Free radicals and antioxidants at a glance using EPR spectroscopy

Critical Reviews in Clinical Laboratory Sciences

Volumn 48, Issue 3, 2011, Pages 114-142

  Spasojević, Ivan ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Ascorbyl radical; Hydroxyl radical; Nitric oxide; Oxidative status; Reactive nitrogen species; Reactive oxygen species; Redox signaling; Spin labeling; Spin trapping; Superoxide radical anion

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CARBON; FREE RADICAL; HYDROXYL RADICAL; MELANIN; NATURAL PRODUCT; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THIOL; TOCOPHEROXYL RADICAL; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; BIODOSIMETRY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; DOSIMETRY; ELECTRON SPIN RESONANCE; MEDICAL RESEARCH; MEMBRANE FLUIDITY; OXIDATION; OXIDATIVE STRESS; OXIMETRY; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS;

ANIMALS; ANTIOXIDANTS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HUMANS; OXIDATION-REDUCTION;

EID: 80052239721     PISSN: 10408363     EISSN: 1549781X     Source Type: Journal    
DOI: 10.3109/10408363.2011.591772     Document Type: Review

References (370)

1. Commoner B, Townsend J, Pake GE. Free radicals in biological materials. Nature 1954;174:689-691.
2. Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
3. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244:6049-6055.
4. Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004;3:205-214.
5. Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 1996;313 (Pt 1):17-29. (Pubitemid 26013419)
6. Kurien BT, Hensley K, Bachmann M, Scofield RH. Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 2006;41:549-556. (Pubitemid 44080517)
7. Dreher D, Junod AF. Role of oxygen free radicals in cancer development. Eur J Cancer 1996;32A:30-38.
8. Alexander RW. Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: A new perspective. Hypertension 1995;25:155-161.
9. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988;5:113-124. (Pubitemid 18263730)
10. Farinati F, Cardin R, Bortolami M, Burra P, Russo FP, Rugge M et al. Hepatitis C virus: From oxygen free radicals to hepatocellular carcinoma. J Viral Hepat 2007;14:821-829. (Pubitemid 350211406)
11. Schulz HU, Niederau C, Klonowski-Stumpe H, Halangk W, Luthen R, Lippert H. Oxidative stress in acute pancreatitis. Hepatogastroenterology 1999;46:2736-2750. (Pubitemid 29525271)
12. Bullen J, Griffiths E, Rogers H, Ward G. Sepsis: The critical role of iron. Microbes Infect 2000;2:409-415. (Pubitemid 30241043)
13. Casanueva E, Viteri FE. Iron and oxidative stress in pregnancy. J Nutr 2003;133:1700S-1708S. (Pubitemid 36548678)
14. Williams DL. Oxidative stress and the eye. Vet Clin North Am Small Anim Pract 2008;38:179-92. (Pubitemid 351176592)
15. Pieper GM, Nilakantan V, Nguyen TK, Hilton G, Roza AM, Johnson CP. Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejection. Antioxid Redox Signal 2008;10:1031-1040.
16. Zhao L, Chen YH, Wang H, Ji YL, Ning H, Wang SF et al. Reactive oxygen species contribute to lipopolysaccharide-induced teratogenesis in mice. Toxicol Sci 2008;103:149-157. (Pubitemid 351524486)
17. Lane N. Oxygen: The Molecule that Made the World. Oxford: Oxford University Press, 2002.
18. Mittal CK, Murad F. Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: A physiological regulator of guanosine 3′,5′-monophosphate formation. Proc Natl Acad Sci USA 1977;74:4360-4364. (Pubitemid 8225122)
19. Ignarro LJ, Kadowitz PJ. The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu Rev Pharmacol Toxicol 1985;25:171-191. (Pubitemid 15090979)
20. Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000;28:463-499. (Pubitemid 30110662)
21. Drie W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
22. Kohen R, Nyska A. Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 2002;30:620-650. (Pubitemid 36018731)
23. Lane N. A unifying view of ageing and disease: The double-agent theory. J Theor Biol 2003;225:531-540. (Pubitemid 37393283)
24. D'Autriux B, Toledano MB. ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 2007;8:813-824. (Pubitemid 47462134)
25. Jacob C, Winyard PG. Redox Signaling and Regulation in Biology and Medicine. Weinheim: Wiley-VCH, 2009.
26. Weil JA, Bolton JR. Electron Paramagnetic Resonance: Elementary Theory and Practical Applications. New York: Wiley and Sons, 2007.
27. Hagen WR. Biomolecular EPR spectroscopy. Boca Raton: CRC Press, 2008.
28. Bender CJ, Berliner LJ., EPR: Instrumental Methods. New York: Kluwer Academic/Plenum Publishers, 2004.
29. Eaton SS, Eaton GR, Berliner LJ. Biomedical EPR-Part A: Free Radicals, Metals, Medicine and Physiology. New York: Springer Verlag, 2005.
30. Saifutdinov RG, Larina LI, Vakul'skaya TI, Voronkov MG. Electron Paramagnetic Resonance in Biochemistry and Medicine. New York: Springer Verlag, 2001.
31. Gaffney BJ. Practical considerations for the calculation of order parameter for fatty acid or phospholipids spin labels in membranes. In: Berliner LJ. ed. Spin Labeling: Theory and Applications. New York: Academic Press, 1976, pp. 567-571.
32. Hyde JS, Subczynski WK, Froncisz W, Lai C. Spin label oximetry: Measurement of oxygen concentration in biological samples. Bull Magn Reson 1983;5:180-182.
33. Koppenol WH. What is in a namë Rules for radicals. Free Radic Biol Med 1990;9:225-227.
34. Koppenol WH. NO nomenclaturë Nitric Oxide 2002;6:96-98.
35. Subramanian S, Matsumoto K, Mitchell JB, Krishna MC. Radio frequency continuous-wave and time-domain EPR imaging and Overhauser-enhanced magnetic resonance imaging of small animals: Instrumental developments and comparison of relative merits for functional imaging. Nmr Biomed 2004;17:263-294. (Pubitemid 39255835)
36. Halliwell B. The wanderings of a free radical. Free Radic Biol Med 2009;46:531-542.
37. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford: Clarendon, 2007.
38. Townsend DJ. S-Glutathionylation-Indicator of cell stress and regulator of the unfolded protein response. Mol Intervent 2007;7:313-324.
39. Nikolï Kokï A, Stevï Z, Stojanovï S, Blagojevï DP, Jones DR, Pavlovï S et al. Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Redox Rep 2005;10:265-270.
40. Bogdanovï Pristov J, Spasojevï I, Mikovï Z, Mandï V, Cerovï N, Spasï M. Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. Oxid Med Cell Longev 2009;2:14-18.
41. Slavï M, Appiah I, Nikolï-Kokï A, Radojïï R, Jones DR, Spasï MB et al. The anti-oxidative defence system in the isolated rat uterus during spontaneous rhythmic activity. Acta Physiol Hung 2006;93:335-339.
42. Spasojevï I, Bajï A, Jovanovï K, Spasï M, Andjus P. Protective role of fructose in the metabolism of astroglial C6 cells exposed to hydrogen peroxide. Carbohydr Res 2009;344:1676-1681.
43. Armstrong D. Methods in Molecular Biology Vol 108. Totowa: Humana Press Inc, 1999.
44. Buettner GR. The pecking order of free radicals and antioxidants: Lipid peroxidation, α-tocopherol, and ascorbate. Arch Biochem Biophys 1993;300:535-543. (Pubitemid 23232908)
45. Vquez-Vivar J, Santos AM, Junqueira VB, Augusto O. Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acidderived free radicals. Biochem J 1996;314:869-876. (Pubitemid 26097749)
46. Domazou AS, Koppenol WH, Gebicki JM. Efficient repair of protein radicals by ascorbate. Free Radic Biol Med 2009;46:1049-1057.
47. Buettner GR, Jurkiewicz BA. Catalytic metals, ascorbate and free radicals: Combinations to avoid. Radiat Res 1996;145:532-541. (Pubitemid 26127160)
48. Buettner GR, Jurkiewicz BA. Ascorbate free radical as a marker of oxidative stress: An EPR study. Free Radic Biol Med 1993;14:49-55. (Pubitemid 23024257)
49. Ahola T, Fellman V, Kjellmer I, Raivio KO, Lapatto R. Plasma 8-isoprostane is increased in preterm infants who develop bronchopulmonary dysplasia or periventricular leukomalacia. Pediatr Res 2004;56:88-93. (Pubitemid 38808547)
50. Minetti M, Forte T, Soriani M, Quaresima V, Menditto A, Ferrari M. Iron-induced ascorbate oxidation in plasma as monitored by ascorbate free radical formation. No spin-trapping evidence for the hydroxyl radical in iron-overloaded plasma. Biochem J 1992;282:459-465.
51. Nakagawa K, Kanno H, Miura Y. Detection and analyses of ascorbyl radical in cerebrospinal fluid and serum of acute lymphoblastic leukemia. Anal Biochem 1997;254:31-35. (Pubitemid 27523225)
52. Jirasomprasert T, Morales NP, Limenta LM, Sirijaroonwong S, Yamanont P, Wilairat P et al. Pharmaco/ferrokinetic-related prooxidant activity of deferiprone in β-thalassemia. Free Radic Res 2009;43:485-491.
53. Sharma MK, Buettner GR, Spencer KT, Kerber RE. Ascorbyl free radical as a real-time marker of free radical generation in briefly ischemic and reperfused hearts. An electron paramagnetic resonance study. Circ Res 1994;74:650-658. (Pubitemid 24088525)
54. Spasojevï I, Stevï Z, Nikolï-Kokï A, Jones DR, Blagojevï D, Spasï MB. Different roles of radical scavengers-ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Redox Rep 2010;15:81-86.
