wong, A.M.2
Finch, C.E.3
-
3
-
-
54249149973
-
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span
-
Dixit VD. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J Leukoc Biol. 2008; 84:882-892.
-
(2008)
J Leukoc Biol.
, vol.84
, pp. 882-892
-
-
Dixit, V.D.1
-
4
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, and Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993; 259:87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
5
-
-
0035979775
-
Reversal of Obesity-and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, and Shoelson SE. Reversal of Obesity-and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkbeta. Science. 2001; 293:1673-1677.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
6
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun C, Uysal K, Maeda K, Karin M, and Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature. 2002; 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.4
Uysal, K.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
7
-
-
0036905264
-
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters
-
Brose N, and Rosenmund C. Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci. 2002; 115:4399-4411.
-
(2002)
J Cell Sci.
, vol.115
, pp. 4399-4411
-
-
Brose, N.1
Rosenmund, C.2
-
8
-
-
0141844653
-
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
-
Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, and Hwang DH. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem. 2003; 278:37041-37051.
-
(2003)
J Biol Chem.
, vol.278
, pp. 37041-37051
-
-
Lee, J.Y.1
Ye, J.2
Gao, Z.3
Youn, H.S.4
Lee, W.H.5
Zhao, L.6
Sizemore, N.7
Hwang, D.H.8
-
9
-
-
2642561229
-
Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor kappa B
-
Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, Haring HU, and Schleicher ED. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor kappa B. J. Biol. Chem. 2004; 279:23942-23952.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 23942-23952
-
-
Weigert, C.1
Brodbeck, K.2
Staiger, H.3
Kausch, C.4
Machicao, F.5
Haring, H.U.6
Schleicher, E.D.7
-
10
-
-
3442895916
-
Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes
-
Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, and Ye J. Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes. Mol Endocrinol. 2004; 18:2024-2034.
-
(2004)
Mol Endocrinol.
, vol.18
, pp. 2024-2034
-
-
Gao, Z.1
Zhang, X.2
Zuberi, A.3
Hwang, D.4
Quon, M.J.5
Lefevre, M.6
Ye, J.7
-
11
-
-
47749128507
-
Seven Transmembrane-spanning Receptors for Free Fatty Acids as Therapeutic Targets for Diabetes Mellitus: Pharmacological, Phylogenetic, and Drug Discovery Aspects
-
Costanzi S, Neumann S, and Gershengorn MC. Seven Transmembrane-spanning Receptors for Free Fatty Acids as Therapeutic Targets for Diabetes Mellitus: Pharmacological, Phylogenetic, and Drug Discovery Aspects. J. Biol. Chem. 2008; 283:16269-16273.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16269-16273
-
-
Costanzi, S.1
Neumann, S.2
Gershengorn, M.C.3
-
12
-
-
5644231992
-
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee A-H, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, and Hotamisligil GS. Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes. Science. 2004; 306:457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
13
-
-
75749108288
-
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
-
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, and Hotamisligil GS. Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell. 2010; 140:338-348.
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
Sonenberg, N.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
16
-
-
35148854599
-
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
-
Ye J, Gao Z, Yin J, and He H. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab. 2007; 293:E1118-E1128.
-
(2007)
Am J Physiol Endocrinol Metab.
, vol.293
-
-
Ye, J.1
Gao, Z.2
Yin, J.3
He, H.4
-
17
-
-
58149500277
-
Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin Resistance
-
Ye J. Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin Resistance. Int J Obes. 2009; 33:54-66.
-
(2009)
Int J Obes.
, vol.33
, pp. 54-66
-
-
Ye, J.1
-
18
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, and Shimomura I. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007; 56:901-911.
-
(2007)
Diabetes.
, vol.56
, pp. 901-911
-
-
Hosogai, N.1
Fukuhara, A.2
Oshima, K.3
Miyata, Y.4
Tanaka, S.5
Segawa, K.6
Furukawa, S.7
Tochino, Y.8
Komuro, R.9
Matsuda, M.10
Shimomura, I.11
-
19
-
-
68949159760
-
HIF 1 alpha Induces Fibrosis and Insulin Resistance in White Adipose Tissue
-
Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, and Scherer PE. HIF 1 alpha Induces Fibrosis and Insulin Resistance in White Adipose Tissue. Mol Cell Biol. 2009; 29:4467-4483.