55. Buettner GR, Motten AG, Hall RD, Chignell CF. ESR detection of endogenous ascorbate free radical in mouse skin: Enhancement of radical production during UV irradiation following application of chlorpromazine. Photochem Photobiol 1987;46:161-164.
56. Jurkiewicz BA, Buettner GR. Ultraviolet light-induced free radical formation in skin: An electron paramagnetic resonance study. Photochem Photobiol 1994;59:1-4. (Pubitemid 2042990)
57. Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E et al. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci USA 2007;104:8749-8754. (Pubitemid 47175383)
58. Buettner GR, Chamulitrat W. The catalytic activity of iron in synovial fluid as monitored by the ascorbate free radical. Free Radic Biol Med 1990;8:55-56.
59. Drake IM, Davies MJ, Mapstone NP, Dixon MF, Schorah CJ, White KL et al. Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals. Carcinogenesis 1996;17:559-562. (Pubitemid 26085339)
60. Menditto A, Pietraforte D, Minetti M. Ascorbic acid in human seminal plasma is protected from iron-mediated oxidation, but is potentially exposed to copper-induced damage. Hum Reprod 1997;12:1699-1705. (Pubitemid 27406082)
61. Mueller HW, Tannert S. The significance of electron spin resonance of the ascorbic acid radical in freeze dried human brain tumours and oedematous or normal periphery. Br J Cancer 1986;53:385-391. (Pubitemid 16133109)
62. Silcock JM, Dodd NJ. Electron spin resonance study of changes during development of solid Yoshida tumour. I: Ascorbyl radical. Br J Cancer 1976;34:550-555.
63. Elek G, Rockenbauer A, Magyar E, Jay L. A study of free radicals in paraffin embedded and deparaffinized human heart muscle tissue using electron spin resonance (ESR). Histochemistry 1987;87:499-504.
64. Neubacher H. ESR investigations on lyophilized blood: Mixtures with ascorbic acid. z Naturforsch, c, Biosci 1984;39:174-176.
65. Dodd NJ, Swartz HM. The nature of the ESR signal in lyophilized tissue and its relevance to malignancy. Br J Cancer 1984;49:65-71. (Pubitemid 14194028)
66. Dodd NJ, Giron-Conland JM. Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. II. The ascorbyl radical. Br J Cancer 1975;32:451-455.
67. Marchlewicz M, Wiszniewska B, Gonet B, Baranowska-Bosiacka I, Safranow K, Kolasa A et al. Increased lipid peroxidation and ascorbic Acid utilization in testis and epididymis of rats chronically exposed to lead. Biometals 2007;20:13-19. (Pubitemid 46292024)
68. Masumizu T, Noda Y, Mori A, Packer L. Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures. Brain Res Brain Res Protoc 2005;16:65-69. (Pubitemid 41774073)
69. Pedersen JZ, Bernardi G, Centonze D, Pisani A, Rossi L, Rotilio G et al. Hypoglycemia, hypoxia, and ischemia in a corticostriatal slice preparation: Electrophysiologic changes and ascorbyl radical formation. J Cereb Blood Flow Metab 1998;18:868-875. (Pubitemid 28359904)
70. Kihara T, Sakata S, Ikeda M. Direct detection of ascorbyl radical in experimental brain injury: Microdialysis and an electron spin resonance spectroscopic study. J Neurochem 1995;65:282-286.
71. Sanders SP, Bassett DJ, Harrison SJ, Pearse D, Zweier JL, Becker PM. Measurements of free radicals in isolated, ischemic lungs and lung mitochondria. Lung 2000;178:105-118. (Pubitemid 30247115)
72. Yu MA, Egawa T, Yeh SR, Rousseau DL, Gerfen GJ. EPR characterization of ascorbyl and sulfur dioxide anion radicals trapped during the reaction of bovine Cytochrome c Oxidase with molecular oxygen. J Magn Reson 2010;203:213-219.
73. Ito S, Itoga K, Yamato M, Akamatsu H, Okano T. The co-application effects of fullerene and ascorbic acid on UV-B irradiated mouse skin. Toxicology 2010;267:27-38.
74. Nitescu N, Ricksten SE, Marcussen N, Haraldsson B, Nilsson U, Basu S et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion. Nephrol Dial Transplant 2006;21:1240-1247.
75. Pedro MA, Augusto O, Barbeiro HV, Carvalho MH, da-Luz PL, Laurindo FR. Nonspecific blockade of vascular free radical signals by methylated arginine analogues. Braz J Med Biol Res 1998;31:749-755. (Pubitemid 128528079)
76. Andrade RG Jr, Dalvi LT, Silva JM Jr, Lopes GK, Alonso A, Hermes-Lima M. The antioxidant effect of tannic acid on the in vitro copper-mediated formation of free radicals. Arch Biochem Biophys 2005;437:1-9. (Pubitemid 40463675)
77. Veliquez-Paniagua M, Contreras-Pez R, Gez-Vidales V, Meneses-Pez MA, Prieto-Gez B.Melatonin's effects on free radical levels in rat hippocampus, measured by electronic paramagnetic resonance. Pharmacology 2007;1:170-175.
78. Fabisiak JP, Tyurin VA, Tyurina YY, Borisenko GG, Korotaeva A, Pitt BR et al. Redox regulation of copper-metallothionein. Arch Biochem Biophys 1999;363:171-181. (Pubitemid 29394344)
79. Oubrahim H, Richard JM, Cantin-Esnault D. Peroxidase-mediated oxidation, a possible pathway for activation of the fungal nephrotoxin orellanine and related compounds. ESR and spintrapping studies. Free Radic Res 1998;28:497-505. (Pubitemid 28395813)
80. Wielgus AR, Sarna T. Ascorbate enhances photogeneration of hydrogen peroxide mediated by the iris melanin. Photochem Photobiol 2008;84:683-691. (Pubitemid 351596391)
81. Kytzia A, Korth HG, Sustmann R, de Groot H, Kirsch M. On the mechanism of the ascorbic acid-induced release of nitric oxide from N-nitrosated tryptophan derivatives: Scavenging of NO by ascorbyl radicals. Chemistry 2006;12:8786-8797. (Pubitemid 44852464)
82. Mauriio AQ, Lopes GK, Gomes CS, Oliveira RG, Alonso A, Hermes-Lima M. Pyridoxal isonicotinoyl hydrazone inhibits iron-induced ascorbate oxidation and ascorbyl radical formation. Biochim Biophys Acta 2003;1620:15-24. (Pubitemid 36197892)
83. Sakagami H, Satoh K, Taguchi S, Takeda M. Inhibition of cytotoxic activity of ascorbate by human cancer patient sera. Anticancer Res 1997;17:425-428. (Pubitemid 27116703)
84. Gisone P, Boveris AD, Dubner D, Perez MR, Robello E, Puntarulo S. Early neuroprotective effect of nitric oxide in developing rat brain irradiated in utero. Neurotoxicology 2003;24:245-253. (Pubitemid 36288103)
85. Osterlundh G, Kjellmer I, Lannering B, Rosengren L, Nilsson UA, Mky I. Neurochemical markers of brain damage in cerebrospinal fluid during induction treatment of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2008;50:793-798. (Pubitemid 351354787)
86. Galleano M, Aimo L, Puntarulo S. Ascorbyl radical/ascorbate ratio in plasma from iron overloaded rats as oxidative stress indicator. Toxicol Lett 2002;133:193-201. (Pubitemid 34761976)
87. Okamura M. An improved method for determination of L-ascorbic acid and L-dehydroascorbic acid in blood plasma. Clin Chim Acta 1980;103:259-268. (Pubitemid 10102274)
88. Richard C, Lauzier B, Delemasure S, Talbot S, Ghibu S, Collin B et al. Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats. J Cardiovasc Pharmacol 2008;52:278-285.
89. Marty JC, Bendhadra S, Amoureux S, Guilland JC, Vergely C, Rochette L et al. [Oxidative stress is exacerbated in diabetic patients during cardiopulmonary bypass]. Ann Cardiol Angeiol (Paris) 2008;57:155-160.
90. Courderot-Masuyer C, Lahet JJ, Verges B, Brun JM, Rochette L. Ascorbyl free radical release in diabetic patients. Cell Mol Biol (Noisy-Le-Grand) 2000;46:1397-1401.
91. Sasaki R, Kurokawa T, Tero-Kubota S. Ascorbate radical and ascorbic acid level in human serum and age. J Gerontol 1983;38:26-30. (Pubitemid 13217826)
92. Clarke MW, Burnett JR, Croft KD. Vitamin E in human health and disease. Crit Rev Clin Lab Sci 2008;45:417-450.
93. Sharma MK, Buettner GR. Interaction of vitamin C and vitamin E during free radical stress in plasma: An ESR study. Free Radic Biol Med 1993;14:649-653. (Pubitemid 23172572)
94. Gorbunov NV, Osipov AN, Sweetland MA, Day BW, Elsayed NM, Kagan VE. NO-redox paradox: Direct oxidation of α-tocopherol and α-tocopherol-mediated oxidation of ascorbate. Biochem Biophys Res Commun 1996;219:835-841.
95. Botti H, Trujillo M, Batthyiy C, Rubbo H, Ferrer-Sueta G, Radi R. Homolytic pathways drive peroxynitrite-dependent Trolox C oxidation. Chem Res Toxicol 2004;17:1377-1384. (Pubitemid 39391215)
96. Neuzil J, Witting PK, Stocker R. α-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids. Proc Natl Acad Sci USA 1997;94:7885-7890. (Pubitemid 27343744)
97. Constantinescu A, Maguire JJ, Packer L. Interactions between ubiquinones and vitamins in membranes and cells. Mol Aspects Med 1994;15 Suppl:s57-s65.