-
(2009)
Mol Cell Biol.
, vol.29
, pp. 4467-4483
-
-
Halberg, N.1
Khan, T.2
Trujillo, M.E.3
Wernstedt-Asterholm, I.4
Attie, A.D.5
Sherwani, S.6
Wang, Z.V.7
Landskroner-Eiger, S.8
Dineen, S.9
Magalang, U.J.10
Brekken, R.A.11
Scherer, P.E.12
-
20
-
-
62849107819
-
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
-
Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, and Scherer PE. Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI. Mol. Cell. Biol. 2009; 29:1575-1591.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1575-1591
-
-
Khan, T.1
Muise, E.S.2
Iyengar, P.3
Wang, Z.V.4
Chandalia, M.5
Abate, N.6
Zhang, B.B.7
Bonaldo, P.8
Chua, S.9
Scherer, P.E.10
-
21
-
-
0030972203
-
TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression
-
Xing H, Northrop JP, Grove JR, Kilpatrick KE, Su JL, and Ringold GM. TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression. Endocrinology. 1997; 138:2776-2783.
-
(1997)
Endocrinology
, vol.138
, pp. 2776-2783
-
-
Xing, H.1
Northrop, J.P.2
Grove, J.R.3
Kilpatrick, K.E.4
Su, J.L.5
Ringold, G.M.6
-
22
-
-
0036313033
-
Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory
-
Ruan H, Hacohen N, Golub TR, Van Parijs L, and Lodish HF. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes. 2002; 51:1319-1336.
-
(2002)
Diabetes
, vol.51
, pp. 1319-1336
-
-
Ruan, H.1
Hacohen, N.2
Golub, T.R.3
Parijs, L.V.4
Lodish, H.F.5
-
23
-
-
0037342133
-
Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade
-
Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, and Kato S. Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol. 2003; 5:224-230.
-
(2003)
Nat Cell Biol.
, vol.5
, pp. 224-230
-
-
Suzawa, M.1
Takada, I.2
Yanagisawa, J.3
Ohtake, F.4
Ogawa, S.5
Yamauchi, T.6
Kadowaki, T.7
Takeuchi, Y.8
Shibuya, H.9
Gotoh, Y.10
Matsumoto, K.11
Kato, S.12
-
24
-
-
0030060604
-
Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes
-
Guo D, and Donner DB. Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 1996; 271:615-618.
-
(1996)
J Biol Chem.
, vol.271
, pp. 615-618
-
-
Guo, D.1
Donner, D.B.2
-
25
-
-
0027332738
-
Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
-
Feinstein R, Kanety H, Papa MZ, Lunenfeld B, and Karasik A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993; 268:26055-26058.
-
(1993)
J Biol Chem.
, vol.268
, pp. 26055-26058
-
-
Feinstein, R.1
Kanety, H.2
Papa, M.Z.3
Lunenfeld, B.4
Karasik, A.5
-
26
-
-
58149094542
-
S6K Directly Phosphorylates IRS-1 on Ser270 to Promote Insulin Resistance in Response to TNF-α Signaling Through IKK2
-
Zhang J, Gao Z, Yin J, Quon MJ, and Ye J. S6K Directly Phosphorylates IRS-1 on Ser270 to Promote Insulin Resistance in Response to TNF-α Signaling Through IKK2. J Biol Chem. 2008; 283:35375-35382.
-
(2008)
J Biol Chem.
, vol.283
, pp. 35375-35382
-
-
Zhang, J.1
Gao, Z.2
Yin, J.3
Quon, M.J.4
Ye, J.5
-
27
-
-
48849111484
-
Regulation of PPARg function by TNF-a
-
Ye J. Regulation of PPARg function by TNF-a. Biochem Biophys Res Commun. 2008; 374: 405-408.