98. Mehlhorn RJ. Ascorbate-and dehydroascorbic acid-mediated reduction of free radicals in the human erythrocyte. J Biol Chem 1991;266:2724-2731.
99. Oplider C, Cortese MM, Korth HG, Kirsch M, Mahotka C, Wetzel W et al. The impact of nitrite and antioxidants on ultraviolet-Ainduced cell death of human skin fibroblasts. Free Radic Biol Med 2007;43:818-829. (Pubitemid 47102128)
100. Iglesias J, Pazos M, Andersen ML, Skibsted LH, Medina I. Caffeic acid as antioxidant in fish muscle: Mechanism of synergism with endogenous ascorbic acid and α-tocopherol. J Agric Food Chem 2009;57:675-681.
101. Carini M, Maffei Facino R, Aldini G, Callonii MT, Bombardelli E, Morazzoni P. The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E. Int J Cosmet Sci 1998;20:203-215. (Pubitemid 28526289)
102. Zhou B, Wu LM, Yang L, Liu ZL. Evidence for α-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. Free Radic Biol Med 2005;38:78-84. (Pubitemid 39626911)
103. Pazos M, Torres JL, Andersen ML, Skibsted LH, Medina I. Galloylated polyphenols efficiently reduce α-tocopherol radicals in a phospholipid model system composed of sodium dodecyl sulfate (SDS) micelles. J Agric Food Chem 2009;57: 5042-5048.
104. Meredith P, Powell BJ, Riesz J, Nighswander-Rempel SP, Pederson MR, Moore EG. Towards structure-property-function relationships for eumelanin. Soft Matter 2006;2:37-44.
105. Fuchs J, Packer L. Oxidative Stress in Dermatology. New York: Marcel Dekker Inc, 1993.
106. Collins B, Poehler TO, Bryden WA. EPR persistence measurements of UV-induced melanin free radicals in whole skin. Photochem Photobiol 1995;62:557-560.
107. Seagle BL, Rezai KA, Kobori Y, Gasyna EM, Rezaei KA, Norris JR Jr. Melanin photoprotection in the human retinal pigment epithelium and its correlation with light-induced cell apoptosis. Proc Natl Acad Sci USA 2005;102:8978-8983. (Pubitemid 40881064)
108. RIanowska M, Bober A, Burke JM, Sarna T. The role of retinal pigment epithelium melanin in photoinduced oxidation of ascorbate. Photochem Photobiol 1997;65:472-479. (Pubitemid 27158986)
109. Zecca L, Swartz HM. Total and paramagnetic metals in human substantia nigra and its neuromelanin. J Neural Transm Park Dis Dement Sect 1993;5:203-213. (Pubitemid 23227814)
110. Enochs WS, Nilges MJ, Swartz HM. Purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: Characterization by electron paramagnetic resonance spectroscopy. J Neurochem 1993;61:68-79. (Pubitemid 23175884)
111. Menon IA, Persad SD, Haberman HF, Basu PK, Norfray JF, Felix CC et al. Characterization of the pigment from homogentisic acid and urine and tissue from an alkaptonuria patient. Biochem Cell Biol 1991;69:269-273.
112. Rozanowska M, Kukulski T, Burke J, Nilges M, Pilas B, Korytowski W, Sarna T. Photooxidation of retinal pigment melanin-a model for melanin aging. Pigment Cell Res 1993;6:272-276.
113. RIanowska M, Korytowski W, RIanowski B, Skumatz C, Boulton ME, Burke JM et al. Photoreactivity of aged human RPE melanosomes: A comparison with lipofuscin. Invest Ophthalmol Vis Sci 2002;43:2088-2096. (Pubitemid 34700632)
114. Pilas B, Felix CC, Sarna T, Kalyanaraman B. Photolysis of pheomelanin precursors: An ESR-spin trapping study. Photochem Photobiol 1986;44:689-696.
115. Haywood R, Rogge F, Lee M. Protein, lipid, and DNA radicals to measure skin UVA damage and modulation by melanin. Free Radic Biol Med 2008;44:990-1000.
116. Sulzer D, Bogulavsky J, Larsen KE, Behr G, Karatekin E, Kleinman MH et al. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc Natl Acad Sci USA 2000;97:11869-11874.
117. Herrling T, Jung K, Fuchs J. The role of melanin as protector against free radicals in skin and its role as free radical indicator in hair. Spectrochim Acta a Mol Biomol Spectrosc 2008;69:1429-1435. (Pubitemid 351522528)
118. Wood SR, Berwick M, Ley RD, Walter RB, Setlow RB, Timmins GS. UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production. Proc Natl Acad Sci USA 2006;103:4111-4115.
119. Friedman DS, West SK, Munoz B, Park W, Deremeik J, Massof R et al. Racial variations in causes of vision loss in nursing homes: The Salisbury Eye Evaluation in Nursing Home Groups (SEEING) Study. Arch Ophthalmol 2004;122:1019-1024. (Pubitemid 39037967)
120. Zareba M, Szewczyk G, Sarna T, Hong L, Simon JD, Henry MM et al. Effects of photodegradation on the physical and antioxidant properties of melanosomes isolated from retinal pigment epithelium. Photochem Photobiol 2006;82:1024-1029. (Pubitemid 44450187)
121. Schauer DA, Desrosiers MF, Le FG, Seltzer SM, Links JM. EPR dosimetry of cortical bone and tooth enamel irradiated with X and γ rays: Study of energy dependence. Radiat Res 1994;138:1-8. (Pubitemid 24111179)
122. Romanyukha AA, Schauer DA, Thomas JA, Regulla DF. Parameters affecting EPR dose reconstruction in teeth. Appl Radiat Isot 2005;62:147-154. (Pubitemid 39655648)
123. Regulla DF. ESR spectrometry: A future-oriented tool for dosimetry and dating. Appl Radiat Isot 2005;62:117-127. (Pubitemid 39655645)
124. Fattibene P, Callens F. EPR dosimetry with tooth enamel: A review. Appl Radiat Isot 2010;68:2033-2116.
125. Hawkins BJ, Madesh M, Kirkpatrick CJ, Fisher AB. Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol Biol Cell 2007;18:2002-2012. (Pubitemid 46911353)
126. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161-1208. (Pubitemid 40655271)
127. Kell DB. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol 2010;84:825-889.
128. Baï G, Spasojevï I, Šëerov B, Mojovï M. Spin-trapping of oxygen free radicals in chemical and biological systems: New traps, radicals and possibilities. Spectrochim Acta A Mol Biomol Spectrosc 2008;69:1354-1366.
129. Li JM, Shah AM. Endothelial cell superoxide generation: Regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol 2004;287:R1014-R1030. (Pubitemid 39391043)
130. Szab C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol Lett 2003;140-141:105-112.
131. Michelson AM, Maral J. Carbonate anions; effects on the oxidation of luminol, oxidative hemolysis, γ-irradiation and the reaction of activated oxygen species with enzymes containing various active centres. Biochimie 1983;65:95-104.
132. Jackson SK, Hancock JT, James PE. Biological free radicals and biomedical applications of EPR spectroscopy. Electron Paramag Reson 2007;20:192-244.
133. Roubaud V, Sankarapandi S, Kuppusamy P, Tordo P, Zweier JL. Quantitative measurement of superoxide generation using the spin trap 5-(diethoxyphosphoryl)- 5-methyl-1-pyrroline-N-oxide. Anal Biochem 1997;247:404-411. (Pubitemid 27200178)
134. Karoui H, Hogg N, Friaville C, Tordo P, Kalyanaraman B. Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies. J Biol Chem 1996;271:6000-6009. (Pubitemid 26095401)
135. Hawkins CL, Davies MJ. Comparison of 5,5-dimethyl-1-pyrroline-n-oxide (dmpo) and a new cyclic nitrone spin trap-5-tert-butoxycarbonyl-5-methyl-1- pyrroline-noxide (BMPO) for the trapping of nitrogen-centred radicals. Curr Top Biophys 2002;26:137-144.
136. Stolze K, Udilova N, Nohl H. Spin trapping of lipid radicals with DEPMPO-derived spin traps: Detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase. Free Radic Biol Med 2000;29:1005-1014.
137. Burkitt MJ. Biomedical aspects of free radicals: Recent developments through the application of EPR. Electron Paramag Reson 2004;19:33-81.
138. Ouari O, Hardy M, Karoui H, Tordo P. Recent developments and applications of the coupled EPR/Spin trapping technique (EPR/ST). Electron Paramag Reson 2011;22:1-4.
139. Khramtsov V, Berliner LJ, Clanton TL. NMR spin trapping: Detection of free radical reactions using a phosphorus-containing nitrone spin trap. Magn Reson Med 1999;42:228-234. (Pubitemid 29364700)
140. Khramtsov VV, Reznikov VA, Berliner LJ, Litkin AK, Grigor'ev IA, Clanton TL. NMR spin trapping: Detection of free radical reactions with a new fluorinated DMPO analog. Free Radic Biol Med 2001;30:1099-1107. (Pubitemid 32441834)
141. Xu Y, Kalyanaraman B. Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS Free Radic Res 2007; 41:1-7. (Pubitemid 44896869)
142. Spasojevï I, Mojovï M, Stevï Z, Spasï SD, Jones DR, Morina A et al. Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. Redox Rep 2010;15:29-35.
143. Dikalov S, Skatchkov M, Bassenge E. Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3-carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants. Biochem Biophys Res Commun 1997;231:701-704. (Pubitemid 27217583)
144. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: Implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 2003;278:22546-22554. (Pubitemid 36830310)
145. Rhee SG, Chang TS, Jeong W, Kang D. Methods for detection and measurement of hydrogen peroxide inside and outside of cells. Mol Cell 2010;29:539-549.