-
(2008)
Biochem Biophys Res Commun.
, vol.374
, pp. 405-408
-
-
Ye, J.1
-
28
-
-
0032925340
-
Mechanisms of TNF-alpha-induced insulin resistance
-
Hotamisligil GS. Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes. 1999; 107:119-125.
-
(1999)
Exp Clin Endocrinol Diabetes.
, vol.107
, pp. 119-125
-
-
Hotamisligil, G.S.1
-
29
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, and Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444:840-846.
-
(2006)
Nature.
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
30
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR, and Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001; 414:799-806.
-
(2001)
Nature.
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
31
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, and Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003; 112:1821-1830.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
32
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, and Ferrante AW, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003; 112:1796-1808.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
Mccanns, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, A.W.Jr.6
-
33
-
-
23644446750
-
Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues: Association With Cytokine Expression, Insulin Resistance, and Reduction by Pioglitazone
-
Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, and Kern PA. Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues: Association With Cytokine Expression, Insulin Resistance, and Reduction by Pioglitazone. Diabetes. 2005; 54:2305-2313.
-
(2005)
Diabetes.
, vol.54
, pp. 2305-2313
-
-
Gregorio, G.B.D.1
Yao-Borengasser, A.2
Rasouli, N.3
Varma, V.4
Lu, T.5
Miles, L.M.6
Ranganathan, G.7
Peterson, C.A.8
Mcgehee, R.E.9
Kern, P.A.10
-
34
-
-
33846201363
-
Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells
-
Fain JN. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm. 2006; 74:443-477.
-
(2006)
Vitam Horm.
, vol.74
, pp. 443-477
-
-
Fain, J.N.1
-
35
-
-
52649126788
-
Macrophage Infiltration into Adipose Tissue May Promote Angiogenesis for Adipose Tissue Remodeling in Obesity
-
Pang C, Gao Z, Yin J, Zhang J, Jia W, and Ye J. Macrophage Infiltration into Adipose Tissue May Promote Angiogenesis for Adipose Tissue Remodeling in Obesity. Am J Physiol Endocrinol Metab. 2008; 295:E313-E322.
-
(2008)
Am J Physiol Endocrinol Metab.
, vol.295
-
-
Pang, C.1
Gao, Z.2
Yin, J.3
Zhang, J.4
Jia, W.5
Ye, J.6
-
37
-
-
76749132016
-
Angiogenesis and development of adipose tissue
-
Christiaens V, and Lijnen HR. Angiogenesis and development of adipose tissue. Mol Cell Endocrinol. 2010; 318:2-9.
-
(2010)
Mol Cell Endocrinol.
, vol.318
, pp. 2-9
-
-
Christiaens, V.1
Lijnen, H.R.2
-
38
-
-
34249719581
-
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels
-
Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, and Sugiura S. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes. 2007; 56:1517-1526.
-
(2007)
Diabetes
, vol.56
, pp. 1517-1526
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Hosoya, Y.4
Yamashita, H.5
Fujita, H.6
Ohsugi, M.7
Tobe, K.8
Kadowaki, T.9
Nagai, R.10
Sugiura, S.11
-
39
-
-
33947520741
-
Angiogenic Role of LYVE-1-Positive Macrophages in Adipose Tissue
-
Cho C-H, Jun Koh Y, Han J, Sung H-K, Jong Lee H, Morisada T, Schwendener RA, Brekken RA, Kang G, Oike Y, Choi T-S, Suda T, Yoo O-J, and Koh GY. Angiogenic Role of LYVE-1-Positive Macrophages in Adipose Tissue. Circ Res. 2007; 100:e47-57.
-
(2007)
Circ Res.
, vol.100
-
-
Cho, C-H.1
Jun Koh, Y.2
Han, J.3
Sung, H-K.4
Lee, H.J.5
Morisada, T.6
Schwendener, R.A.7
Brekken, R.A.8
Kang, G.9
Oike, Y.10
Choi, T.-S.11
Suda, T.12
Yoo, O.-J.13
Koh, G.Y.14
-
40
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, and Obin MS. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005; 46:2347-2355.