146. Ramirez DC, Gomez-Mejiba SE, Mason RP. Immuno-spin trapping analyses of DNA radicals. Nat Protoc 2007;2:512-522. (Pubitemid 47040015)
147. Gomez-Mejiba SE, Zhai Z, Akram H, Deterding LJ, Hensley K, Smith N et al. Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process. Free Radic Biol Med 2009;46:853-865.
148. Lamas S. Nitric Oxide, Cell Signaling, and Gene Expression. Boca Raton: CRC Press, 2005.
149. Van Faassen E, Vanin AF. Radicals for Life. The Various Forms of Nitric Oxide. Oxford: Elsevier, 2007.
150. Thomas DD, Liu X, Kantrow SP, Lancaster JR Jr. The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci USA 2001;98:355-360.
151. Takizawa T, Yoshikawa H, Yamada M, Morita H. Expression of nitric oxide synthase isoforms and detection of nitric oxide in rat placenta. Am J Physiol, Cell Physiol 2002;282:C762-C767. (Pubitemid 34663138)
152. Mordvintcev P, Msch A, Busse R, Vanin A. On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy. Anal Biochem 1991;199:142-146.
153. Vanin AF, Poltorakov AP, Mikoyan VD, Kubrina LN, van Faassen E. Why iron-dithiocarbamates ensure detection of nitric oxide in cells and tissues. Nitric Oxide 2006;15:295-311. (Pubitemid 44647887)
154. Kleschyov AL, Wenzel P, Munzel T. Electron paramagnetic resonance (EPR) spin trapping of biological nitric oxide. J Chromatogr B Analyt Technol Biomed Life Sci 2007;851:12-20. (Pubitemid 46720140)
155. Hogg N. Detection of nitric oxide by electron paramagnetic resonance spectroscopy. Free Radic Biol Med 2010;49:122-129.
156. Fujii S, Suzuki Y, Yoshimura T, Kamada H. In vivo threedimensional EPR imaging of nitric oxide production from isosorbide dinitrate in mice. Am J Physiol 1998;274:G857-G862.
157. Hall DM, Buettner GR, Gisolfi CV. In vivo detection of nitric oxide and NOx species using ex vivo electron paramagnetic resonance spectroscopy. Microchem J 1997;56:165-170. (Pubitemid 127402424)
158. Okamoto M, Tsuchiya K, Kanematsu Y, Izawa Y, Yoshizumi M, Kagawa S et al. Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney. Am J Physiol Renal Physiol 2005;288:F182-F187. (Pubitemid 40038690)
159. Filipovï MR, Stanï D, Raïevï S, Spasï M, Niketï V. Consequences of MnSOD interactions with nitric oxide: Nitric oxide dismutation and the generation of peroxynitrite and hydrogen peroxide. Free Radic Res 2007;41:62-72.
160. Basu TK, Temple NJ, Garg ML. Antioxidants in Human Health and Disease. Oxon: CABI Publishing, 1999.
161. Cadenas E, Packer L. Handbook of Antioxidants. New York: Marcel Dekker, 2002.
162. Halliwell B. Antioxidant characterization. Methodology and mechanism. Biochem Pharmacol 1995;49:1341-1348.
163. EFSA Panel on NDA. Scientific Opinion on the substantiation of health claims related to various food(s)/food constituent(s) and protection of cells from premature aging, antioxidant activity, antioxidant content and antioxidant properties, and protection of DNA, proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 2010;8:1752.
164. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay. Anal Biochem 1996;239:70-76.
165. Spasojevï I, Mojovï M, Blagojevï D, Spasï S, Jones D, Nikolï-Kokï A et al. Relevance of the capacity of phosphorylated fructose to scavenge the hydroxyl radical. Carbohydr Res 2009;344:80-84.
166. Živkovï J, Zekovï Z, Mujï I, Godevac D, Mojovï M, Mujï A, Spasojevï I. EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of Castanea sativa. Food Biophys 2009;4:126-133
167. Niwano Y, Saito K, Yoshizaki F, Kohno M, Ozawa T. Extensive screening for herbal extracts with potent antioxidant properties. J Clin Biochem Nutr 2011;48:78-84.
168. Wettasinghe M, Shahidi F. Scavenging of reactive-oxygen species and DPPH free radicals by extracts of borage and evening primrose meals. Food Chem 2000;70:17-26. (Pubitemid 30227577)
169. Lee Y, Jian S, Lian P, Mau J. Antioxidant properties of extracts from a white mutant of the mushroom Hypsizigus marmoreus. J Food Compos Anal 2008;21:116-124. (Pubitemid 350154440)
170. Mau J, Tsai S, Tseng Y, Huang S. Antioxidant properties of methanolic extracts from Ganoderma tsugae. Food Chem 2005;93:641-649. (Pubitemid 40804277)
171. Yen G, Chen H. Antioxidant activity of various tea extracts in relation to their antimutagenicity. J Agric Food Chem 1995;43:27-32.
172. Madsen HL, Nielsen BR, Bertelsen G, Skibsted LH. Screening of antioxidative activity of spices. A comparison between assays based on ESR spin trapping and electrochemical measurement of oxygen consumption. Food Chem 1996;57:331-337. (Pubitemid 26376793)
173. Lens M, Medenica L, Citernesi U. Antioxidative capacity of C(60) (buckminsterfullerene) and newly synthesized fulleropyrrolidine derivatives encapsulated in liposomes. Biotechnol Appl Biochem 2008;51:135-140.
174. Pasanphan W, Buettner GR, Chirachanchai S. Chitosan gallate as a novel potential polysaccharide antioxidant: An EPR study. Carbohydr Res 2010;345:132-140.
175. Stocker P, Lesgards JF, Vidal N, Chalier F, Prost M. ESR study of a biological assay on whole blood: Antioxidant efficiency of various vitamins. Biochim Biophys Acta 2003;1621:1-8. (Pubitemid 36349691)
176. Alvarez-Suarez JM, Tulipani S, Diz D, Estevez Y, Romandini S, Giampieri F et al. Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds. Food Chem Toxicol 2010;48:2490-2499.
177. Rimbach G, De Pascual-Teresa S, Ewins BA, Matsugo S, Uchida Y, Minihane AM et al. Antioxidant and free radical scavenging activity of isoflavone metabolites. Xenobiotica 2003;33: 913-925. (Pubitemid 37255402)
178. Sato E, Kato M, Kohno M, Niwano Y. Clindamycin phosphate scavenges hydroxyl radical. Int J Dermatol 2007;46:1185-1187. (Pubitemid 350055891)
179. Gavella M, Kveder M, Lipovac V, Jurasin D, Filipovi-Vincekovic N. Antioxidant properties of ganglioside micelles. Free Radic Res 2007;41:1143-1150. (Pubitemid 47470852)
180. Kladna A, Aboul-Enein HY, Kruk I, Lichszteld K, Michalska T. Scavenging of reactive oxygen species by some nonsteroidal anti-inflammatory drugs and fenofibrate. Biopolymers 2006;82:99-105. (Pubitemid 43798158)
181. Jang MH, Kim HY, Kang KS, Yokozawa T, Park JH. Hydroxyl radical scavenging activities of isoquinoline alkaloids isolated from Coptis chinensis. Arch Pharm Res 2009;32:341-345.
182. Richter Y, Fischer B. Nucleotides and inorganic phosphates as potential antioxidants. J Biol Inorg Chem 2006;11:1063-1074. (Pubitemid 44786394)
183. Das KC, Misra HP. Hydroxyl radical scavenging and singlet oxygen quenching properties of polyamines. Mol Cell Biochem 2004;262:127-133. (Pubitemid 39158062)
184. Endo N, Oowada S, Sueishi Y, Shimmei M, Makino K, Fujii H et al. Serum hydroxyl radical scavenging capacity as quantified with iron-free hydroxyl radical source. J Clin Biochem Nutr 2009;45:193-201.
185. Saito K, Kohno M, Yoshizaki F, Niwano Y. Extensive screening for edible herbal extracts with potent scavenging activity against superoxide anions. Plant Foods Hum Nutr 2008;63:65-70.
186. Schafer FQ, Wang HP, Kelley EE, Cueno KL, Martin SM, Buettner GR. Comparing β-carotene, vitamin E and nitric oxide as membrane antioxidants. Biol Chem 2002;383:671-681. (Pubitemid 34506304)
187. Jones CM, Lawrence A, Wardman P, Burkitt MJ. Electron paramagnetic resonance spin trapping investigation into the kinetics of glutathione oxidation by the superoxide radical: Re-evaluation of the rate constant. Free Radic Biol Med 2002;32:982-990. (Pubitemid 34465650)
188. Dobšak P, Courderot-Masuyer S, Siegelova J, Svainova H, Janik J, Vergely-Vanriessen C, Rochette L. Antioxidant properties of aminoguanidine: A paramagnetic resonance test. Scripta Medica (Brno) 2001;74:45-54.
189. Zhao W, Richardson JS, Mombourquette MJ, Weil JA. An in vitro EPR study of the free-radical scavenging actions of the lazaroid antioxidants U-74500A and U-78517F. Free Radic Biol Med 1995;19:21-30.
190. Ichikawa H, Satoh K, Tobe T, Yasuda I, Ushio F, Matsumoto K et al. Free radical scavenging activity of propolis. Redox Rep 2002;7:347-350. (Pubitemid 36032931)
191. Dikalov S, Losik T, Arbiser JL. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem Pharmacol 2008;76:589-596.
192. Oziol L, Faure P, Vergely C, Rochette L, Artur Y, Chomard P et al. In vitro free radical scavenging capacity of thyroid hormones and structural analogues. J Endocrinol 2001;170:197-206. (Pubitemid 32677581)
193. Schroeder SR, White CW, Jones TN, Hendry-Hofer TB, Day BJ, Eaton SS. Impact of SOD-mimetic manganoporphyrins on spin trapping of superoxide and related artifacts. Appl Magn Reson 2010;40:125-134.
194. Braga PC, Culici M, Dal Sasso M, Falchi M, Spallino A. Free radical scavenging activity of erdosteine metabolite I investigated by electron paramagnetic resonance spectroscopy. Pharmacology 2010;85:195-202.
195. Ingold KU, Paul T, Young MJ, Doiron L. Invention of the first azo compound to serve as a superoxide thermal source under physiological conditions: Concept, synthesis, and chemical properties. J Am Chem Soc 1997;119:12364- 12365.
196. Hummel SG, Fischer AJ, Martin SM, Schafer FQ, Buettner GR. Nitric oxide as a cellular antioxidant: A little goes a long way. Free Radic Biol Med 2006;40:501-506. (Pubitemid 43139685)
197. Šentjurc M, Nemec M, Connor HD, Abram V. Antioxidant activity of Sempervivum tectorum and its components. J Agric Food Chem 2003;51:2766-2771.
198. Reed GH, Cohn M. Structural changes induced by substrates and anions at the active site of creatine kinase. Electron paramagnetic resonance and nuclear magnetic relaxation rate studies of the manganous complexes. J Biol Chem 1972;247:3073-3081.
199. Wente SR, Villalba M, Schramm VL, Rosen OM. Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor. Proc Natl Acad Sci USA 1990;87:2805-2809.
200. Bajï A, Zakrzewska J, Godjevac D, Andjus P, Jones DR, Spasï M et al. Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions. Carbohydr Res 2011;346:416-420.
201. Berliner LJ, Fujii H. In vivo spin trapping of nitric oxide. Antioxid Redox Signal 2004;6:649-656. (Pubitemid 38625385)
202. Ueda Y, Yokoyama H, Nakajima A, Takaki M, Nagatomo K, Doi T et al. In vivo EPR estimation of bilateral hippocampal antioxidant ability of rats with epileptogenesis induced by amygdalar FeCl3 microinjection. Epilepsia 2007;48:1947-1951. (Pubitemid 47537435)
203. Kocherginsky N, Swartz HM. Nitroxide Spin Labels. Reactions in Biology and Chemistry. Boca Raton: CRC Press, 1995.
204. Hemminga MA, Berliner LJ. ESR Spectroscopy in Membrane Biophysics. New York: Springer, 2007.
205. Hyde JS, Subczynski W. Spin-label oximetry. In: Berliner LJ, Reuben J, eds. Spin-labeling: Theory and Applications. New York: Plenum Press, 1989, pp. 399-425.
206. Dolenc D, Šentjurc M, Serša G. EPR oximetry: Reduction of cell respiration by vinblastine. Pflugers Arch 1996;431:R261-R262. (Pubitemid 26140986)
207. James PE, Grinberg OY, Michaels G, Swartz HM. Intraphagosomal oxygen in stimulated macrophages. J Cell Physiol 1995;163:241-247.
208. Liu KJ, Gast P, Moussavi M, Norby SW, Vahidi N, Walczak T et al. Lithium phthalocyanine: A probe for electron paramagnetic resonance oximetry in viable biological systems. Proc Natl Acad Sci USA 1993;90:5438-5442. (Pubitemid 23176175)
209. James PE, Grinberg OY, Goda F, Panz T, O'Hara JA, Swartz HM. Gloxy: An oxygen-sensitive coal for accurate measurement of low oxygen tensions in biological systems. Magn Reson Med 1997;38:48-58. (Pubitemid 27284263)
210. Ardenkjaer-Larsen JH, Laursen I, Leunbach I, Ehnholm G, Wistrand LG, Petersson JS et al. EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. J Magn Reson 1998;133:1-12. (Pubitemid 128450605)
211. Elas M, Williams BB, Parasca A, Mailer C, Pelizzari CA, Lewis MA et al. Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): Methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magn Reson Med 2003;49:682-691. (Pubitemid 36389978)
212. Bobko AA, Dhimitruka I, Eubank TD, Marsh CB, Zweier JL, Khramtsov VV. Trityl-based EPR probe with enhanced sensitivity to oxygen. Free Radic Biol Med 2009;47:654-658.
213. Goda F, O'Hara JA, Rhodes ES, Liu KJ, Dunn JF, Baï G et al. Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation. Cancer Res 1995;55: 2249-2252.
214. James PE, Baï G, Grinberg OY, Goda F, Dunn JF, Jackson SK et al. Endotoxin-induced changes in intrarenal pO2, measured by in vivo electron paramagnetic resonance oximetry and magnetic resonance imaging. Free Radic Biol Med 1996;21:25-34. (Pubitemid 26230402)
215. Liu KJ, Baï G, Hoopes PJ, Jiang J, Du H, Ou LC et al. Assessment of cerebral pO2 by EPR oximetry in rodents: Effects of anesthesia, ischemia, and breathing gas. Brain Res 1995;685:91-98.
216. Honzak L, Schara M, Koren A. EPR spin-probe oximetry of isolated skeletal muscle mitochondria. Acta Chim Slov 1993;40: 123-132.
217. Lai CS, Hopwood LE, Hyde JS, Lukiewicz S. ESR studies of O2 uptake by Chinese hamster ovary cells during the cell cycle. Proc Natl Acad Sci USA 1982;79:1166-1170. (Pubitemid 12105568)
218. Froncisz W, Lai CS, Hyde JS. Spin-label oximetry: Kinetic study of cell respiration using a rapid-passage T1-sensitive electron spin resonance display. Proc Natl Acad Sci USA 1985;82: 411-415. (Pubitemid 15128276)
219. Baï G. In vivo EPR oximetry. Jugoslav Physiol Pharmaol Acta 1998;34:429-445.
220. Glockner JF, Norby SW, Swartz HM. Simultaneous measurement of intracellular and extracellular oxygen concentrations using a nitroxide-liposome system. Magn Reson Med 1993;29:12-18. (Pubitemid 23063063)
221. Brustolon M, Giamello E. Electron Paramagnetic Resonance. A Practitioner's Toolkit. Hoboken: John Wiley & Sons, 2009.
222. Holli S. Membrane fluidity of blood cells. Haematologia (Budap) 1996;27:109-127.
223. Zicha J, Kunes J, Devynck MA. Abnormalities of membrane function and lipid metabolism in hypertension: A review. Am J Hypertens 1999;12:315-331. (Pubitemid 29147359)
224. Tsuda K, Nishio I. Membrane fluidity and hypertension. Am J Hypertens 2003;16:259-261. (Pubitemid 36293074)
225. Dominiczak AF, Lazar DF, Das AK, Bohr DF. Lipid bilayer in genetic hypertension. Hypertension 1991;18:748-757.
226. Koter M, Franiak I, Strychalska K, Broncel M, Chojnowska-Jezierska J. Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia. Int J Biochem Cell Biol 2004;36:205-215. (Pubitemid 37487756)
227. Korkmaz M. In vitro effects of sodium fluoride and sodium dichromate on dynamic properties of human erythrocyte membrane. Biophys Chem 2000;83:111-120.
228. Cooper P, Kudynska J, Buckmaster HA, Kudynski R. An EPR investigation of spin-labelled erythrocytes as a diagnostic technique for malignant hyperthermia. Biochim Biophys Acta 1992;1139:70-76.
229. Tsuda K, Kimura K, Nishio I. Leptin improves membrane fluidity of erythrocytes in humans via a nitric oxide-dependent mechanism-an electron paramagnetic resonance investigation. Biochem Biophys Res Commun 2002;297:672-681.
230. Holmes DE, Piette LH. Effects of phenothiazine derivatives on biological membranes: Drug-induced changes in electron spin resonance spectra from spin-labeled erythrocyte ghost membranes. J Pharmacol Exp Ther 1970;173:78-84.
231. AjdŽanovï V, Spasojevï I, Filipovï B, ŠoŠï-Jurjevï B, Sekulï M, MiloŠevï V. Effects of genistein and daidzein on erythrocyte membrane fluidity: An electron paramagnetic resonance study. Can J Physiol Pharmacol 2010;88:497-500.
232. Stali A, Šentjuri M, SerŠa G, Novakovï S. The influence of TNF on the membrane fluidity of tumor cells. Cancer Lett 1992;65:183-187.
233. Vigo-Pelfrey C. Membrane lipid oxidation. Boca Raton: CRC Press, 1990.
234. Watanabe H, Kobayashi A, Yamamoto T, Suzuki S, Hayashi H, Yamazaki N. Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium. Free Radic Biol Med 1990;8:507-514. (Pubitemid 20204415)
235. Winterbourn CC, Hampton MB. Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 2008;45:549-561.
236. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-77.
237. Khramtsov VV, Yelinova VI, Weiner LM, Berezina TA, Martin VV, Volodarsky LB. Quantitative determination of SH groups in low-and high-molecular-weight compounds by an electron spin resonance method. Anal Biochem 1989;182:58-63. (Pubitemid 19251282)
238. Khramtsov VV, Yelinova VI, Glazachev YuI, Reznikov VA, Zimmer G. Quantitative determination and reversible modification of thiols using imidazolidine biradical disulfide label. J Biochem Biophys Methods 1997;35:115-128. (Pubitemid 27414542)
239. Berliner LJ, Khramtsov V, Fujii H, Clanton TL. Unique in vivo applications of spin traps. Free Radic Biol Med 2001;30:489-499. (Pubitemid 32162955)
240. Yelinova V, Glazachev Y, Khramtsov V, Kudryashova L, Rykova V, Salganik R. Studies of human and rat blood under oxidative stress: Changes in plasma thiol level, antioxidant enzyme activity, protein carbonyl content, and fluidity of erythrocyte membrane. Biochem Biophys Res Commun 1996;221:300-303. (Pubitemid 26136466)
241. Nohl H, Stolze K, Weiner LM. Noninvasive measurement of thiol levels in cells and isolated organs. Meth Enzymol 1995;251:191-203.