-
(2005)
J Lipid Res.
, vol.46
, pp. 2347-2355
-
-
Cinti, S.1
Mitchell, G.2
Barbatelli, G.3
Murano, I.4
Ceresi, E.5
Faloia, E.6
Wang, S.7
Fortier, M.8
Greenberg, A.S.9
Obin, M.S.10
-
41
-
-
36849012057
-
Adipocyte death, adipose tissue remodeling, and obesity complications
-
2nd
-
Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW, 2nd, DeFuria J, Jick Z, Greenberg AS, and Obin MS. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007; 56:2910-2918.
-
(2007)
Diabetes
, vol.56
, pp. 2910-2918
-
-
Strissel, K.J.1
Stancheva, Z.2
Miyoshi, H.3
Perfield, J.W.4
Defuria, J.5
Jick, Z.6
Greenberg, A.S.7
Obin, M.S.8
-
42
-
-
60849121937
-
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue
-
Yin J, Gao Z, He Q, and Ye J. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab. 2009; 296: E333-E342.
-
(2009)
Am J Physiol Endocrinol Metab.
, vol.296
-
-
Yin, J.1
Gao, Z.2
He, Q.3
Ye, J.4
-
43
-
-
36749027249
-
IL-6 signalling in exercise and disease
-
Pedersen BK. IL-6 signalling in exercise and disease. Biochem Soc Trans. 2007; 35:1295-1297.
-
(2007)
Biochem Soc Trans.
, vol.35
, pp. 1295-1297
-
-
Pedersen, B.K.1
-
44
-
-
37249074063
-
The role of interleukin-6 in insulin resistance, body fat distribution and energy balance
-
Hoene M, and Weigert C. The role of interleukin-6 in insulin resistance, body fat distribution and energy balance. Obesity Reviews. 2008; 9:20-29.
-
(2008)
Obesity Reviews
, vol.9
, pp. 20-29
-
-
Hoene, M.1
Weigert, C.2
-
45
-
-
33745315308
-
Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice
-
Chida D, Osaka T, Hashimoto O, and Iwakura Y. Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice. Diabetes. 2006; 55:971-977.
-
(2006)
Diabetes
, vol.55
, pp. 971-977
-
-
Chida, D.1
Osaka, T.2
Hashimoto, O.3
Iwakura, Y.4
-
46
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, and Jansson JO. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med. 2002; 8:75-79.
-
(2002)
Nat Med.
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
Wallenius, K.2
Ahren, B.3
Rudling, M.4
Carlsten, H.5
Dickson, S.L.6
Ohlsson, C.7
Jansson, J.O.8
-
47
-
-
7844225147
-
Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta
-
Anforth HR, Bluthe RM, Bristow A, Hopkins S, Lenczowski MJ, Luheshi G, Lundkvist J, Michaud B, Mistry Y, Van Dam AM, Zhen C, Dantzer R, Poole S, Rothwell NJ, Tilders FJ, and Wollman EE. Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta. Eur Cytokine Netw. 1998; 9:279-288.
-
(1998)
Eur Cytokine Netw.
, vol.9
, pp. 279-288
-
-
Anforth, H.R.1
Bluthe, R.M.2
Bristow, A.3
Hopkins, S.4
Lenczowski, M.J.5
Luheshi, G.6
Lundkvist, J.7
Michaud, B.8
Mistry, Y.9
Dam, A.M.V.10
Zhen, C.11
Dantzer, R.12
Poole, S.13
Rothwell, N.J.14
Tilders, F.J.15
Wollman, E.E.16
-
48
-
-
33745302882
-
Mature-onset obesity in interleukin-1 receptor I knockout mice
-
Garcia MC, Wernstedt I, Berndtsson A, Enge M, Bell M, Hultgren O, Horn M, Ahren B, Enerback S, Ohlsson C, Wallenius V, and Jansson JO. Mature-onset obesity in interleukin-1 receptor I knockout mice. Diabetes. 2006; 55:1205-1213.