242. Weiner LM. Stable nitroxyl radicals as pH, thiol and electron transfer probes. Appl Magn Reson 2007;31:357-373.
243. Roshchupkina GI, Bobko AA, Bratasz A, Reznikov VA, Kuppusamy P, Khramtsov VV. In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe. Free Radic Biol Med 2008;45:312-320.
244. Bergamini S, Rota C, Staffieri M, Tomasi A, Iannone A. Prooxidant activity of ferrioxamine in isolated rat hepatocytes and linoleic acid micelles. Chem Res Toxicol 1999;12:365-370. (Pubitemid 29193913)
245. Welin AK, Sandberg M, Lindblom A, Arvidsson P, Nilsson UA, Kjellmer I et al. White matter injury following prolonged free radical formation in the 0.65 gestation fetal sheep brain. Pediatr Res 2005;58:100-105. (Pubitemid 40967437)
246. Garner B, Davies MJ, Truscott RJ. Formation of hydroxyl radicals in the human lens is related to the severity of nuclear cataract. Exp Eye Res 2000;70:81-88. (Pubitemid 30046877)
247. Timmins GS, Davies MJ. Free radical formation in murine skin treated with tumour promoting organic peroxides. Carcinogenesis 1993;14:1499-1503. (Pubitemid 23249349)
248. KasparoVS, BrezoVV, Valko M, Horecḱ J, Mlynik V, Liptaj T et al. Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem Int 2005;46:601-611.
249. Schoenberg MH, Hierl TC, Zhao J, Wohlgemuth N, Nilsson UA. The generation of oxygen radicals after drinking of oxygenated water. Eur J Med Res 2002;7:109-116.
250. Benderitter M, Hadj-Saad F, Lhuissier M, Maupoil V, Guilland JC, Rochette L. Effects of exhaustive exercise and vitamin B6 deficiency on free radical oxidative process in male trained rats. Free Radic Biol Med 1996;21:541-549. (Pubitemid 26313952)
251. Rousseau I, Puntarulo S. Ferritin-dependent radical generation in rat liver homogenates. Toxicology 2009;264:155-161.
252. Duan S, Gu L, Wang Y, Zheng R, Lu J, Yin J et al. Regulation of influenza virus-caused oxidative stress by Kegan Liyan oral prescription, as monitored by ascorbyl radical ESR signals. Am J Chin Med 2009;37:1167-1177.
253. Pietri S, Culcasi M, Stella L, Cozzone PJ. Ascorbyl free radical as a reliable indicator of free-radical-mediated myocardial ischemic and post-ischemic injury. A real-time continuous-flow ESR study. Eur J Biochem 1990;193:845-854. (Pubitemid 20381717)
254. Vergely C, Maupoil V, Benderitter M, Rochette L. Influence of the severity of myocardial ischemia on the intensity of ascorbyl free radical release and on postischemic recovery during reperfusion. Free Radic Biol Med 1998;24:470-479. (Pubitemid 28008792)
255. Matsuo Y, Kihara T, Ikeda M, Ninomiya M, Onodera H, Kogure K. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: Effect of neutrophil depletion on extracellular ascorbyl radical formation. J Cereb Blood Flow Metab 1995;15:941-947.
256. Minakata K, Suzuki O, Saito S, Harada N. Ascorbate radical levels in human sera and rat plasma intoxicated with paraquat and diquat. Arch Toxicol 1993;67:126-130. (Pubitemid 23054303)
257. Hubel CA, Kagan VE, Kisin ER, McLaughlin MK, Roberts JM. Increased ascorbate radical formation and ascorbate depletion in plasma from women with preeclampsia: Implications for oxidative stress. Free Radic Biol Med 1997;23: 597-609. (Pubitemid 27287343)
258. Galley HF, Davies MJ, Webster NR. Xanthine oxidase activity and free radical generation in patients with sepsis syndrome. Crit Care Med 1996;24:1649-1653. (Pubitemid 26347376)
259. Stark JM, Jackson SK, Rowlands CC, Evans JC. Increases in ascorbate free radical concentration after endotoxin in mice. In: Rice-Evans C, Halliwell B, eds. Free Radicals: Methodology and Concepts. London: Richelieu Press, 1988, pp. 201-209.
260. Purohit SB, Saxena D, Laloraya M, Kumar G P. Altered molecular dynamics and antioxidant status in the spermatozoa in testosterone-induced oligospermia in mouse. Mol Reprod Dev 2000;55:316-325. (Pubitemid 30082893)
261. Chi C, Tanaka R, Okuda Y, Ikota N, Yamamoto H, Urano S et al. Quantitative measurements of oxidative stress in mouse skin induced by X-ray irradiation. Chem Pharm Bull 2005;53:1411-1415. (Pubitemid 41634208)
262. Lavi R, Shainberg A, Shneyvays V, Hochauser E, Isaac A, Zinman T et al. Detailed analysis of reactive oxygen species induced by visible light in various cell types. Lasers Surg Med 2010;42:473-480.
263. Hay A, Burkitt MJ, Jones CM, Hartley RC. Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7′-carboxyhept-1′-yloxy) benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes. Arch Biochem Biophys 2005;435:336-346. (Pubitemid 40222473)
264. Anderson RA, Ellis GR, Chirkov YY, Holmes AS, Payne N, Blackman DJ et al. Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure. Eur J Heart Fail 2004;6:47-54. (Pubitemid 38169604)
265. Matsui S, Takahashi C, Tsujimoto Y, Matsushima K. Stimulatory effects of low-concentration reactive oxygen species on calcification ability of human dental pulp cells. J Endod 2009;35:67-72.
266. Zweier JL, Broderick R, Kuppusamy P, Thompson-Gorman S, Lutty GA. Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. J Biol Chem 1994;269:24156-24162. (Pubitemid 24300954)
267. Ueda Y, Noor JI, Nagatomo K, Doi T, Ikeda T, Nakajima A et al. Generation of lipid radicals in the hippocampus of neonatal rats after acute hypoxic-ischemic brain damage. Exp Brain Res 2006;169:117-121. (Pubitemid 43286728)
268. Pieper GM, Felix CC, Kalyanaraman B, Turk M, Roza AM. Detection by ESR of DMPO hydroxyl adduct formation from islets of Langerhans. Free Radic Biol Med 1995;19:219-225.
269. Togashi H, Shinzawa H, Matsuo T, Takeda Y, Takahashi T, Aoyama M et al. Analysis of hepatic oxidative stress status by electron spin resonance spectroscopy and imaging. Free Radic Biol Med 2000;28:846-853. (Pubitemid 30235156)
270. Deschacht M, Horemans T, Martinet W, Bult H, Maes L, Cos P. Comparative EPR study of different macrophage types stimulated for superoxide and nitric oxide production. Free Radic Res 2010;44:763-772.
271. O'Donnell V, Burkitt MJ. Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: An electron spin resonance spin-trapping investigation. Biochem J 1994;304:707-713.
272. Chen YR, Chen CL, Yeh A, Liu X, Zweier JL. Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase. J Biol Chem 2006;281:13159- 13168. (Pubitemid 43855227)
273. Ali SS, Young JW, Wallace CK, Gresack J, Jeste DV, Geyer MA et al. Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice. Brain Res 2011;1368:65-70.
274. Reguli J, DurackoVZ, PoGy J, MartisoVD, Stasko A. [EPR spin trapping of reactive oxygen products of the respiratory burst of phagocytes (use of EPR spectroscopy in biology and medicine. II)]. Bratisl Lek Listy 1992;93:557-567.
275. Priai L, Ichimori K, Nozaki H, Nakazawa H, Okino H, Carmichael AJ et al. Investigation of the existence and biological role of L-arginine/nitric oxide pathway in human platelets by spintrapping/EPR studies. Eur J Biochem 1991;202:923-930.
276. Hsiao G, Shen MY, Chou DS, Chang Y, Lee LW, Lin CH et al. Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies. Eur J Pharmacol 2004;487:159-166. (Pubitemid 38368993)
277. Kim SR, Jockusch S, Itagaki Y, Turro NJ, Sparrow JR. Mechanisms involved in A2E oxidation. Exp Eye Res 2008;86:975-982.
278. Zhang H, Zheng RL. Promotion of human sperm capacitation by superoxide anion. Free Radic Res 1996;24:261-268. (Pubitemid 26144649)
279. Asada R, Kageyama K, Tanaka H, Matsui H, Kimura M, Saitoh Y et al. Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Oncol Rep 2010;24:1463-1470.
280. Luo Z, Chen Y, Chen S, Welch WJ, Andresen BT, Jose PA et al. Comparison of inhibitors of superoxide generation in vascular smooth muscle cells. Br J Pharmacol 2009;157:935-943.
281. Ranguelova K, Bonini MG, Mason RP. (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radicalinitiated protein radical formation. Environ Health Perspect 2010;118:970-975.
282. Yu Q, Purwaha P, Ni K, Sun C, Mallik S, Qian SY. Characterization of novel radicals from COX-catalyzed arachidonic acid peroxidation. Free Radic Biol Med 2009;47:568-576.
283. Ranguelova K, Chatterjee S, Ehrenshaft M, Ramirez DC, Summers FA, Kadiiska MB et al. Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite. J Biol Chem 2010;285:24195-24205.