-
(2006)
Diabetes
, vol.55
, pp. 1205-1213
-
-
Garcia, M.C.1
Wernstedt, I.2
Berndtsson, A.3
Enge, M.4
Bell, M.5
Hultgren, O.6
Horn, M.7
Ahren, B.8
Enerback, S.9
Ohlsson, C.10
Wallenius, V.11
Jansson, J.O.12
-
49
-
-
0036212593
-
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance
-
Xu H, Hirosumi J, Uysal KT, Guler AD, and Hotamisligil GS. Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology. 2002; 143:1502-1511.
-
(2002)
Endocrinology
, vol.143
, pp. 1502-1511
-
-
Xu, H.1
Hirosumi, J.2
Uysal, K.T.3
Guler, A.D.4
Hotamisligil, G.S.5
-
50
-
-
69249154762
-
Receptors for Tumor Necrosis Factor-{alpha} Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status
-
Pamir N, McMillen TS, Kaiyala KJ, Schwartz MW, and LeBoeuf RC. Receptors for Tumor Necrosis Factor-{alpha} Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status. Endocrinology. 2009; 150:4124-4134.
-
(2009)
Endocrinology.
, vol.150
, pp. 4124-4134
-
-
Pamir, N.1
Mcmillen, T.S.2
Kaiyala, K.J.3
Schwartz, M.W.4
Leboeuf, R.C.5
-
51
-
-
0031739028
-
Cytokines and fever. Mechanisms and sites of action
-
Luheshi GN. Cytokines and fever. Mechanisms and sites of action. Ann N Y Acad Sci. 1998; 856:83-89.
-
(1998)
Ann N Y Acad Sci.
, vol.856
, pp. 83-89
-
-
Luheshi, G.N.1
-
52
-
-
0027515268
-
Role of hypothalamic interleukin-6 and tumor necrosis factor-alpha in LPS fever in rat
-
Klir JJ, Roth J, Szelenyi Z, McClellan JL, and Kluger MJ. Role of hypothalamic interleukin-6 and tumor necrosis factor-alpha in LPS fever in rat. Am J Physiol. 1993; 265:R512-517.
-
(1993)
Am J Physiol.
, vol.265
-
-
Klir, J.J.1
Roth, J.2
Szelenyi, Z.3
Mcclellan, J.L.4
Kluger, M.J.5
-
53
-
-
0034084163
-
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity
-
Karin M, and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 2000; 18:621-663.
-
(2000)
Annu Rev Immunol.
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
54
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
-
U S A
-
Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, Godson C, Nielsen JE, Moynagh P, Pouyssegur J, and Taylor CT. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A. 2006; 103:18154-18159.
-
(2006)
Proc Natl Acad Sci.
, vol.103
, pp. 18154-18159
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
Ginouves, A.4
Fitzgerald, K.T.5
Seeballuck, F.6
Godson, C.7
Nielsen, J.E.8
Moynagh, P.9
Pouyssegur, J.10
Taylor, C.T.11
-
55
-
-
39049183044
-
Regulation and function of IKK and IKK-related kinases
-
Hacker H, and Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006; 2006:re13.
-
(2006)
Sci STKE
, vol.2006
-
-
Hacker, H.1
Karin, M.2
-
56
-
-
0028174061
-
Function and activation of NF-kappa B in the immune system
-
Baeuerle PA, and Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994; 12:141-179.
-
(1994)
Annu Rev Immunol.
, vol.12
, pp. 141-179
-
-
Baeuerle, P.A.1
Henkel, T.2
-
57
-
-
0025943986
-
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B
-
Schmitz ML, and Baeuerle PA. The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J. 1991; 10:3805-3817.
-
(1991)
EMBO J.
, vol.10
, pp. 3805-3817
-
-
Schmitz, M.L.1
Baeuerle, P.A.2
-
58
-
-
0032211810
-
Regulation of an Essential Innate Immune Response by the p50 Subunit of NF-kappa B
-
Bohuslav J, Kravchenko VV, Parry GCN, Erlich JH, Gerondakis S, Mackman N, and Ulevitch RJ. Regulation of an Essential Innate Immune Response by the p50 Subunit of NF-kappa B. J. Clin. Invest. 1998; 102:1645-1652.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1645-1652
-
-
Bohuslav, J.1
Kravchenko, V.V.2
Parry, G.C.N.3
Erlich, J.H.4
Gerondakis, S.5
Mackman, N.6
Ulevitch, R.J.7
-
59
-
-
33645225429
-
Regulation of Nuclear Translocation of HDAC3 by I{kappa}B{alpha} Is Required for Tumor Necrosis Factor Inhibition of Peroxisome Proliferator-activated Receptor {gamma} Function
-
Gao Z, He Q, Peng B, Chiao PJ, and Ye J. Regulation of Nuclear Translocation of HDAC3 by I{kappa}B{alpha} Is Required for Tumor Necrosis Factor Inhibition of Peroxisome Proliferator-activated Receptor {gamma} Function. J Biol Chem. 2006; 281:4540-4547.
-
(2006)
J Biol Chem.
, vol.281
, pp. 4540-4547
-
-
Gao, Z.1
He, Q.2
Peng, B.3
Chiao, P.J.4
Ye, J.5
-
60
-
-
55249108745
-
Appraisal of current and experimental approaches to the treatment of cachexia
-
Strasser F. Appraisal of current and experimental approaches to the treatment of cachexia. Curr Opin Support Palliat Care. 2007; 1:312-316.
-
(2007)
Curr Opin Support Palliat Care
, vol.1
, pp. 312-316
-
-
Strasser, F.1
-
61
-
-
0030665384
-
Biology of cachexia
-
Tisdale MJ. Biology of cachexia. J Natl Cancer Inst. 1997; 89:1763-1773.
-
(1997)
J Natl Cancer Inst.
, vol.89
, pp. 1763-1773
-
-
Tisdale, M.J.1
-
62
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, and Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005; 11:183-190.
-
(2005)
Nat Med.
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
63
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, and Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005; 11:191-198.
-
(2005)
Nat Med.
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
64
-
-
52949096557
-
Hypothalamic IKK[beta]/NF-[kappa]B and ER Stress Link Overnutrition to Energy Imbalance and Obesity
-
Zhang X, Zhang G, Zhang H, Karin M, Bai H, and Cai D. Hypothalamic IKK[beta]/NF-[kappa]B and ER Stress Link Overnutrition to Energy Imbalance and Obesity. Cell. 2008; 135:61-73.
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
-
65
-
-
77951181327
-
Uncoupling of Inflammation and Insulin Resistance by NF-kB in Transgenic Mice through Induction of Energy Expenditure
-
Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Mynatt R, Martin RJ, Keenan M, Gao Z, and Ye J. Uncoupling of Inflammation and Insulin Resistance by NF-kB in Transgenic Mice through Induction of Energy Expenditure. J Biol Chem. 2010; 285:4637-4644.
-
(2010)
J Biol Chem.
, vol.285
, pp. 4637-4644
-
-
Tang, T.1
Zhang, J.2
Yin, J.3
Staszkiewicz, J.4
Gawronska-Kozak, B.5
Mynatt, R.6
Martin, R.J.7
Keenan, M.8
Gao, Z.9
Ye, J.10
-
66
-
-
67650566364
-
Inactivation of NF-κB P50 Leads to Insulin Sensitization in liver through Post-Translational Inhibition of p70S6K
-
Gao Z, Yin J, J. Z, He Q, McGuinness OP, and Ye J. Inactivation of NF-κB P50 Leads to Insulin Sensitization in liver through Post-Translational Inhibition of p70S6K. J Biol Chem. 2009; 284:18368-18376
-
(2009)
J Biol Chem.