284. Zhu H, Jia Z, Mahaney JE, Ross D, Misra HP, Trush MA et al. The highly expressed and inducible endogenous NAD(P) H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger. Cardiovasc Toxicol 2007;7: 202-211. (Pubitemid 47575005)
285. Cheng Q, Antholine WE, Myers JM, Kalyanaraman B, Arn ES, Myers CR. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. J Biol Chem 2010;285:21708-21723.
286. Tada M, Kohno M, Kasai S, Niwano Y. Generation mechanism of radical species by tyrosine-tyrosinase reaction. J Clin Biochem Nutr 2010;47:162-166.
287. Sennoun N, Nacira S, Meziani F, Dessebe O, Cattan V, Collin S et al. Activated protein C improves lipopolysaccharide-induced cardiovascular dysfunction by decreasing tissular inflammation and oxidative stress. Crit Care Med 2009;37:246-255.
288. Ghio AJ, Kadiiska MB, Xiang QH, Mason RP. In vivo evidence of free radical formation after asbestos instillation: An ESR spin trapping investigation. Free Radic Biol Med 1998;24:11-17. (Pubitemid 28006431)
289. Reszka KJ, McGraw DW, Britigan BE. Peroxidative metabolism of β2-agonists salbutamol and fenoterol and their analogues. Chem Res Toxicol 2009;22:1137-1150.
290. Sato K, Tashiro Y, Chibana S, Yamashita A, Karakawa T, Kohrogi H. Role of lipid-derived free radical in bleomycin-induced lung injury in mice: Availability for ESR spin trap method with organic phase extraction. Biol Pharm Bull 2008;31:1855-1859.
291. Liu J, Qian SY, Guo Q, Jiang J, Waalkes MP, Mason RP et al. Cadmium generates reactive oxygen-and carbon-centered radical species in rats: Insights from in vivo spin-trapping studies. Free Radic Biol Med 2008;45:475-481.
292. Hataji K, Watanabe T, Oowada S, Nagaya M, Kamibayashi M, Murakami E et al. Effects of a calcium-channel blocker (CV159) on hepatic ischemia/reperfusion injury in rats: Evaluation with selective NO/pO2 electrodes and an electron paramagnetic resonance spin-trapping method. Biol Pharm Bull 2010;33:77-83.
293. Usami N, Yamamoto I, Watanabe K. Generation of reactive oxygen species during mouse hepatic microsomal metabolism of cannabidiol and cannabidiol hydroxy-quinone. Life Sci 2008;83:717-724.
294. Lamblin G, Leprince J, Devaux J, Mestdagh M, Gallez B, Leloup G. Hydroxyl radical release from dental resins: Electron paramagnetic resonance evidence. Acta Biomater 2010;6:3193-3198.
295. Aliaga ME, LIez-Alarc C, Barriga G, Olea-Azar C, Speisky H. Redox-active complexes formed during the interaction between glutathione and mercury and/or copper ions. J Inorg Biochem 2010;104:1084-1090.
296. Lev-Goldman V, Mester B, Ben-Aroya N, Hanoch T, Rupp B, Stanoeva T et al. Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation. Bioorg Med Chem 2008;16:6789-6798.
297. Bhattacharjee S, Deterding LJ, Jiang J, Bonini MG, Tomer KB, Ramirez DC et al. Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: Spin trapping analysis. J Am Chem Soc 2007;129:13493-13501. (Pubitemid 350071777)
298. Van der Zee J. Formation of peroxide-and globin-derived radicals from the reaction of methaemoglobin and metmyoglobin with t-butyl hydroperoxide: An ESR spin-trapping investigation. Biochem J 1997;322 (Pt 2):633-639. (Pubitemid 127737319)
299. Rees MD, McNiven TN, Davies MJ. Degradation of extracellular matrix and its components by hypobromous acid. Biochem J 2007;401:587-596. (Pubitemid 46166440)
300. Hempel SL, Buettner GR, Wessels DA, Galvan GM, O'Malley YQ. Extracellular iron (II) can protect cells from hydrogen peroxide. Arch Biochem Biophys 1996;330:401-408. (Pubitemid 26172377)
301. Panzella L, Szewczyk G, d'Ischia M, Napolitano A, Sarna T. Zincinduced structural effects enhance oxygen consumption and superoxide generation in synthetic pheomelanins on UVA/visible light irradiation. Photochem Photobiol 2010;86:757-764.
302. Mori T, Ito S, Namiki M, Suzuki T, Kobayashi S, Matsubayashi K et al. Involvement of free radicals followed by the activation of phospholipase A2 in the mechanism that underlies the combined effects of methamphetamine and morphine on subacute toxicity or lethality in mice: Comparison of the therapeutic potential of fullerene, mepacrine, and cooling. Toxicology 2007;236:149-157. (Pubitemid 46992694)
303. Noda Y, Mankura M. Inhibitory effect of antioxidants on hydroxyl radical generation from methylguanidine: An ESR study. Neurochem Res 2009;34:734-738.
304. Voinov MA, Sosa PaG JO, Morrison E, Smirnova TI, Smirnov AI. Surface-mediated production of hydroxyl radicals as a mechanism of iron oxide nanoparticle biotoxicity. J Am Chem Soc 2011;133:35-41.
305. Crouzier D, Follot S, Gentilhomme E, Flahaut E, Arnaud R, Dabouis V et al. Carbon nanotubes induce inflammation but decrease the production of reactive oxygen species in lung. Toxicology 2010;272:39-45.
306. Velayutham M, Muthukumaran RB, Sostaric JZ, McCraken J, Fishbein JC, Zweier JL. Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: A novel pathway for cancer chemoprevention. Free Radic Biol Med 2007;43:1076-1085. (Pubitemid 47307416)
307. Kadiiska MB, Hanna PM, Mason RP. In vivo ESR spin trapping evidence for hydroxyl radical-mediated toxicity of paraquat and copper in rats. Toxicol Appl Pharmacol 1993;123:187-192. (Pubitemid 23359260)
308. Cruz TS, Faria PA, Santana DP, Ferreira JC, Oliveira V, Nascimento OR et al. On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca2+ dependence, and cyt c release. Biochem Pharmacol 2010;80:1284-1295.
309. Martins J, Almeida L, Laranjinha J. Simultaneous production of superoxide radical and singlet oxygen by sulphonated chloroaluminum phthalocyanine incorporated in human lowdensity lipoproteins: Implications for photodynamic therapy. Photochem Photobiol 2004;80:267-273.
310. Masuda K, Hori T, Tanabe K, Kano Y, Hirayama A, Nagase S. Proanthocyanidin promotes free radical-scavenging activity in muscle tissues and plasma. Appl Physiol Nutr Metab 2007;32:1097-1104.
311. Imaram W, Gersch C, Kim KM, Johnson RJ, Henderson GN, Angerhofer A. Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry. Free Radic Biol Med 2010;49:275-281.
312. Shinde SS, Hay MP, Patterson AV, Denny WA, Anderson RF. Spin trapping of radicals other than the OH? radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase. J Am Chem Soc 2009;131:14220-14221.
313. Hiramatsu M, Kohno M, Edamatsu R, Mitsuta K, Mori A. Increased superoxide dismutase activity in aged human cerebrospinal fluid and rat brain determined by electron spin resonance spectrometry using the spin trap method. J Neurochem 1992;58:1160-1164.
314. Ogura A, Oowada S, Kon Y, Hirayama A, Yasui H, Meike S et al. Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells. Cancer Lett 2009;277:64-71.
315. Busik JV, Mohr S, Grant MB. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes 2008;57:1952-1965.
316. Butterfield DA, Hensley K, Harris M, Mattson M, Carney J. β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease. Biochem Biophys Res Commun 1994;200:710-715.
317. Iannone A, Marconi A, Zambruno G, Giannetti A, Vannini V, Tomasi A. Free radical production during metabolism of organic hydroperoxides by normal human keratinocytes. J Invest Dermatol 1993;101:59-63. (Pubitemid 23213013)
318. Valavanidis A, Vlahoyianni T, Fiotakis K. Comparative study of the formation of oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct from the nucleoside 2′-deoxyguanosine by transition metals and suspensions of particulate matter in relation to metal content and redox reactivity. Free Radic Res 2005;39:1071-1081. (Pubitemid 41358561)
319. Yokoyama K, Tomino Y, Yaguchi Y, Koide H, Ohmori D, Yamakura F. [Serum superoxide dismutase (SOD) activity in patients with renal disease by a spintrap method using electron spin resonance (ESR)]. Nippon Jinzo Gakkai Shi 1993;35:809-814.
320. Constantin D, Bini A, Meletti E, Moldeus P, Monti D, Tomasi A. Age-related differences in the metabolism of sulphite to sulphate and in the identification of sulphur trioxide radical in human polymorphonuclear leukocytes. Mech Ageing Dev 1996;88:95-109. (Pubitemid 26184635)
321. Li H, van Berlo D, Shi T, Speit G, Knaapen AM, Borm PJ et al. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl Pharmacol 2008;227:115-124. (Pubitemid 351179846)
322. Pincemail J, Defraigne JO, Franssen C, Defechereux T, Canivet JL, Philippart C et al. Evidence of in vivo free radical generation by spin trapping with α-phenyl N-tert-butyl nitrone during ischemia/reperfusion in rabbit kidneys. Free Radic Res Commun 1990;9:181-186. (Pubitemid 20376770)
323. Ihara Y, Mori A, Hayabara T, Namba R, Nobukuni K, Sato K et al. Free radicals, lipid peroxides and antioxidants in blood of patients with myotonic dystrophy. J Neurol 1995;242: 119-122.