, vol.284
, pp. 18368-18376
-
-
Gao, Z.1
Yin, J.J.Z.2
He, Q.3
Mcguinness, O.P.4
Ye, J.5
-
67
-
-
0141784866
-
IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions
-
Matsuki T, Horai R, Sudo K, and Iwakura Y. IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions. J. Exp. Med. 2003; 198:877-888.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 877-888
-
-
Matsuki, T.1
Horai, R.2
Sudo, K.3
Iwakura, Y.4
-
68
-
-
33144466102
-
Decreased fat mass in interleukin-1 receptor antagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure
-
Somm E, Henrichot E, Pernin A, Juge-Aubry CE, Muzzin P, Dayer JM, Nicklin MJ, and Meier CA. Decreased fat mass in interleukin-1 receptor antagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure. Diabetes. 2005; 54:3503-3509.
-
(2005)
Diabetes
, vol.54
, pp. 3503-3509
-
-
Somm, E.1
Henrichot, E.2
Pernin, A.3
Juge-Aubry, C.E.4
Muzzin, P.5
Dayer, J.M.6
Nicklin, M.J.7
Meier, C.A.8
-
69
-
-
18244399631
-
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
-
Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, and Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001; 8:971-982.
-
(2001)
Mol Cell
, vol.8
, pp. 971-982
-
-
Puigserver, P.1
Rhee, J.2
Lin, J.3
Wu, Z.4
Yoon, J.C.5
Zhang, C.Y.6
Krauss, S.7
Mootha, V.K.8
Lowell, B.B.9
Spiegelman, B.M.10
-
71
-
-
0034730251
-
NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia
-
Guttridge DC, Mayo MW, Madrid LV, Wang CY, and Baldwin AS, Jr. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science. 2000; 289:2363-2366.
-
(2000)
Science
, vol.289
, pp. 2363-2366
-
-
Guttridge, D.C.1
Mayo, M.W.2
Madrid, L.V.3
Wang, C.Y.4
Baldwin, A.S.Jr.5
-
72
-
-
43449113550
-
Visceral adipose tissue modulates mammalian longevity
-
Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, and Barzilai N. Visceral adipose tissue modulates mammalian longevity. Aging Cell. 2008; 7:438-440.
-
(2008)
Aging Cell
, vol.7
, pp. 438-440
-
-
Muzumdar, R.1
Allison, D.B.2
Huffman, D.M.3
Ma, X.4
Atzmon, G.5
Einstein, F.H.6
Fishman, S.7
Poduval, A.D.8
Mcvei, T.9
Keith, S.W.10
Barzilai, N.11
-
73
-
-
0000567961
-
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
-
Barzilai N, Banerjee S, Hawkins M, Chen W, and Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest. 1998; 101:1353-1361.
-
(1998)
J Clin Invest.
, vol.101
, pp. 1353-1361
-
-
Barzilai, N.1
Banerjee, S.2
Hawkins, M.3
Chen, W.4
Rossetti, L.5
-
74
-
-
0036787345
-
Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
-
Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, and Barzilai N. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes. 2002; 51:2951-2958.
-
(2002)
Diabetes
, vol.51
, pp. 2951-2958
-
-
Gabriely, I.1
Ma, X.H.2
Yang, X.M.3
Atzmon, G.4
Rajala, M.W.5
Berg, A.H.6
Scherer, P.7
Rossetti, L.8
Barzilai, N.9
-
75
-
-
42649144463
-
Beneficial effects of subcutaneous fat transplantation on metabolism
-
Tran TT, Yamamoto Y, Gesta S, and Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 2008; 7:410-420.
-
(2008)
Cell Metab.
, vol.7
, pp. 410-420
-
-
Tran, T.T.1
Yamamoto, Y.2
Gesta, S.3
Kahn, C.R.4
-
77
-
-
45349087130
-
Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes
-
Redman LM, Martin CK, Williamson DA, and Ravussin E. Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes. Physiol Behav. 2008; 94:643-648.
-
(2008)
Physiol Behav.
, vol.94
, pp. 643-648
-
-
Redman, L.M.1
Martin, C.K.2
Williamson, D.A.3
Ravussin, E.4
|