324. Tan EC, Bahrami S, Kozlov AV, Kurvers HA, Ter Laak HJ, Nohl H et al. The oxidative response in the chronic constriction injury model of neuropathic pain. J Surg Res 2009;152:84-88.
325. Kennedy CH, Hatch GE, Slade R, Mason RP. Application of the EPR spin-trapping technique to the detection of radicals produced in vivo during inhalation exposure of rats to ozone. Toxicol Appl Pharmacol 1992;114:41-46.
326. Nowak P, Kostrzewa RA, Skaba D, Kostrzewa RM. Acute L:-DOPA effect on hydroxyl radical-and DOPAC-levels in striatal microdialysates of parkinsonian rats. Neurotox Res 2010;17:299-304.
327. Dalal NS, Newman J, Pack D, Leonard S, Vallyathan V. Hydroxyl radical generation by coal mine dust: Possible implication to coal workers' pneumoconiosis (CWP). Free Radic Biol Med 1995;18:11-20.
328. Miyakawa H, Mason RP, Jiang J, Kadiiska MB. Lipid-derived free radical production in superantigen-induced interstitial pneumonia. Free Radic Biol Med 2009;47:241-249.
329. Atkins JL, Gorbunov NV, Trabosh V, Van Duyne R, Kashanchi F, Komarov AM. Ferrous iron is found in mesenteric lymph bound to TIMP-2 following hemorrhage/resuscitation. Biometals 2011;24:279-289.
330. Chatterjee S, Lardinois O, Bhattacharjee S, Tucker J, Corbett J, Deterding L et al. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med 2011;50:988-999.
331. Shi X, Mao Y, Daniel LN, Saffiotti U, Dalal NS, Vallyathan V. Silica radical-induced DNA damage and lipid peroxidation. Environ Health Perspect 1994;102 Suppl 10:149-154.
332. Ueno S, Kashimoto T, Susa N, Ishikawa M, Kawagoe T, Mizuta K et al. Smoking induces bimodal DNA damage in mouse lung. Toxicol Sci 2011;120:322-330.
333. Reszka K, Eldred GE, Wang RH, Chignell C, Dillon J. The photochemistry of human retinal lipofuscin as studied by EPR. Photochem Photobiol 1995;62:1005-1008.
334. Dohi K, Satoh K, Nakamachi T, Ohtaki H, Yofu S, Nakamura S et al. Novel free radical monitoring in patients with neurological emergency diseases. Acta Neurochir Suppl 2010;106:315-319.
335. Weaver J, Porasuphatana S, Tsai P, Budzichowski T, Rosen GM. Spin trapping nitric oxide from neuronal nitric oxide synthase: A look at several iron-dithiocarbamate complexes. Free Radic Res 2005;39:1027-1033. (Pubitemid 41358557)
336. Khoo JP, Alp NJ, Bendall JK, Kawashima S, Yokoyama M, Zhang YH et al. EPR quantification of vascular nitric oxide production in genetically modified mouse models. Nitric Oxide 2004;10:156-161. (Pubitemid 38678616)
337. Bayir H, Kagan VE, Borisenko GG, Tyurina YY, Janesko KL, Vagni VA et al. Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: Support for a neuroprotective role of iNOS. J Cereb Blood Flow Metab 2005;25:673-684. (Pubitemid 40705603)
338. Kleschyov AL, Oelze M, Daiber A, Huang Y, Mollnau H, Schulz E et al. Does nitric oxide mediate the vasodilator activity of nitroglycerin Circ Res 2003;93:e104-e112.
339. Sorrentino SA, Doerries C, Manes C, Speer T, Dessy C, Lobysheva I et al. Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional 1-blockade. J Am Coll Cardiol 2011;57:601-611.
340. Trujillo-Ferrara J, Campos-Rodriuez R, Lara-Padilla E, RaMez-Rosales D, Correa Basurto J, Miliar Garcia A et al. Caloric restriction increases free radicals and inducible nitric oxide synthase expression in mice infected with Salmonella Typhimurium. Biosci Rep 2011;31:273-282.
341. Zerr-Fouineau M, Jourdain M, Boesch C, Hecker M, Bronner C, Schini-Kerth VB. Certain progestins prevent the enhancing effect of 17β-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells. Arterioscler Thromb Vasc Biol 2009;29:586-593.
342. Oak JH, Youn JY, Cai H. Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice. Cardiovasc Diabetol 2009;8:65.
343. Auger C, Chaabi M, Anselm E, Lobstein A, Schini-Kerth VB. The red wine extract-induced activation of endothelial nitric oxide synthase is mediated by a great variety of polyphenolic compounds. Mol Nutr Food Res 2010;54 Suppl 2:S171-S183.
344. Suga A, Narita T, Zhou L, Sakagami H, Satoh K, Wakabayashi H. Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by benzo[b]cyclohept[e] [1,4]oxazine and 2-aminotropone derivatives. In Vivo 2009;23:691-697.
345. Katsumi H, Nishikawa M, Yasui H, Yamashita F, Hashida M. Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice. J Control Release 2009;140:12-17.
346. Sun H, Gutierrez P, Jackson MJ, Kundu N, Fulton AM. Essential role of nitric oxide and interferon-γ for tumor immunotherapy with interleukin-10. J Immunother 2000;23:208-214. (Pubitemid 30165170)
347. Ponnuswamy P, Ostermeier E, Schritle A, Chen J, Huang PL, Ertl G et al. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 2009;174:2400-2410.
348. Bratasz A, Selvendiran K, Wasowicz T, Bobko A, Khramtsov VV, Ignarro LJ et al. NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. J Transl Med 2008;6:9.
349. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M et al. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am J Physiol Heart Circ Physiol 2009;297:H331-H339.
350. RIsig L, Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Msch A et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem 1999;274:6823-6826.
351. Fujii S, Akaike T, Maeda H. Role of nitric oxide in pathogenesis of herpes simplex virus encephalitis in rats. Virology 1999;256:203-212. (Pubitemid 29393355)
352. Adrianov VV, Sitdikov FG, Gainutdinov KhL, Iurtaeva SV, Iafarova GG, Muranova LN et al. [Changes in nitric oxide in heart of intact and sympathectomized rats of different age]. Ontogenez 2008;39:437-442.
353. Csont T, Csonka C, KoVs P, Jancs G, Ferdinandy P. Capsaicinsensitive sensory neurons regulate myocardial nitric oxide and cGMP signaling. Eur J Pharmacol 2003;476:107-113. (Pubitemid 37315542)
354. Kline ER, Kleinhenz DJ, Liang B, Dikalov S, Guidot DM, Hart CM et al. Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. Am J Physiol Heart Circ Physiol 2008;294:H2792-H2804.
355. Yuan ZR, Liu B, Zhang Y, Yuan L, Muteliefu G, Lu J. Upregulated expression of neuronal nitric oxide synthase by insulin in both neurons and astrocytes. Brain Res 2004;1008:1-10. (Pubitemid 38469970)
356. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 2003;111:1201-1209. (Pubitemid 36519937)
357. Akaike T, Fujii S, Kato A, Yoshitake J, Miyamoto Y, Sawa T et al. Viral mutation accelerated by nitric oxide production during infection in vivo. Faseb J 2000;14:1447-1454. (Pubitemid 30439754)
358. Lecour S, Maupoil V, Zeller M, Laubriet A, Briot T, Rochette L. Levels of nitric oxide in the heart after experimental myocardial ischemia. J Cardiovasc Pharmacol 2001;37:55-63. (Pubitemid 32012932)
359. Bashkatova V, Vitskova G, Narkevich V, Vanin A, Mikoyan V, Rayevsky K. Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures. J Mol Neurosci 2000;14:183-190. (Pubitemid 30660808)
360. Lenasi H, Kohlstedt K, Fichtlscherer B, Msch A, Busse R, Fleming I. Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495. Cardiovasc Res 2003;59:844-853. (Pubitemid 38366240)
361. Yonekura Y, Koshiishi I, Yamada K, Mori A, Uchida S, Nakamura T et al. Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxidegenerating activity in adjuvant arthritis in rats. Nitric Oxide 2003;8:164-169. (Pubitemid 36765449)
362. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L et al. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol Heart Circ Physiol 2005;288:H7-12. (Pubitemid 40023821)
363. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001;88:E14-E22.
364. Mishra OP, Zanelli S, Ohnishi ST, Delivoria-Papadopoulos M. Hypoxia-induced generation of nitric oxide free radicals in cerebral cortex of newborn guinea pigs. Neurochem Res 2000;25:1559-1565. (Pubitemid 32052017)
365. Quaresima V, Takehara H, Tsushima K, Ferrari M, Utsumi H. In vivo detection of mouse liver nitric oxide generation by spin trapping electron paramagnetic resonance spectroscopy. Biochem Biophys Res Commun 1996;221:729-734. (Pubitemid 26153931)
366. Zweier JL, Wang P, Kuppusamy P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem 1995;270:304-307.
367. Kuppusamy P, Ohnishi ST, Numagami Y, Ohnishi T, Zweier JL. Three-dimensional imaging of nitric oxide production in the rat brain subjected to ischemia-hypoxia. J Cereb Blood Flow Metab 1995;15:899-903.
368. Kuppusamy P, Shankar RA, Roubaud VM, Zweier JL. Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: Detection of intrinsic nitrosoheme complexes. Magn Reson Med 2001;45:700-707. (Pubitemid 32260093)
369. Khan N, Wilmot CM, Rosen GM, Demidenko E, Sun J, Joseph J et al. Spin traps: In vitro toxicity and stability of radical adducts. Free Radic Biol Med 2003;34:1473-1481. (Pubitemid 36570419)
370. Weiner LM, Hu H, Swartz HM. EPR method for the measurement of cellular sulfhydryl groups. febs Lett 1991;290:243-246.